Dr. Niranjan Chavan well known Obstetrician & Gynaecologist gave a talk on "Recent advances in adhesion prevention post laparoscopic surgery" at 18th AAGL International Congress on "Unravelling Uterine Issues and Beyond."
Ovarian Hyperstimulation Syndrome(OHSS), is a Rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy where a patient's ovaries become swollen and fluid builds up around her abdomen
Cervical and broad ligament fibroids are rare; with incidence of only 2% and 1% respectively.
Cervical fibroid often present with pressure symptoms and often pose surgical difficulties due to its proximity to bladder and rectum.
Broad ligament fibroid though rare , but have the propensity of growing into large adnexal masses and may mimic ovarian malignancy.
Ovarian Hyperstimulation Syndrome(OHSS), is a Rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy where a patient's ovaries become swollen and fluid builds up around her abdomen
Cervical and broad ligament fibroids are rare; with incidence of only 2% and 1% respectively.
Cervical fibroid often present with pressure symptoms and often pose surgical difficulties due to its proximity to bladder and rectum.
Broad ligament fibroid though rare , but have the propensity of growing into large adnexal masses and may mimic ovarian malignancy.
Adhesions are an important yet often neglected cause of impaired fertility
The use of adhesion prevention agents should be considered in laparoscopic surgeries as well as Open Surgeries, where adhesion formation is expected
Adhesions are an important yet often neglected cause of impaired fertility
The use of adhesion prevention agents should be considered in laparoscopic surgeries as well as Open Surgeries, where adhesion formation is expected
Postoperative adhesions by dr alka mukherjee nagpur m.s.alka mukherjee
Postoperative adhesions have become the most common complication of open or laparoscopic abdominal surgery and a source of major concern because of their potentially dramatic consequences. The proposed guideline is the beginning of a major campaign to enhance the awareness of adhesions and to provide surgeons with a reference guide to adhesion prevention adapted to the conditions of their daily practice. The risk of postoperative adhesions should be systematically discussed with any patient scheduled for open or laparoscopic abdominal surgery prior to obtaining her informed consent. Surgeons should adopt a routine adhesion reduction strategy with good surgical technique. Anti-adhesion agents are an additional option, especially in procedures with a high risk of adhesion formation, such as ovarian, endometriosis and tubal surgery and myomectomy. We conclude that good surgical practice is paramount to reduce adhesion formation and that anti-adhesion agents may contribute to adhesion prevention in certain cases.Any surgery in the abdomen can lead to adhesion formation and potential morbidity. There is evidence to support the use of hyaluronic acid derivatives, PEG based derivatives and solid barrier agents derived from oxidized regenerated cellulose, namely Interceed, during laparoscopy or laparotomy in benign gynaecological surgery to reduce the incidence, severity and proportion of adhesion formation. There is also evidence to support the use of hyaluronic acid derivatives during hysteroscopic surgery to reduce the incidence of intra–uterine adhesion formation. However, there is little evidence to support the use of pharmacological and hydrofloatation agents including Icodextrin in gynaecological surgery. There is no apparent benefit of using adhesion prevention agents at caesarean section. As most of the economic modelling is not based in contemporary health economies, further evidence is required before recommending anti–adhesion agents in current gynaecological practice.
Adhesion are defined as abnormal attachments between tissues and organs. Intra-abdominal adhesions classified as congenital or acquired. Acquired adhesions result from the inflammatory response of the peritoneum that arises after intra-abdominal inflammatory processes for example acute appendicitis, pelvic inflammatory disease, exposure to intestinal contents, radiation and surgical trauma.
DR. NNC LAPAROSCOPY IN PREGNANCY IAGE VARANASI, 17TH MARCH 2024.pptxNiranjan Chavan
Our journey will navigate the evolution of laparoscopy in the context of pregnancy, detailing key milestones, breakthroughs, and advancements in technology and techniques. The presentation highlights how laparoscopy has revolutionized the diagnosis and treatment of conditions such as ectopic pregnancy, ovarian cysts and other gynecological disorders during pregnancy.
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Case Report on Invasive Mole. Gestational Trophoblastic Neoplasia (GTN) encom...Niranjan Chavan
Gestational Trophoblastic Neoplasia (GTN) encompasses a suite of rare but significant gynecological malignancies arising from aberrant placental trophoblast cells. As medical professionals and researchers, our comprehension of GTN's complexities is crucial for accurate diagnosis and effective treatment. This introduction serves to illuminate the key features, diagnostic procedures, and treatment protocols associated with GTN, helping to navigate the intricate landscape of this disease.
Peripartum cardiomyopathy (PPCM) is a rare form of heart failure that occurs during the last month of pregnancy or within the first five months postpartum. It presents significant challenges in diagnosis and treatment due to its overlap with symptoms of normal pregnancy and postpartum changes. This condition varies in incidence across different racial groups and geographical locations, with a notable occurrence in the United States and southern India.
Optimising Delivery Of 1kg Fetus - Special Considerations.pptxNiranjan Chavan
After an uncomplicated vaginal birth in a health facility, healthy mothers and newborns should receive care in the facility for at least 24 hours after birth.
VACCINE IN WOMEN TOWARDS SDG 2030 DR.N N CHAVAN 10012024 AICOG HYDERABAD.pptxNiranjan Chavan
In our presentation today, we will unravel the transformative power of vaccines in women, aligning with the Sustainable Development Goals (SDGs) for 2030. By exploring the pivotal role of vaccinations, we aim to elucidate how they contribute to women's health, empowerment, and overall well-being. Through this lens, we envision a future where widespread vaccine access propels us closer to achieving the SDGs and ensures a healthier, more equitable world for women globally.
RRRR IN OBSTETRIC HEMORRHAGE 09012024 AICOG 2024 HEYDERABAD.pptxNiranjan Chavan
This presentation focuses on a critical aspect of maternal care: "Reducing Maternal Mortality through Rapid Response in Obstetric Haemorrhage" (RRRR). As we navigate through this presentation, let us collectively work towards advancing our understanding and application of RRRR in obstetric care to safeguard the well-being of mothers during childbirth.
Anemia is a condition in which the number of red blood cells and/OR their oxy...Niranjan Chavan
Anemia is a condition in which the number of red blood cells and/OR their
oxygen-carrying capacity is insufficient to meet the body’s physiological needs.
HELLP syndrome is a pregnancy complication. It is a type of preeclampsia. It ...Niranjan Chavan
HELLP syndrome is a pregnancy complication. It is a type of preeclampsia. It usually occurs during the third trimester of pregnancy. But it also can develop in the first week after childbirth
Guidelines & Identification of Early Sepsis DR. NN CHAVAN 02122023.pptxNiranjan Chavan
Here is a highly informative session on guidelines and identification of early sepsis as it is critical for timely intervention and improved patient outcomes.
PAST, PRESENT AND FUTURE IN OBGYN INFECTIONS 01102023.pptxNiranjan Chavan
Today, we face new infectious threats; but also benefit from advanced diagnostics and treatments. Looking ahead, it’s crucial to continue
adapting to emerging pathogens, implement stringent preventive measures, and
leverage cutting-edge technologies to ensure the safety and well-being of our patients in the ever-evolving landscape of obstetrics and gynecology.
Vaccination during pregnancy is crucial to protect both the mother and the developing baby. It helps prevent serious complications and ensures a healthier start in life. #VaccinateForTwo 🤰💉
Explore a comprehensive presentation on Invasive Cervical Carcinoma, shedding light on its causes, symptoms, diagnosis, treatment options, and preventive measures.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
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Recent advances in adhesion prevention post laparoscopic surgery.pptx
1. RECENT ADVANCES IN ADHESION
PREVENTION POST LAPAROSCOPIC
SURGERY
Dr Niranjan Chavan
AAGL INDIA MUMBAI
4TH June 2023
Westin Hotel, Mumbai
2. Professor and Unit Chief, L.T.M.M.C & L.T.M.G.H, Sion Hospital
President, MOGS (2022-2023)
Joint Treasurer, FOGSI (2021-2025)
Organising Secretary, AICOG Mumbai 2025
Treasurer, AFG (2023-2024)
Member Oncology Committee, SAFOG (2021-2023)
Dean AGOG & Chief Content Director, HIGHGRAD & FEMAS Courses
Editor-in-Chief, FEMAS, JGOG & TOA Journal
67 publications in International and National Journals with 162 Citations
National Coordinator, FOGSI Medical Disorders in Pregnancy Committee (2019-2022)
Chair & Convener, FOGSI Cell Violence Against Doctors (2015-16)
Member, Oncology Committee AOFOG (2013-2015)
Coordinator of 11 batches of MUHS recognized Certificate Course of B.I.M.I.E at
L.T.M.G.H (2010-16)
Member, Managing Committee IAGE (2013-17), (2018-20), (2022-2023)
Editorial Board, European Journal of Gynaec. Oncology (Italy)
Course Coordinator of 3 batches of Advanced Minimal Access Gynaec Surgery (AMAS) at
LTMGH (2018-19)
DR. NIRANJAN CHAVAN
MD, FCPS, DGO, MICOG, DICOG, FICOG, DFP,
DIPLOMA IN ENDOSCOPY (USA)
3.
4. INTRODUCTION
• Pelvic adhesions are considered to be post-inflammatory scar tissues that are formed after
abdominal surgery, endometriosis, and intrabdominal infections.
• Adhesions may also be a severe and sometimes life-threatening complication.
• Although no universal nomenclature exists, they can be described as dense or flimsy, thick
or thin, opaque or translucent, and vascular or avascular.
5. PERITONEALADHESIONS
• Peritoneal adhesions are pathological bonds usually between the omentum, intraoperative
organs, and the abdominal wall.
• These bonds may be a thin film of connective tissue, a thick fibrous bridge containing blood
vessels and nerve tissue, or a direct contact between two organ surfaces.
• Peritoneal adhesions are a consequence of peritoneal irritation by infection or surgical
trauma.
• Their prevalence after major abdominal procedures has been evaluated at 63%-97%.
6.
7. PATHOPHYSIOLOGY
• Abnormal connective tissue attachments between tissues
and organs (Internal scars).
• Congenital or Acquired.
• Trauma to the peritoneum:
Surgical or inflammatory.
Ischemia:
Desiccation or overheating
Irritation from foreign materials
Wound healing
8. TYPES OF POST OPERATIVE
ADHESONS
• Type 1: De novo adhesion formation: adhesions formed at sites that did not have previous
adhesions.
• Type 1A: No previous operative procedure at the site of adhesions
• Type 1B: Previous operative procedures at the site of adhesions
• Type 2: Adhesion Reformation
• Type 2A: No operative procedure at the site of adhesions besides adhesiolysis
• Type 2B: Other operative procedures at the site of adhesions besides adhesiolysis
10. • On approximately day 3 after surgery, macrophages
form the foundation of the advancing adhesion.
• Fibrin matrix advancement occurs with the
proliferation of fibroblasts and vascularization.
• By day 5, the advancing adhesions are increasingly
vascular and organized in structure.
• No new adhesion formation occurs after day 7
13. DIAGNOSTIC CONSIDERATIONS
• Only a small percentage of patients with
chronic pelvic pain have laparoscopically
documented adhesions.
• 27% of patients without any remarkable
history of adhesions present on laparoscopy.
• Approximately 50% of patients with 2 or
more factors in their history really have
adhesions.
• An abnormal pelvic examination is useful in
predicting the presence of adhesions in 74%
of the cases.
14. MORBIDITY OF PERITONEAL
ADHESIONS
• Intestinal obstruction:
5.7 percent of 21,347 readmissions were
classified as relating directly to adhesions, and
3.8 percent required operation.
• Infertility:
10% of female infertility is caused by
adhesion.
• Chronic abdominal pain:
Dense adhesions can limit organ mobility,
which may cause visceral pain.
17. GOOD SURGICAL TECHNIQUE
• Reduce the duration of surgery.
• Meticulous hemostasis.
• Irrigation to prevent drying of surfaces.
• Use of sub-serosal sutures. Limit the use of sutures and choose fine
non-reactive
• sutures.
• Avoid foreign bodies when possible.
• Avoid non-peritonitis implants and meshes.
• Reduce the risk of infection.
Consensus In Adhesion Reduction management, TOG 2004:6(2),
RCOG Press
18. GOOD SURGICAL TECHNIQUE
• Minimal use of dry towels or sponges..
• Use starch and latex-free gloves.
• Reduce pressure and duration of pneumoperitoneum in laparoscopic
surgery.
• Use frequent irrigation and aspiration in laparoscopic and laparotomic
surgery when needed.
• Reduce cautery time and frequency and aspirate aerosolized tissue
following cautery.
• Excise tissue—reduce fulguration.
Consensus In Adhesion Reduction management, TOG 2004:6(2),
RCOG Press
19. AVERAGE ADHESION
FORMATION RATE
LAPAROSCOPIC SURGERY AVERAGE ADHESION
FORMATION RATE
Myomectomy 40%
Ovarian Drilling 30-40%
Endometriosis surgery 70-80%
Adhesiolysis 70-80%
Diamond MP (2000): Incidence of Post-surgical adhesions- Peritoneal Surgery, Springer Verlag, New York
20. LAPAROSCOPY AND ADHESIONS
• Minimally invasive surgery offers the advantages of less tissue and
organ handling and trauma.
• Minimally invasive laparoscopic surgery with up to 10-fold
magnification helps to maintain tissue moisture and avoids
contamination with foreign bodies such as surgical gloves powder.
• Facilitates more precise tissue manipulation.
• Pneumoperitoneum has a tamponade effect that facilitates hemostasis.
• Laparoscopy is associated with a lower incidence of postoperative
infection.
• The abdominal incisions are small and thus it reduces the risk for
adhesion formation, especially to the abdominal wall.
Uptodate.com ~ Nov 2015
21. IMPACT OF POST-OPADHESIONS
AFTER LAPAROSCOPY
• Pelvic Pain
• Intestinal Obstruction: Major cause, 31-40%
• Important cause of hospital readmissions & subsequent repeat
surgery
• Infertility: 15-20% of secondary infertility is solely adhesion-related
• Even after adhesiolysis, 85% of adhesions will re-form.
Consensus In Adhesion Reduction management, TOG 2004:6(2),
RCOG PressDiamond MP (2000): Incidence of Post surgical
adhesions- Peritoneal Surgery,Springer Verlag, New York
22. OLD CONCEPT
Laparoscopy= less adhesiolysis
• Less tissue handling.
• Better magnification.
• Precise hemostasis.
• Less drying of the surface.
NEW CONCEPT
• Adhesion formation depends on TYPE of
surgery performed
• High risk: Lap adhesiolysis, endometrioma
drainage.
• Low risk: Lap tubal sterilisation.
• Medium risk: All others.
Surgical & Clinical Adhesion ResearchStudy (SCAR & SCAR-2) , 1999
23.
24.
25. INTERCEED
• Oxidized Regenerated Cellulose absorbable Adhesion Barrier
• It is applied at the end of the procedure.
• Remove all irrigating fluid and installations from the peritoneal cavity.
• Cut to size.
• Apply intercede (if it turns black, then blood is present, remove intercede and achieve
hemostasis).
• No sutures needed.
• Moisten with 5ml of irrigant/ 3*4 inch piece.
26. INTERCEDE ABSORBABLE
ADHESION BARRIER
• Sterile, absorbable, off-white, knitted fabric prepared by the
controlled, off-white, knitted fabric prepared by the controlled
oxidation of regenerated cellulose.
• Mechanism of action: Forms a continuous protective covering over
raw tissue surfaces during the peritoneal healing period.
• Availability: 3x4 inches
5x6 inches
27. HOW IT WORKS
• Forms continuous gelatinous protective coat over raw tissue
surface.
• Maintains integrity during peritoneal healing (~5-7 days).
• Removed through hydrolysis.
• All is absorbed and secreted from the body within 28 days.
33. METHODS OF ADHESION
PREVENTION IN LAPAROSCOPIC
SURGERY
• Preventing Gas-Induced drying of
peritoneal surfaces by using pre-
warmed, humidified CO2
(Thermoflator, Karl Storz)+
• Adhesion barrier substances
34. • The PNP hydrogel adhesion barrier reported here resulted in a significant reduction in the
severity and incidence of peritoneal adhesions.
• This treatment approach has the potential to positively impact patients and prevent adhesion
formation as a result of surgery of any kind in any part of the body.
• Overall, this work establishes a proof of concept translation across surgery indications and
demonstrates an adhesion barrier system that is simple to deploy, stable over extended
timeframes, and successfully prevent post-operative adhesions.
Ahmad G, et al. Cochrane Database Syst Rev. 2020
35. • Postoperative adhesions represent a frequent complication of abdominal surgery. Adhesions can result
from infection, ischemia, and foreign body reaction, but commonly develop after any surgical
procedure.
• The morbidity caused by adhesions affects quality of life and, therefore, it is paramount to continue to
raise awareness and scientific recognition of the burden of adhesions in healthcare and clinical
research.
• This 2021 Global Expert Consensus Group worked together to produce consented statements to
guide future clinical research trials and advise regulatory authorities. It is critical to harmonize the
expectations of research, to both develop and bring to market improved anti-adhesion therapies, with
the ultimate, shared goal of improved patient outcomes.
Rudy Leon De Wilde et al. J Clin Med. 2022
36. • The aim of this review is to appraise critically the literature over the past year with respect to
new developments in adhesion prevention strategies.
• The majority of the work continues to be focused on animal models, and interest continues
in the usage of heterologous barriers, which are increasingly derived from or related to
hyaluronic acid.
• The recent trend has been to develop barriers that are not only effective but also technically
easy to use for the laparoscopic surgeon--hence the development of barrier gels.
• It is only through the development of these user-friendly barriers that many laparoscopic
surgeons will be willing to incorporate these important preventative measures into their busy
daily practice.
• Routine usage of adhesion prevention measures will ultimately reduce patient morbidity and
mortality and relieve the burden on health service provision.
N Panay et al. Curr Opin Obstet Gynecol. 1999 Aug
37. This work reports the use of a dynamically crosslinked polymer‐nanoparticle (PNP) hydrogel
adhesion barrier comprised of hydrophobically modified hydroxypropylmethylcellulose and
biodegradable PEG‐PLA nanoparticles.
The PNP hydrogel significantly reduced peritoneal adhesion severity compared to commercial
control products when assessed by a standardized 5‐point scale (3.18 ± 1.07 versus 1.35 ± 0.63;
p = 0.0014).
These results suggest that the PNP hydrogel adhesion barrier is a simple and effective solution
for the prevention of peritoneal adhesions.