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Ebola presentation

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Ebola presentation

  1. 1. Presented by:Jon BrownLeonard Bagwala
  2. 2. WHAT IS EBOLA- Ebola hemorrhagic fever:Named after a river in the Congowhere it was first found- Often-fataldisease in humans andnonhuman primates (monkeys,gorillas, and chimpanzees)- Has appeared sporadically sinceits initial recognition in 1976- Mortality rate can reach 90%
  3. 3. -Family: Filoviridae -Order: MononegaviralesFamily and Order -5 distinct sub-species -Cote d’Ivorie(Ivory Coast) ebolavirus -Reston ebolavirus -Sudan ebolavirus -Zaire ebloavirus -Bundibugyo ebolavirus - Characteristics of Filoviruses: - Filamentous form with a uniform diameter of approximately 80 nm but display great variation in length. - Nonsegmented negative-stranded RNA genome containing 7 structural and regulatory genes.
  4. 4. Where is the Ebola virus found in nature• Natural reservoir of the Ebola virus remains unknown.• Zoonotic (animal-borne)• Four of the 5 subtypes occur in an animal host native to Africa 1 occurs in Philippine monkeys .• Origination: Africa...The virus is not known to be native to other continents, such as North America.
  5. 5. Modes of Infection
  6. 6. Early Symptoms During the incubation period, (2 to 21 days), symptoms include:• Arthritic pain• Backache (low-back pain)• Chills• Diarrhea• Fatigue• Fever• Headache• Malaise (general feeling of being unwell)• Nausea• Sore throat• Vomiting
  7. 7. Late SymptomsLate symptoms include:• Bleeding from eyes, ears, and nose• Bleeding from the mouth and rectum (gastrointestinal bleeding)• Depression• Eye inflammation (conjunctivitis)• Genital swelling (labia and scrotum)• Increased feeling of pain in skin• Rash over the entire body that often contains blood (hemorrhagic)• Roof of mouth looks red• Seizures, coma, deliriumAs many as 90% of patients die from the disease. Patients usuallydie from shock rather than from blood loss.
  8. 8. How it worksTetherin: A human cellular proteinwhich inhibits retrovirus infectionby preventing the diffusion of virusparticles after budding frominfected cells Threadlike Ebola virions bud from a cell. The Ebola virus disables a cells tetherin protein.
  9. 9. Hope on the Horizon? Ebola virus glycoprotein, or "spike protein,"

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