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Scientific Computing in the Cloud
Speeding Access for Drug Discovery
Jacob Feala, Bioinformatics Platform Lead, H3 Biomedicine
Bret Martin, Principal Research Computing Architect, H3 Biomedicine
Scott Jeschonek, Director of Product Management, Cloud Solutions, Avere Systems
Sabina Joseph, Global Ecosystem Segment Leader, Partnerships & Alliances, Amazon Web Services
September 22, 2015
Today’s Speakers
Jacob Feala Bret Martin Scott Jeschonek Sabina Joseph
Bioinformatics
Platform Lead
Principal Research
Computing Architect
Director of Product
Management, Cloud
Global Ecosystem
Segment Leader,
Partnerships & Alliances
Housekeeping
•  Recording
•  Resources
•  Questions
•  Please rate this webinar
Bioinformatics on the
cloud at H3
H3 vision:
Translate cancer patients’ genomes into powerful therapeutics
Cancer cells hijack the mRNA splicing machinery
•  Spliceosome genes have
recurrent mutations in some
types of cancer
•  These “hotspot” mutations
have been shown to alter
splicing in hundreds of mRNA
transcripts
mutations
DNA
pre-mRNA
splicing
mRNA
altered splicing normal splicing
RNA-seq is the driver for our mRNA splicing research
•  H3’s chemistry platform generates
compounds that can modulate splicing
•  H3 biologists can genetically engineer
the spliceosome mutations in cell lines
•  RNA-seq allows us to detect novel
splicing caused by drugs or mutations
mutations
drugs
DNA
pre-mRNA
splicing
mRNA
mRNA sequencing
altered splicing
When in doubt, just sequence it!
Plummeting
sequencing costs
+
Powerful
insights
=
Mounds of data
Early days on AWS: StarCluster and Amazon S3
•  Bash scripts submitted to
SunGrid Engine scheduler
•  All data downloaded and
uploaded to/from Amazon S3
•  Completely disjoint from local
development environment
Evolution of H3 NGS workflows: Luigi, Docker, and Avere
•  Atomic, idempotent workflow
scheduling with Luigi
•  Environment management with
Docker
•  Unified local/cloud filesystem
with Avere
•  Seamless transitions from
interactive work, to pipeline dev,
to scale-out
Evolving H3 Biomedicine’s
Bioinformatics Platform
Challenges
•  Management
–  Native AWS features (especially VPC and IAM)
–  Configuration management with Ansible
•  Compute challenges
–  Scalable compute infrastructure on Amazon EC2
–  Improving user experience with CycleCloud
•  Storage challenges
–  Pace of growth
–  Want to focus on science, not IT and storage management
–  Protect investment in on-premises storage in the medium term
–  Present traditional file system to “bridge” users to the cloud
H3 Biomedicine Architecture Overview
•  2 VPCs
•  1 Gbps Direct
Connect with VPN
backup
•  AWS services
accessed over
Direct Connect
H3 Biomedicine Architecture Overview
•  2 VPCs
•  1 Gbps Direct
Connect with VPN
backup
•  AWS services
accessed over
Direct Connect
H3 Biomedicine Architecture Overview
•  2 VPCs
•  1 Gbps Direct
Connect with VPN
backup
•  AWS services
accessed over
Direct Connect
What is Avere vFXT?
•  Virtual deployment of AvereOS using Amazon EC2 instances
–  3 x r3.2xlarge
–  4 TB encrypted Amazon EBS (10 x 400 GB volumes)
•  Deployed with AWS CloudFormation
•  Managed using web interface and SSH
•  Metrics available on things like hot files, hot clients, IOPS
Avere vFXT Enables H3 Biomedicine in the Cloud
•  Avere vFXT makes our on-premises EMC Isilon NAS storage usable
at AWS
•  Latency reduced from ~15ms to under 1ms for hot data
•  Same shared filesystems are available at AWS as “at home”
–  Home directories
–  Group directories (including many software tools)
–  Lab data directories
–  Scratch space
•  Provides a familiar environment to scientific staff, but with the
benefits of the cloud
Avere vFXT Tips
•  Setup will take under an hour, if you’re ready with
–  AWS account
–  VPC with connectivity to core filer
–  Security groups
•  Proper EC2/VPC security groups and firewall rules are essential
–  Allow traffic to your core filer from the vFXT
–  Allow traffic from your core filer to the vFXT
•  vFXT is not magic
–  You need permanent, reliable connectivity to your core filer
H3 Biomedicine Future Storage Plans
•  Replace some on-premises NAS capacity with physical Avere FXT
Series filers, providing NFS front end with S3 as backing store
•  Use Avere FlashMove migration capabilities to transparently move
data from on-premises NAS to S3 – without disrupting user access
•  Use vFXT for CIFS clients at AWS (Amazon WorkSpaces, regular
EC2 Windows instances)
•  Replace tape with S3 using AWS Storage Gateway
Avere Hybrid Cloud NAS
Enterprise Grade NAS for the Cloud
Avere combines Enterprise-grade NAS
with a complete feature set for the cloud.
Enterprise-
grade NAS
100% Cloud
Enabled
Cloud
Gateway
Vendors
Traditional
NAS
Vendors
•  NFS & SMB/
CIFS access
•  Clustering for
performance and
capacity scaling
•  Efficient use of
EBS and ECS
optimizes
performance and
cost
•  Cloud snapshots
Benefits to Meet Scientific Computing Challenges
Industry Challenges
•  Add compute resources at peak
times
•  Need for 1-3 months, no long-
term commitment
•  Do NOT want to rewrite
applications
•  Do NOT want to move data to
the cloud
Avere Benefits
•  Virtual FXT: scalable NAS for
compute cloud
•  Hide latency to on-prem NAS and
object storage
•  Easy setup, easy teardown
•  Pay only for what is used
•  Future: move data to the cloud for
better economics
Avere/AWS Cloud Platform Use Cases
On-Prem Compute
Bucket 2
Bucket n
Bucket 1
Physical FXT
Virtual FXT
Virtual Compute Farm
Cloud
On-prem
NAS
Cloud NAS
NAS Optimization
Amazon EC2 Amazon S3
On-Prem Storage
Avere Edge-Core Architecture
Private Object
Core Filers
Amazon S3WAN
WAN
Legacy NAS (local & remote)
Avere FXT Edge FilerClient
Workstations
Compute
Farm
Low latency read,
write & metadata ops
Add performance
& capacity
Place data
Avere Hybrid Cloud Feature Set
Customer Need Avere Feature
Low-latency file access Edge-Core Architecture
Scalable Performance and Availability Scale-out Cluster with HA
File System access whether the storage is File or
Object
FlashCloudTM File System for Object-based storage
Familiar File System Interfaces NFS and SMB client support
A single storage topology Avere Global Name Space
Data Protection Cloud Snapshots, FlashMirror
Security AES-256 Bit Encryption
Integration with AWS STS
Integration with KMIP Servers
Amazon Web Services
Reduce Costs Broad Set of ServicesSecure
Ecosystem Enabling Compliance
What sets AWS apart?
Building and managing cloud since 2006
50+ services to support any cloud workload
History of rapid, customer-driven releases
11 regions, 30 availability zones, 53 edge locations
49 proactive price reductions to date
Thousands of partners; 2,100+ Marketplace products
Experience
Service Breadth & Depth
Pace of Innovation
Global Footprint
Pricing Philosophy
Ecosystem
*as of July 31, 2014
TECHNICAL &
BUSINESS
SUPPORT
Account
Management
Support
Professional
Services
Solutions
Architects
Training &
Certification
Security
& Pricing
Reports
Partner
Ecosystem
AWS
MARKETPLACE
Backup
Big Data
& HPC
Business
Apps
Databases
Development
Industry
Solutions
Security
MANAGEMENT
TOOLS
Queuing
Notifications
Search
Orchestration
Email
ENTERPRISE
APPS
Virtual
Desktops
Storage
Gateway
Sharing &
Collaboration
Email &
Calendaring
Directories
HYBRID CLOUD
MANAGEMENT
Backups
Deployment
Direct
Connect
Identity
Federation
Integrated
Management
SECURITY &
MANAGEMENT
Virtual Private
Networks
Identity &
Access
Encryption
Keys Configuration Monitoring Dedicated
INFRASTRUCTURE
SERVICES
Regions
Availability
Zones Compute
Storage
Objects, Blocks,
Files
Databases
SQL, NoSQL,
Caching
CDNNetworking
PLATFORM
SERVICES
App
Mobile
& Web
Front-end
Functions
Identity
Data Store
Real-time
Development
Containers
Source
Code
Build
Tools
Deployment
DevOps
Mobile
Sync
Identity
Push
Notifications
Mobile
Analytics
Mobile
Backend
Analytics
Data
Warehousing
Hadoop
Streaming
Data
Pipelines
Machine
Learning
Elas%c	
  Block	
  Store,	
  Elas%c	
  File	
  System,	
  S3	
  and	
  Glacier	
  	
  
Fundamental Storage Options
Simple	
  Storage	
  
Service	
  
Highly	
  scalable	
  object	
  storage	
  
1	
  byte	
  to	
  5TB	
  per	
  object	
  
99.999999999%	
  durability	
  
Elas1c	
  Block	
  Store	
  
High	
  performance	
  block	
  storage	
  device	
  
	
  1GB	
  to	
  16TB	
  per	
  volume	
  
Mount	
  as	
  drives	
  to	
  instances	
  with	
  
snapshot/cloning	
  func%onali%es	
  
Glacier	
  
Long	
  term	
  object	
  archive	
  
Extremely	
  low	
  cost	
  per	
  gigabyte	
  
99.999999999%	
  durability	
  
Disks	
  for	
  
instances	
  
Slow,	
  rare	
  access	
  
Managed	
  archival	
  
system	
  
Managed	
  object	
  
storage	
  
Elas1c	
  File	
  System	
  
File	
  System	
  for	
  EC2	
  
SSD	
  based,	
  NFSv4	
  
Fully	
  managed	
  
Mul%-­‐AZ	
  redundancy	
  
Managed	
  file	
  
storage	
  
Global Footprint
Over 1 million active customers across
190 countries
1,700 government agencies
4,500 educational institutions
11 regions
30 availability zones
53 edge locations
Everyday, AWS adds enough new server capacity to support
Amazon.com when it was a $7 billion global enterprise.
Region
Edge Location
Security: A Shared Responsibility
§  You retain ownership of your IP and content – AWS does not have access
§  You control region(s) where your data is stored
§  You can build end-to-end compliance, including HIPAA compliance
§  AWS data centers always “on”; robust connectivity and bandwidth
§  Ongoing audit and assurance program
§  Industry certificationsAWS secures the
infrastructure....
....so you can
secure your
patient data
Enabling Compliance
Build HIPAA-compliant applications that store, process and transmit PHI
Business Associate Agreement (BAA) addendum available
HIPAA-eligible services:
Amazon EC2
 Amazon S3
 Amazon Glacier
 Amazon Redshift
 Amazon EBS
Elastic Load Balancing
Data Warehousing
Compute
 Object Storage
 Data Archiving
 Block Storage Volumes
Traffic Distribution
Amazon EMR
 Amazon RDS*
 DynamoDB
Managed Big Data
 Relational Database
 NoSQL Database
*MySQL and Oracle engines only
Josh Siegel
Systems Architect
Amazon's ability to sign a business
associate agreement with us as well as
their track record of security and
compliance really helped us make our
customers feel comfortable
We completed the equivalent
of thirty-nine years of
computational chemistry in just
under 9 hours for a cost of
around $4200.
Steve Litster
Global Head of Scientific Computing, Novartis
”
“
Novartis: Acceleration of pre-clinical R&D
•  Existing infrastructure to screen 10
million compounds in a computational
model not available
•  New infrastructure would have cost
approximately $40 million to build
Novartis used AWS for HPC
computational chemistry
“
”
•  Clinical lab based in Massachusetts; spin-off of
Boston Children’s Hospital
•  As a result of spin-off, Claritas lost access to data
centers at Boston Children’s and Harvard Medical
School
•  Needed cost-effective infrastructure to support the
lab’s business
•  Result:
•  Clinical lab running with production on AWS
•  Rapid (4-6 week) turnaround time for results
"[AWS] allowed me to not have to build
out a data center which was going to
be such a high cost....at least $5 million
dollars; we’ve also decreased our
turnaround time for clinical [tests]….some
companies are looking at 4-6 months,
we’re looking at 4-6 weeks
Elizabeth Boudreau
IT – Senior Manager, Claritas Genomics
Claritas Genomics – Cost-effective IT Diagnostic
Labs
An Expansive Ecosystem - Healthcare
An Expansive Ecosystem – Life Sciences
Alex Dickinson
SVP, Strategic Initiatives
Working with AWS lets us focus
on what we’re good at, which is
doing sequencing
Next Steps
•  Enter your questions
•  Please download resources
•  Please rate this webinar
•  How to reach our panelists
Contact Us
Jacob Feala Bret Martin Scott Jeschonek Sabina Joseph
Bioinformatics Platform
Lead
Jacob_Feala@h3biomedicine.com
Principal Research
Computing Architect
Bret_Martin@h3biomedicine.com
Twitter: @bret_martin
Director of Product
Management, Cloud
sjeschonek@averesystems.com
Global Ecosystem
Segment Leader
sabinaj@amazon.com
Averesystems.com aws.amazon.comH3biomedicine.com

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Scientific Computing in the Cloud: Speeding Access for Drug Discovery

  • 1. Scientific Computing in the Cloud Speeding Access for Drug Discovery Jacob Feala, Bioinformatics Platform Lead, H3 Biomedicine Bret Martin, Principal Research Computing Architect, H3 Biomedicine Scott Jeschonek, Director of Product Management, Cloud Solutions, Avere Systems Sabina Joseph, Global Ecosystem Segment Leader, Partnerships & Alliances, Amazon Web Services September 22, 2015
  • 2. Today’s Speakers Jacob Feala Bret Martin Scott Jeschonek Sabina Joseph Bioinformatics Platform Lead Principal Research Computing Architect Director of Product Management, Cloud Global Ecosystem Segment Leader, Partnerships & Alliances
  • 3. Housekeeping •  Recording •  Resources •  Questions •  Please rate this webinar
  • 5. H3 vision: Translate cancer patients’ genomes into powerful therapeutics
  • 6. Cancer cells hijack the mRNA splicing machinery •  Spliceosome genes have recurrent mutations in some types of cancer •  These “hotspot” mutations have been shown to alter splicing in hundreds of mRNA transcripts mutations DNA pre-mRNA splicing mRNA altered splicing normal splicing
  • 7. RNA-seq is the driver for our mRNA splicing research •  H3’s chemistry platform generates compounds that can modulate splicing •  H3 biologists can genetically engineer the spliceosome mutations in cell lines •  RNA-seq allows us to detect novel splicing caused by drugs or mutations mutations drugs DNA pre-mRNA splicing mRNA mRNA sequencing altered splicing
  • 8. When in doubt, just sequence it! Plummeting sequencing costs + Powerful insights = Mounds of data
  • 9. Early days on AWS: StarCluster and Amazon S3 •  Bash scripts submitted to SunGrid Engine scheduler •  All data downloaded and uploaded to/from Amazon S3 •  Completely disjoint from local development environment
  • 10. Evolution of H3 NGS workflows: Luigi, Docker, and Avere •  Atomic, idempotent workflow scheduling with Luigi •  Environment management with Docker •  Unified local/cloud filesystem with Avere •  Seamless transitions from interactive work, to pipeline dev, to scale-out
  • 12. Challenges •  Management –  Native AWS features (especially VPC and IAM) –  Configuration management with Ansible •  Compute challenges –  Scalable compute infrastructure on Amazon EC2 –  Improving user experience with CycleCloud •  Storage challenges –  Pace of growth –  Want to focus on science, not IT and storage management –  Protect investment in on-premises storage in the medium term –  Present traditional file system to “bridge” users to the cloud
  • 13. H3 Biomedicine Architecture Overview •  2 VPCs •  1 Gbps Direct Connect with VPN backup •  AWS services accessed over Direct Connect
  • 14. H3 Biomedicine Architecture Overview •  2 VPCs •  1 Gbps Direct Connect with VPN backup •  AWS services accessed over Direct Connect
  • 15. H3 Biomedicine Architecture Overview •  2 VPCs •  1 Gbps Direct Connect with VPN backup •  AWS services accessed over Direct Connect
  • 16. What is Avere vFXT? •  Virtual deployment of AvereOS using Amazon EC2 instances –  3 x r3.2xlarge –  4 TB encrypted Amazon EBS (10 x 400 GB volumes) •  Deployed with AWS CloudFormation •  Managed using web interface and SSH •  Metrics available on things like hot files, hot clients, IOPS
  • 17. Avere vFXT Enables H3 Biomedicine in the Cloud •  Avere vFXT makes our on-premises EMC Isilon NAS storage usable at AWS •  Latency reduced from ~15ms to under 1ms for hot data •  Same shared filesystems are available at AWS as “at home” –  Home directories –  Group directories (including many software tools) –  Lab data directories –  Scratch space •  Provides a familiar environment to scientific staff, but with the benefits of the cloud
  • 18. Avere vFXT Tips •  Setup will take under an hour, if you’re ready with –  AWS account –  VPC with connectivity to core filer –  Security groups •  Proper EC2/VPC security groups and firewall rules are essential –  Allow traffic to your core filer from the vFXT –  Allow traffic from your core filer to the vFXT •  vFXT is not magic –  You need permanent, reliable connectivity to your core filer
  • 19. H3 Biomedicine Future Storage Plans •  Replace some on-premises NAS capacity with physical Avere FXT Series filers, providing NFS front end with S3 as backing store •  Use Avere FlashMove migration capabilities to transparently move data from on-premises NAS to S3 – without disrupting user access •  Use vFXT for CIFS clients at AWS (Amazon WorkSpaces, regular EC2 Windows instances) •  Replace tape with S3 using AWS Storage Gateway
  • 21. Enterprise Grade NAS for the Cloud Avere combines Enterprise-grade NAS with a complete feature set for the cloud. Enterprise- grade NAS 100% Cloud Enabled Cloud Gateway Vendors Traditional NAS Vendors •  NFS & SMB/ CIFS access •  Clustering for performance and capacity scaling •  Efficient use of EBS and ECS optimizes performance and cost •  Cloud snapshots
  • 22. Benefits to Meet Scientific Computing Challenges Industry Challenges •  Add compute resources at peak times •  Need for 1-3 months, no long- term commitment •  Do NOT want to rewrite applications •  Do NOT want to move data to the cloud Avere Benefits •  Virtual FXT: scalable NAS for compute cloud •  Hide latency to on-prem NAS and object storage •  Easy setup, easy teardown •  Pay only for what is used •  Future: move data to the cloud for better economics
  • 23. Avere/AWS Cloud Platform Use Cases On-Prem Compute Bucket 2 Bucket n Bucket 1 Physical FXT Virtual FXT Virtual Compute Farm Cloud On-prem NAS Cloud NAS NAS Optimization Amazon EC2 Amazon S3 On-Prem Storage
  • 24. Avere Edge-Core Architecture Private Object Core Filers Amazon S3WAN WAN Legacy NAS (local & remote) Avere FXT Edge FilerClient Workstations Compute Farm Low latency read, write & metadata ops Add performance & capacity Place data
  • 25. Avere Hybrid Cloud Feature Set Customer Need Avere Feature Low-latency file access Edge-Core Architecture Scalable Performance and Availability Scale-out Cluster with HA File System access whether the storage is File or Object FlashCloudTM File System for Object-based storage Familiar File System Interfaces NFS and SMB client support A single storage topology Avere Global Name Space Data Protection Cloud Snapshots, FlashMirror Security AES-256 Bit Encryption Integration with AWS STS Integration with KMIP Servers
  • 27. Reduce Costs Broad Set of ServicesSecure Ecosystem Enabling Compliance
  • 28. What sets AWS apart? Building and managing cloud since 2006 50+ services to support any cloud workload History of rapid, customer-driven releases 11 regions, 30 availability zones, 53 edge locations 49 proactive price reductions to date Thousands of partners; 2,100+ Marketplace products Experience Service Breadth & Depth Pace of Innovation Global Footprint Pricing Philosophy Ecosystem *as of July 31, 2014
  • 29. TECHNICAL & BUSINESS SUPPORT Account Management Support Professional Services Solutions Architects Training & Certification Security & Pricing Reports Partner Ecosystem AWS MARKETPLACE Backup Big Data & HPC Business Apps Databases Development Industry Solutions Security MANAGEMENT TOOLS Queuing Notifications Search Orchestration Email ENTERPRISE APPS Virtual Desktops Storage Gateway Sharing & Collaboration Email & Calendaring Directories HYBRID CLOUD MANAGEMENT Backups Deployment Direct Connect Identity Federation Integrated Management SECURITY & MANAGEMENT Virtual Private Networks Identity & Access Encryption Keys Configuration Monitoring Dedicated INFRASTRUCTURE SERVICES Regions Availability Zones Compute Storage Objects, Blocks, Files Databases SQL, NoSQL, Caching CDNNetworking PLATFORM SERVICES App Mobile & Web Front-end Functions Identity Data Store Real-time Development Containers Source Code Build Tools Deployment DevOps Mobile Sync Identity Push Notifications Mobile Analytics Mobile Backend Analytics Data Warehousing Hadoop Streaming Data Pipelines Machine Learning
  • 30. Elas%c  Block  Store,  Elas%c  File  System,  S3  and  Glacier     Fundamental Storage Options Simple  Storage   Service   Highly  scalable  object  storage   1  byte  to  5TB  per  object   99.999999999%  durability   Elas1c  Block  Store   High  performance  block  storage  device    1GB  to  16TB  per  volume   Mount  as  drives  to  instances  with   snapshot/cloning  func%onali%es   Glacier   Long  term  object  archive   Extremely  low  cost  per  gigabyte   99.999999999%  durability   Disks  for   instances   Slow,  rare  access   Managed  archival   system   Managed  object   storage   Elas1c  File  System   File  System  for  EC2   SSD  based,  NFSv4   Fully  managed   Mul%-­‐AZ  redundancy   Managed  file   storage  
  • 31. Global Footprint Over 1 million active customers across 190 countries 1,700 government agencies 4,500 educational institutions 11 regions 30 availability zones 53 edge locations Everyday, AWS adds enough new server capacity to support Amazon.com when it was a $7 billion global enterprise. Region Edge Location
  • 32. Security: A Shared Responsibility §  You retain ownership of your IP and content – AWS does not have access §  You control region(s) where your data is stored §  You can build end-to-end compliance, including HIPAA compliance §  AWS data centers always “on”; robust connectivity and bandwidth §  Ongoing audit and assurance program §  Industry certificationsAWS secures the infrastructure.... ....so you can secure your patient data
  • 33. Enabling Compliance Build HIPAA-compliant applications that store, process and transmit PHI Business Associate Agreement (BAA) addendum available HIPAA-eligible services: Amazon EC2 Amazon S3 Amazon Glacier Amazon Redshift Amazon EBS Elastic Load Balancing Data Warehousing Compute Object Storage Data Archiving Block Storage Volumes Traffic Distribution Amazon EMR Amazon RDS* DynamoDB Managed Big Data Relational Database NoSQL Database *MySQL and Oracle engines only
  • 34. Josh Siegel Systems Architect Amazon's ability to sign a business associate agreement with us as well as their track record of security and compliance really helped us make our customers feel comfortable
  • 35. We completed the equivalent of thirty-nine years of computational chemistry in just under 9 hours for a cost of around $4200. Steve Litster Global Head of Scientific Computing, Novartis ” “ Novartis: Acceleration of pre-clinical R&D •  Existing infrastructure to screen 10 million compounds in a computational model not available •  New infrastructure would have cost approximately $40 million to build Novartis used AWS for HPC computational chemistry
  • 36. “ ” •  Clinical lab based in Massachusetts; spin-off of Boston Children’s Hospital •  As a result of spin-off, Claritas lost access to data centers at Boston Children’s and Harvard Medical School •  Needed cost-effective infrastructure to support the lab’s business •  Result: •  Clinical lab running with production on AWS •  Rapid (4-6 week) turnaround time for results "[AWS] allowed me to not have to build out a data center which was going to be such a high cost....at least $5 million dollars; we’ve also decreased our turnaround time for clinical [tests]….some companies are looking at 4-6 months, we’re looking at 4-6 weeks Elizabeth Boudreau IT – Senior Manager, Claritas Genomics Claritas Genomics – Cost-effective IT Diagnostic Labs
  • 37. An Expansive Ecosystem - Healthcare
  • 38. An Expansive Ecosystem – Life Sciences
  • 39. Alex Dickinson SVP, Strategic Initiatives Working with AWS lets us focus on what we’re good at, which is doing sequencing
  • 40. Next Steps •  Enter your questions •  Please download resources •  Please rate this webinar •  How to reach our panelists
  • 41. Contact Us Jacob Feala Bret Martin Scott Jeschonek Sabina Joseph Bioinformatics Platform Lead Jacob_Feala@h3biomedicine.com Principal Research Computing Architect Bret_Martin@h3biomedicine.com Twitter: @bret_martin Director of Product Management, Cloud sjeschonek@averesystems.com Global Ecosystem Segment Leader sabinaj@amazon.com Averesystems.com aws.amazon.comH3biomedicine.com