Down regulationof forkheadboxm1transcriptionfactorleadstotheinhibitionofinvas...Chau Chan Lao
Down-regulation of Forkhead Box M1 Transcription Factor Leads to the Inhibition of Invasion and Angiogenesis of Pancreatic Cancer Cells.
Zhiwei Wang, Sanjeev Banerjee, Dejuan Kong, Yiwei Li, and Fazlul H. Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
Cancer Res 2007; 67: (17). September 1, 2007
Jak2 protein knockdown was achieved in BaF3 cells using siRNA nucleofection to study the effects on proliferation dependent on GCSF receptor isoforms. Results showed that Jak2 knockdown halted proliferation of cells with isoform IV but not isoform I, validating previous findings of Jak2's essential role in isoform IV signaling. Future experiments are planned to further examine downstream effects of Jak2 knockdown and address issues with cell viability in the absence of Jak2.
Down regulationof forkheadboxm1transcriptionfactorleadstotheinhibitionofinvas...Chau Chan Lao
Down-regulation of Forkhead Box M1 Transcription Factor Leads to the Inhibition of Invasion and Angiogenesis of Pancreatic Cancer Cells.
Zhiwei Wang, Sanjeev Banerjee, Dejuan Kong, Yiwei Li, and Fazlul H. Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
Cancer Res 2007; 67: (17). September 1, 2007
Jak2 protein knockdown was achieved in BaF3 cells using siRNA nucleofection to study the effects on proliferation dependent on GCSF receptor isoforms. Results showed that Jak2 knockdown halted proliferation of cells with isoform IV but not isoform I, validating previous findings of Jak2's essential role in isoform IV signaling. Future experiments are planned to further examine downstream effects of Jak2 knockdown and address issues with cell viability in the absence of Jak2.