The document discusses Alzheimer's disease and dementia. It provides epidemiological data showing that the number of people with Alzheimer's is increasing significantly and will rise to over 40 million worldwide by 2025. It describes the diagnostic criteria and clinical presentation of different types of dementia including Alzheimer's disease, vascular dementia, dementia with Lewy bodies, frontotemporal dementia, and rapidly progressive dementias like Creutzfeldt-Jakob disease. It discusses tools for assessing cognition and mental status in diagnosing dementia.
La enfermedad de Alzheimer (EA), también denominada demencia senil de tipo Alzheimer (DSTA) o simplemente alzhéimer,1 es una enfermedad neurodegenerativa que se manifiesta como deterioro cognitivo y trastornos conductuales. Se caracteriza en su forma típica por una pérdida de la memoria inmediata y de otras capacidades mentales (tales como las capacidades cognitivas superiores), a medida que mueren las células nerviosas (neuronas) y se atrofian diferentes zonas del cerebro. La enfermedad suele tener una duración media aproximada —después del diagnóstico— de 10 años,2 aunque esto puede variar en proporción directa con la severidad de la enfermedad al momento del diagnóstico.
Alzheimer's disease: Clinical Assessment and ManagementRavi Soni
This PPT is a seminar on the Alzheimer's disease which was prepared for sensitizing post graduate psychiatry students on the day of World Alzheimer's Day.
La enfermedad de Alzheimer (EA), también denominada demencia senil de tipo Alzheimer (DSTA) o simplemente alzhéimer,1 es una enfermedad neurodegenerativa que se manifiesta como deterioro cognitivo y trastornos conductuales. Se caracteriza en su forma típica por una pérdida de la memoria inmediata y de otras capacidades mentales (tales como las capacidades cognitivas superiores), a medida que mueren las células nerviosas (neuronas) y se atrofian diferentes zonas del cerebro. La enfermedad suele tener una duración media aproximada —después del diagnóstico— de 10 años,2 aunque esto puede variar en proporción directa con la severidad de la enfermedad al momento del diagnóstico.
Alzheimer's disease: Clinical Assessment and ManagementRavi Soni
This PPT is a seminar on the Alzheimer's disease which was prepared for sensitizing post graduate psychiatry students on the day of World Alzheimer's Day.
Childhood demyelinating syndromes
In the past decade, the number of studies related to demyelinating diseases in children has exponentially increased. Demyelinating disease in children may be monophasic or chronic. Typical monophasic disorders in children are acute disseminated encephalomyelitis and clinically isolated syndromes, including optic neuritis and transverse myelitis. However, some cases of acute disseminated encephalomyelitis or clinically isolated syndrome progress to become chronic disorders, including multiple sclerosis and neuromyelitis optica. This review summarizes the current knowledge on monophasic and chronic demyelinating disorders in children, focusing on an approach to diagnosis and management.
LGS Foundation 2016 Conference - Friday AfternoonLGS Foundation
Topics include: Understanding Cognitive Problems in LGS presented by Michael Chez, MD, Effective Communication presented by Patricia Moore and, National Resources for Individuals with LGS presented by Jennifer Wolfenbarger, MPH
A presentation about Alzheimer's disease, it's definition, it's etiology, its mechanism of development as well as actual treatment and developing treatments.
More than 15 million Americans provide unpaid care for someone with Alzheimer's disease or dementia. View our infographic for caregiving facts, the global impact of Alzheimer's disease, symptoms, and more.
Childhood demyelinating syndromes
In the past decade, the number of studies related to demyelinating diseases in children has exponentially increased. Demyelinating disease in children may be monophasic or chronic. Typical monophasic disorders in children are acute disseminated encephalomyelitis and clinically isolated syndromes, including optic neuritis and transverse myelitis. However, some cases of acute disseminated encephalomyelitis or clinically isolated syndrome progress to become chronic disorders, including multiple sclerosis and neuromyelitis optica. This review summarizes the current knowledge on monophasic and chronic demyelinating disorders in children, focusing on an approach to diagnosis and management.
LGS Foundation 2016 Conference - Friday AfternoonLGS Foundation
Topics include: Understanding Cognitive Problems in LGS presented by Michael Chez, MD, Effective Communication presented by Patricia Moore and, National Resources for Individuals with LGS presented by Jennifer Wolfenbarger, MPH
A presentation about Alzheimer's disease, it's definition, it's etiology, its mechanism of development as well as actual treatment and developing treatments.
More than 15 million Americans provide unpaid care for someone with Alzheimer's disease or dementia. View our infographic for caregiving facts, the global impact of Alzheimer's disease, symptoms, and more.
This is a presentation I did last spring in which I discuss how the OTPF applies to Alzheimer's Dementia. I collected data from scholarly as well as non-scholarly resources. I hope you find this to be helpful.
Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior. Alzheimer's is the most common form of dementia, a general term for memory loss and other intellectual abilities serious enough to interfere with daily life.
Dementia dementedness could be a neurological disease that aff.docxtheodorelove43763
Dementia
dementedness could be a neurological disease that affects your ability to assume, speak, reason keep in mind and move. whereas Alzheimer’s malady is that the most typical reason for dementedness, several different conditions can also cause similar symptoms. a number of these disorders exacerbate with time and can't be cured, whereas others respond well to treatment and their symptoms will even be reversed.
What will it mean once somebody is claimed to possess dementia? for a few folks, the word conjures up scarey pictures of crazy behavior and loss of management. In fact, the word dementedness describes a bunch of symptoms that has remembering loss, confusion, the shortcoming to downside solve, the shortcoming to finish multi-step activities like making ready a mean or equalisation a chequebook, and, generally temperament changes or uncommon behavior.
dementedness is that the general term for a bunch of disorders. sure conditions will cause reversible dementias, like medication interactions, depression, nutriment deficiencies or thyroid abnormalities. it's necessary that these conditions be known early and be treated taken over so symptoms is improved. There are irreversible dementias called chronic dementias, of those Alzheimer’s malady is that the most typical. There square measure variety of different chronic dementias, however, which will appear as if Alzheimer’s, however have distinct or completely different|completely different} options which require special attention and different treatment.
For those who have a lover that has one in every of the numerous completely different dementias, the road ahead is a really difficult one.
urban center Ronald Reagan maybe aforementioned it best in Associate in Nursing interview with J.D. Heyman of individuals magazine, in December of 2003, she referred to as Alzheimer’s malady “the long goodbye” (Heyman, 2003).
Dementia: Definition and designation
dementedness is that the general term for a bunch of disorders that cause irreversible psychological feature decline as a results of varied biological mechanisms that injury brain cells. it's a really common downside, significantly within the older, and it's going to go unrecognized for quite it slow. Studies indicate that up to twenty or a lot of of persons UN agency have symptoms suggestive dementedness end up to possess treatable diseases and regarding 1/2 them can have medical specialty issues.(Shenk, 2001).
many issues arise once attempting to determine whether or not or not a consumer is really insane. First, gentle defects in memory commonly occur with age, therefore any psychological testing has to take this under consideration. Secondly, as a result of dementedness is outlined as a loss of perform, with shoppers UN agency have a history of retardation, or previous learning or psychological feature disabilities it's necessary to get instructional and activity histories so as to establish if there.
A brief discussion about Neurocognitive disorders.
NCD are on the rise especially due to the ageing population and good treatment modalities leading to less mortality.
The burden of NCD is to increase with time especially due to the little interventions available
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
1. ALZHEIMERS AND DEMENTIA UPDATE TOMA 2006 G. BARRY ROBBINS, D.O., FACN Associate Professor and Chair Department of Neurobehavioral Sciences KCOM a college of ATSU
2.
3.
4. Number of People Age 65 and Over, by Age Group, Selected Years 1990-2000 and Projected 2010-2050 Federal Interagency Forum on Aging-Related Statistics 2004 , Older Americans
22. Differential Diagnosis of Dementia 5% 10% 65% 5% 7% 8% Dementia with Lewy bodies Parkinson’s disease Diffuse Lewy body disease Lewy body variant of AD Vascular dementias and AD Other dementias Frontal lobe dementia Creutzfeldt-Jakob disease Corticobasal degeneration Progressive supranuclear palsy Many others AD and dementia with Lewy bodies Vascular dementias Multi-infarct dementia Binswanger’s disease AD Small et al, 1997; APA, 1997; Morris, 1994.
58. Diagnosing AD in primary care cognitive assessment The Clock Draw Test Cognitive Assessment Time: 5.00 Score: 7 (normal) Time: 'no real time' Score: 2 (demented) Thalmann et al 1996. Time: .10.30 Score: 3 (demented) Time: 1/4 past 25 Score: 3 (demented)
68. Reduction of A burden in entorhinal cortex In PDAPP mice following A injection
69.
70. Cardiovascular Disease: Heart Disease and Stroke The Human Value Death Rates for Coronary Heart Disease, 1950-1998 National Center for Chronic Disease Prevention and Health Promotion 2003, The Burden of Chronic Disease and the Future of Public Health
Editor's Notes
This lecture which has been developed to provide you with the latest information about the diagnosis and treatment of Alzheimer's disease. Alzheimer's disease was ignored by the research and medical communities for many years and was felt to be an untreatable condition with an inexorable and relentless declining course. This has changed. Funding for Alzheimer's disease research is now the third largest item in the NIH budget . As a result, new discoveries are occurring every day and our knowledge of this disease and our ability to treat it are increasing rapidly. This module is designed to provide you with an update on some of that new knowledge. We will first discuss the epidemiology and pathogenesis of Alzheimer's disease. Then, we will talk about the diagnosis and treatment of this condition.
