Pub/Sub is a messaging paradigm that allows publishers to send messages to subscribers through a broker. In Drupal, it allows content like nodes to be published from one site to another. Key aspects of Pub/Sub in Drupal include topics defined by views, filtering content via rules, and supporting push and pull of content between loosely coupled systems. It can integrate with other modules via hooks and is used on a case study site to sync over 57k nodes across 21 channels.