Why the world needs preventive HIV vaccines

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The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines

http://www.pamoja.uk.com

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Why the world needs preventive HIV vaccines

  1. 1. Why the world needs preventive HIV vaccines An impact modeling perspective Hester Kuipers International AIDS Vaccine Initiative London, May 18 2012
  2. 2. AIDS vaccines hold tremendous promise
  3. 3. Current efforts in HIV prevention are not having thedesired impact
  4. 4. Doing better with what we have today: the UNAIDS Investment FrameworkExpected new HIV infections per year in LMICs under the new investment approach compared with abaseline scenario (2011-2020)Schwartlander et al. “Towards an improved investment approach for an effective response to HIV/AIDS.” The Lancet. 2011.
  5. 5. A vaccine’s potential to drive new HIVinfections towards zero: a perspective on impact modeling Would a vaccine still be needed if current prevention programs and antiretroviral therapy (ART) are significantly expanded under the UNAIDS Investment Framework while the vaccine is still being developed? Would a vaccine be useful if it was partially effective? Would a vaccine result in cost-savings?
  6. 6. Modeling the impact of an HIV vaccine New infections under current trends of HIV/AIDS programming Millions 3 2.5 26.8 million infections, 2020-2030 2 Without continued progress in HIV prevention, 1.5 population growth overtakes recent trend of lowered incidence 1 0.5 0IAVI/Futures Institute 2012 (published May 18 )
  7. 7. Modeling the impact of an HIV vaccine New infections under current trends of HIV/AIDS programming Millions 3 Vaccine Introduction 2020 2.5 No vaccine 26.8 million infections, 2020-2030 2 Low Vaccine Scenario 1.5 50% effective, 30% coverage 5.2 million (19.4%) infections averted Medium Vaccine Scenario 70% effective, 40% coverage 1 8.9 million (33.2%) infections averted High Vaccine Scenario 90% effective, 40% coverage 0.5 10.7 million (39.9%) infections averted 0IAVI/Futures Institute 2012 (published May 18 )
  8. 8. Modeling the impact of an HIV vaccine New infections under the UNAIDS Investment Framework Base Millions 3 2.5 Investment Framework scaled up 2 1.5 1 8.8 million infections, 2020-2030 0.5 0IAVI/Futures Institute 2012 (unpublished)
  9. 9. Modeling the impact of an HIV vaccine New infections under the UNAIDS Investment Framework Millions 3 2.5 Investment Framework scaled up 2 No vaccine 8.8 million infections, 2020-2030 1.5 1 Low Vaccine Scenario 50% effective, 30% coverage 1.6 million (18.2%) infections averted 0.5 Medium Vaccine Scenario Vaccine 70% effective, 40% coverage Introduction 2020 2.7 million (30.7%) infections averted 0 High Vaccine Scenario 90% effective, 40% coverage 3.3 million (37.5%)infections avertedIAVI/Futures Institute 2012 (unpublished)
  10. 10. Preventive vaccines are needed in the responseto HIV/AIDS  A preventive AIDS vaccine can make a substantial impact in reducing the number of new HIV infections, and would get us towards zero new HIV infections faster and with substantial cost savings  Vaccines are proven interventions and offer a tremendous promise in the response to HIV/AIDS  A long-term strategy to end the AIDS pandemic must include both the strategic scale-up of existing HIV prevention, treatment, and care programmes, and sustained investment in the development of additional prevention tools, including a preventive AIDS vaccine.
  11. 11. Interactive Website: www.iavi.org/impact
  12. 12. World AIDS Vaccine Day is observed annually on May 18. HIV vaccine advocates mark the dayby promoting the continued urgent need for a vaccine to prevent HIV infection and AIDS. Weacknowledge and thank the thousands of volunteers, community members, health professionals,supporters and scientists who are working together to find a safe and effective AIDS vaccine. Wealso urge the international community to recognize the importance of investing in newtechnologies as a critical element of a comprehensive response to the HIV/AIDS epidemic.www.iavi.org
  13. 13. BACKUP SLIDES
  14. 14. Investment framework coverage targets for 2015 Epidemic type (by country) Hyper-endemic Generalized Concentrated Low prevalenceGeneral PopulationMass media 80% 80% 20% 20%Community mobilization 70% 70% 0% 0%Counseling and testing 3% 3% 1% 1%Condoms: discordant couples 60% 60% 60% 60%Vulnerable populationsYouth in school 100% 100% 30% 30%Youth out of school 0% 0% 0% 0%CSW and clients 60% 60% 60% 60%MSM 60% 60% 60% 60%IDU outreach 60% 60% 60% 60%IDU needle exchange 60% 60% 60% 60%IDU drug substitution 0% 0% 40% 40%Workplace 50% 50% 0% 0%Condoms: high risk populations 50% 50% 50% 50%Condoms: medium risk populations 60% 60% 20% 20%Medical servicesPMTCT 90% 90% 90% 90%Male circumcision 60% 60% 0% 0%ART 90% 90% 90% 90%
  15. 15. Why the world needs preventive HIV vaccines

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