This document summarizes the development of a radiation indicator ink that changes color based on absorbed radiation dose.
The ink was developed to allow quick and simple assessment of radiation doses used for sterilizing medical supplies. It contains diethylaminoazobenzene, which changes the ink color from yellow to orange, red, and purple as the radiation dose increases from 10 to 50 kGy.
Testing found the ink color change corresponds directly to radiation dose, regardless of dose rate from 1.41 to 33.4 kGy/h. Electron beam irradiation also produced consistent results. The ink provides a convenient way to check sterilization doses for large quantities of supplies.
Determination of metronidazole from the solid dosage formAtai Rabby
Metronidazole is determined or assayed spectrophotometrically as the present methods abbeys Beer’s Law in the concentration range of 100-150 µg at about 500nm. By using the absorbance of standard solution of Metronidazole, the unknown amount of this drug in the sample can be calculated. The unknown amount of metronidazole is generally calculated by drawing the standard curve.
The impact of flow rate and bed height on the adsorption behavior of methylene blue, Bismarck brown y, and indigo dyes on to Cedrus libani was investigated. The biomass was characterized by scanning electron microscopy as well as Fourier transformed infrared spectroscopy before and after adsorption to ascertain the functional groups responsible for the adsorption. The amount of dye adsorbed per unit mass of the biomass (qe) was calculated and was found to be dependent on the variables investigated within the experimental range. It was discovered that increase in bed height and flow rate increased the value of the dye adsorbed on to the biomass. The results obtained show that methylene blue dye adsorbed more onto the biomass, while indigo dye adsorbed at the least level.
FT-NIR as a real-time QC tool for polymer manufacturingGalaxy Scientific
Near infrared spectroscopy has been used widely in the polymer industry. Compared to traditional methods such as wet chemistry and chromatographic methods, NIR spectroscopy provides considerable advantages in process and quality control applications through fundamental benefits such as low to no cost of consumables such as solvents, columns, reagents; real time analysis - generally less than 10 seconds measurement time; multiple components per analysis; elimination of sample preparation time; and elimination of many sources of systematic error.
This presentation will present three FT-NIR polymer applications: 1) at line polyether polyols’ hydroxyl value analysis; 2) real time isocyanate number monitoring during a polyurethane reaction; and 3) off-line quality control of percentage styrene in styrene copolymers.
Determination of metronidazole from the solid dosage formAtai Rabby
Metronidazole is determined or assayed spectrophotometrically as the present methods abbeys Beer’s Law in the concentration range of 100-150 µg at about 500nm. By using the absorbance of standard solution of Metronidazole, the unknown amount of this drug in the sample can be calculated. The unknown amount of metronidazole is generally calculated by drawing the standard curve.
The impact of flow rate and bed height on the adsorption behavior of methylene blue, Bismarck brown y, and indigo dyes on to Cedrus libani was investigated. The biomass was characterized by scanning electron microscopy as well as Fourier transformed infrared spectroscopy before and after adsorption to ascertain the functional groups responsible for the adsorption. The amount of dye adsorbed per unit mass of the biomass (qe) was calculated and was found to be dependent on the variables investigated within the experimental range. It was discovered that increase in bed height and flow rate increased the value of the dye adsorbed on to the biomass. The results obtained show that methylene blue dye adsorbed more onto the biomass, while indigo dye adsorbed at the least level.
FT-NIR as a real-time QC tool for polymer manufacturingGalaxy Scientific
Near infrared spectroscopy has been used widely in the polymer industry. Compared to traditional methods such as wet chemistry and chromatographic methods, NIR spectroscopy provides considerable advantages in process and quality control applications through fundamental benefits such as low to no cost of consumables such as solvents, columns, reagents; real time analysis - generally less than 10 seconds measurement time; multiple components per analysis; elimination of sample preparation time; and elimination of many sources of systematic error.
This presentation will present three FT-NIR polymer applications: 1) at line polyether polyols’ hydroxyl value analysis; 2) real time isocyanate number monitoring during a polyurethane reaction; and 3) off-line quality control of percentage styrene in styrene copolymers.
A novel label-free cocaine assay based on aptamer-wrapped single-walled carbo...Nanomedicine Journal (NMJ)
Objective(s):
This paper describes a selective and sensitive biosensor based on the dissolution and aggregation of aptamer wrapped single-walled carbon nanotubes. We report on the direct detection of aptamer–cocaine interactions, namely between a DNA aptamer and cocaine molecules based on near-infrared absorption at λ807.
Materials and Methods:
First a DNA aptamer recognizing cocaine was non-covalently immobilized on the surface of single walled carbon nanotubes and consequently dissolution of SWNTs was occurred. Vis-NIR absorption (A807nm) of dispersed, soluble aptamer-SWNTs hybrid, before and after incubation with cocaine was measured using a CECIL9000 spectrophotometer.
Results:
This carbon nanotube setup enabled the reliable monitoring of the interaction of cocaine with its cognate aptamer by aggregation of SWNTs in the presence of cocaine.
Disscusion:
This assay system provides a mean for the label-free, concentration-dependent, and selective detection of cocaine with an observed detection limit of 49.5 nM.
Presented by Yonas Asmare, ILRI, at the Workshop on Identifying Investment Opportunities for Livestock Feed Resources Development in the Eastern Africa Sub-Region, ILRI Addis, 13–15 December 2017
A polymethyl-methacrylate (PMMA) acrylic sample cell using flow injection is developed in this research for the determination of nitrite in an aqueous media. The research focuses on exhibiting direct absorbance spectrophotometry of nitrite using concentration of samples ranging from 0.1078 to 1.725 ppm. Nitrite determination is done colorimetrically using the Greiss reagent method. This method is based on the reaction of nitrite with sulphanilamide acid and N-1-napthylamine (NED) utilizing diazo coupling, and a syringe is used to administer the nitrite solution. The sample cell being used possesses a diameter of 1
mm with an overall size of 7.35×22 mm2. To gauge the direct absorbance, a wavelength range from 400 to 650 nm has been selected for the testing, and the maximum absorbance is found to be at 545 nm. The validity of the proposed cell is explained in this letter.
Study the effect of thin film thickness on the optical features of (IR5 laser...TELKOMNIKA JOURNAL
The linear optical features such as (transmittance T, absorbance A, the effective length 퐿푒푓푓, absorption coefficient 훼 and refractive index 푛 ) for the thin films samples of (3x10-3 mol/l of (IR5) laser dye, 0.02 gm of (CdS) nanoparticles and 0.04 gm of pp polymer) had been studied at different values of film thickness in one time and at different number of Yb:GdVO4 laser pulses. The non-linear optical features in terms of transmittance difference Δ푇푝−푣, non-linear refractive index 푛2, non–linear phase shift Δ훷표 non-linear absorption coefficient 훽 and minimum normalized transmittance 푇(푍) have been computed in relation to obtained normalized transmittance data from setup of Z-scan with open and closed apertures, calculated for (3x10-3 mol/l of (IR5) laser dye, 0.02 gm of (CdSe) nanoparticles and 0.04 gm of (pp) polymer) thin films at different values of film thickness at in one time and at different Yb:GdVO4 laser pulses. Thick films causes in deleting the non-linear effects generated by different layers. The (CdSe) nanoparticles leads to an absorption shifting of the wavelengths to lengthier wavelengths of red shift. So, this can be used in selecting the nanoparticles and medium with applicable exciting wavelengths. The film thickness and the laser pulses have the main effects in consolidating the Non-linear optical features.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
Gel matrix dependence on the dose response properties and diffusion phenomena...inventionjournals
Fricke-gel dosimeters proved to be suitable tools to perform 3D radiotherapy pre-treatment dosimetry. The tissue equivalent gel matrix helpsto preserve the spatial information of the dose. Several gel matrices proved to be suitable for dosimetric purposes. The influence of the gel matrices on both system dose response and diffusion processwasinvestigated. Three gel matrices were considered: Gelatinfrom porcine skin, Agaroseand polyvinyl alcohol (PVA) cross-linked with glutaraldehyde(GTA). In these systems, Xylenol-Orange (XO), an iron(III)chelator, forms red-colored complexeswith Fe3+ that eases the optical determination of the dose. However, the dose evaluationresults to be affectedbydifferent XO-Fe3+ complexes that absorb at different wavelengths. In particular,this phenomenon influences the dose response, the calibration curveand the dose threshold.Therefore, a deeper study of the XO-Fe3+ speciation mechanism could lead to a more accurate evaluation of the dose. A novel procedure, based on a laser-beam irradiation, was implemented for the diffusion process evaluation. The diffusion coefficients were calculated for the three gel matrices tested. PVAmatrix proved to highly limit the diffusion with respect to the other matrices. Further investigations are needed to verify the influence of XO-Fe3+complexeson the diffusion phenomenon.
Можно ли защитить идею?
Что можно охраняется копирайтом в вашем продукте?
Почему перерисовать картину другим цветом нельзя, а переписать программу на другом языке можно.
Альтернативные способы защиты кода и других произведений.
Как сделать чтобы Ваши права интеллектуальной собственности распространялись не только на территорию Украины.
A novel label-free cocaine assay based on aptamer-wrapped single-walled carbo...Nanomedicine Journal (NMJ)
Objective(s):
This paper describes a selective and sensitive biosensor based on the dissolution and aggregation of aptamer wrapped single-walled carbon nanotubes. We report on the direct detection of aptamer–cocaine interactions, namely between a DNA aptamer and cocaine molecules based on near-infrared absorption at λ807.
Materials and Methods:
First a DNA aptamer recognizing cocaine was non-covalently immobilized on the surface of single walled carbon nanotubes and consequently dissolution of SWNTs was occurred. Vis-NIR absorption (A807nm) of dispersed, soluble aptamer-SWNTs hybrid, before and after incubation with cocaine was measured using a CECIL9000 spectrophotometer.
Results:
This carbon nanotube setup enabled the reliable monitoring of the interaction of cocaine with its cognate aptamer by aggregation of SWNTs in the presence of cocaine.
Disscusion:
This assay system provides a mean for the label-free, concentration-dependent, and selective detection of cocaine with an observed detection limit of 49.5 nM.
Presented by Yonas Asmare, ILRI, at the Workshop on Identifying Investment Opportunities for Livestock Feed Resources Development in the Eastern Africa Sub-Region, ILRI Addis, 13–15 December 2017
A polymethyl-methacrylate (PMMA) acrylic sample cell using flow injection is developed in this research for the determination of nitrite in an aqueous media. The research focuses on exhibiting direct absorbance spectrophotometry of nitrite using concentration of samples ranging from 0.1078 to 1.725 ppm. Nitrite determination is done colorimetrically using the Greiss reagent method. This method is based on the reaction of nitrite with sulphanilamide acid and N-1-napthylamine (NED) utilizing diazo coupling, and a syringe is used to administer the nitrite solution. The sample cell being used possesses a diameter of 1
mm with an overall size of 7.35×22 mm2. To gauge the direct absorbance, a wavelength range from 400 to 650 nm has been selected for the testing, and the maximum absorbance is found to be at 545 nm. The validity of the proposed cell is explained in this letter.
Study the effect of thin film thickness on the optical features of (IR5 laser...TELKOMNIKA JOURNAL
The linear optical features such as (transmittance T, absorbance A, the effective length 퐿푒푓푓, absorption coefficient 훼 and refractive index 푛 ) for the thin films samples of (3x10-3 mol/l of (IR5) laser dye, 0.02 gm of (CdS) nanoparticles and 0.04 gm of pp polymer) had been studied at different values of film thickness in one time and at different number of Yb:GdVO4 laser pulses. The non-linear optical features in terms of transmittance difference Δ푇푝−푣, non-linear refractive index 푛2, non–linear phase shift Δ훷표 non-linear absorption coefficient 훽 and minimum normalized transmittance 푇(푍) have been computed in relation to obtained normalized transmittance data from setup of Z-scan with open and closed apertures, calculated for (3x10-3 mol/l of (IR5) laser dye, 0.02 gm of (CdSe) nanoparticles and 0.04 gm of (pp) polymer) thin films at different values of film thickness at in one time and at different Yb:GdVO4 laser pulses. Thick films causes in deleting the non-linear effects generated by different layers. The (CdSe) nanoparticles leads to an absorption shifting of the wavelengths to lengthier wavelengths of red shift. So, this can be used in selecting the nanoparticles and medium with applicable exciting wavelengths. The film thickness and the laser pulses have the main effects in consolidating the Non-linear optical features.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
Gel matrix dependence on the dose response properties and diffusion phenomena...inventionjournals
Fricke-gel dosimeters proved to be suitable tools to perform 3D radiotherapy pre-treatment dosimetry. The tissue equivalent gel matrix helpsto preserve the spatial information of the dose. Several gel matrices proved to be suitable for dosimetric purposes. The influence of the gel matrices on both system dose response and diffusion processwasinvestigated. Three gel matrices were considered: Gelatinfrom porcine skin, Agaroseand polyvinyl alcohol (PVA) cross-linked with glutaraldehyde(GTA). In these systems, Xylenol-Orange (XO), an iron(III)chelator, forms red-colored complexeswith Fe3+ that eases the optical determination of the dose. However, the dose evaluationresults to be affectedbydifferent XO-Fe3+ complexes that absorb at different wavelengths. In particular,this phenomenon influences the dose response, the calibration curveand the dose threshold.Therefore, a deeper study of the XO-Fe3+ speciation mechanism could lead to a more accurate evaluation of the dose. A novel procedure, based on a laser-beam irradiation, was implemented for the diffusion process evaluation. The diffusion coefficients were calculated for the three gel matrices tested. PVAmatrix proved to highly limit the diffusion with respect to the other matrices. Further investigations are needed to verify the influence of XO-Fe3+complexeson the diffusion phenomenon.
Можно ли защитить идею?
Что можно охраняется копирайтом в вашем продукте?
Почему перерисовать картину другим цветом нельзя, а переписать программу на другом языке можно.
Альтернативные способы защиты кода и других произведений.
Как сделать чтобы Ваши права интеллектуальной собственности распространялись не только на территорию Украины.
Exploiting Context-awareness and Social Interaction to Provide Help in Large-...nasim.mahmud
The research presented here explores how to unlock the enormous power of
human processing that is still underutilized, in a social, congenial and convenient way.
This is still not well explored but is an emerging area of research.
In the frame of the thesis I propose several context–aware social computing prototype
systems that assist people to find context–sensitive suitable help and guidance
from trusted social peers. I also illustrate the help seeking scenario in different
ranges from large–scale city environments to people with dementia. Furthermore, I
demonstrate the help seeking scenario in a simulated large and dynamic social network
such as, a simulated vehicular network. I also propose approaches that can
assist users to select required contextual information and assist to find suitable help
providers.
This presentation was a part of the PhD public defense of Nasim Mahmud. Place Hasselt University, Expertise Center for Digital Media, Aula (Large Auditorium), Diepenbeek, Belgium on April 25, 2012.
PhD supervisors:
Promoter : Professor Dr. Karin Coninx
(Vice-dean, Hasselt University, Belgium)
Co-promoter: Professor Dr. Kris Luyten
Jury/Committee:
Prof. Dr. Frank Van Reeth (Chairperson, Hasselt University),
Prof. Dr. Karin Coninx (Advisor, Hasselt University),
Prof. Dr. Kris Luyten (Co-advisor, Hasselt University),
Prof. dr. Wim Lamotte (Doctoral committee member, Hasselt University),
Dr. Jan Van den Bergh (Hasselt University),
Prof. Dr. Yolande Berbers (Distrinet, University of Leuven),
Dr. Ann Ackaert (IBCN, Ghent University)
Dette er min besvarelse på oppgave 10 på Mooc'en som jeg deltar på ved Høgskolen i Sør Trønderlag.
Håper den kan være nyttig for andre som skal i gang med dette og at det kan gi noen ideer til bruk.
Uv radiation assisted photocatalytic transformation of azo dye direct yellow 9eSAT Journals
Abstract
Advanced oxidation process (AOP) is best for treatment of textile industries effluents (waste water). Methylene blue immobilized resin dowex-11; a photocatalyst is used for transformation of azo dyes. The mechanism of the photo transformation depends on the radiation used. Activity of catalyst remains unaffected on continuous use. The process follows pseudo first order kinetics according to Langmuir Hinshelwood model, the value of rate constant k is 1.43*10-2 min-1 and approximately 94.60% of the dye was transforms within 160 min of irradiation.
Keywords: Transformation, Direct Yellow-9, Methylene blue immobilized resin, Textile effluents; Dowex-11, Photocatalyst.
PHOTOCATALYTIC DEGRADATION OF RB21 DYE BY TIO2 AND ZNO UNDER NATURAL SUNLIGHT...IAEME Publication
The present work aims to degrade the RB21 dye from synthetic wastewater using
semiconductors TiO2 and ZnO. The activity of photocatalytic degradation process of dye was
carried out using different light sources of 900 W/m
2
intensity in natural sunlight from 02:00 to
04:00 pm with 48°C temperature in Ahmedabad city in the month of May, 600 Watt microwave
oven and high pressure UV-light photocatalytic reactor of wavelength 200-450 nm. All the
experiments were performed with dye concentration 50 mg/L, catalyst dosage 0.8 g, pH 7, room
temperature, irradiation time 240 min followed by 30 min in dark. All the samples were collected at
different time intervals of 30, 60, 90, 120, 150, 180, 210, 240 min for the analysis of COD
degradation and color removal. The best performances was achieved using high pressure UVphotocatalytic
reactor using TiO2. The successful result obtained using TiO2is 80% COD
degradation and 99% color removal followed by 75% COD and 99% color removal with ZnO.
Chemical kinetics was found to follow first order mechanism. The formation of intermediate
compounds and identification of the final products were carried out using LCMS/MS analysis and
FT-IR techniques.
Austin Biomolecules: open access is a peer reviewed, scholarly journal dedicated to publish articles covering all areas of Biomolecules.
The journal aims to promote latest information and provide a forum for doctors, researchers, physicians, and healthcare professionals to find most recent advances in the areas of Biomolecules. Austin Biomolecules: open access accepts research articles, reviews, mini reviews, case reports and rapid communications covering all aspects of Biomolecules.
Austin Biomolecules: open access strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Ceftriaxone is one of the third generations of cephalosporin antibiotics and commercially found as a sodium salt. The market demand for it is still high in recent years, including in Indonesia. However, there is no local production manufacture yet. A high yield of ceftriaxone sodium would be an advantage in industrial scale. Ceftriaxone was synthesized by reacting 7–amino–3–[(2,5–dihydro–6–hydroxy–2–methyl–5–oxo–1,2,4–triazin–3–yl) thiomethyl] cephalosporanic acid (7-ACT) with 2-Mercaptobenzothiazolyl (Z)-2-(2-Aminothiazole-4-yl)-2-Methoxyimino Acetate (MAEM) then with sodium salt in basic condition. The product was generated by solventing-out using acetone. The products were analyzed by HPLC quantitatively and the structure was confirmed using FTIR, MS and NMR. In this research, the variation in the mole ratio of reactants against the yield of product was evaluated. The result showed that the variations in mole ratio reactants affect the yield production. The higher ratio of MAEM would be the higher yield is obtained. The results show that the yield was 72,17% at mole ratio 1:2 which has 99,32% purity. This result could be a consideration in industrial production scale in ceftriaxone sodium preparation.
Determination of Satranidazole through Ion-Associative Complex ReactionRatnakaram Venkata Nadh
A simple, selective, accurate and low-cost spectrophotometric method
has been described for determination of satranidazole in bulk and
pharmaceutical formulations. The developed method involves the
formation of chloroform extractable colored ion-association complex
of satranidazole with Tropaeolin OOO (TPooo). The extracted colored
complex showed absorbance maximum at wavelength 484 nm and
obeying Beer′s law in the concentration 4-20 μg mL-1 with the
correlation coeffiecent of 0.9998. The results of statistical analysis of
the proposed method reveals high accuracy and good precession. Thus,
the proposed method can be used commercially for the determination
of satranidazole in bulk and pharmaceutical formulations.
Determination of Satranidazole through Ion-Associative Complex ReactionRatnakaram Venkata Nadh
A simple, selective, accurate and low-cost spectrophotometric method
has been described for determination of satranidazole in bulk and
pharmaceutical formulations. The developed method involves the
formation of chloroform extractable colored ion-association complex
of satranidazole with Tropaeolin OOO (TPooo). The extracted colored
complex showed absorbance maximum at wavelength 484 nm and
obeying Beer′s law in the concentration 4-20 μg mL-1 with the
correlation coeffiecent of 0.9998. The results of statistical analysis of
the proposed method reveals high accuracy and good precession. Thus,
the proposed method can be used commercially for the determination
of satranidazole in bulk and pharmaceutical formulations.
Fluorescent disperse dyes reflectance spectra, relative strength and perfor...eSAT Journals
Abstract
This study attempted to focus on some important properties of regular fluorescent disperse dyes on polyester/cotton fabric. A 60/40 p/c blended woven fabric was used to dye only the polyester part in pad-thermosol dyeing process (continuous method) with different concentrations of fluorescent disperse dyes. The selected dyestuff was Terasil Flavine 10GFF belonging to coumarin class of fluorescent dye. This paper mainly aims to investigate Spectral parameters such as Reflectance curve, K/S values (with Kubelka-Munk equation) and Relative strength percentage with different concentrations of fluorescent dyes. Different color fastness properties like wash, water, rubbing, perspiration and light fastness were also assessed to evaluate performance of polyester substrate dyed with fluorescent dyes.
Keywords: Fluorescence, disperse dye, pad-thermosol dyeing, reflectance, k/s value, relative strength, color fastness.
Characterization of excitation source LEDs and sensors without filters for me...TELKOMNIKA JOURNAL
This paper presents the characterization of excitation source LEDs and sensors without filters for measuring fluorescence in fluorescein and green leaf extract. For this purpose, eight light-emitting diodes (LEDs) were used with the following characteristics: one blue, one green, one red, one infrared, and four violets. The first four LEDs were used as sensors without filters to detect fluorescence induced by the other four violet LEDs in 11 samples of different fluorescein concentrations and in 14 samples of different dilutions of green leaf extract. The results show that infrared LEDs can detect the red emission of green leaf extract and red and infrared LEDs detect the fluorescence of fluorescein in concentrations of up to 1.8 μM. The developed system allows and facilitates teaching optical spectroscopy in basic education without incurring high costs.
Adsorption studies of some dyes on acacia concinna powdereSAT Journals
Abstract
The low cost activated carbon from Acacia Concinna was processed by treating with 2% HCl and 2% NaOH. The treated Acacia Concinna (Shikakai powder) was then roasted to get activated carbon. The influence of parameters like pH, concentration, dose and contact time were studied on adsorption of activated carbon for Congo red, Rhodamine-B, Crysoidine, Bismark brown and Titan yellow. The adsorption capacity of activated carbon was found to be 97, 98, 95, 98 and 96% respectively at pH 2 and contact time 24-48 hrs for all the dyes. The effect of concentration indicated that, as concentration increases adsorption decreases, hence increase in dose amount increases the adsorption. The data obtained through batch adsorption study was applied for Langmuir, Freundlich and Dubinin-Radushkevich(D-R) isotherms. The curve was linear for all the three isotherms and correlation coefficient (R2) was 0.92, 0.970 and 0.977 respectively indicating that the developed model was favourable.
Keywords: Adsorption, Acacia Concinna, dyes, isotherms, XRD.
1. Journal of Photopolymer Science and Technology
Volume 5, Number 2(1992) 309 - 314
RADIATION INDICATOR INK
1. PHOTOGRAVURE INK
Masayuki YAMAGAMI,Akira KAWATA+,Set suo NISHIDA+, Akira HANAOKA+,
Tokuhiro OHNISHI, Masakazu FURUTA, Hirofumi MIYOSHI, and Mitsuo CHUBACHI
Research Institute for Advanced Science and Technology,
University of Osaka Prefecture, 1-2, Gakuen-cho, Sakai, Osaka 593, Japan
+ Koyo Chemicals Inc., 2-3-5, Norinomiya, Jyoto-ku, Osaka 536, Japan
we recently developed a radiation indicator using a photogravure
ink. This indicator allows simple assessment of absorbed doses of
7 -rays used for sterilization of medical supplies and absorbed doses
of 7 -rays and electron beams emploied in various kinds of industrial
fields. This indicator was prepared by coating the packing paper with
an indicator ink made primarily of diethylaminoazobenzene. When 7 -
rays were irradiated onto this indicator at a dose rate of 25.7 kGy/h,
a color of the indicator changed in proportion to the strength of a
dose and was well reproducible. Prior to irradiation, the color of
the indicator was yellow. This color changed to orange from yellow at
an absorbed dose of 10 kGy, to red at 25 kGy (a dose used for sterili-
zation) and to purplish red at 50 kGy. Within dose rate ranges of
1.41-' 33.4 kGy/h, the color was changed in proportional to only
absorbed doses as independent of the dose rate. The dose-response
curve of the indicator for electron beam irradiation which was
generated by a linear electron accelerator is in good agreement with
that for 7 -ray irradiation.
Received April 7 , 1992
Accepted May I1, 1992 309
2. J. Photopolym. Sci. Technol., Vol.5, No.2,1992
1. Introduction
For determination of absorbed doses in radiation sterilization of medical
supplies or in physical and chemical utilization of radiation, a variety of
indicators which can be symply measured absorbed doses have been commercialized.
In previous papers [1,2], the authors reported the method of manufacturing and
using a label-formed color indicator designed for checking absorbed doses
emploied for y -ray sterilization of medical supplies. The supply and demand
of medical supplies have been increasing in recent years. In respect of this
trend, a more efficient method of sterilization of medical supplies is now
required.
To satisfy such a jemand, we attempted to develop a radiation indicator ink
instead of a label-shaped indicator which consumed a lot of time for attaching
the label. If an indicator ink is printed directly onto the packing material
or the label of medical supplies, absorbed doses on large quantities of medical
supplies can be checked in a short period of time. In addition, the thus-
prepared indicator is less likely to become detached from medical supplies,
compared with the conventional label-formed indicator. This paper will present
the manufacturing method and the features of this radiation indicator ink for
photogravure printing.
The principle of color-changing at this indicator is shown in the equation 1.
When the indicator is exposed to radiation, hydrogen chloride is released from
polyvinyl chloride. Hydrogen chloride reacts with diethylaminoazobenzene (an
acid-sensitive dye), resulting in a change of the indicator color from yellw to
red.
2. Method
By using a
(commonly used
aminoazobenzene
ratio 9:1, 20.0
cyclohexane ( 2
bar coater ( No.
for sterilization)
(0.7 % by weight)
?), methyl ethyl
.8 %), chlorinated
10, Osaka Richo Co., Ltd.), a packing paper
was coated with a solution containing diethyl-
, vinyl chloride-vinyl acetate copolymer (molar
ketone ( 58.0 %), toluene ( 5.1 %), hexachloro-
paraffin ( Enpara-70, Sanko Inc., 13.3 %), and
310
3. J. Photopolym. Sci. Technol.,Vol.5, No.2, 1992
an antioxidant ( AD-51, Sakai Chem. Ind. Co., Ltd., 0.1 %). The paper was then
dried at room temperature for 10 minutes and was cut into size of 1.5cm x 2cm
test pieces. The thickness of the indicator ink was 3--6 u m when the paper was
dried.
Various kinds of dose rates of y -rays using 60Co sources were irradiated
onto the test pieces at room temperature for prescribed periods. Table 1 shows
the values of Curie numbers and the dose rates at the center of the basket of
the 60Co sources used in the present study. A standard absorbed dose of y -ray
irradiation in this study was determined by using an ionization chamber (Oyo
Giken Co., Ltd.)
Electron beam irradiation
was carried out at room temper-
ature, using a linear electron
accelerator (Highvoltage Engi-
neering Co., Ltd., U.S.A.).
The absorbed dose in electron
beam irradiation were
calculated by the equation of
Okabe et al.[3] (Equation 2).
Where 10, S and Y denote
electron-beam current, con-
veyer speed and irradiation
width, respectively.
Using a color densitometer
KRD-2100 (Ihara Electric Co.,
Ltd.) which is complied with
the ANSI ( American National
Standard for Photography), the
color of the indicator was
resolved into four components,
i.e., magenta (red), cyan
(blue), yellow and visual
(lightness), and the density
of each component was determined.
Table 1. 60Co sources.
311
4. J. Photopolym. Sci. Technol., Vol.5, No.2, 1992
3. Results and Discussion
The color of the indicator ink is a bright yellow before irradiation. The
amounts of diethylaminoazobenzene were adjusted so that the indicator ink
changed to red at an absorbed dose of 25 kGy (a standard dose used for y -ray
sterilization of medical supplies, see 2. Method). Table 2 shows the relation
between the color of the indicator and 7 -ray irradiation. The yellow color
of the non-irradiated indicator was increasingly tinged with red as the dose
increased, and the color changed red at a dose of 25 kGy.
After resolving the hue of the
indicator into four components, i.e.,
magenta (red), cyan (blue), yellow
and visual (lightness), we measured
the density of each color component.
Figure 1 shows a relationship between
the color density and the absorbed
dose. The density of the yellow
component gradually decreased as the
dose exceeded about 25 kGy. On the
other hand, the density of the red
component increased linearly in a
dose range between 5 and 50 kGy.
These results indicate that this
indicator ink can be utilized to
check the absorbed irradiation doses
between 5 and 50 kGy that are used
for sterilization.
Table 2. Color change of the indicator ink by 7 -ray irradiatione ) .
Fig.l Relation between the color
density and the 7 -ray irradiation
dose with dose rate of 25.7 kGy/h.
312
5. J. Photopolym. Sci. Technol., Vol.5,No.2, 1992
Figure 2 shows the relationship between the density of the red component
and the absorbed doses of 7 -ray generated from 5 sources with different dose
rates as shown in Table 1. (see 2. Method). In this Figure, all plots at
different dose rates lay approximately on a single curve. Therefore, in a dose
rate range from 1.41 to 33.4 kGy/h, the red density is proportional only to the
absorbed dose, regardless of the dose rate.
In Figure 3, the density of the red color by electron beam irradiation, used
a linear electron accelerator compares with that by y -ray irradiation. The
values of the color density by electron beam irradiation are in good agreement
with those by -ray irradiation. This result indicates that this indicator ink
can also be used to verify the measurement of electron doses.
Figure 4 shows the relation between the time and the density of the red color
of indicators stored in a dark place at room temperature. The non-irradiated
Fig.2 Plot of color density of the
indicator against 7 -ray irradiated
dose with various kinds of dose rates.
(L~:1.41, V:4.21, 0:8.52, []:25.7,
0 : 33.4 kGy/h).
Fig.3 Coloration of the indicator by y -
ray irradiation(0 :dose rate 25.7 kGy/h)
and electron beam-irradiation (d :energy
10 Mev, beam current 15^ 50 u A, irradi-
ation width 20 cm,conveyer speed 30 cm/min).
313
6. indicators
(below 10
storage.
decreased
indicator
J. Photopolym. Sci. Technol., Vol.5, No.2, 1992
and the indicators exposed to relatively low
kGy) showed hardly any change in the red density
The density of the red color in indicators by 25 kGy
5 % or less during a 50-day storage. Thus, fading of
with time was found to be negligible.
dose irradiation
during a 50-day
dose irradiation
the color of the
4. Conclusion
Aconvenient radiation indicator ink to check the doses of radiation was
developed for radiation sterilization. The indicator was prepared by coating or
printing the packing paper with the indicator ink made primarily of diethyl-
aminoazobenzen. The color of the indicator changes from yellow to red at 25 kGy
which is the optimum dose for y -ray sterilization. This new indicator is supe-
rior to the conventional label-formed indicators because the former indicator
is very shorter time to attach labels than the latter one. This indicator was
also found to be useful for determining absorbed doses of electron beams.
Fig.4 Discoloration test of the y -ray irradiated indicator.
References
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