This study identified a novel HLA-A allele, HLA-A*01:195, in a UAE national. Sequencing analysis revealed a single nucleotide polymorphism (SNP) that results in an amino acid substitution - a valine instead of an isoleucine at position 124 of the alpha 1 chain of the HLA-A protein. Prediction tools indicate this mutation is likely intolerant and may impact the structure and function of the HLA-A protein. The allele was officially named HLA-A*01:195 by the WHO Nomenclature Committee and submitted to genetic databases. This finding provides new insights into genetic variations in the UAE population.