Radioactive waste from nuclear medicine needs safe management to protect human health and the environment. Waste management should be planned from the start and includes segregating, collecting, treating, storing, transporting, and disposing of different types of solid, liquid, and gaseous waste. Regulations require minimizing waste volume and exposure to the public, as well as optimizing control of discharges. Proper infrastructure includes legislation, regulatory oversight, trained staff, and treatment facilities for different waste types based on factors like half-life and form.