The document provides diagnostic criteria and treatment guidelines for various headache conditions including migraine without aura, cluster headaches, chronic daily headaches, and trigeminal neuralgia. It discusses diagnostic features, first-line and alternative treatment options involving medications like triptans, topiramate, propranolol, verapamil, and carbamazepine. It also notes risk factors, complications, and when to consider specialist referral for certain headache conditions.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
5. Headache has at least two of the following
characteristics :
* Unilateral location .
* Pulsating quality ( varying with heartbeat )
* Moderate or severe pain intensity .
* Aggravation by or causing avoidance of
routine physical activity e.g walking or
climbing stairs .
6. During headache at least one of the
following :
* Nausea and / or vomiting .
* Photophobia and phonophobia .
7. Not attributed to another disorder ( history
& examination do not suggest a secondary
headache disorder ) .
8. Attacks may be shorter lasting .
Headache is more commonly bilateral .
Gastrointestinal disturbance is more
prominent .
9. A typical aura may occur hours prior to the
headache .
Include a transient hemianopic disturbance
, spreading scintilling scotoma & sensory
symptoms may also occur .
10. Is one which results in hemi sensory or
hemi motor finding associated with a typical
migraine presentation .
It is like TIA but the pt. is Young age & has
past medical history for migraines .
12. Acute : ( Triptan + NSAID ) or ( Triptan +
Paracetamol ) .
Young People aged 12-17 Years consider a
nasal triptan in perference to an oral
triptan.
13. If the above measures are not effective or
not tolerated offer a non-oral preparation
of metoclopramide or prochlorperazine &
consider adding a non-oral NSAID or
Triptan .
15. Prophylaxis should be given if pts. are
experiencing > or = 2 attacks per month .
Nice advice either Topiramate or
propranolol according to person’s
preference , comorbidities & risk of adverse
events .
16. Propranolol should be used in preference to
topiramate in women of child bearing age
as it may be teratogenic & it can reduce the
effectiveness of hormonal contraceptives .
17. If these measures fail NICE recommend a
course of up to 10 sessions of acupuncture
over 5-8 weeks or gabapentin .
18. NICE recommend : Advise people with
migraine that riboflavin ( 400 mg once a
day ) may be effective in reducing migraine
frequency & intensity for some people .
19. For women with predictable menstrual
migraine treatment NICE recommend either
frovatriptan or zolmitriptan as a type of
mini-prophylaxis .
20. Paracetamol 1g is first-line .
Aspirin 300 mg or Ibuprofen 400 mg can be
used second-line in the first & second
trimester .
21. Frequency & severity of migraines increase
around the time of menstruation .
SIGN recommends that women are treated
with mefanamic acid or a combination of
aspirin , paracetamol & caffeine .
22. Triptans are also recommended in the acute
situation .
NICE recommend either frovatriptan or
zolmitriptan as a type of mini-prophylaxis .
23. If pts. Have migraine with aura then the
COC is absolutely CI due to an increased
risk of stroke .
Ergot derived compounds & Triptans are CI
for treatment of hemiplegic migraine
because of the risk of precipitating a stroke.
24. Safe to prescribe Hormone replacement
therapy for pts. With a history of migraine
but it may make migraines worse .
26. Pain typical occurs once or twice a day .
Episode lasting 15 minutes – 2 hours .
Clusters typically last 4 – 12 weeks .
27. Intense pain around one eye ( recurrent
attacks always affect same side ) .
Accompained by eye redness , lacrimation &
lid swelling .
Miosis & Ptosis in a minority .
28. Nasal stuffiness , Rhinorrhoea .
Pt. is restless during an attack .
Examination between the attacks should be
normal .
31. Consider specialist referral .
Sumatriptan associated with chest pain
possibly due to vasospasm & also ass. With
MI so contraindicated in pts. With known
IHD .
32. It is one of the most common causes of
chronic daily headache .
33. Present for > 15 days per month .
Developed or worsened while taking regular
symptomatic medication .
34. Pts. Using opioids & Triptans are at most
risk .
May be Psychiatric co-morbidity .
38. A unilateral disorder characterised by brief
electric shock-like pains , abrupt in onset &
termination , limited to one or more
divisions of the trigeminal nerve .
39. The pain is commonly evoked by light touch
including washing , shaving , smoking ,
talking & brushing the teeth ( trigger factors
) & frequently occurs spontaneously .
40. Small areas in the nasolabial fold or chin
may be particularly susceptible to the
precipitation of pain ( trigger areas ) .
The pain usually remit for variable periods .
41. Majority of cases are idiopathic .
Compression of the trigeminal roots by
tumours or vascular problems may occur .
42. Carbamazepine is first line .
Failure to respond to treatment or atypical
features ( e.g < 50 Years old ) should
prompt referral to neurology .
43. Sudden enlargement of pituitary tumour
secondary to haemorrhage or infarction .
45. Visual field defects .
Extra ocular nerve palsies with third nerve
palsy the commonest finding .
Features of pituitary insufficiency e.g
Hypotension secondary to hypoadrenalism .
48. Avoid aspirin in children < 16 Years as risk of
Reye’s Syndrome .
Codeine would also be a poor choice as it has
limited benefit in migraine .
49. Pts. With migraine experience delayed gastric
emptying during acute attacks so decrease effect of
analgesics , for this reason analgesics are often
combined prokinetic agents as metoclopramide .