In the late 15th century, European powers sought new trade routes to Asia to share in its wealth. Pope Alexander VI drew a Line of Demarcation to determine which lands newly discovered west and east would belong to Spain and Portugal, respectively. However, Portugal demanded a change, and the 1494 Treaty of Tordesillas moved the line significantly west, allowing for further Spanish and Portuguese exploration. This led Spain to conquer the major Aztec and Inca empires in Central and South America through alliances with enemies, disease, and brutality towards native populations.