Progeria, a condition characterized by premature aging, is believed to result from a dominant gene mutation affecting the lamin A protein, causing cellular instability. It is not hereditary, manifesting in children as early as 10 to 24 months with symptoms like growth failure, joint stiffness, and cardiovascular issues, with an average life expectancy of 13 years. Currently, there is no cure, but treatments exist to slow progression, affecting approximately 1 in 4-8 million newborns globally.

1. Progeria
Submitted to: Mrs.Kennedy&Miss O’neill
Submitted by: Morgan DeGruchy

2. What is progeria?
 Progeria means premature aging.
 It comes from the Greek word progeros.
‘Pro’ meaning before, and ‘geras’
meaning old age.

3. Dominant or Recessive?
 The gene for progeria is unknown but
believed to be dominant.
 Children with progeria have a mutation
on the gene that encodes Lamin A, a
protein that holds the nucleus of the cell
together.
 It’s believed that the defective Lamin A
causes the nucleus of the cell to
become unstable.

4. How does one get progeria?
 Progeria appears to occur without
cause.
 It is not seen in siblings of affected
children.

5. Diagnosis.
 Children with Progeria are born looking
healthy. When they are about 10 to 24 months
old, features of accelerated aging start to
appear. Signs of Progeria may include:
 Growth failure
 Loss of body fat
 Loss of hair
 Skin starts to look aged
 Stiffness in the joints
 Hip dislocation
 Heart problems
 Stroke

7. Heredity?
 Experts do not believe that Progera is
hereditary.
 It is due to a rare gene change which
happens purely by chance. So It’s hard
to say is heredity.
 In about 1 in every 100 cases is passed
down to the next generation within the
same family.

8. Is there a cure?
 There is no for sure cure but they have
found something to slow it down.
 They’re doing their best to find a way to
stop it completely but they’re yet to
figure it out for sure.

9. How prevalent is progeria?
 Progeria affects approximately 1 in 4 - 8
million newborns.
 There are an estimated 200-250 children
living with Progeria worldwide at any one
time.
 It affects both sexes equally and all
races.

10. Life expectancy.
 Progeria patients generally die between
the ages of 8 and 21 - with the average
age being 13.

11. Karyotype?
 The most common cause of progeria will
not show up on a karyotype; it is a point
mutation of a gene on chromosome
one.

12. Everyday life
 People with progeria can do things just
like normal people, but for them their is a
down fall because where their bodies
are aging so much faster they mostly all
are getting arthritis in their joints, and
very stiff muscles which causes them
pain.

13. › http://www.youtube.com/watch?v=Cp_b2K
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