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ReVeaLD: A User-driven
                      Domain Specific Interactive Search
                      Platform for Biomedical Research
                                     Maulik R. Kamdar, Ali Hasnain, Helena F. Deus




 Copyright 2011 Digital Enterprise Research Institute. All rights reserved.




                                                                               Enabling Networked Knowledge
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        Enabling Networked Knowledge
“Are there Drugs with molecular weight
~300 000
                                                                    under 400 tested against ‘Colon Cancer’?”
compounds
                                   ~300 interesting
                                   compounds
                                                                   ~ 10 interesting
                                                                   compounds




                                                 Query databases
            Virtual Screening



                                                                                              ~5 compounds




                                                                                 Literature
                                (Linked) Data
                                                                                                       Hypothesis
                                                                                                       Generation



                                          “Do any Publications refer to assays using ‘Aspirin’ as
                                          the primary Drug in treatment of ‘Prostrate Cancer’?


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                   Hasnain et. al., EKAW 2012



    Enabling Networked Knowledge
CanCO                                                               Query
                         Query Logging
                Saved
               Queries
                                                    SPARQL
                                                     Query            Engine           ?molec a Granatum:Molecule
  RDFization                                                  Transformation
      Experimental                                                                  Chebi:Compound void-ext:subClassOf   Granatum:Molecule
        Datasets                          Rule Templates                            DrugBank:Drug  void-ext:subClassOf   Granatum:Molecule

                         Transformed     Transformed    Transformed   Transformed
Social Collaborative        Query           Query          Query         Query
    Workspace

     LSLOD
    Catalogue

                            Chebi        DrugBank        UniProt        Others
                                                                                         ?molec a Chebi:Compound
       Cataloguing &
       Links Creation
                                                                                         ?molec a DrugBank:Drug
                               Life Sciences Linked Open Data
                                           (LSLOD)




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Availability: http://srvgal78.deri.ie:8080


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    Enabling Networked Knowledge
Enabling Networked Knowledge
Enabling Networked Knowledge
Enabling Networked Knowledge
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>

PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>

PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

PREFIX granatum: <http://chem.deri.ie/granatum/>

PREFIX uniprot: <http://bio2rdf.org/ns/uniprot:>

PREFIX dc: <http://purl.org/dc/elements/1.1/>

SELECT DISTINCT * WHERE {

?x0_Journal_Citation a uniprot:Journal_Citation ;

                    uniprot:pages ?x1_pages ;

                    dc:identifier ?x2_identifier ;

                    uniprot:volume ?x3_volume ;

                    uniprot:date ?x4_date ;

                    uniprot:author ?x5_author ;

                    rdf:void ?x6_void ;

                    granatum:title ?x7_title .

FILTER( regex( xsd:string( ?x7_title ), "mouse", "is" ) ) .

}




                Enabling Networked Knowledge
Enabling Networked Knowledge
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    Enabling Networked Knowledge
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ReVeaLD: A User-driven Domain Specific Interactive Search Platform for Biomedical Research

  • 1. ReVeaLD: A User-driven Domain Specific Interactive Search Platform for Biomedical Research Maulik R. Kamdar, Ali Hasnain, Helena F. Deus  Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Enabling Networked Knowledge
  • 2.           Enabling Networked Knowledge
  • 3. “Are there Drugs with molecular weight ~300 000 under 400 tested against ‘Colon Cancer’?” compounds ~300 interesting compounds ~ 10 interesting compounds Query databases Virtual Screening ~5 compounds Literature (Linked) Data Hypothesis Generation “Do any Publications refer to assays using ‘Aspirin’ as the primary Drug in treatment of ‘Prostrate Cancer’? Enabling Networked Knowledge
  • 4.      Enabling Networked Knowledge
  • 5.        Enabling Networked Knowledge
  • 6.     Enabling Networked Knowledge
  • 7. Hasnain et. al., EKAW 2012 Enabling Networked Knowledge
  • 8. CanCO Query Query Logging Saved Queries SPARQL Query Engine ?molec a Granatum:Molecule RDFization Transformation Experimental Chebi:Compound void-ext:subClassOf Granatum:Molecule Datasets Rule Templates DrugBank:Drug void-ext:subClassOf Granatum:Molecule Transformed Transformed Transformed Transformed Social Collaborative Query Query Query Query Workspace LSLOD Catalogue Chebi DrugBank UniProt Others ?molec a Chebi:Compound Cataloguing & Links Creation ?molec a DrugBank:Drug Life Sciences Linked Open Data (LSLOD) Enabling Networked Knowledge
  • 9.   Availability: http://srvgal78.deri.ie:8080 Enabling Networked Knowledge
  • 10.     Enabling Networked Knowledge
  • 14. PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> PREFIX xsd: <http://www.w3.org/2001/XMLSchema#> PREFIX granatum: <http://chem.deri.ie/granatum/> PREFIX uniprot: <http://bio2rdf.org/ns/uniprot:> PREFIX dc: <http://purl.org/dc/elements/1.1/> SELECT DISTINCT * WHERE { ?x0_Journal_Citation a uniprot:Journal_Citation ; uniprot:pages ?x1_pages ; dc:identifier ?x2_identifier ; uniprot:volume ?x3_volume ; uniprot:date ?x4_date ; uniprot:author ?x5_author ; rdf:void ?x6_void ; granatum:title ?x7_title . FILTER( regex( xsd:string( ?x7_title ), "mouse", "is" ) ) . } Enabling Networked Knowledge
  • 16.        Enabling Networked Knowledge
  • 21.     Enabling Networked Knowledge
  • 22.       Enabling Networked Knowledge