This document lists 32 selected publications and 6 presentations by Dr. Wang L related to research in head and neck squamous cell carcinoma and renal fibrosis. The publications include journal articles from 2004-2015 addressing topics such as increased expression of HER2/HER3 in HPV-positive HNSCC, subcellular localization of MDM2 in HNSCC, roles of STAT1 and EGFR in HNSCC treatment response, challenges in detecting EGFRvIII in HNSCC, quantifying tumor heterogeneity in HNSCC, roles of chemokines in HNSCC metastasis, and identifying mutations in receptor tyrosine phosphatases and the PI3K pathway in HNSCC. The presentations described findings from Dr. Wang L's
This document lists 30 publications and 6 presentations by Dr. Lin Wang related to head and neck cancer research. The publications cover topics such as increased expression of HER2/HER3 in HPV-positive head and neck squamous cell carcinoma, differential significance of subcellular MDM2 expression in HNSCC, targeting of STAT3 to abrogate EGFR inhibitor resistance, and the mutational landscape of head and neck squamous cell carcinoma. The presentations were given at American Society of Nephrology conferences between 2001-2006 on topics including the role of MKK3-p38 MAPK pathways in mediating TGF-β1 signaling.
This document lists 29 publications by Lin Wang and others from 1999-2014. The publications cover a range of topics related to head and neck cancer, including:
1) Identification of increased expression of HER2 and HER3 in HPV-positive head and neck squamous cell carcinoma.
2) Examination of subcellular MDM2 expression and its pathological significance in head and neck squamous cell carcinoma.
3) Quantification of metabolic heterogeneity in head and neck tumors in real time.
4) Randomized clinical trials examining erlotinib and other drugs for treatment of head and neck cancer.
The majority of publications focus on signaling pathways involved in head and neck cancer such as EGFR,
1. This document lists original articles and book chapters published by Dr. Lee BC and collaborators related to hematopoietic stem cells and cancer.
2. The publications span from 1988 to 2017 and cover topics such as the role of specific genes and receptors in regulating hematopoietic stem cells and their response to stressors like radiation.
3. Many of the articles examine how the bone marrow microenvironment influences hematopoietic stem cells through factors secreted by other cell types.
This document lists publications from 2014-2005 authored or co-authored by researchers including K. Stefanius, K. Tuppurainen, and M.J. Makinen. The publications relate to research on cancer types such as renal cell carcinoma, kidney cancer, colorectal cancer, pituitary adenomas, and thyroid cancer. Many of the publications analyze gene mutations, expression, and their involvement in tumorigenesis and cancer progression. Conference presentations on related topics from 2009-2008 are also listed.
Human genetic variation can influence treatment prognosis for hepatitis C virus (HCV). A single nucleotide polymorphism near the IFNL3 gene indicates natural resistance to type 1 HCV, with the T variant associated with poorer treatment outcomes. Additionally, a polymorphism in the interleukin-23 receptor gene correlates with reduced risk of HCV-related liver cancer. HCV appears to have evolved to benefit from allelic variations between geographic regions. Future treatment may focus on precise virus-genome interactions. Mapping the entire human genome could increase understanding of connections between HCV and its human host.
This document discusses several studies that have examined gene polymorphisms related to atherosclerosis. It focuses on polymorphisms in genes involved in inflammation, immune response, endothelial function, and lipid metabolism. The studies presented had varying and sometimes conflicting results on the association between specific gene variants and coronary artery disease or myocardial infarction. In general, the document indicates that coronary artery disease has a complex genetic basis, with many genes and environmental factors involved.
This document discusses several studies that have examined gene polymorphisms related to atherosclerosis. It focuses on polymorphisms in genes involved in inflammation, immune response, endothelial function, and lipid metabolism. The studies presented had varying and sometimes conflicting results on the association between specific gene variants and coronary artery disease or myocardial infarction. In general, the document indicates that coronary artery disease has a complex genetic basis, with many genes and environmental factors involved.
This document lists 72 publications by G.J.L.H. van Leenders. The publications are listed in reverse chronological order from 2012 to 2010 and include journal articles, book chapters, and other published works. The publications cover a range of topics including prostate cancer, bladder cancer, coronary artery imaging, and cancer biomarkers. Many of the publications are in high impact factor journals like European Urology, British Journal of Cancer, and Human Molecular Genetics.
This document lists 30 publications and 6 presentations by Dr. Lin Wang related to head and neck cancer research. The publications cover topics such as increased expression of HER2/HER3 in HPV-positive head and neck squamous cell carcinoma, differential significance of subcellular MDM2 expression in HNSCC, targeting of STAT3 to abrogate EGFR inhibitor resistance, and the mutational landscape of head and neck squamous cell carcinoma. The presentations were given at American Society of Nephrology conferences between 2001-2006 on topics including the role of MKK3-p38 MAPK pathways in mediating TGF-β1 signaling.
This document lists 29 publications by Lin Wang and others from 1999-2014. The publications cover a range of topics related to head and neck cancer, including:
1) Identification of increased expression of HER2 and HER3 in HPV-positive head and neck squamous cell carcinoma.
2) Examination of subcellular MDM2 expression and its pathological significance in head and neck squamous cell carcinoma.
3) Quantification of metabolic heterogeneity in head and neck tumors in real time.
4) Randomized clinical trials examining erlotinib and other drugs for treatment of head and neck cancer.
The majority of publications focus on signaling pathways involved in head and neck cancer such as EGFR,
1. This document lists original articles and book chapters published by Dr. Lee BC and collaborators related to hematopoietic stem cells and cancer.
2. The publications span from 1988 to 2017 and cover topics such as the role of specific genes and receptors in regulating hematopoietic stem cells and their response to stressors like radiation.
3. Many of the articles examine how the bone marrow microenvironment influences hematopoietic stem cells through factors secreted by other cell types.
This document lists publications from 2014-2005 authored or co-authored by researchers including K. Stefanius, K. Tuppurainen, and M.J. Makinen. The publications relate to research on cancer types such as renal cell carcinoma, kidney cancer, colorectal cancer, pituitary adenomas, and thyroid cancer. Many of the publications analyze gene mutations, expression, and their involvement in tumorigenesis and cancer progression. Conference presentations on related topics from 2009-2008 are also listed.
Human genetic variation can influence treatment prognosis for hepatitis C virus (HCV). A single nucleotide polymorphism near the IFNL3 gene indicates natural resistance to type 1 HCV, with the T variant associated with poorer treatment outcomes. Additionally, a polymorphism in the interleukin-23 receptor gene correlates with reduced risk of HCV-related liver cancer. HCV appears to have evolved to benefit from allelic variations between geographic regions. Future treatment may focus on precise virus-genome interactions. Mapping the entire human genome could increase understanding of connections between HCV and its human host.
This document discusses several studies that have examined gene polymorphisms related to atherosclerosis. It focuses on polymorphisms in genes involved in inflammation, immune response, endothelial function, and lipid metabolism. The studies presented had varying and sometimes conflicting results on the association between specific gene variants and coronary artery disease or myocardial infarction. In general, the document indicates that coronary artery disease has a complex genetic basis, with many genes and environmental factors involved.
This document discusses several studies that have examined gene polymorphisms related to atherosclerosis. It focuses on polymorphisms in genes involved in inflammation, immune response, endothelial function, and lipid metabolism. The studies presented had varying and sometimes conflicting results on the association between specific gene variants and coronary artery disease or myocardial infarction. In general, the document indicates that coronary artery disease has a complex genetic basis, with many genes and environmental factors involved.
This document lists 72 publications by G.J.L.H. van Leenders. The publications are listed in reverse chronological order from 2012 to 2010 and include journal articles, book chapters, and other published works. The publications cover a range of topics including prostate cancer, bladder cancer, coronary artery imaging, and cancer biomarkers. Many of the publications are in high impact factor journals like European Urology, British Journal of Cancer, and Human Molecular Genetics.
This document discusses vitamin D and its potential relationship to ovarian cancer risk. It notes that vitamin D receptor (VDR) expression is higher in ovarian cancer cells than normal ovarian cells. Studies have found that vitamin D administration can inhibit growth and induce apoptosis in ovarian cancer cell lines. The document reviews several studies that found associations between the VDR Fok1 polymorphism and increased ovarian cancer risk. In particular, there is evidence that women with the CT and TT genotypes may have higher risk. Based on these findings, the document calls for larger studies to further evaluate the relationship between the VDR Fok1 polymorphism and epithelial ovarian cancer risk, as well as measuring serum vitamin D levels in ovarian cancer patients.
This document summarizes the publications of Prof. Amnon Peled from 2011-2015. It lists 24 publications with citation information. Prof. Peled's publications focus on the roles of chemokines and chemokine receptors in areas like cancer, inflammation, and stem cell mobilization. Many of the publications examine the therapeutic potential of CXCR4 antagonists for treating cancers like lung cancer, multiple myeloma, and acute myeloid leukemia.
This document lists 11 publications related to cancer research authored by Hay T and others:
1. A 2015 study identifying hepatic progenitor cells with liver repopulation capacity.
2. A 2015 study showing c-Myc-conjugated nanoparticles can suppress breast and colorectal cancer models.
3. A 2009 study finding PARP-1 inhibitor treatment can regress BRCA2/p53-mutant mammary tumors and delay relapse when combined with carboplatin.
This document provides a curriculum vitae for Dr. Siva P. Raman for academic promotion. It includes demographic information, current appointments, education and training history, professional experience, and a list of 27 peer-reviewed research articles. It also lists invited review articles, inventions/patents, extramural sponsorship, educational activities, and educational publications authored by Dr. Raman. The CV demonstrates Dr. Raman's qualifications and accomplishments in radiology research and education over his career.
Potential of Targeting Bone Metastases with Immunotherapies_Crimson PublishersCrimsonpublishersCancer
Potential of Targeting Bone Metastases with Immunotherapies
Bone metastases are common in many cancers and result in low survival rates. Immunotherapies have shown promise in treating some patients with bone metastases. Case reports have shown individual patients experiencing decreased bone lesion growth or complete remission of bone metastases using immunotherapies targeting PD-1, PD-L1, or CTLA-4. However, immunotherapies may also cause harmful skeletal effects like fractures or spinal cord compression. Further research is still needed to determine if immunotherapies are effective against bone metastases in large patient groups and to understand their potential skeletal side effects.
This document lists 32 peer-reviewed journal articles authored or co-authored by Bal Sanghera related to positron emission tomography (PET) imaging. The articles cover a range of topics including evaluating PET tracers and reconstruction algorithms for assessing tumor hypoxia and proliferation, optimizing PET-CT protocols to reduce radiation dose, and assessing the impact of various factors on standardized uptake value (SUV) measurements. Dates of publication range from 1991 to 2016.
This document provides a bibliography of research papers related to cancer organized by topic. It includes 3-7 references for each of 17 cancer-related topics, such as 3D tumor imaging, angiogenesis, bladder cancer, breast cancer, contrast imaging, and others. The references provided for each topic are journal articles published between 2005-2010 that describe research on imaging, molecular markers, treatment responses, and other aspects of various cancers.
The document announces a paediatric leukaemia symposium to be held on March 18, 2011 in Kuala Lumpur, Malaysia. The keynote speaker will be Dr. Pui Ching-Hon from St. Jude Children's Research Hospital who will give a lecture on clofarabine for paediatric leukaemia. The symposium will include discussions on difficult paediatric leukaemia cases and potential research initiatives in Malaysia. It will be held at the Auditorium Ungku Omar of the Institute for Medical Research and is sponsored by Genzyme Malaysia through the Malaysian Society of Paediatric Haematology and Oncology.
Carotid intima-media thickness (IMT) is predictive of cardiovascular risk. A study of 222 patients who suffered their first myocardial infarction found that 88% were in the low to intermediate risk category according to Framingham risk scores, but would have been considered high risk and treated aggressively if carotid IMT was also considered. Prospective population studies show carotid IMT is associated with future cardiovascular events independently of traditional risk factors. Higher IMT levels correlate with greater risks of myocardial infarction, stroke, and cardiovascular death. Measuring carotid IMT could help identify patients at higher risk who may benefit from more intensive prevention efforts.
1) The study analyzed DNA methylation patterns between young (<45 years old) and older (>=45 years old) women with breast cancer using data from The Cancer Genome Atlas.
2) Machine learning identified 17 differentially methylated sites between the two groups, including hypomethylation of the ITPR3 promoter and hypermethylation of the ARID3A gene in young women.
3) Differential methylation of these genes, particularly ITPR3 which stimulates breast cancer cell proliferation, may help explain the increased aggressiveness of breast cancer in young women. Further investigation of these genes is warranted.
This document provides a summary of the 11th edition of Wintrobe's Clinical Hematology, a comprehensive textbook on clinical hematology. The textbook is edited by John P. Greer, John Foerster, and John N. Lukens, and contains contributions from over 100 experts in hematology. It is organized into 7 parts covering laboratory hematology, normal hematopoiesis, therapeutic modalities, disorders of red blood cells, disorders of hemostasis and coagulation, nonmalignant disorders of leukocytes and related topics, and hematologic malignancies. The textbook provides an in-depth review of the basic science and clinical aspects of hematologic diseases and disorders.
Ton Beniers_publicatielijst overzicht 2015Ton Beniers
This document lists publications by Beniers and others from 1987-2001 related to experimental cytokine therapy for renal cell carcinoma and Wilms' tumor. It includes 18 journal publications, 5 book chapters, and 1 PhD thesis by Beniers on experimental cytokine therapy for renal cell carcinoma. The publications examine the in vitro and in vivo effects of interferons and tumor necrosis factor on renal tumor cell lines and xenografts, and differential expression of drug resistance and heat shock proteins in histological compartments of nephroblastomas.
Vit D Disease incidence prev chart 051317JA Larson
This document presents evidence that higher serum 25(OH)D levels are associated with reduced risk of various diseases. It shows that levels above 30 ng/mL are linked to substantially lower rates of breast cancer, colorectal cancer, non-Hodgkin's lymphoma, multiple sclerosis, and falls in women. Levels between 40-60 ng/mL may be needed to prevent most chronic diseases, as this range is associated with significantly reduced incidence of cancer, cardiovascular disease, diabetes, and autoimmune conditions. Reference data is provided on average 25(OH)D levels in different populations, with tribal East Africans having the highest at 115 nmol/L.
Myeloablative Umbilical Cord Blood Transplantation for Hematologic Malignanci...cordbloodsymposium
This study retrospectively analyzed outcomes for 566 patients undergoing hematopoietic stem cell transplantation for hematologic malignancies with either umbilical cord blood (CBT, n=112) or unrelated donor (URD, n=454) transplantation between 2006-2012. Disease free survival, relapse rates, and non-relapse mortality were comparable between CBT and URD recipients. Younger CBT patients had lower mortality risks compared to younger URD patients, but this advantage disappeared in older patients. Relapse was also less frequent after CBT. The risk of chronic graft-versus-host disease was lower for matched unrelated donor bone marrow recipients. Overall, outcomes were not inferior for CBT compared to URD
Este documento trata sobre el análisis de seguridad del trabajo (AST). Explica los fundamentos del AST, incluyendo definiciones importantes. Detalla los pasos para realizar un AST, como seleccionar el trabajo, dividirlo en tareas, identificar riesgos y prevenirlos. El AST busca identificar riesgos laborales para proteger a los trabajadores.
Este documento presenta un análisis de riesgos ocupacionales para cinco puestos de trabajo. Analiza factores físicos, organizativos y ergonómicos para cada puesto, identificando posibles riesgos como fatiga visual, estrés, trastornos musculoesqueléticos y síndrome del túnel carpiano. El objetivo es proteger la salud y seguridad de los trabajadores.
Este documento presenta un análisis de riesgos en una planta de producción de alimentos. Identifica varios peligros físicos, químicos, biológicos, ergonómicos y psicolaborales presentes, como ruido, temperaturas extremas, vapores químicos, cargas pesadas y trabajo repetitivo. También describe posibles consecuencias como quemaduras, lumbalgias, fatiga y enfermedades. Finalmente, establece normas generales de seguridad para controlar los riesgos.
El Análisis de Seguridad del Trabajo (A.S.T) es un método para identificar los riesgos asociados a cada etapa de la ejecución de un trabajo con el fin de eliminar o disminuir esos riesgos y proteger a los trabajadores. El A.S.T involucra dividir el trabajo en etapas sucesivas, identificar los riesgos potenciales en cada etapa, y desarrollar maneras de eliminar esos riesgos para mejorar la productividad, salud de los trabajadores y las relaciones humanas.
El documento presenta una metodología para el análisis de riesgos en el trabajo. Describe los pasos para identificar peligros, estimar riesgos mediante una matriz, y controlar los riesgos más significativos. También explica métodos cualitativos y cuantitativos para el análisis de riesgos, así como consideraciones clave para desarrollar un análisis de seguridad en el trabajo.
Este documento presenta una guía sobre el Análisis de Riesgo en el Trabajo (ART). Explica que el ART identifica peligros y evalúa riesgos potenciales antes y durante un trabajo para establecer medidas de prevención. Detalla los pasos básicos para elaborar un ART, que incluyen seleccionar el trabajo, dividirlo en partes e identificar riesgos potenciales y medidas preventivas. Además, explica factores a considerar como la frecuencia de accidentes y cómo determinar medidas preventivas a través de la eliminación, contenc
This document discusses vitamin D and its potential relationship to ovarian cancer risk. It notes that vitamin D receptor (VDR) expression is higher in ovarian cancer cells than normal ovarian cells. Studies have found that vitamin D administration can inhibit growth and induce apoptosis in ovarian cancer cell lines. The document reviews several studies that found associations between the VDR Fok1 polymorphism and increased ovarian cancer risk. In particular, there is evidence that women with the CT and TT genotypes may have higher risk. Based on these findings, the document calls for larger studies to further evaluate the relationship between the VDR Fok1 polymorphism and epithelial ovarian cancer risk, as well as measuring serum vitamin D levels in ovarian cancer patients.
This document summarizes the publications of Prof. Amnon Peled from 2011-2015. It lists 24 publications with citation information. Prof. Peled's publications focus on the roles of chemokines and chemokine receptors in areas like cancer, inflammation, and stem cell mobilization. Many of the publications examine the therapeutic potential of CXCR4 antagonists for treating cancers like lung cancer, multiple myeloma, and acute myeloid leukemia.
This document lists 11 publications related to cancer research authored by Hay T and others:
1. A 2015 study identifying hepatic progenitor cells with liver repopulation capacity.
2. A 2015 study showing c-Myc-conjugated nanoparticles can suppress breast and colorectal cancer models.
3. A 2009 study finding PARP-1 inhibitor treatment can regress BRCA2/p53-mutant mammary tumors and delay relapse when combined with carboplatin.
This document provides a curriculum vitae for Dr. Siva P. Raman for academic promotion. It includes demographic information, current appointments, education and training history, professional experience, and a list of 27 peer-reviewed research articles. It also lists invited review articles, inventions/patents, extramural sponsorship, educational activities, and educational publications authored by Dr. Raman. The CV demonstrates Dr. Raman's qualifications and accomplishments in radiology research and education over his career.
Potential of Targeting Bone Metastases with Immunotherapies_Crimson PublishersCrimsonpublishersCancer
Potential of Targeting Bone Metastases with Immunotherapies
Bone metastases are common in many cancers and result in low survival rates. Immunotherapies have shown promise in treating some patients with bone metastases. Case reports have shown individual patients experiencing decreased bone lesion growth or complete remission of bone metastases using immunotherapies targeting PD-1, PD-L1, or CTLA-4. However, immunotherapies may also cause harmful skeletal effects like fractures or spinal cord compression. Further research is still needed to determine if immunotherapies are effective against bone metastases in large patient groups and to understand their potential skeletal side effects.
This document lists 32 peer-reviewed journal articles authored or co-authored by Bal Sanghera related to positron emission tomography (PET) imaging. The articles cover a range of topics including evaluating PET tracers and reconstruction algorithms for assessing tumor hypoxia and proliferation, optimizing PET-CT protocols to reduce radiation dose, and assessing the impact of various factors on standardized uptake value (SUV) measurements. Dates of publication range from 1991 to 2016.
This document provides a bibliography of research papers related to cancer organized by topic. It includes 3-7 references for each of 17 cancer-related topics, such as 3D tumor imaging, angiogenesis, bladder cancer, breast cancer, contrast imaging, and others. The references provided for each topic are journal articles published between 2005-2010 that describe research on imaging, molecular markers, treatment responses, and other aspects of various cancers.
The document announces a paediatric leukaemia symposium to be held on March 18, 2011 in Kuala Lumpur, Malaysia. The keynote speaker will be Dr. Pui Ching-Hon from St. Jude Children's Research Hospital who will give a lecture on clofarabine for paediatric leukaemia. The symposium will include discussions on difficult paediatric leukaemia cases and potential research initiatives in Malaysia. It will be held at the Auditorium Ungku Omar of the Institute for Medical Research and is sponsored by Genzyme Malaysia through the Malaysian Society of Paediatric Haematology and Oncology.
Carotid intima-media thickness (IMT) is predictive of cardiovascular risk. A study of 222 patients who suffered their first myocardial infarction found that 88% were in the low to intermediate risk category according to Framingham risk scores, but would have been considered high risk and treated aggressively if carotid IMT was also considered. Prospective population studies show carotid IMT is associated with future cardiovascular events independently of traditional risk factors. Higher IMT levels correlate with greater risks of myocardial infarction, stroke, and cardiovascular death. Measuring carotid IMT could help identify patients at higher risk who may benefit from more intensive prevention efforts.
1) The study analyzed DNA methylation patterns between young (<45 years old) and older (>=45 years old) women with breast cancer using data from The Cancer Genome Atlas.
2) Machine learning identified 17 differentially methylated sites between the two groups, including hypomethylation of the ITPR3 promoter and hypermethylation of the ARID3A gene in young women.
3) Differential methylation of these genes, particularly ITPR3 which stimulates breast cancer cell proliferation, may help explain the increased aggressiveness of breast cancer in young women. Further investigation of these genes is warranted.
This document provides a summary of the 11th edition of Wintrobe's Clinical Hematology, a comprehensive textbook on clinical hematology. The textbook is edited by John P. Greer, John Foerster, and John N. Lukens, and contains contributions from over 100 experts in hematology. It is organized into 7 parts covering laboratory hematology, normal hematopoiesis, therapeutic modalities, disorders of red blood cells, disorders of hemostasis and coagulation, nonmalignant disorders of leukocytes and related topics, and hematologic malignancies. The textbook provides an in-depth review of the basic science and clinical aspects of hematologic diseases and disorders.
Ton Beniers_publicatielijst overzicht 2015Ton Beniers
This document lists publications by Beniers and others from 1987-2001 related to experimental cytokine therapy for renal cell carcinoma and Wilms' tumor. It includes 18 journal publications, 5 book chapters, and 1 PhD thesis by Beniers on experimental cytokine therapy for renal cell carcinoma. The publications examine the in vitro and in vivo effects of interferons and tumor necrosis factor on renal tumor cell lines and xenografts, and differential expression of drug resistance and heat shock proteins in histological compartments of nephroblastomas.
Vit D Disease incidence prev chart 051317JA Larson
This document presents evidence that higher serum 25(OH)D levels are associated with reduced risk of various diseases. It shows that levels above 30 ng/mL are linked to substantially lower rates of breast cancer, colorectal cancer, non-Hodgkin's lymphoma, multiple sclerosis, and falls in women. Levels between 40-60 ng/mL may be needed to prevent most chronic diseases, as this range is associated with significantly reduced incidence of cancer, cardiovascular disease, diabetes, and autoimmune conditions. Reference data is provided on average 25(OH)D levels in different populations, with tribal East Africans having the highest at 115 nmol/L.
Myeloablative Umbilical Cord Blood Transplantation for Hematologic Malignanci...cordbloodsymposium
This study retrospectively analyzed outcomes for 566 patients undergoing hematopoietic stem cell transplantation for hematologic malignancies with either umbilical cord blood (CBT, n=112) or unrelated donor (URD, n=454) transplantation between 2006-2012. Disease free survival, relapse rates, and non-relapse mortality were comparable between CBT and URD recipients. Younger CBT patients had lower mortality risks compared to younger URD patients, but this advantage disappeared in older patients. Relapse was also less frequent after CBT. The risk of chronic graft-versus-host disease was lower for matched unrelated donor bone marrow recipients. Overall, outcomes were not inferior for CBT compared to URD
Este documento trata sobre el análisis de seguridad del trabajo (AST). Explica los fundamentos del AST, incluyendo definiciones importantes. Detalla los pasos para realizar un AST, como seleccionar el trabajo, dividirlo en tareas, identificar riesgos y prevenirlos. El AST busca identificar riesgos laborales para proteger a los trabajadores.
Este documento presenta un análisis de riesgos ocupacionales para cinco puestos de trabajo. Analiza factores físicos, organizativos y ergonómicos para cada puesto, identificando posibles riesgos como fatiga visual, estrés, trastornos musculoesqueléticos y síndrome del túnel carpiano. El objetivo es proteger la salud y seguridad de los trabajadores.
Este documento presenta un análisis de riesgos en una planta de producción de alimentos. Identifica varios peligros físicos, químicos, biológicos, ergonómicos y psicolaborales presentes, como ruido, temperaturas extremas, vapores químicos, cargas pesadas y trabajo repetitivo. También describe posibles consecuencias como quemaduras, lumbalgias, fatiga y enfermedades. Finalmente, establece normas generales de seguridad para controlar los riesgos.
El Análisis de Seguridad del Trabajo (A.S.T) es un método para identificar los riesgos asociados a cada etapa de la ejecución de un trabajo con el fin de eliminar o disminuir esos riesgos y proteger a los trabajadores. El A.S.T involucra dividir el trabajo en etapas sucesivas, identificar los riesgos potenciales en cada etapa, y desarrollar maneras de eliminar esos riesgos para mejorar la productividad, salud de los trabajadores y las relaciones humanas.
El documento presenta una metodología para el análisis de riesgos en el trabajo. Describe los pasos para identificar peligros, estimar riesgos mediante una matriz, y controlar los riesgos más significativos. También explica métodos cualitativos y cuantitativos para el análisis de riesgos, así como consideraciones clave para desarrollar un análisis de seguridad en el trabajo.
Este documento presenta una guía sobre el Análisis de Riesgo en el Trabajo (ART). Explica que el ART identifica peligros y evalúa riesgos potenciales antes y durante un trabajo para establecer medidas de prevención. Detalla los pasos básicos para elaborar un ART, que incluyen seleccionar el trabajo, dividirlo en partes e identificar riesgos potenciales y medidas preventivas. Además, explica factores a considerar como la frecuencia de accidentes y cómo determinar medidas preventivas a través de la eliminación, contenc
Este documento presenta lineamientos sobre higiene y seguridad, incluyendo señalización de seguridad y formación de brigadas. Describe la organización de brigadas de evacuación, primeros auxilios, prevención de incendios y comunicación. También presenta funciones específicas de cada brigada y requisitos para ser miembro de una brigada como vocación de servicio y buena salud. Finalmente, explica el propósito y significado de diferentes colores usados en señalización de seguridad.
Este documento proporciona información sobre equipos de protección personal para trabajos en alturas. Explica los diferentes tipos de sistemas de protección contra caídas como arneses, cables de vida autoretráctiles y dispositivos de desaceleración. También cubre recomendaciones de seguridad para ayudantes de piso y changos que realizan trabajos en altura. El objetivo es educar al personal sobre el uso adecuado de equipos de protección para prevenir accidentes durante tareas en altura.
Este documento describe los fundamentos de la seguridad para trabajos en altura. Explica que un trabajo en altura es cualquier labor realizada a más de 1.8 metros de altura que presenta riesgo de caída libre. Detalla los riesgos de caída libre, como las lesiones graves o la muerte. También cubre los procedimientos para casos de caídas, incluyendo detener las tareas, informar a las autoridades y solo reanudar los trabajos con autorización. Finalmente, identifica algunas causas comunes de caídas como actos person
Seguridad, la importancia de los EPP en la industria Cata Uzuga
En este documento se dan a conocer los puntos básicos de seguridad industrial que deben emplear los obreros dentro de la industria y la importancia de la salud ocupacional como garante de la seguridad industrial..
Gama de discos abrasivos de TYROLIT para el desbaste y rectificado de todo tipo de superficies, en BRETTIS somos especialistas en suministros industriales, consúltenos! http://www.brettis.com/productos/herramientas/abrasivos.html
Este manual presenta lineamientos sobre seguridad y salud ocupacional para la empresa SuperSprint S.A. de C.V. Incluye secciones sobre identificación de la empresa, objetivo y alcance, normas de referencia, comportamiento de empleados, uso de equipo de protección, maquinaria, materiales peligrosos, y planes para emergencias. El manual provee una guía para la creación de un sistema de gestión que permita controlar riesgos y mejorar el desempeño de la empresa.
El documento define los elementos de protección personal (EPP) como artículos que protegen al trabajador de riesgos, preveniendo lesiones. Aunque los EPP son el último recurso para controlar riesgos, a menudo deben usarse para impedir contacto directo con el riesgo. Antes de usarlos, deben agotarse opciones como controlar el riesgo en su origen o medio. El documento luego lista varios riesgos comunes y los EPP apropiados para proteger la cabeza, ojos, cara, oídos, pies, manos, cuerpo
Este documento presenta una guía para empleados sobre el Sistema de Identificación de Materiales Peligrosos (HMIS), que codifica información sobre peligros químicos usando colores y números. Explica que las etiquetas HMIS brindan información rápida sobre los peligros asociados con materiales y las precauciones necesarias. También describe los diferentes tipos de peligros para la salud (agudos, crónicos, de órgano objetivo) y la escala numérica para clasificarlos.
La hoja de seguridad resume la información sobre una sustancia peligrosa en 12 secciones. Proporciona detalles sobre la composición e ingredientes peligrosos, los efectos en la salud y el medio ambiente, procedimientos de emergencia, manipulación y almacenamiento seguros, y pruebas de toxicidad. El objetivo es dar información crítica para la seguridad a quienes trabajan con la sustancia.
Las hojas de datos de seguridad de materiales (MSDS) proporcionan información crucial sobre sustancias químicas peligrosas, incluyendo los ingredientes, riesgos para la salud, medidas de protección y procedimientos de emergencia. Los empleadores deben proveer las hojas MSDS correspondientes y los empleados tienen derecho a recibir esta información para trabajar de manera segura con sustancias químicas.
El documento habla sobre los equipos de protección personal (EPP) requeridos para trabajos en altura. Explica que la Ley No 16.744 establece que las empresas deben adoptar medidas de higiene y seguridad en el trabajo y proporcionar EPP a los trabajadores. Los EPP a utilizar incluyen cascos de seguridad, arneses de seguridad y calzado con suela antideslizante. Los cascos deben resistir impactos y proteger la cabeza, mientras que los arneses deben reducir las consecuencias de caídas y
Este documento describe los principales riesgos asociados con las máquinas y las medidas de seguridad para prevenirlos. Explica que las máquinas presentan riesgos mecánicos, eléctricos, térmicos, por radiación, ruido, vibraciones, materiales y factores ergonómicos. También detalla medidas de seguridad integradas en la máquina y no integradas como formación y protección personal.
This document lists 29 publications by Lin Wang and others from 1999-2014. The publications cover a range of topics related to head and neck cancer, including:
1) Identification of increased expression of HER2 and HER3 in HPV-positive head and neck squamous cell carcinoma.
2) Examination of subcellular MDM2 expression and its pathological significance in head and neck squamous cell carcinoma.
3) Quantification of metabolic heterogeneity in head and neck tumors in real time.
4) Randomized clinical trials examining erlotinib and cetuximab for treatment of head and neck cancer.
The majority of publications focus on signaling pathways involved in head and neck cancer such as E
This document provides a summary of Olivier Grenet's scientific publications, patents, and presentations. It includes 18 peer-reviewed publications, many focusing on using omics technologies like microarrays and real-time PCR to study drug-induced changes in gene expression. It also lists several patents related to predictive biomarkers for drug toxicity and clinical response. Grenet has given numerous invited talks on applying genomics and pharmacogenomics in drug development to improve safety evaluation and clinical translation.
This document lists 14 selected publications by the author Yang S and their collaborators. The publications cover a range of topics including the roles of various genes and microRNAs in processes like cancer cell growth, pulmonary fibrosis, macrophage polarization, and inflammation. The publications appeared in journals like International Journal of Oncology, Oncology Reports, Journal of Biological Chemistry, and Oncotarget between 1999-2014.
This study aims to evaluate the gene expression profile of FOXE1 mRNA in paired thyroid tumor and non-tumor tissue samples. Preliminary results from the first 10 paired samples show variation in FOXE1 gene expression levels between tumor and non-tumor tissues, with non-tumor tissue appearing to have higher FOXE1 expression compared to tumor tissue. Analysis of more sample pairs is ongoing, and FOXE1 expression levels will be compared to patient clinical data and tumor pathological characteristics. The results so far indicate there may be a profile of FOXE1 expression in thyroid cancer.
This document provides a bibliography of 45 peer-reviewed publications by Dr. Finlay between 1978-1993. The publications cover a range of topics including bone marrow transplantation, leukemia, brain tumors, and other pediatric oncology issues. Many of the publications involve clinical trials and case studies conducted at the Children's Hospital of Philadelphia where Dr. Finlay worked.
The document is a curriculum vitae for Rajendra Prasad Gajula, who holds a Ph.D. in Biotechnology from the University of Pune in India. He has held several postdoctoral research positions in the United States, including at Johns Hopkins University, where he currently works in the Department of Radiation Oncology and Molecular Radiation Sciences. The CV lists his education history, positions, honors received, and selected peer-reviewed publications in biomedical research journals.
This document contains summaries of several research articles and publications related to the treatment of chronic lymphocytic leukemia using nanoparticles, photodynamic therapy, and mesenchymal stem cells. Many of the publications were authored or co-authored by Eduardo Mansilla and focus on developing new therapeutic approaches for blood cancers using nanotechnology and regenerative medicine techniques.
1. The document lists 29 publications with the author Lu Y, demonstrating their expertise in biomedical research related to neurodegenerative diseases and therapeutic antibody development.
2. Many of the publications focus on characterizing antibody delivery across the blood-brain barrier and targeting proteins involved in diseases like Alzheimer's.
3. The publications span from 2004 to the present and represent collaborative work with numerous co-authors investigating topics like antibody pharmacokinetics and biomarkers.
The documents summarize research conducted by Paula Ladne and colleagues on various hematological malignancies and stem cell transplantation outcomes. The research includes studies on: 1) the role of PRAME in inhibiting myeloid differentiation; 2) the impact of CTGF expression on outcomes in acute lymphoblastic leukemia; 3) evidence of donor-derived hematologic malignancies after stem cell transplantation; and 4) development of techniques to detect minimal residual disease in leukemia patients.
This document lists publications by Dr. Taylor from 1980-2005 related to oncology. It includes:
- 28 journal publications from 1980-2005 reporting on Dr. Taylor's research into chemotherapy and radiotherapy treatments for various cancers including lung cancer, lymphomas, breast cancer, testicular cancer, bladder cancer, and more.
- Publications cover topics like treatment outcomes, toxicity of treatments, use of markers to monitor cancers, and case reports of rare cancer presentations.
- The publications span Dr. Taylor's career and show a focus on pediatric oncology research from the 1990s onward, including several publications on medulloblastoma treatments.
- Molecular and cellular biologist with extensive experience in oncology research including target validation, biomarker discovery, drug mechanism, immunology, and translational research.
- Experienced project leader able to effectively manage collaborative projects and communicate across teams.
- Background includes positions at Pharmacyclics, Inc., Stanford University, and MD Anderson Cancer Center investigating various areas of cancer research including B cell lymphomas, acute myeloid leukemias, biomarkers, drug combinations, and tumor microenvironment.
Dr. David Guillespie - Identificación de dianas de daño en el DNA en la terap...CIBICAN - ULL
Presentación del Dr. David Guillespie, investigador contratado por el CIBICAN - Universidad de La Laguna gracias al Proyecto Europeo IMBRAIN, en relación a los resultados alcanzados durante la ejecución del mismo y los planes de futuro. La misma se presentó durante las Jornadas IMBRAIN llevadas a cabo el 13 de Octubre de 2015 en la Sección de Física en la Universidad de La Laguna
This document is a curriculum vitae for Hui Zhang, a professor at Johns Hopkins University School of Medicine. It lists his current appointments, education history, professional experience, and publications. Specifically, it details that he is currently a professor in the Department of Pathology at JHU and director of the Mass Spectrometry Core Facility. It provides information on his education from Beijing University and University of Pennsylvania. It also lists over 45 publications in peer-reviewed journals related to proteomics and mass spectrometry research.
Publications v10 - Martha A. Waters, PhD, MPH, CIH, FAIHADrMarthaWaters
This document provides a list of 16 publications by Martha A. Waters related to occupational exposures and health outcomes. The publications cover topics such as cancer incidence among workers exposed to polychlorinated biphenyls, occupational exposure to chlorinated solvents and kidney cancer, maternal occupational exposure to polycyclic aromatic hydrocarbons and birth defects, and cancer risk among airline pilots from cosmic radiation exposure. The list demonstrates Waters' extensive research investigating relationships between occupational exposures and cancer, birth defects, and other health effects.
This document provides biographical and professional information about Jennifer Susan Ko in 3 paragraphs:
Jennifer Susan Ko is a dermatopathologist currently practicing at Cleveland Clinic in Cleveland, OH. She received her MD from Northeastern Ohio Universities College of Medicine in 2003 and completed residency training in Anatomic and Clinical Pathology at Cleveland Clinic from 2010-2014. She then completed a fellowship in Dermatopathology at Cleveland Clinic from 2014-2015. Her areas of research focus include myeloid-derived suppressor cells, ganglioside suppression of immune function, and diagnostically challenging epithelioid vascular tumors. She has over 15 peer-reviewed publications and has received several honors and awards for her research presentations
What is exposome?
The exposome can be defined as the measure of all the exposures of an individual in a lifetime and how those exposures relate to health.
The aging of the skin may be influenced by various internal or external factors.
Here, we explore the role of various exposures in skin aging.
This document summarizes several studies on osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients and ongoing work related to treating MM. It discusses the natural history of ONJ in MM patients, the effect of zoledronic acid on oral cells potentially contributing to ONJ, and plans for future intervention studies. It also mentions ongoing clinical trials of combinations of bortezomib, vorinostat, and other agents to treat relapsed/refractory MM.
This document is a resume for Angela Thetford, who is seeking a position as a Medical Laboratory Technician. She has extensive experience working in medical laboratories through both her clinical rotations and previous positions at the National Institutes of Health and a veterinary hospital. She has strong skills in a variety of laboratory techniques and maintains certifications and a high GPA. The resume lists her education, skills, experience, publications, and volunteer activities to demonstrate her qualifications for an MLT role.
1. SELECTED PUBLICATIONS
1. Wang L, Pollock N, Wallweber J, Gooding WE, Huang WD, Winslow J,. Grandis JR.
Increased expression of HER2 and HER3 in HPV-positive HNSCC using a novel proximity-
based assay. Clin Cancer Res. (Submitted)
2. Wang L, Chiosea S, Grandis JR. Differential pathological significance of subcellular
MDM2 expression in head and neck squamous cell carcinoma (HNSCC). (Manuscript)
3. Srivastava RM, Trivedi S, Concha-Benavente F, Jie HB, Wang L, Seethala RR, Branstetter
BF, Ferrone S, Ferris RL. STAT1 Induced HLA class I Upregulation Enhances Immunogenicity
and Clinical Response to anti-EGFR mAb Cetuximab Therapy in HNC Patients. Cancer
Immunol Res. 2015 May 13. pii: canimm.0053.2015. [Epub ahead of print]
4. Wheeler SE, Egloff AM, Wang L, James CD, Hammerman PS, Grandis JR. Challenges in
EGFRvIII detection in head and neck squamous cell carcinoma. PLoS One. 2015 Feb
6;10(2):e0117781.
5. Nakajima EC, Laymon C, Oborski M, Hou W, Wang L, Grandis JR, Ferris RL, Mountz JM,
Van Houten B. Quantifying Metabolic Heterogeneity in Head and Neck Tumors in Real Time:
2-DG Uptake Is Highest in Hypoxic Tumor Regions. PLoS One. 2014 Aug 15;9(8):e102452.
doi: 10.1371/journal.pone.0102452. eCollection 2014.
6. Egloff AM, Lee JW, Langer CJ, Quon H, Vaezi A, Grandis JR, Seethala RR, Wang L, Shin
DM, Argiris A, Yang D, Mehra R, Ridge JA, Patel UA, Burtness BA, Forastiere AA. Phase II
study of cetuximab in combination with cisplatin and radiation in unresectable, locally
advanced head and neck squamous cell carcinoma: Eastern cooperative oncology group trial
E3303. Clin Cancer Res. 2014 Oct 1;20(19):5041-51
7. Gross ND, Bauman JE, Gooding WE, Denq W, Thomas SM, Wang L, Chiosea S, Hood BL,
Flint MS, Sun M, Conrads TP, Ferris RL, Johnson JT, Kim S, Argiris A, Wirth L, Nikiforova
MN, Siegfried JM, Grandis JR. Erlotinib, erlotinib-sulindac versus placebo: a randomized,
double-blind, placebo-controlled window trial in operable head and neck cancer. Clin Cancer
Res. 2014 Jun 15;20(12):3289-98.
8. Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ,
Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata
M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu
2. B, Yan H, Cheng SY. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates
AKT-promoted tumorigenesis. J Clin Invest. 2014 Sep 2; 124 (9):3741-5.
9. Vaezi AE, Bepler G, Bhagwat NR, Malysa A, Rubatt JM, Chen W, Hood BL, Conrads TP,
Wang L, Kemp CE, Niedernhofer LJ. Choline phosphate cytidylyltransferase-α is a novel
antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung
and head and neck squamous cell carcinomas. Cancer. 2014 June 15; 120 (12): 1898-1907.
10. Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ,
Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA,
Mills GB, Johnson DE, Grandis JR. Frequent mutation of receptor protein tyrosine
phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer; Proc
Natl Acad Sci U S A. 2014 Jan 21;111(3):1114-9.
11. Sen M, Paul K, Freilino ML, Li H, Li C, Johnson DE, Wang L, Eiseman J, Grandis JR.
Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3)
decoy oligonucleotide inhibits tumor growth without inducing toxicological effects. Mol Med.
2014 Mar 18;20:46-56
12. Troy JD, Weissfeld JL, Youk AO, Thomas S, Wang L, Grandis JR. Expression of EGFR,
VEGF, and NOTCH1 Suggest Differences in Tumor Angiogenesis in HPV-Positive and HPV-
Negative Head and Neck Squamous Cell Carcinoma. Head Neck Pathol. Head Neck Pathol.
2013 Dec;7(4):344-55
13. Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y,
Gilbert B, Freilino M, Sauerwein S, Peyser N, Xiao D, Diergaarde B, Wang L, Chiosea S,
Seethala RR, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Ng PK,
Garraway LA, Hammerman P, Mills GB, Grandis JR. Frequent mutation of the PI3K pathway
in head and neck cancer defines predictive biomarkers. Cancer Discov. 2013 Jul;3(7):761-9.
14. Leibowitz MS, Srivastava RM, Andrade Filho PA, Egloff AM, Wang L, Seethala RR,
Ferrone S, Ferris RL. SHP2 is overexpressed and inhibits pSTAT1-mediated APM component
expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer
cells. Clin Cancer Res. 2013 Feb 15;19(4):798-808.
15. Cassell A, Freilino ML, Lee J, Barr S, Wang L, Panahandeh MC, Thomas SM, Grandis JR.
Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer
preclinical models. Neoplasia. 2012 Nov;14(11):1005-14
3. 16. Sen M, Joyce S, Panahandeh M, Li C, Thomas SM, Maxwell J, Wang L, Gooding WE,
Johnson DE, Grandis JR. Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin
Cancer Res. 2012 Sep 15;18(18):4986-96. doi: 10.1158/1078-0432.CCR-12-0792.
17. Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N,
Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S,
Seethala RR, Gooding WE, Chen X, Kaminski N, Pandit K, Johnson DE, Grandis JR. First-in-
human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer
therapy. Cancer Discov. 2012 Aug;2(8):694-705. doi: 10.1158/2159-8290.
18. Wheeler SE, Siwak DR, Chai RL, Lavalle CR, Seethala RR, Wang L, Cieply KM, Sherer
C, Joy C, Mills GB, Argiris A, Siegfried JM, Grandis JR, Egloff AM.Tumor epidermal growth
factor receptor (EGFR) and EGFR PY1068 are independent prognostic indicators for head and
neck squamous cell carcinoma. Clin Cancer Res. 2012 Apr 15;18(8):2278-89
19. Mburu YK, Egloff AM, Walker WH, Wang L, Seethala RR, van Waes C, Ferris RL.
Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1
(AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN). J Biol Chem. 2012
Jan 27;287(5):3581-90.
20. Argiris A, Lee SC, Feinstein T, Thomas S, Branstetter BF 4th, Seethala R, Wang L,
Gooding W, Grandis JR, Ferris RL. Serum biomarkers as potential predictors of antitumor
activity of cetuximab-containing therapy for locally advanced head and neck cancer. Oral
Oncol. 2011 Oct;47(10):961-6
21. Argiris A, Feinstein TM, Wang L, Yang T, Agrawal S, Appleman LJ, Stoller RG, Grandis
JR, Egloff AM. Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with
advanced solid malignancies. Invest New Drugs. 2011 Sep 1
22. Vaezi A, Wang X, Buch S, Gooding W, Wang L, Seethala RR, Weaver DT, D'Andrea AD,
Argiris A, Romkes M, Niedernhofer LJ, Grandis JR. XPF expression correlates with clinical
outcome in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2011 Aug
15;17(16):5513-22.
23. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV,
Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D,
Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M,
Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-
Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES,
4. Getz G, Golub TR, Garraway LA, Grandis JR. The Mutational Landscape of Head and Neck
Squamous Cell Carcinoma. Science 26 August 2011: Vol. 333 no. 6046 pp. 1157-1160.
24. Argiris A, Heron DE, Smith RP, Kim S, Gibson MK, Lai SY, Branstetter BF, Posluszny
DM, Wang L, Seethala RR, Dacic S, Gooding W, Grandis JR, Johnson JT, Ferris RL.
Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin,
and cetuximab and maintenance cetuximab in patients with locally advanced head and neck
cancer. J Clin Oncol. 2010 Dec 20; 28(36):5294-300.
25. Kropf PL, L Wang, Y Zang, RL Redner and DE Johnson. Dasatinib promotes ATRA-
induced differentation of AML cells. Leukemia 24(3):663-665, 2010.
26. JE Jones, L Wang, PL Kropf, R Duan, DE Johnson. Src family kinase gene targets during
myeloid differentiation: identification of the EGR-1 gene as a direct target. Leukemia. 2009
October; 23(10): 1933–1935.
27. Kim SI, Kwak JH, Wang L, Choi ME. Protein phosphatase 2A is a negative regulator of
transforming growth factor-beta 1-induced TAK1 in mesangial cells. J Biol Chem. 2008 Apr
18; 283(16):10753-10763.
28. Wang L, Lee JY, Kwak JH, He Y, Kim SI, Choi ME.Protective effects of low-dose carbon
monoxide against renal fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal
Physol. 2008 Mar; 294(3):F508-517.
29. Kim SI, Kwak JH, Zachariah M, He Y, Wang L, Choi ME TGF-beta - activated kinase 1
and TAK1-binding protein 1 cooperate to mediate TGF-beta1-induced MKK3-p38 MAPK
activation and stimulation of type I collagen. Am J Physiol Renal Physiol. 2007 May;
292(5):F1471- 1478.
30. Wang L, Kwak JH, Kim SI, He Y, Choi ME. Transforming growth factor-beta1 stimulates
vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha
and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells. J
Biol Chem. 2004 Aug 6; 279 (32):33213-33219.
31. Wang L, Ma R, Flavell RA, Choi ME.Requirement of Mitogen-activated Protein Kinase
Kinase 3 (MKK3) for Activation of p38 α and p38 δ MAPK isoforms by TGF-ß1 in murine
mesangial cells. J Biol Chem 2002 Dec 6; 277 (49), 47257-47262.
5. 32. Wang L, Xiong M, Che DY, et al. Effect of hypoxia on proliferation and differentiation of
the pulmonary vascular pericytes. Chinese Journary of Tuberculosis and Respiratory Disease,
1999, 22(3):176-178.
PRESENTATIONS
1. Mitogen-Activated Protein Kinase Kinase 3 (MKK3) Mediates Activation of p38 MAPK by
TGF-beta1 in Mesangial Cells. (Poster), ASN (America Society of Nephrology) conference,
San Francisco, California, Oct, 2001
2. Selective Activation of p38 MAPK Isoforms p38 alpha and p38delta by TGF-beta1 Is
Mediated Via Mitogen-Activated Protein Kinase Kinase (MKK3) in Mouse Mesangial Cells.
(Oral), ASN (America Society of Nephrology) conference, Philadelphia, Pennsylvania, Nov,
2002
3. Mitogen-Activated Protein Kinase Kinase 3 (MKK3)-p38MAPK (p38 alpha and p38 delta)
Pathway Mediates TGF- beta1 induced – Expression of Vascular Endothelial Growth Factor
(VEGF) in Mouse Mesangial Cells. (Poster), ASN (America Society of Nephrology)
conference, San Diego, Nov, 2003
4. Protective Effects of Carbon Monoxide (CO) To Inhibit Renal Fibrosis in Obstructive
Nephropathy. (Poster), ASN (America Society of Nephrology) conference, St. Louis, Missouri,
Nov, 2004
5. Protective effects of low-dose carbon monoxide (CO) against renal fibrosis induced by
unilateral ureteral obstruction. (Oral), Research Day, Department of Medicine, University of
Pittsburgh School of Medicine, May, 2006
6. Carbon monoxide (CO) inhibits profibrotic effects of TGF-ß1 in renal tubular epithelial
cells, via the MKK3-p38β MAPK pathway. (Poster), American Society of Nephrology (ASN)
conference. Philadelphia, Pennsylvania, Nov , 2006