This document outlines various safety measures that should be followed in a clinical laboratory. Personal safety measures include proper hygiene, protective equipment like eye protection and gloves. Biological safety involves preventing contact with specimens and proper procedures after accidental contact like washing. Chemical safety requires storing chemicals properly and taking appropriate actions for minor or large chemical splashes. Fire safety involves safe handling of electrical equipment, combustibles and flammable liquids. Radiation safety follows principles of reducing time of exposure, increasing distance from sources, using shielding and monitoring personnel. Laser safety guidelines include restricting access and use of appropriate eye protection. Proper disposal of waste and good housekeeping are also important.