Ebola virus is the virus which first found in the africa , in sudan. This is deadly virus named as ebola by taking the name of Ebola river in Africa

1. REVIEW ON EBOLA VIRUS
Submitted by:
Dnyaneshwar Mahadev Waghmode
Guidance by
Mr. Rahul.A.Wandre (Assistant Professor)
Project submitted to
PRINCIPAL(I/C)
Mr. L.D.Hingane (M.Pharm, Ph.D Scholar)
Aditya Pharmacy College, Beed

2. INTRODUCTION:
• 1st time ebola virus identified by PETER PIOT.
• The ebola virus is deadly disease in human and primates.
• Ebola first appeared in 1976 in Sudan and democratic republic of
Congo near the ebolla river in Africa.
• 2nd appeared in 1989 in Reston.
• 3rd appeared in 2014 in Africa.

3. - Ebola virus is called as heamorrahagic (because bleeding
start in illness).
- Heamorrahagic fever are the group of diseases caused by
four viruses.
-These included :
1) Ebola
2) Marburg virus
3) Lass fever
4) Yellow fever

4. 1) EBOLA VIRUS.
• A virus that causes severe bleeding, organ failure and can lead to death.
• Humans may spread the virus to other humans through contact with bodily
fluids such as blood.
• Ebola is negative RNA virus.
2)MARBURG VIRUS.
Symptoms:
- Red eyes
- Rashesh
- Stomach Pain
- Weight loss

5. 3) LASSA FEVER.
• It is caused by Arena virus.
• It is transmitted through rodent to Human.
• It is viral illness.
• It occurs in west Africa.
Symptoms:
- Headache
- Fever
- Weekness
- Confusion

6. 4) YELLOW FEVER.
• It is caused by particular species of mosquitos.
• The symptoms of yellow fever occurs in three to four days after
exposures.
• Yellow fever originated in central Africa.
Symptoms:
- Headache
- Fever
- Nausea
- Weakness

7. Defination :
• It is infectious and deadly disease marked by fever and internal bleeding spread
through a contact with infected body fluids.
• Such as Body fluids, Saliva ,sweat, Mucous, Tears, Urine and sexual fluids.

8. TYPES OF EBOLA VIRUS:
1) Zaire ebola virus
2) Sudan ebola virus
3) Reston ebola virus
4) Tai forest
1) Zaire Ebola virus:
-Most dangerous species of ebola . Fig: Zaire Ebola Virus
- This species responsible for outbreak of ebola in western Africa.
- In 2014-16 in western Africa found 28,464 suspected cases and 11,323confirmed deaths.

9. 2) Sudan Ebola virus:
- It is first time discovered in Sudan.
- It is also responsible for causes ebola virus in Human and Primates.
- In 2014 24 cases found in Uganada and seventeen deaths.

10. 3) Restone Ebola Virus:
- It is non-pathogenic to human.
- It is pathogenic to primates.
- Restone ebola virus found in cra-eting macaques.

11. 4) Tai Forest Ebola Virus:
- Tai forest ebolavirus only seen in single human because they human came in contact
with chimpanzee.

12. PATHOPHYSIOLOGY:
-Endothelial cells ,mononuclear phagocytes, and hepatocytes are main target
of ebola virus.
-The Gp forms a trimeric complex, which bind the virus to endothelial cells.
The sGP forms a diameric protein which interferes with the signalling of
white blood cells.
-Those white blood cells also serve as carriers to transport the virus throught
the entire body to places as the lymphnodess, lungs and spleen.

13. CASES OF EBOLA VIRUS:

14. MODE OF TRANSMISSION:
-Unsterillised needles
-Personal contact.
-Human to Human transmission.
-Reusing needles and blood gloves
In hospitals.
-Sub optical hospital condition.

15. MECHANISM OF ACTION:
- Every tissue affected except bones and muscles.
- Ebola virus creates a blood clots.
- The blood clots goes towards the internal organs.
- The blood clots prevent oxygen to rise tissue.
- Ebola virus also destroy the connective tissue.

16. SIGN AND SYMPTOMS:

17. TREATMENT:
As of july of 2015 no medication has been proven safe ans effective for
treating ebola.
By the time the ebola virus epidemic in west Africa began in 2013.
There were at least nine different candidate treatments. Several trials
were conducted in kate 2014, but some were abandoned due to lack of efficacy
or lac of people to study.
As of Augest 2019, two experimental treatments knows as REGN-EB3
and mAb114 were found to be 90% effective.

18. CONCLUSION:
Ebola virus has been a threat to human health due to dangerous, highly
lethal and infectious behavior since its discovery in 1976.
Ebola fever has come out as one of the most fatal identified forms of
hemorrhagic fever, for which there is no specific remedy available

19. REFERENCE:
1)Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet. 2011 Mar
5;377(9768):849-62.Full text external link opens in a new window Abstract
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2)Kortepeter MG, Bausch DG, Bray M. Basic clinical and laboratory features of
filoviral hemorrhagic fever. J Infect Dis. 2011 Nov;204 Suppl 3:S810-6Full text
external link opens in a new window Abstract external link opens in a new
window

20. Thank
You…