Retrovirus & oncogenes

Design by ChauChanLao 2010.05 Retroviruses & Oncogenes

病毒致癌理論 ,[object Object],jkweb.mcb.berkeley.edu

[object Object],www.dnalc.org 但RSV到底是透過什麼機制致癌？

RNA 病毒如何嵌入宿主 DNA 中？ ,[object Object],www.dnalc.org

RSV 是一種反轉錄病毒 (retrovirus) ,[object Object],www.dnalc.org Howard Temin David Baltimore

RSV 之 life cycle http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/RSV.html

Oncogene 之發現… ,[object Object],src gene可能就是致癌之原因 http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/RSV.html

RSV 之 gene ,[object Object],[object Object],[object Object],[object Object],[object Object],http://pathmicro.med.sc.edu/ Tyrosine kinase扮演加速細胞生長之角色

電腦的發展產生了影響…… ,[object Object],Organization of the human SRC gene. The exon–intron boundaries of the human SRC gene on chromosome 20q12.3 are shown. Exons 1A, 1α, 1B, and 1C constitute the 5′ noncoding region (white boxes), and Exons 2–12 constitute the open reading frame and 3′ noncoding region of c-Src mRNA (dark and light grey boxes, respectively). Two separate promoters are associated with exons 1α and 1A, and are termed the SRC 1α and SRC 1A promoters, respectively. The primary cis -acting DNA elements in these promoters that have been identified and characterized are shown, and are discussed in detail in the text. Alternative promoter use results in two distinct c-Src mRNA species that are shown at the bottom. These c-Src transcripts are identical in their coding capacity, but differ in their extreme 5′ ends. Biochem. Cell Biol. Vol. 82, 2004

Gain-of-function mutation ,[object Object],http://219.221.200.61/

除了病毒，多種因素亦會引起癌症… ,[object Object],[object Object],[object Object],基因層面的傷害容易使細胞走向癌化，特別是poto-oncogene 的突變

多種動物及人類本身的 poto-oncogene 陸續被發現 Principles of Cancer Biology, Lewis J. Kleinsmith, Pearson Higher Education, chapter 9

多種動物及人類本身的 poto-oncogene 陸續被發現 (con.) 世界上約15%癌症病患由病毒感染所致 Principles of Cancer Biology, Lewis J. Kleinsmith, Pearson Higher Education, chapter 9

Retrovirus之研究使人類發現oncogene之存在，幫助了癌症研究之發展

Retrovirus & oncogenes

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Retrovirus & oncogenes