This patient is at high risk for prerenal acute kidney injury secondary to dehydration from her diarrhea. Key things to assess:
- Volume status and hydration status
- Urine output
- Serum creatinine and BUN (to monitor for worsening renal function)
- Stool studies to check for C. difficile (given the nursing home outbreaks)
- Electrolytes to monitor for abnormalities like hypokalemia
- Consider IV fluids for rehydration if volume depleted
The goals of treatment would be rehydration, treatment of any infection if present, and monitoring for worsening kidney function which may require renal replacement therapy like dialysis. Addressing the underlying cause of the diarrhea
PowerPoint presentation reviewing renal failure. The review discusses both acute and chronic renal failure. Etiology, assessment, diagnosis and treatment are discussed.
The document provides an overview of acute renal failure for medical interns, discussing key points to consider such as causes, classifications, diagnostic testing, management, and prognosis. It classifies acute renal failure into pre-renal, intrinsic renal, and post-renal causes and emphasizes the importance of establishing the cause through history, physical exam, and urine/lab studies to guide treatment and predict outcomes.
This document provides an overview of pediatric nephrology topics including haematuria (blood in the urine), renal failure, proteinuria, urinary tract infections, and congenital anomalies. It discusses evaluation and causes of haematuria including glomerular diseases like post-streptococcal glomerulonephritis. Acute and chronic renal failure are summarized along with their etiologies, clinical manifestations, diagnosis, and management. Dialysis options for end-stage renal failure are also briefly covered.
Acute renal failure (ARF) is defined as a rapid reduction in kidney function resulting in build-up of waste products. It can be prerenal (functional), renal (structural), or postrenal (obstruction). Common causes include decreased blood flow, nephrotoxins, and urinary tract obstruction. Patients may present with edema, electrolyte abnormalities, and uremic symptoms. Diagnosis involves urine and blood tests. Treatment focuses on treating the underlying cause, fluid management, and sometimes dialysis.
This document provides an overview of acute kidney injury (AKI), chronic kidney disease (CKD), end-stage renal disease (ESRD), and their treatment and management. It discusses the pathophysiology, stages, symptoms, complications, medical and surgical interventions, and nursing care for each condition. Dialysis methods like hemodialysis and peritoneal dialysis are explained in detail. Surgical procedures for the kidneys like nephrectomy and transplantation are also summarized.
An abrupt (within 48hr) reduction in kidney function currently defined as an absolute increase in serum creatinine of either >0.3 mg/dL or a percentage increase of >50% or a reduction in UOP (documented as oliguria of <0.5 ml/kg/hr for >6hr)
Mr. Henle hasn't urinated in the night and may have acute renal failure (ARF). Key things to assess include urine output measured over the last few hours and days, symptoms, vital signs, and labs. ARF has multiple potential etiologies including prerenal from hypoperfusion, postrenal from obstruction, and intrinsic renal disease. Management involves treating the underlying cause, supporting the kidneys, and addressing complications like fluid overload and electrolyte abnormalities. Outcomes depend on severity and patient factors, with mortality around 50% for ARF.
PowerPoint presentation reviewing renal failure. The review discusses both acute and chronic renal failure. Etiology, assessment, diagnosis and treatment are discussed.
The document provides an overview of acute renal failure for medical interns, discussing key points to consider such as causes, classifications, diagnostic testing, management, and prognosis. It classifies acute renal failure into pre-renal, intrinsic renal, and post-renal causes and emphasizes the importance of establishing the cause through history, physical exam, and urine/lab studies to guide treatment and predict outcomes.
This document provides an overview of pediatric nephrology topics including haematuria (blood in the urine), renal failure, proteinuria, urinary tract infections, and congenital anomalies. It discusses evaluation and causes of haematuria including glomerular diseases like post-streptococcal glomerulonephritis. Acute and chronic renal failure are summarized along with their etiologies, clinical manifestations, diagnosis, and management. Dialysis options for end-stage renal failure are also briefly covered.
Acute renal failure (ARF) is defined as a rapid reduction in kidney function resulting in build-up of waste products. It can be prerenal (functional), renal (structural), or postrenal (obstruction). Common causes include decreased blood flow, nephrotoxins, and urinary tract obstruction. Patients may present with edema, electrolyte abnormalities, and uremic symptoms. Diagnosis involves urine and blood tests. Treatment focuses on treating the underlying cause, fluid management, and sometimes dialysis.
This document provides an overview of acute kidney injury (AKI), chronic kidney disease (CKD), end-stage renal disease (ESRD), and their treatment and management. It discusses the pathophysiology, stages, symptoms, complications, medical and surgical interventions, and nursing care for each condition. Dialysis methods like hemodialysis and peritoneal dialysis are explained in detail. Surgical procedures for the kidneys like nephrectomy and transplantation are also summarized.
An abrupt (within 48hr) reduction in kidney function currently defined as an absolute increase in serum creatinine of either >0.3 mg/dL or a percentage increase of >50% or a reduction in UOP (documented as oliguria of <0.5 ml/kg/hr for >6hr)
Mr. Henle hasn't urinated in the night and may have acute renal failure (ARF). Key things to assess include urine output measured over the last few hours and days, symptoms, vital signs, and labs. ARF has multiple potential etiologies including prerenal from hypoperfusion, postrenal from obstruction, and intrinsic renal disease. Management involves treating the underlying cause, supporting the kidneys, and addressing complications like fluid overload and electrolyte abnormalities. Outcomes depend on severity and patient factors, with mortality around 50% for ARF.
13 Evaluation And Management Of Acute Renal FailureDang Thanh Tuan
The document discusses evaluation and management of acute renal failure (ARF). It defines ARF as a rapid decline in kidney function over hours to weeks. ARF can be prerenal, intrinsic renal, or postrenal. Prerenal ARF is caused by reduced blood flow to the kidneys and is often reversible. Intrinsic renal ARF involves direct kidney damage from conditions like acute tubular necrosis. Postrenal ARF occurs when urine outflow is blocked. Management involves treating underlying causes, preventing further injury, managing complications conservatively, and initiating renal replacement therapy if needed.
This document discusses glomerular disease and glomerulonephritis. It begins by defining glomerular disease and glomerulonephritis, noting that glomerulonephritis is a type of glomerular disease involving inflammation of the glomeruli. It then discusses the main clinical presentations of glomerular disease, including nephrotic syndrome, acute glomerulonephritis, and asymptomatic urinary abnormalities. The causes, symptoms, investigations, and management of various glomerular diseases are subsequently outlined. Throughout, examples are provided of specific diseases like post-streptococcal glomerulonephritis, membranous nephropathy, and crescentic glomerulone
08 Al Ghonaim Approach To Acute Renal FailureDang Thanh Tuan
The document discusses acute renal failure (ARF), including its definition, epidemiology, etiology, diagnosis, and treatment. ARF can be pre-renal, renal, or post-renal in origin. The most common cause is acute tubular necrosis, often from hypotension, sepsis, or nephrotoxins. Diagnosis involves lab tests of kidney function and urinalysis. Treatment focuses on fluid management, avoiding nephrotoxins, and possibly dialysis.
08 Al Ghonaim Approach To Acute Renal Failureguest2379201
The document discusses acute renal failure (ARF), including its definition, epidemiology, etiology, diagnosis, and treatment. ARF can be pre-renal, renal, or post-renal in etiology. The most common cause is acute tubular necrosis, often from hypotension, sepsis, or nephrotoxins. Diagnosis involves lab tests of kidney function and urinalysis. Treatment focuses on fluid management, avoiding nephrotoxins, and possibly dialysis.
The kidneys play an important role in removing waste and regulating various functions in the body. Chronic kidney disease occurs when the kidneys become damaged and can no longer filter blood properly. It has stages from mild to severe and can progress to end-stage renal disease where dialysis or transplant is needed to survive. Treatment focuses on managing symptoms, slowing progression, and replacing kidney function through dialysis or transplant for end-stage disease.
The document summarizes renal support in patients with hepatic disease. It defines hepatorenal syndrome as renal failure that develops in patients with advanced liver disease due to alterations in renal physiology. HRS is diagnosed when renal dysfunction occurs in the absence of other identifiable kidney problems. The document outlines risk factors, types, diagnostic criteria, and management approaches for HRS, including prevention through infection control and treatment with vasoconstrictors, renal support, and liver transplantation.
Cirrhosis is a serious chronic disease characterized by widespread disruption of the normal liver structure by fibrosis and regenerative nodules caused by conditions like long-term alcohol abuse or hepatitis. Common causes include alcohol abuse, hepatitis B/C, and certain drugs. Symptoms include enlarged liver, jaundice, fluid in the abdomen, and changes to circulation, hormones, and bleeding risk. Treatment depends on the cause but may include medications, procedures to control bleeding, antibiotics, dialysis, and liver transplantation in severe cases.
This document discusses renal function tests and their importance in assessing kidney function and detecting impairment. It describes various tests including urine analysis, blood tests of creatinine and urea, and glomerular function tests. Common indications for evaluating renal function are listed, such as older age, diabetes, and hypertension. The document also outlines approaches to interpreting test results and diagnosing different kidney conditions like acute injury, nephritic syndrome, and nephrotic syndrome.
Acute renal failure is a medical emergency characterized by a rapid deterioration of renal function over hours to days. It is often reversible. It accounts for 1% of hospital admissions and complicates around 7% of inpatient episodes, with mortality rates of 5-10% in uncomplicated cases and 50-70% in severe cases involving sepsis or the need for dialysis. Causes include pre-renal factors reducing renal perfusion (40-70% of cases), intrinsic renal disease (10-50% of cases), and post-renal urinary outflow obstruction (10% of cases). Management focuses on treating the underlying cause, monitoring fluid balance, and considering dialysis for uraemic patients. Comp
1. The document provides an overview of renal anatomy and physiology, clinical manifestations of renal diseases, methods for estimating renal function, and common renal disease syndromes.
2. Key aspects of renal anatomy discussed include the structure and function of nephrons, the glomerular filtration barrier, and countercurrent exchange mechanisms.
3. Common clinical signs of renal diseases include edema, hypertension, flank pain, urinary abnormalities, and changes in estimated glomerular filtration rate.
4. Major renal disease syndromes covered are nephrotic syndrome, nephritic syndrome, acute renal failure, and chronic renal failure.
04 Differential Diagnosis Of Acute Renal Failureguest2379201
The document provides an overview of the differential diagnosis of acute renal failure (ARF). It discusses various causes that can lead to prerenal ARF including volume depletion, liver disease, heart failure, renal arterial disease, perinatal issues in newborns. It also covers intrinsic renal failure due to tubular diseases, interstitial diseases, glomerular diseases, vascula diseases, and nephrotoxins. Post-renal ARF due to urinary tract obstruction is also summarized. The document provides details on evaluation and laboratory findings that can help in differential diagnosis of ARF.
04 Differential Diagnosis Of Acute Renal FailureDang Thanh Tuan
The document provides an overview of the differential diagnosis of acute renal failure (ARF). It discusses various causes that can lead to prerenal ARF including volume depletion, liver disease, heart failure, renal arterial disease, hemorrhage, and asphyxia in newborns. Intrinsic renal failure can be caused by tubular diseases, interstitial diseases, glomerular diseases, or vascula diseases. Acute tubular necrosis is described as the most common cause. Post-renal ARF can result from urinary tract obstruction. Laboratory findings that can aid in diagnosis are also summarized.
04 Differential Diagnosis Of Acute Renal FailureDang Thanh Tuan
The document provides an overview of the differential diagnosis of acute renal failure. It discusses prerenal, intrinsic renal, and postrenal causes of acute renal failure. Prerenal causes include volume depletion, advanced liver disease, congestive heart failure, and renal arterial disease. Intrinsic renal causes include tubular diseases, interstitial diseases, glomerular diseases, and vascula diseases. Postrenal causes involve urinary obstruction.
The kidneys filter blood and regulate fluid levels in the body by selectively reabsorbing or secreting solutes. Urine passes from the kidneys through ureters into the bladder, then through the urethra. The kidneys contain nephrons which filter blood and reabsorb or excrete products. Hematuria, the presence of blood in urine, can indicate issues ranging from minor infections to serious conditions like cancer and requires medical evaluation.
This document discusses the clinical approach to a patient presenting with generalized edema. It defines edema and discusses mechanisms that can cause fluid accumulation. The main causes of generalized edema are cardiac (congestive heart failure), renal (nephrotic syndrome), hepatic (liver cirrhosis), nutritional (malnutrition), allergic reactions, and drugs. Investigations and treatment focus on identifying the underlying cause and using diuretics and fluid restriction to increase excretion of sodium and water. Diuretic classes - thiazides, loops, and potassium-sparing - are described along with their mechanisms, indications, side effects and contraindications. Diuretic resistance and its management are also covered.
This document discusses the clinical approach to a patient presenting with generalized edema. It defines edema and discusses mechanisms that can cause fluid accumulation. The main causes of generalized edema are cardiac (congestive heart failure), renal (nephrotic syndrome), hepatic (liver cirrhosis), nutritional (malnutrition), allergic reactions, and drugs. Investigations and treatment focus on identifying the underlying cause and using diuretics and fluid restriction to increase excretion of sodium and water. Diuretic classes - thiazides, loops, and potassium-sparing - are described along with their mechanisms, indications, side effects and contraindications. Diuretic resistance and its management are also covered.
The document discusses acute renal failure (ARF), defining it as the loss of renal function over hours to days resulting in the accumulation of nitrogenous waste products in the blood. It classifies the etiologies of ARF into prerenal, intrinsic renal, and postrenal causes. Prerenal ARF is due to decreased effective blood volume leading to renal vasoconstriction, while postrenal ARF results from urinary tract obstruction. Intrinsic renal ARF includes acute tubular necrosis, acute interstitial nephritis, and glomerulonephritis. Clinical evaluation involves assessing for risk factors and distinguishing between the types of ARF to guide management and treatment.
The document discusses acute renal failure (ARF), defining it as the loss of renal function over hours to days resulting in the accumulation of nitrogenous waste products in the blood. It classifies the etiologies of ARF into prerenal, intrinsic renal, and postrenal causes. Prerenal ARF is due to decreased effective blood volume leading to renal vasoconstriction, while postrenal ARF results from urinary tract obstruction. Intrinsic renal ARF includes acute tubular necrosis, acute interstitial nephritis, and glomerulonephritis. Clinical evaluation involves assessing for risk factors and distinguishing between the types of ARF to guide treatment and management.
Acute renal failure is a medical emergency characterized by a rapid deterioration of renal function over hours to days that is often reversible. It accounts for 1% of hospital admissions and complicates around 7% of inpatient episodes, with mortality rates of 5-10% in uncomplicated cases and 50-70% in severe cases involving sepsis or the need for dialysis. Acute renal failure is commonly caused by pre-renal factors that decrease renal perfusion such as hypovolemia, post-renal obstruction of urinary outflow, or intrinsic renal disease including acute tubular necrosis, interstitial nephritis, or glomerular disease. Management involves treating the underlying cause, monitoring fluid balance, and considering
13 Evaluation And Management Of Acute Renal FailureDang Thanh Tuan
The document discusses evaluation and management of acute renal failure (ARF). It defines ARF as a rapid decline in kidney function over hours to weeks. ARF can be prerenal, intrinsic renal, or postrenal. Prerenal ARF is caused by reduced blood flow to the kidneys and is often reversible. Intrinsic renal ARF involves direct kidney damage from conditions like acute tubular necrosis. Postrenal ARF occurs when urine outflow is blocked. Management involves treating underlying causes, preventing further injury, managing complications conservatively, and initiating renal replacement therapy if needed.
This document discusses glomerular disease and glomerulonephritis. It begins by defining glomerular disease and glomerulonephritis, noting that glomerulonephritis is a type of glomerular disease involving inflammation of the glomeruli. It then discusses the main clinical presentations of glomerular disease, including nephrotic syndrome, acute glomerulonephritis, and asymptomatic urinary abnormalities. The causes, symptoms, investigations, and management of various glomerular diseases are subsequently outlined. Throughout, examples are provided of specific diseases like post-streptococcal glomerulonephritis, membranous nephropathy, and crescentic glomerulone
08 Al Ghonaim Approach To Acute Renal FailureDang Thanh Tuan
The document discusses acute renal failure (ARF), including its definition, epidemiology, etiology, diagnosis, and treatment. ARF can be pre-renal, renal, or post-renal in origin. The most common cause is acute tubular necrosis, often from hypotension, sepsis, or nephrotoxins. Diagnosis involves lab tests of kidney function and urinalysis. Treatment focuses on fluid management, avoiding nephrotoxins, and possibly dialysis.
08 Al Ghonaim Approach To Acute Renal Failureguest2379201
The document discusses acute renal failure (ARF), including its definition, epidemiology, etiology, diagnosis, and treatment. ARF can be pre-renal, renal, or post-renal in etiology. The most common cause is acute tubular necrosis, often from hypotension, sepsis, or nephrotoxins. Diagnosis involves lab tests of kidney function and urinalysis. Treatment focuses on fluid management, avoiding nephrotoxins, and possibly dialysis.
The kidneys play an important role in removing waste and regulating various functions in the body. Chronic kidney disease occurs when the kidneys become damaged and can no longer filter blood properly. It has stages from mild to severe and can progress to end-stage renal disease where dialysis or transplant is needed to survive. Treatment focuses on managing symptoms, slowing progression, and replacing kidney function through dialysis or transplant for end-stage disease.
The document summarizes renal support in patients with hepatic disease. It defines hepatorenal syndrome as renal failure that develops in patients with advanced liver disease due to alterations in renal physiology. HRS is diagnosed when renal dysfunction occurs in the absence of other identifiable kidney problems. The document outlines risk factors, types, diagnostic criteria, and management approaches for HRS, including prevention through infection control and treatment with vasoconstrictors, renal support, and liver transplantation.
Cirrhosis is a serious chronic disease characterized by widespread disruption of the normal liver structure by fibrosis and regenerative nodules caused by conditions like long-term alcohol abuse or hepatitis. Common causes include alcohol abuse, hepatitis B/C, and certain drugs. Symptoms include enlarged liver, jaundice, fluid in the abdomen, and changes to circulation, hormones, and bleeding risk. Treatment depends on the cause but may include medications, procedures to control bleeding, antibiotics, dialysis, and liver transplantation in severe cases.
This document discusses renal function tests and their importance in assessing kidney function and detecting impairment. It describes various tests including urine analysis, blood tests of creatinine and urea, and glomerular function tests. Common indications for evaluating renal function are listed, such as older age, diabetes, and hypertension. The document also outlines approaches to interpreting test results and diagnosing different kidney conditions like acute injury, nephritic syndrome, and nephrotic syndrome.
Acute renal failure is a medical emergency characterized by a rapid deterioration of renal function over hours to days. It is often reversible. It accounts for 1% of hospital admissions and complicates around 7% of inpatient episodes, with mortality rates of 5-10% in uncomplicated cases and 50-70% in severe cases involving sepsis or the need for dialysis. Causes include pre-renal factors reducing renal perfusion (40-70% of cases), intrinsic renal disease (10-50% of cases), and post-renal urinary outflow obstruction (10% of cases). Management focuses on treating the underlying cause, monitoring fluid balance, and considering dialysis for uraemic patients. Comp
1. The document provides an overview of renal anatomy and physiology, clinical manifestations of renal diseases, methods for estimating renal function, and common renal disease syndromes.
2. Key aspects of renal anatomy discussed include the structure and function of nephrons, the glomerular filtration barrier, and countercurrent exchange mechanisms.
3. Common clinical signs of renal diseases include edema, hypertension, flank pain, urinary abnormalities, and changes in estimated glomerular filtration rate.
4. Major renal disease syndromes covered are nephrotic syndrome, nephritic syndrome, acute renal failure, and chronic renal failure.
04 Differential Diagnosis Of Acute Renal Failureguest2379201
The document provides an overview of the differential diagnosis of acute renal failure (ARF). It discusses various causes that can lead to prerenal ARF including volume depletion, liver disease, heart failure, renal arterial disease, perinatal issues in newborns. It also covers intrinsic renal failure due to tubular diseases, interstitial diseases, glomerular diseases, vascula diseases, and nephrotoxins. Post-renal ARF due to urinary tract obstruction is also summarized. The document provides details on evaluation and laboratory findings that can help in differential diagnosis of ARF.
04 Differential Diagnosis Of Acute Renal FailureDang Thanh Tuan
The document provides an overview of the differential diagnosis of acute renal failure (ARF). It discusses various causes that can lead to prerenal ARF including volume depletion, liver disease, heart failure, renal arterial disease, hemorrhage, and asphyxia in newborns. Intrinsic renal failure can be caused by tubular diseases, interstitial diseases, glomerular diseases, or vascula diseases. Acute tubular necrosis is described as the most common cause. Post-renal ARF can result from urinary tract obstruction. Laboratory findings that can aid in diagnosis are also summarized.
04 Differential Diagnosis Of Acute Renal FailureDang Thanh Tuan
The document provides an overview of the differential diagnosis of acute renal failure. It discusses prerenal, intrinsic renal, and postrenal causes of acute renal failure. Prerenal causes include volume depletion, advanced liver disease, congestive heart failure, and renal arterial disease. Intrinsic renal causes include tubular diseases, interstitial diseases, glomerular diseases, and vascula diseases. Postrenal causes involve urinary obstruction.
The kidneys filter blood and regulate fluid levels in the body by selectively reabsorbing or secreting solutes. Urine passes from the kidneys through ureters into the bladder, then through the urethra. The kidneys contain nephrons which filter blood and reabsorb or excrete products. Hematuria, the presence of blood in urine, can indicate issues ranging from minor infections to serious conditions like cancer and requires medical evaluation.
This document discusses the clinical approach to a patient presenting with generalized edema. It defines edema and discusses mechanisms that can cause fluid accumulation. The main causes of generalized edema are cardiac (congestive heart failure), renal (nephrotic syndrome), hepatic (liver cirrhosis), nutritional (malnutrition), allergic reactions, and drugs. Investigations and treatment focus on identifying the underlying cause and using diuretics and fluid restriction to increase excretion of sodium and water. Diuretic classes - thiazides, loops, and potassium-sparing - are described along with their mechanisms, indications, side effects and contraindications. Diuretic resistance and its management are also covered.
This document discusses the clinical approach to a patient presenting with generalized edema. It defines edema and discusses mechanisms that can cause fluid accumulation. The main causes of generalized edema are cardiac (congestive heart failure), renal (nephrotic syndrome), hepatic (liver cirrhosis), nutritional (malnutrition), allergic reactions, and drugs. Investigations and treatment focus on identifying the underlying cause and using diuretics and fluid restriction to increase excretion of sodium and water. Diuretic classes - thiazides, loops, and potassium-sparing - are described along with their mechanisms, indications, side effects and contraindications. Diuretic resistance and its management are also covered.
The document discusses acute renal failure (ARF), defining it as the loss of renal function over hours to days resulting in the accumulation of nitrogenous waste products in the blood. It classifies the etiologies of ARF into prerenal, intrinsic renal, and postrenal causes. Prerenal ARF is due to decreased effective blood volume leading to renal vasoconstriction, while postrenal ARF results from urinary tract obstruction. Intrinsic renal ARF includes acute tubular necrosis, acute interstitial nephritis, and glomerulonephritis. Clinical evaluation involves assessing for risk factors and distinguishing between the types of ARF to guide management and treatment.
The document discusses acute renal failure (ARF), defining it as the loss of renal function over hours to days resulting in the accumulation of nitrogenous waste products in the blood. It classifies the etiologies of ARF into prerenal, intrinsic renal, and postrenal causes. Prerenal ARF is due to decreased effective blood volume leading to renal vasoconstriction, while postrenal ARF results from urinary tract obstruction. Intrinsic renal ARF includes acute tubular necrosis, acute interstitial nephritis, and glomerulonephritis. Clinical evaluation involves assessing for risk factors and distinguishing between the types of ARF to guide treatment and management.
Acute renal failure is a medical emergency characterized by a rapid deterioration of renal function over hours to days that is often reversible. It accounts for 1% of hospital admissions and complicates around 7% of inpatient episodes, with mortality rates of 5-10% in uncomplicated cases and 50-70% in severe cases involving sepsis or the need for dialysis. Acute renal failure is commonly caused by pre-renal factors that decrease renal perfusion such as hypovolemia, post-renal obstruction of urinary outflow, or intrinsic renal disease including acute tubular necrosis, interstitial nephritis, or glomerular disease. Management involves treating the underlying cause, monitoring fluid balance, and considering
The document provides guidance on performing a clinical breast examination. It discusses the anatomy of the breast and lymphatics, assessing risk factors, performing visual inspection and palpation of the breasts and axillae, documenting abnormal findings, and teaching breast self-examination techniques. The goal of the examination is to evaluate for masses, tenderness, discharge, skin changes, and lymphadenopathy that could indicate breast abnormalities.
Differential equations relate a function with its derivatives. They model systems where quantities change, with derivatives representing rates of change. There are two main types: ordinary differential equations containing ordinary derivatives of a single variable, and partial differential equations with partial derivatives of multiple variables. Differential equations are classified by order, degree, linearity and type. Solutions are determined using general solutions along with initial or boundary conditions.
This document provides an introduction to differentials and infinitessimals. It discusses how differentials represent infinitesimal changes in calculus and how they can be understood through the hyperreal number system containing nonzero infinitesimals. While differentials are essentially zero with respect to real numbers, their ratios and sums can provide finite results. The document cautions that differentials cannot always be canceled and provides an example using discontinuous functions to illustrate this point. It concludes by summarizing the appropriate conditions for canceling differentials.
This document discusses menopause, its causes, symptoms, diagnosis, and treatment options. It defines menopause and related terms, and notes that the average age of menopause is around 51 years old. Symptoms can include hot flashes, mood changes, and vaginal dryness. Diagnosis is made if a woman has not had a period in 12 months. Treatment options include lifestyle changes, hormone therapy, and medications to help with symptoms. Hormone therapy has risks but can help treat menopausal symptoms and prevent osteoporosis.
Headache Syndromes presentation Dr. Tarek .pptxAhmedalmahdi16
The document provides diagnostic criteria and treatment guidelines for various headache conditions including migraine without aura, cluster headaches, chronic daily headaches, and trigeminal neuralgia. It discusses diagnostic features, first-line and alternative treatment options involving medications like triptans, topiramate, propranolol, verapamil, and carbamazepine. It also notes risk factors, complications, and when to consider specialist referral for certain headache conditions.
- Herpesviruses are a leading cause of human viral diseases and can cause overt disease or remain latent for many years.
- They have a DNA genome surrounded by an envelope and tegument. Human herpesviruses are classified into three subfamilies.
- Herpes simplex virus types 1 and 2 can cause diseases like gingivostomatitis, genital herpes, and neonatal herpes. Varicella zoster virus causes chickenpox and shingles.
- Cytomegalovirus and Epstein-Barr virus are associated with mononucleosis and some cancers. Human herpesvirus 6 causes roseola infantum. Human herpesvirus 8 causes Kaposi
This document provides an overview of epilepsy including definitions, types of seizures, causes, risk factors, diagnostic approach, treatment options, and antiepileptic drug management. Key points include: epilepsy is defined as recurrent unprovoked seizures; status epilepticus is a medical emergency; common causes include vascular, infectious, traumatic, autoimmune and metabolic factors; evaluation involves clinical history, EEG, MRI and video telemetry; treatment involves acute seizure control and chronic antiepileptic drug management to prevent recurrence; drug selection depends on seizure type and side effect profile; surgery is an option for drug-resistant cases.
The document discusses cerebellar disorders. It is presented by Dr. Ahmed Ali Alhareb, a senior specialist in internal medicine. The cerebellum is an important part of the brain that controls motor coordination, balance and muscle tone.
Stroke presentation final Dr. Tarek (1).pptxAhmedalmahdi16
This document summarizes key information about stroke including types, symptoms, diagnosis, and treatment. It discusses that ischemic stroke is the most common type, resulting from artery occlusion. Transient ischemic attacks (TIAs) are defined as temporary neurological deficits without infarction. Computed tomography (CT) and magnetic resonance imaging (MRI) are important diagnostic tools. Treatment depends on the type of stroke, but may include thrombolysis for ischemic strokes within 4.5 hours if hemorrhage is excluded, and controlling blood pressure for hemorrhagic strokes.
1. The document discusses neuroinflammatory demyelinating disorders, focusing on multiple sclerosis. It defines MS as an inflammatory demyelinating disease of the central nervous system characterized by dissemination in space and time.
2. The document reviews the epidemiology of MS, noting it predominantly affects young white women and those living in northern latitudes. It also outlines the McDonald criteria for diagnosing MS.
3. Treatment options discussed include pulse corticosteroids for acute exacerbations and disease-modifying therapies to reduce frequency of relapses.
MALToma is a type of extranodal marginal zone B-cell lymphoma that occurs in the stomach. It is often caused by H. pylori infection or genetic translocations that activate the NF-κB pathway. H. pylori treatment is effective for MALTomas without genetic changes. Carcinoid tumors occur most commonly in the stomach and small intestine. Their aggressiveness depends on their location, with midgut tumors being the most aggressive. GISTs arise from interstitial cells of Cajal in the stomach and have mutations in KIT or PDGFRA genes. They are typically treated with imatinib but resistance can develop.
This person loves winter because they were born in it and enjoy going for walks in the rain or snow, finding winter weather comfortable without heat or humidity. While most people prefer summer, they can walk or be active in winter without worrying about sweating or heat stroke unlike in hot summer weather.
Dr. Alshehri's presentation covered intravenous fluids and acid-base balance for surgical patients. The key points discussed included:
1) Calculating daily fluid requirements using the 4-2-1 formula and understanding electrolyte needs.
2) Comparing different types of intravenous fluids including crystalloids like normal saline and lactated ringer's and colloids like albumin.
3) Identifying common fluid and electrolyte disturbances in surgical patients such as dehydration, hyponatremia, and hypokalemia and their treatment.
4) Explaining acid-base balance and different acid-base disorders like respiratory acidosis and metabolic alkalosis that can be analyzed on an
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central19various
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
2. Assessment of Renal Function
Glomerular Filtration Rate (GFR)
= the volume of water filtered from the plasma per unit of
time.
Gives a rough measure of the number of functioning
nephrons
Normal GFR:
Men: 130 mL/min./1.73m2
Women: 120 mL/min./1.73m2
Cannot be measured directly, so we use creatinine and
creatinine clearance to estimate.
3. Assessment of Renal Function (cont.)
Creatinine
A naturally occurring amino acid, predominately found in skeletal
muscle
Freely filtered in the glomerulus, excreted by the kidney and
readily measured in the plasma
As plasma creatinine increases, the GFR exponentially
decreases.
Limitations to estimate GFR:
Patients with decrease in muscle mass, liver disease, malnutrition,
advanced age, may have low/normal creatinine despite underlying
kidney disease
15-20% of creatinine in the bloodstream is not filtered in glomerulus,
but secreted by renal tubules (giving overestimation of GFR)
Medications may artificially elevate creatinine:
Trimethroprim (Bactrim)
Cimetidine
4. Assessment of Renal Function (cont.)
Creatinine Clearance
Best way to estimate GFR
GFR = (creatinine clearance) x (body surface area in m2/1.73)
Ways to measure:
24-hour urine creatinine:
Creatinine clearance = (Ucr x Uvol)/ plasma Cr
Cockcroft-Gault Equation:
(140 - age) x lean body weight [kg]
CrCl (mL/min) = ——————————————— x 0.85 if
Cr [mg/dL] x 72 female
Limitations: Based on white men with non-diabetes kidney disease
Modification of Diet in Renal Disease (MDRD) Equation:
GFR (mL/min./1.73m2) = 186 X (SCr)-1.154 X (Age)-0.203 X (0.742 if
female) X (1.210 if African-American )
7. Vascular Disease
Acute
Vasculitis – Wegener’s granulomatosis
Thromboembolic disease
TTP/HUS
Malignant hypertension
Scleroderma renal crisis
Chronic
Benign hypertensive nephrosclerosis
Intimal thickening and luminal narrowing of the large and small renal arteries and the
glomerular arterioles usually due to hypertension.
Most common in African Americans
Treatment:
Hypertension control
Bilateral renal artery stenosis
should be suspected in patients with acute, severe, or refractory hypertension who also
have otherwise unexplained renal insufficiency
Treatment:
Medical therapy, surgery, stents.
8. Glomerular Disease
Nephritis
Inflammation seen on histologic exam
Active sediment: Red cells, white cells, granular casts, red
cell casts
Variable degree of proteinuria (< 3g/day)
Nephrotic
No inflammation
Bland sediment: No cells, fatty casts
Nephrotic range proteinuria (>3.5 g/day)
Nephrotic syndrome = proteinuria + hyperlipidemia + edema
18. Obstructive Uropathy
Obstruction of the urinary flow anywhere
from the renal pelvis to the urethra
Can be acute or chronic
Most commonly caused by tumor or
prostatic enlargement (hyperplasia or
malignancy)
Need to have bilateral obstruction in order
to have renal insufficiency
19. Chronic Kidney Disease
= a GFR of < 60 for 3 months or more.
Most common causes:
Diabetes Mellitus
Hypertension
Management:
Blood pressure control!
Diabetic control!
Smoking cessation
Dietary protein restriction
Phosphorus lowering drugs/ Calcium replacement
Most patients have some degree of hyperparathyroidism
Erythropoietin replacement
Start when Hgb < 10 g/dL
Bicarbonate therapy for acidosis
Dialysis?
20. Stages of Chronic Kidney Disease
Stage Description GFR (mL/min/1.73 m2)
1 Kidney damage with normal or
increased GFR
≥ 90
2 Kidney damage with mildly
decreased GFR
60-89
3 Moderately decreased GFR 30-59
4 Severely decreased GFR 15-29
5 Kidney Failure < 15
21. Acute Renal Failure
An abrupt decrease in renal function
sufficient to cause retention of metabolic
waste such as urea and creatinine.
Frequently have:
Metabolic acidosis
Hyperkalemia
Disturbance in body fluid homeostasis
Secondary effects on other organ systems
22. Acute Renal Failure
Most community acquired acute renal
failure (70%) is prerenal
Most hospital acquired acute renal failure
(60%) is due to ischemia or nephrotoxic
tubular epithelial injury (acute tubular
necrosis).
Mortality rate 50-70%
23. Advanced age
Preexisting renal parenchymal disease
Diabetes mellitus
Underlying cardiac or liver disease
Risk factor for acute renal failure
24. Urine Output in Acute Renal failure
Oliguria
= daily urine output < 400 mL
When present in acute renal failure, associated with a
mortality rate of 75% (versus 25% mortality rate in non-
oliguric patients)
Most deaths are associated with the underlying disease
process and infectious complications
Anuria
No urine production
Uh-oh, probably time for dialysis
25. Most common causes of ACUTE
Renal Failure
Prerenal
Acute tubular necrosis (ATN)
Acute on chronic renal failure (usually due to
ATN or prerenal)
Obstructive uropathy
Glomerulonephritis/Vasculitis
Acute Interstitial nephritis
Atheroemboli
26. Assessing the patient with acute renal
failure
History:
Cancer?
Recent Infections?
Blood in urine?
Change in urine output?
Flank Pain?
Recent bleeding?
Dehydration? Diarrhea? Nausea? Vomiting?
Blurred vision? Elevated BP at home? Elevated sugars?
27. Assessing the patient with acute renal
failure (cont.)
Family History:
Cancers?
Polycystic kidney disease?
Meds:
Any non-compliance with diabetic or
hypertensive meds?
Any recent antibiotic use?
Any NSAID use?
29. Assessing the patient with acute renal
failure – Laboratory analysis
Fractional excretion of sodium:
(UrineNa+ x PlasmaCreatinine)
FENa= ______________________ x 100
(PlasmaNa+ x UrineCreatinine)
FENa < 1% → Prerenal
FENa > 2% → Epithelial tubular injury (acute tubular
necrosis), obstructive uropathy
If patient receiving diuretics, can check FE of urea.
30. Assessing the patient with acute renal
failure -- Radiology
Renal Ultrasound
Look for signs of hydronephrosis as sign of
obstructive uropathy.
31. Assessing the patient with acute renal
failure – Urinalysis
Hematuria
Non-glomerular:
Urinary sediment: intact red blood cells
Causes:
Infection
Cancer
Obstructive Uropathy
Rhabdomyolysis
myoglobinuria; Hematuria with no RBCs
Glomerular:
Urine sediment: dysmorphic red blood cells, red cell casts
Causes:
Glomerulonephritis
Vasculitis
Atheroembolic disease
TTP/HUS (thombotic microangiopathy)
32. Assessing Patient with Acute Renal
Failure – Urinalysis (cont.)
Protein
Need microscopic urinalysis to see microabluminemia
Can check 24-hour urine protein collection
Nephrotic syndrome - ≥ 3.5 g protein in 24 hours
Albuminuria
Glomerulonephritis
Atheroembolic disease
(TTP/HUS) Thrombotic microangiopathy
Nephrotic syndrome
Tubular proteinuria
Tubular epithelial injury (acute tubular necrosis)
Interstitial nephritis
33. Assessing patient with acute renal
failure – Urinary Casts
Red cell casts Glomerulonephritis
Vasculitis
White Cell casts Acute Interstitial
nephritis
Fatty casts Nephrotic
syndrome, Minimal
change disease
Muddy Brown casts Acute tubular
necrosis
34. Assessing patient with acute renal
failure – Renal Biopsy
If unable to discover cause of renal
disease, renal biopsy may be warranted.
Renal biopsy frequently performed in
patient’s with history of renal transplant with
worsening renal function.
36. Indications for Hemodialysis
Refractory fluid overload
Hyperkalemia (plasma potassium concentration >6.5 meq/L)
or rapidly rising potassium levels
Metabolic acidosis (pH less than 7.1)
Azotemia (BUN greater than 80 to 100 mg/dL [29 to 36
mmol/L])
Signs of uremia, such as pericarditis, neuropathy, or an
otherwise unexplained decline in mental status
Severe dysnatremias (sodium concentration greater than 155
meq/L or less than 120 meq/L)
Hyperthermia
Overdose with a dialyzable drug/toxin
37. Question # 1
A 82-year old female with a history of
Alzheimer’s dementia presents from her
nursing home with diarrhea for three days.
Per nursing home documents, there have
been multiple recent outbreaks of C.
difficile colitis among their residents.
41. Question # 1 (cont.)
What further information would be helpful in
evaluating this patient?
What are some possible diagnoses in this
patient?
What further studies would you like to do?
What might you see in urinary sediment?
43. Question # 1 (cont.)
What kind of renal failure do you think this
patient has?
How would you treat this patient?
44. Question #2
A 75-year old woman is admitted to the
hospital for confusion. The patient is
oriented to person but not time or place.
She has a history of cervical cancer,
treated with total hysterectomy and
radiation 18 months ago. Previous
evaluation in her private physician’s office 3
months ago showed her serum creatinine
concentration was 1.0 mg/dL.
45. Question #2 (cont.)
Physical examination shows a temperature of 36.2° C, a
regular pulse rate of 98/min., a regular respiration rate of
20/min., and a blood pressure of 110/60 mmHg. There is no
orthostasis. There is no neck vein distention at 45 degrees,
and the chest is clear. S1 and S2 are normal, without gallop
or murmur. Liver span is 18 cm, and the edge is three finger
breadths below the right costal margin. The spleen tip is
palpable before the left costal margin. There is shifting
dullness and bowel sounds are present. There is 2+ pedal
edema. Cranial nerves and reflexes are normal, and the
neurologic examination did not elicit focal findings.
47. Question # 2 (cont.)
The most appropriate initial step in the
clinical management of this patient is:
(A) Renal ultrasound
(B) Renal Biopsy
(C) A trial of normal saline at 300 mL/hr for 2 hours
(D) Continuous arteriovenous hemofiltration
(E) Renal scintigraphy
48. Question # 3
A 45-year old male with a history of metastatic
colon cancer is admitted to the hospital for pain
control. Patient has known metastases to the
spine and pelvis, and has had worsening pain
over the last several weeks. Palliative care is
consulted and helps with pain control. However,
his hospitalization is complicated by nosocomial
pneumonia. He underwent a staging CT on
Hospital #6, which showed a mild increase in size
of spinal, pelvic mets. On hospital day #8, his
daily chemistry shows an increase in his
creatinine from 1.0 the day before to 1.9.
49. Question # 3 (cont.)
PMH:
Colon cancer (diagnosed 4 years ago, s/p partial colectomy,
chemo., radiation; known mets to liver, lungs, spine/pelvis)
GERD
Allergies: PCN
Current Meds:
Ciprofloxacin
Vancomycin
Amikacin
Dilaudid PCA
Pericolace
Nexium
50. Question #3
What are some possible causes of renal
failure in this patient?
What would you do the urine sediment
shows muddy brown casts?
What would you suspect if urine
eosinophils are seen?