The document discusses research and development (R&D) ratios and Sanofi-Aventis' R&D expenditures over time. It notes that Sanofi-Aventis was formed through the merger of Sanofi and Aventis in 2004. From 2001-2004, both companies maintained an R&D intensity of around 16%, but in 2004 after the merger, R&D intensity increased dramatically to 50% as R&D expenditures rose significantly that year. The document also presents Sanofi-Aventis' continued R&D spending and intensity levels from 2004-2008.