This case report describes the successful use of maggot therapy to treat an acute burn on the foot of a diabetic patient. Maggots were applied to the burn wound after initial treatment with silver sulfadiazine and saline soaks failed to adequately debride necrotic tissue. Over three applications of maggots spanning two weeks, the maggots effectively cleaned and debrided the wound. This accelerated healing and reduced the need for surgical debridement and skin grafting. The report concludes that maggot therapy can be a useful treatment even for some acute burns when standard treatments are ineffective or unsuitable due to patient comorbidities.
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A complete wound history along with knowledge of the healing potential of the wound, as it relates to the specific medical and environmental considerations for each patient, provides the basis of decision making for wound management.
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Low back pain remains the common reason to see the doctors in the clinics and in United states
it remains the second most common reason to see neurosurgeon or orthopedic doctor in their respective outpatient departments. However as the presentation is common so is the surgery for the
disease is common and as with all surgeries this also carries a small risk of complications. Bowel
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Management of ulcers,physical therapy interventions, characteristics, how to asses different ulcer,examination, prognosis, evidence based medicine, drug therapy and other therapies
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Post-traumatic wounds especially after run over accidents are difficult to manage. The vascularity and regenerative potential of the tissues is severely compromised. Surgical intervention is of limited value. A conservative approach with concomitant hyperbaric oxygen therapy (HBOT) serves as a great salvage in such cases. A case of post-traumatic forefoot gangrene in a 27-year-old laborer is presented to highlight and create an awareness of the potential benefit of HBOT in salvage of distal parts of the lower extremity where the blood supply is severely compromised.
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See why Doctors are switching their patients to RecoveryRx® for reliable, drug-free pain relief and faster healing with no side-effects. Safer, and more effective, see why RecoveryRx is the #1 most innovative pain and healing product and is now available in the US.
The variety of wounds present challenges to the physician to select the most appropriate management to facilitate healing.
A complete wound history along with knowledge of the healing potential of the wound, as it relates to the specific medical and environmental considerations for each patient, provides the basis of decision making for wound management.
It is essential to consider each wound individually in order to create the optimal conditions for wound healing.
Understanding of wound healing is as important as knowing the pathogenesis of disease, because satisfactory wound healing is the ultimate goal of treatment.
If we are able to understand the mechanism of wound healing, we can design treatment approaches that maximize favorable conditions for wound healing to occur.
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1. Case report: maggot therapy in an acute burn
Case report: maggot therapy in an acute
burn
Author(s) Contents
Daniel Thornton ● Introduction
MB ChB MRCS ● The case
Senior House Officer ● Discussion
Dept of Reconstructive Plastic and Burns Surgery
● Conclusion
Northern General Hospital, Herries Road, Sheffield S5 7AU
Email: djathornton@yahoo.co.uk ● References
Miles Berry
MS, FRCS
LAT Registrar
David Ralston
MD, FRCS(Plast)
Consultant
Published: August 2002
Last updated: August 2002
Revision: 1.0
Keywords: maggot therapy; acute burn; infection.
Key Points
1. The beneficial effects of maggots on wounds have been observed since
ancient times and have an established role in necrotic or difficult to heal
chronic wounds.
2. Maggot therapy can accelerate debridement of sloughy and necrotic
wounds and reduce the bacterial load of the wound, leading to earlier
healing, reduced wound odour and less pain.
3. Although maggots can be used successfully in a wide variety of wounds,
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2. Case report: maggot therapy in an acute burn
they remain underutilised.
Abstract
Maggot therapy has an established role in the management of necrotic or chronic
wounds, but its use in acute burns has received scant attention in the literature. In this
case report, we present a challenging case in which maggots were used to good effect in
a burn that was difficult to manage by conventional means.
Introduction
The beneficial effects of maggots on wounds have been observed since ancient times,
with reports of their success by Maya Indians and aboriginal tribes [1]. Observations of
favourable outcomes following maggot colonisation of battle wounds [2], [3] have
highlighted the ability of maggots to eliminate necrotic tissue whilst sparing living tissue.
Zacharius is the first on record to have intentionally introduced maggots to wounds
during the American Civil War in the nineteenth century [2], [3]. More recently, during
the First World War, Baer recognised their efficacy in infection, later using maggots in
peace time to achieve a success rate of 90% in the treatment of chronic osteomyelitis
[3]. The advent of antibiotics during the 1940s heralded the demise of maggot therapy
and this has remained the case until recently. The emergence of multi-resistant bacterial
strains has brought about renewed interest in their use in certain wounds, particularly
heavily contaminated/non-healing chronic wounds, or in patients unfit for anaesthesia.
Therapeutic maggots used most commonly today are those of the greenbottle fly (Lucilia
sericata), a facultative parasite that, in humans, only attacks necrotic tissue. The
maggots hatch from eggs laid by mature adult flies. These initial maggots (first instars)
grow from 1-2mm to 8-10mm, moulting twice to become third instars some five days
later. They then pupate in a dry location and undergo metamorphosis to adult flies after
a further week. They can only be used in wound debridement during the maggot stages,
when they are incapable of reproduction; metamorphosis to adult flies only occurs
outside the recommended time limits for their clinical application.
The case
A 61 year-old man sustained a 1% predominantly full-thickness burn to the sole of his
right foot (Figure 1) following direct contact with a microwaved 'wheat-filled' heat bag.
He had been using this to ease a long-term aching pain in his foot. He was referred to
the department two days following injury. Initial treatment included chlorhexidine
paraffin gauze (Bactigras) dressing and oral antibiotics (Augmentin). The patient had
type 1 insulin-dependent diabetes with a history of poor blood glucose control. He had
well-established, bilateral 'stocking distribution' sensory neuropathy (reduced sensation)
and a 'rockerbottom' Charcot foot on the affected right side, as evidenced by plain
radiology (Figure 2).
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3. Case report: maggot therapy in an acute burn
Figure 1 - Full thickness burn to sole of right foot two days after admission (4 days post
injury) prior to application of LarvE
Figure 2 - Lateral radiograph of right foot showing Charcot arthropathy
Management
Initial treatment included leg elevation and application of topical silver sulphadiazine
(Flamazine) to soften the eschar. In view of the patient's poor state of health and
anticipated difficulties with skin grafting or flap reconstruction of the insensate, deformed
foot, it was decided to commence maggot therapy four days post injury.
For maggots to function optimally they require a moist environment; saline soaks were
therefore applied for 48 hours to moisten the wound and remove excess silver
sulphadiazine prior to application of maggots. Three batches of LarvE were applied to the
burn, each remaining in-situ for three days. At the end of maggot therapy (day 16), the
anterior portion of the wound was found to be healing well with a virtual absence of
slough (Figure 3). It was more difficult to maintain viable maggots over the posterior,
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4. Case report: maggot therapy in an acute burn
more prominent part of the burn, due to the patient's lack of compliance with non-
weightbearing. The patient underwent surgical debridement and split skin grafting to this
area, although this was considerably smaller than initially anticipated. The patient was
discharged home seven days postoperatively, with an estimated 70% graft take. Follow-
up demonstrated healing of the anterior LarvE treated ulcer, but slower progress in the
grafted area requiring prolonged conservative treatment.
Figure 3 - View of burn following three LarvE treatments
Discussion
Successful wound healing involves a complex interaction between the patient and local
wound factors. Healing is known to be impaired by:
● poor nutrition (vitamin deficiencies, hypoalbuminaemia)
● comorbidity (diabetes mellitus, anaemia, renal failure, vascular disease)
● pharmacotherapy (steroids, immunosuppressants)
● smoking.
An appropriate wound environment is critical for healing; this needs to be moist and have
an adequate supply of blood and oxygen. These conditions are enhanced by local
debridement, wound hygiene and appropriate dressings (hydrogels, silver sulphadiazine).
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5. Case report: maggot therapy in an acute burn
Maggots constitute a living biological dressing, which acts in a number of ways. Maggot
secretions appear to amplify the healing effects of host epidermal growth factor and IL-6
in addition to their haemostatic properties [4]. Secretions include allantoin and urea
(antimicrobial activity) [2], [3], calcium carbonate (stimulation of phagocytosis) [5], and
proteolytic enzymes (slough/necrotic tissue breakdown) [3]. The resultant enzymatic
degradation products are subsequently ingested and digested by the maggots. In vitro
studies have shown maggots to inhibit and destroy a wide range of pathogenic bacteria
including Staphylococcus aureus (including MRSA), group A and B streptococci, Gram
positive, aerobic and anaerobic strains [2], [3], [6].
Micromassage of the wound by maggot movement is thought to stimulate the formation
of granulation tissue and wound exudate by the host [2]. The net effects of maggot
therapy are accelerated debridement of slough and necrosis and a reduction in the
bacterial load of the wound, leading to earlier healing, reduced wound odour and less
pain.
Once applied, maggots remain local to the wound and have no systemic adverse effects.
They rely on air for respiration and act in the absence of good blood supply. This makes
maggots particularly useful in wounds which are otherwise unsuited for surgical
treatment. Contraindications to their use include:
● active haemorrhage
● excess wound exudate
● wounds in body cavities or in close proximity to large vessels.
There is now evidence to suggest that maggots can be used successfully in a wide variety
of wounds (trauma, vascular, infected, malignant and a single report in an infected burn
wound [2]). Despite this they remain underutilised. This may, in part, be due to a
reluctance of staff, and to a lesser extent patients, to use them because of a misguided
perception that maggots are dirty or carry disease.
Conclusion
This case would appear to challenge the view that maggots are a treatment of last resort
only for the chronic wound unresponsive to other therapies. From our experience, it is
recommended that maggot therapy be considered in the management of acute burns.
References
1. Church JC. The traditional use of maggots in wound healing and the development of
larval therapy (biosurgery) in modern medicine. J Altern Complement Med 1996; 2(4):
525-27.
2. Namias N, Varela JE, Varas RP, Quintana O, Ward CG. A case report of maggot
therapy for limb salvage after fourth-degree burns. J Burn Care Rehab 2000; 21(3): 254-
57.
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