Transport in Human
At the end of the lesson, you should be able to

    State the functions of blood:
      Red blood cells – haemoglobin which aids in oxygen
       transport
      White blood cells – phagocytosis, antibody
       formation and tissue rejection
      Platelets – fibrinogen to fibrin, causing clotting

      Plasma – transport of blood cells, ions, soluble food
       substances, hormones, carbon dioxide, urea,
       vitamins, plasma proteins


                                                           2
What is Blood?             Blood
3 types of cells present in the
human blood cell:
• red blood cells
  (erythrocytes)
• white blood cells
  (leukocytes)                     plasma, 55%
• platelets (thrombocytes)
Plasma is a liquid consisting
91% water which has
                                   blood cells, 45%
inorganic ions, nutrients,
waste products, hormones
and soluble proteins dissolved
in it.
                                                      3
Red Blood Cells           Blood
   Formed in bone marrows of long bones.
   Formed from nucleated cells called erythroblasts.
   Exposed to maximum surface area for the exchange of
    oxygen and carbon dioxide.
   95% of the protein in red blood cell is haemoglobin and
    5% of the protein are enzymes that allow the cell to
    survive for about 120 days.
       cytoplasm
       containing
      haemoglobin




        plasma
       membrane



                                                              4
Red Blood Cells            Blood
   The binding of oxygen to haemoglobin is reversible.
   In the lungs, where oxygen concentration is high, oxygen
    combines with haemoglobin to form oxyhaemoglobin.
   When blood arrives at cells where the oxygen concentration
    is low, it unloads and becomes maroon haemoglobin once
    again.
                      high oxygen concentration
       Hb + 4O2                                        Hb(O2)4
     (haemoglobin)    low oxygen concentration    (oxyhaemoglobin)




                                                                     5
Red Blood Cells             Blood
     As red blood cells pass through tissues, they pick up carbon dioxide.
     Most of the carbon dioxide combines with water to form carbonic acid.
                  CO2 + H2O                   H2CO3
                                              carbonic
                                              acid

     The carbonic acid then ionises to form hydrogen ions and hydrogen
      carbonate ions.

                 H2CO3               H+ + HCO¯
                                             3
                  carbonic acid    hydrogen     hydrogen
                                      ion     carbonate ion


     About 70% of the ions leave the red blood cells and remain in plasma.
     When the blood reaches the lungs, carbon dioxide is released and
      diffuses out of the blood to enter the alveoli.
     Carbon dioxide is then breathed out.


                                                                        6
What is anaemia?
 Lower red blood cell count
 Caused by deficiency in
  iron in diet leading to less
  haemoglobin being
  produced
Symptoms:
 Easily tired, looks pale,
  breathless
 Who’s vulnerable? Pregnant
  ladies, people who have lost large
  amounts of blood
Why do people
   living in high
altitudes have rosy
       cheeks?
   Concentration of oxygen in air is lower
   Absorb insufficient oxygen for respiration
   Acclimatisation  Body produces more red
    blood cells  increase amount of haemoglobin
    per unit volume of blood
   Hence more oxygen can be transported to cells
Blood group
   Red blood cells carry special protein called antigens
    on their cell surfaces. Blood plasma contains
    antibodies.
   Blood groups are classified according to the
    antibodies and antigens present in their blood.
   There are four groups of blood, named A, B, AB and
    O.
   Each group is named after the antigen present.




                                                        9
10

Red blood cells in Blood

  • 1.
  • 2.
    At the endof the lesson, you should be able to  State the functions of blood:  Red blood cells – haemoglobin which aids in oxygen transport  White blood cells – phagocytosis, antibody formation and tissue rejection  Platelets – fibrinogen to fibrin, causing clotting  Plasma – transport of blood cells, ions, soluble food substances, hormones, carbon dioxide, urea, vitamins, plasma proteins 2
  • 3.
    What is Blood? Blood 3 types of cells present in the human blood cell: • red blood cells (erythrocytes) • white blood cells (leukocytes) plasma, 55% • platelets (thrombocytes) Plasma is a liquid consisting 91% water which has blood cells, 45% inorganic ions, nutrients, waste products, hormones and soluble proteins dissolved in it. 3
  • 4.
    Red Blood Cells Blood  Formed in bone marrows of long bones.  Formed from nucleated cells called erythroblasts.  Exposed to maximum surface area for the exchange of oxygen and carbon dioxide.  95% of the protein in red blood cell is haemoglobin and 5% of the protein are enzymes that allow the cell to survive for about 120 days. cytoplasm containing haemoglobin plasma membrane 4
  • 5.
    Red Blood Cells Blood  The binding of oxygen to haemoglobin is reversible.  In the lungs, where oxygen concentration is high, oxygen combines with haemoglobin to form oxyhaemoglobin.  When blood arrives at cells where the oxygen concentration is low, it unloads and becomes maroon haemoglobin once again. high oxygen concentration Hb + 4O2 Hb(O2)4 (haemoglobin) low oxygen concentration (oxyhaemoglobin) 5
  • 6.
    Red Blood Cells Blood  As red blood cells pass through tissues, they pick up carbon dioxide.  Most of the carbon dioxide combines with water to form carbonic acid. CO2 + H2O H2CO3 carbonic acid  The carbonic acid then ionises to form hydrogen ions and hydrogen carbonate ions. H2CO3 H+ + HCO¯ 3 carbonic acid hydrogen hydrogen ion carbonate ion  About 70% of the ions leave the red blood cells and remain in plasma.  When the blood reaches the lungs, carbon dioxide is released and diffuses out of the blood to enter the alveoli.  Carbon dioxide is then breathed out. 6
  • 7.
    What is anaemia? Lower red blood cell count  Caused by deficiency in iron in diet leading to less haemoglobin being produced Symptoms:  Easily tired, looks pale, breathless  Who’s vulnerable? Pregnant ladies, people who have lost large amounts of blood
  • 8.
    Why do people living in high altitudes have rosy cheeks?  Concentration of oxygen in air is lower  Absorb insufficient oxygen for respiration  Acclimatisation  Body produces more red blood cells  increase amount of haemoglobin per unit volume of blood  Hence more oxygen can be transported to cells
  • 9.
    Blood group  Red blood cells carry special protein called antigens on their cell surfaces. Blood plasma contains antibodies.  Blood groups are classified according to the antibodies and antigens present in their blood.  There are four groups of blood, named A, B, AB and O.  Each group is named after the antigen present. 9
  • 10.