Publications and conferences
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This document provides a list of publications and conference presentations by Tian L. The publications section lists 10 peer-reviewed journal articles published between 2014-2009 covering topics related to T cell receptor signaling, regulatory T cells, autoimmunity, and CD8+ T cell differentiation. The conferences section lists 3 conferences between 2012-2010 where Tian L presented oral presentations on immune tolerance and regulatory T cells.
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This document lists 32 selected publications and 6 presentations by Dr. Wang L related to research in head and neck squamous cell carcinoma and renal fibrosis. The publications include journal articles from 2004-2015 addressing topics such as increased expression of HER2/HER3 in HPV-positive HNSCC, subcellular localization of MDM2 in HNSCC, roles of STAT1 and EGFR in HNSCC treatment response, challenges in detecting EGFRvIII in HNSCC, quantifying tumor heterogeneity in HNSCC, roles of chemokines in HNSCC metastasis, and identifying mutations in receptor tyrosine phosphatases and the PI3K pathway in HNSCC. The presentations described findings from Dr. Wang L's
Publications and Presentations
This document lists 32 publications and 2 presentations by the author. The publications cover a range of topics related to head and neck squamous cell carcinoma (HNSCC) including studies on the roles of HER2, MDM2, STAT1, EGFRvIII, PI3K pathway mutations, receptor protein tyrosine phosphatases, STAT3, and chemokine receptor CCR7 in HNSCC. Many of the publications report on clinical trials of targeted therapies for HNSCC such as cetuximab, erlotinib, dasatinib, and STAT3 decoy oligonucleotides. Earlier publications covered research on TGF-beta signaling and its role in mesangial cell proliferation and fibrosis.
Basics of cancer immunotherapy 2017
This presentation is part of MIU CE Pharmacy Program and is designed primarily for pharmacists with the following learning objectives:
1- Explain the mechanisms of action behind immune response to cancer and the application of immunotherapy in cancer treatment
2- Distinguish new and emerging immunotherapy classes and individual agents efficacy, safety to therapy in cancer treatment
3-Strategies to counsel and assist patients to overcome barriers to therapy, including Treatment side effects to improve adherence to therapy
T cell mediated immunity
The document summarizes a lecture on T-cell mediated immunity delivered by Dr. Dinesh Dabhadkar. It discusses that T-cells recognize intracellular antigens associated with MHC molecules and help activate macrophages, induce cytotoxic T-cells, and stimulate antibody production by B-cells. The main types of T-cells are helper T-cells, cytotoxic T-cells, delayed hypersensitivity T-cells, and suppressor T-cells. Cytotoxic T-cells directly kill infected cells, while helper T-cells activate other immune cells.
Publications and Presentations
This document lists 30 publications and 6 presentations by Dr. Lin Wang related to head and neck cancer research. The publications cover topics such as increased expression of HER2/HER3 in HPV-positive head and neck squamous cell carcinoma, differential pathological significance of subcellular MDM2 expression in HNSCC, targeting of STAT3 to abrogate EGFR inhibitor resistance in cancer, and the mutational landscape of head and neck squamous cell carcinoma. The presentations were given at American Society of Nephrology conferences between 2001-2006 on topics including the role of MKK3-p38 MAPK pathways in TGF-β1 signaling and renal fibrosis.
Publications and Presentations
This document lists 30 publications and 6 presentations by Dr. Lin Wang related to head and neck cancer research. The publications cover topics such as increased expression of HER2/HER3 in HPV-positive head and neck squamous cell carcinoma, differential significance of subcellular MDM2 expression in HNSCC, targeting of STAT3 to abrogate EGFR inhibitor resistance, and the mutational landscape of head and neck squamous cell carcinoma. The presentations were given at American Society of Nephrology conferences between 2001-2006 on topics including the role of MKK3-p38 MAPK pathways in mediating TGF-β1 signaling.
IDO pathway from bench to clinic
This document outlines the history and mechanisms of the indoleamine-2,3-dioxygenase (IDO) pathway and its role in cancer immunotherapy. It discusses key findings such as:
1) Munn's 1999 discovery that IDO suppresses T-cell mediated rejection of tumors and fetal allografts by depleting tryptophan.
2) Mechanistic studies showing IDO induces T-cell arrest and inhibits proliferation through tryptophan depletion and kynurenine production, leading to Treg differentiation and CTL inhibition.
3) Preclinical studies combining IDO inhibitors with chemotherapy or vaccines, showing enhanced anti-tumor effects.
4) Ongoing clinical
Salon b 18 kasim 2011 11.30 11.50 benan bayrakci
1. Hemophagocytosis frequently occurs during systemic inflammation and is associated with increased heme oxygenase-1 (HO-1) expression.
2. Within bone marrow of sepsis patients, macrophages constitute the principal source of HO-1 expression, which reflects heme breakdown.
3. Very high serum ferritin levels in pediatric patients with systemic inflammation are associated with increased risk of critical care and death.
histo
This document discusses transplant immunology and the major histocompatibility complex (MHC). It covers MHC structure and function, inheritance of MHC antigens, humoral and cellular immunity, antigen presentation, HLA associations with disease, types of transplants, mechanisms of graft rejection, pre-transplant immunological evaluations, and immunosuppressive strategies.
CV NOV 2014 Kazuyoshi KOHU
This document is a curriculum vitae for Kazuyoshi Kohu that provides biographical and career information in 3 sections - Personal Information, Education History, and Professional Experience. It lists his name, date and place of birth, contact information, education credentials including undergraduate and graduate degrees from Hiroshima University and Osaka University, as well as his current position as Senior Research Scientist at the Cancer Science Institute of Singapore and past research roles.
Basic Immunology of Liver transplantation.pptx
1. Liver transplantation has significantly improved since the first transplant in 1963 due to advances in surgical techniques, perioperative care, immunosuppression, and understanding of alloimmune responses.
2. The liver is an immune tolerant organ that can induce tolerance or immune responses depending on antigen presentation. Unique liver cells like LSECs can prime T cells but fail to stimulate proliferation, inducing tolerance through regulatory T cells and inhibitory molecules.
3. Acute cellular rejection is the most common form of rejection and typically occurs within the first month, presenting with non-specific symptoms but requiring biopsy for diagnosis. With current immunosuppression, the risk of acute rejection is 10-40% and chronic rejection is below 5%.
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Elements of cancer immunity and the cancer-immune set point
Elements of cancer immunity and the cancer-immune set point
Publications and conferences
- 1. Publications ·A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T cell receptor signaling. 2014. Immunology, 141(3), 377-87. Cauwe B*, Tian L*, Franckaert D, Pierson W, Staats KA, Schlenner SM, Liston A. (*co-first author) ·Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals. 2014. Journal of Autoimmunity, 50:23-32. Mayer CT, Tian L, Hesse C, Kühl AA, Swallow M, Kruse F, Thiele M, Gershwin ME, Liston A, Sparwasser T. ·Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice. 2012. Journal of Autoimmunity, 38 (1), 39-48. Tian L, De Hertogh G, Fedeli M, Staats KA, Schönefeldt S, Humblet-Baron S, Van Den Bosch L, Dellabona P, Dooley J, Liston A. ·Immune tolerance: are regulatory T cell subsets needed to explain suppression of autoimmunity? 2012. BioEssays, 34 (7), 569-75. Tian L, Humblet-Baron S, Liston A. ·Foxp3(+) regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. 2011. Blood, 118 (7), 1845-1853. Tian L, Altin JA, Makaroff LE, Franckaert D, Cook MC, Goodnow CC, Dooley J, Liston A. ·Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy. 2011. Journal of Allergy and Clinical Immunology, 127 (5), 1277-85.e5. Altin JA, Tian L, Liston A, Bertram EM, Goodnow CC, Cook MC. ·Influence of antigen dose and DC number on CD8+ T cell differentiation and proliferation of OT-Ⅰ transgenic mice. 2009. Journal of Northwest A & F University (Nature Science Edition) 37 (9). Tian L, Chen DW, Ji YW, Liu X, Zhang MH, Chen DK. ·Microglia and microglia-like cell differentiated from DC inhibit CD4 T cell proliferation. 2009. Plos One. Nov 17; 4(11): e7869. Bai B, Song WG, Ji YW, Liu X, Tian L, Wang C, Chen DW, Zhang X, Zhang MH.
- 2. Conferences (participated with oral presentations) ·42nd Annual Scientific Meeting of the Australasian Society for Immunology. Melbourne, Dec. 2012. ·2nd International Conference on Immune Tolerance. Amsterdam, Oct. 2011. ·The Second International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Disease in China. Shanghai, July 2010.