Epidemiology is the study of disease patterns in populations and the application of this study to disease control. This course will introduce students to epidemiology, covering its history, importance, and role in public health. The key topics will include the definition of epidemiology, its goals and differences from infectious disease study, and its contributions to disease control and eradication, as seen in the global eradication of smallpox through vaccination programs and surveillance led by the World Health Organization.
Introduction to Epidemiology
History of Epidemiology.
Definition of Epidemiology and its components.
Epidemiological Basic concepts.
Aims of Epidemiology.
Ten Uses of Epidemiology.
Scope or The Areas of Application .
Types of Epidemiological Studies.
population medicine has been referred to as hygiene, public health, preventive medicine, social medicine or community medicine. All these aim for promotion of health and prevention of disease.
This presentation is created by Ruby Sinha Mahapatra, 1st Year MHA student of Future School of Hospital Management. The presentation is aimed to create a basic health awareness amongst students aspiring to pursue hospital management. For more information go to www.futurehospitalmanagement.in or visit us at our Future School of Hospital Management, Sonarpur Campus.
Epidemiology, Triad of epidemiology, Brief epidemiology, Terminology used in Epidemiology, Epidemiology, traid, modes of disease transmission, disease control and prevention, Basic epidemiology, John Snow and Cholera with Epidemiology
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Introduction to Epidemiology
History of Epidemiology.
Definition of Epidemiology and its components.
Epidemiological Basic concepts.
Aims of Epidemiology.
Ten Uses of Epidemiology.
Scope or The Areas of Application .
Types of Epidemiological Studies.
population medicine has been referred to as hygiene, public health, preventive medicine, social medicine or community medicine. All these aim for promotion of health and prevention of disease.
This presentation is created by Ruby Sinha Mahapatra, 1st Year MHA student of Future School of Hospital Management. The presentation is aimed to create a basic health awareness amongst students aspiring to pursue hospital management. For more information go to www.futurehospitalmanagement.in or visit us at our Future School of Hospital Management, Sonarpur Campus.
Epidemiology, Triad of epidemiology, Brief epidemiology, Terminology used in Epidemiology, Epidemiology, traid, modes of disease transmission, disease control and prevention, Basic epidemiology, John Snow and Cholera with Epidemiology
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
3. EVALUATION
Two tests (in classroom)
Midterm (20% )
Final exam (50%)
Class participation (10%)
Assignment exercises( 20%) at back of
chapters.assigned exercises but be prepared to
go over exercises at back of chapters in class
4. Course modules
module 1: Introduction to epidemiology.
Goal:
Introduce epidemiology to students
Explain the history and importance of epidemiology
Discuss the differences between epidemiology and infectious diseases
Identify the goals of epidemiology
7. Definition of Health
World health organization (WHO) defined
health: «as a state of complete physical,
mental, social and spiritual well-being
and not merely the absence of disease
or infirmity.»
8. it means perfect functioning
of the body. All the organs of
the body are of average size
and function normally; all
the special senses are intact;
the resting pulse rate, BP and
exercise tolerance are all
within the range of normality
for the individual’s age and
sex.
it is defined as the state of
balance between the
individual and the
surrounding world, a state of
harmony between oneself and
others.
social well-being implies harmony
and integration within the
individual, between each
individual and other members of
the society and between
individuals and the world in
which they live.
1. Physical
dimension
3.
Socioeconomi
c dimension:
2. Mental
dimension:
Dimensions
of Health
4. Spiritual
dimension
: it includes principles and ethics,
the purpose in life, religious
beliefs and values; all are
important components of the
way the person behaves in health
and illness.
5. Other
dimensions
such as: vocational,
environmental, educational,
nutritional, emotional,
political, etc.
10. Public health is defined as : «
the sciences and art of preventing
diseases, promotion of health
and pro-longing of live
11. TOOLS OF PUBLIC HEALTH
1. Epidemiology
2. Biostatistics
3. Social Sciences
4. Principles of
administration
5. Preventing
Diseases
12. Definition:
The term epidemiology is derived from three Greek
roots (epi = upon, demos = people and ology =
study)
Epidemiology is a branch of public health which
attempts to discover the causes of disease in order to
make disease prevention possible
What is Epidemiology?
13. Epidemiology has been defined as (Last, 1988):
"the study of the distribution and
determinants of health-related
states or events in specified
populations, and the application of
this study to control of health
problems"
14. Key Aspects of This Definition
includes: surveillance, observation, hypothesis
testing, analytic research and experiments.
refers to analysis of: times, persons, places and
classes of people affected.
include factors that influence health: biological,
chemical, physical, social, cultural, economic,
genetic and behavioral.
refer to: diseases, causes of death, behaviors such
as use of tobacco, positive health states, reactions
to preventive regimes and provision and use of
health services.
include those with identifiable
characteristics, such as occupational groups.
the aims of public health—to promote,
protect, and restore health.
Study …………………………….
Distribution ……………….
Determinants …………….
Health-related states and
Specified populations …
Application to prevention
and control
Term Explanation
15. Epidemiology: A Brief History of Development
Epidemiology is the study of the frequency, distribution, and risk factors for
diseases in populations. It has been a developing science since ancient times,
when people began to observe that some diseases were more common in
certain places than others.
One of the earliest epidemiologists was the Greek physician Hippocrates (460-
370 BC). Hippocrates described many infectious diseases and proposed some
preventive measures, such as personal hygiene and social distancing.
In the 16th century, the Italian physician Girolamo Fracastoro (1483-1553)
developed the concept of contagion, proposing that infectious diseases are
spread by small, invisible particles that pass from an infected person to a healthy
person.
In the 18th century, the English physician John Snow (1813-1858) conducted the
first modern epidemiological study. Snow tracked the outbreak of a cholera
epidemic in London and found that the source of the epidemic was contaminated
drinking water. This study led to the implementation of public sanitation in
London, which resulted in a significant decrease in cholera cases.
In the 19th century, epidemiology saw a major development, with the discovery
of many infectious disease agents, such as bacteria and viruses. This led to the
development of vaccines and drugs for infectious diseases, which contributed
significantly to improved public health.
16. In the 20th century, epidemiology continued to develop, with the
development of new methods for studying diseases, such as biostatistics
and data analysis. This contributed to the development of new methods
for preventing diseases, such as vaccination programs and disease
surveillance.
Today, epidemiology is a fundamental science in public health.
Epidemiologists use their knowledge of epidemiology to study and
prevent diseases in populations.
Some of the most notable recent developments in
epidemiology include:
Development of new methods for diagnosing diseases, such as DNA
testing.
Use of modern technology in disease surveillance, such as data analysis
and geographic information systems.
Participation in efforts to respond to public health emergencies, such as
outbreaks of infectious diseases and epidemics.
Overall, epidemiology is a vital science in public health, and it has played
a key role in improving human health around the world
17. Importance of epidemiology:
1. Estimate the prevalence (number of cases) of a
disease.
2. Describe the pattern of disease
(who is affected)
( where )
(and when).
3. Identify causation of the diseases; causative
agent(s) and factors behind occurrence and
conditions favor spread of the disease.
4. Identify modes (ways) of spread (transmission).
• 5. Prevention and control of the disease.
18. Epidemiology is a fundamental science in preventive medicine, which aims to improve the
health of the community by focusing on the causes of diseases and identifying ways to
prevent them. Epidemiology has made significant contributions to disease control around
the world, including the following:
Development and improvement of vaccines and drugs for infectious diseases.** Epidemiology has been
a major factor in the development and improvement of vaccines and drugs for infectious diseases, such as the
smallpox vaccine, which led to the eradication of smallpox worldwide, and the polio vaccine, which has led to
a significant reduction in cases of polio.
Improvement of public hygiene and sanitation.
Epidemiology has also contributed to the improvement of public hygiene and sanitation, which has helped to
reduce the spread of infectious diseases. For example, efforts to improve public hygiene and sanitation have
led to the eradication of malaria from many countries.
Development of public health programs.** Epidemiology is used to develop public health programs that
help to improve community health. For example, vaccination programs help to protect people from
infectious diseases, and disease surveillance programs help to quickly detect new infectious diseases.
Development of new methods for diagnosing diseases.** Epidemiologists have developed new methods
for diagnosing diseases, such as DNA testing, which has helped to detect diseases more quickly and accurately.
Use of modern technology in disease surveillance.** Epidemiologists use modern technology, such as
data analysis and geographic information systems, to monitor diseases more effectively.
Participation in efforts to respond to public health emergencies.** Epidemiologists participate in efforts
to respond to public health emergencies, such as outbreaks of infectious diseases and epidemics.
In general, epidemiology is a fundamental science in preventive medicine, and it has played an important role
in improving human health around the world..
Contributions of Epidemiology to Disease Control
19. Examples for epidemiology role in eradication of smallpox
from the world
Before the eradication program, smallpox was one of the most common and deadly
diseases in the world. It is estimated that smallpox killed 300 million people in the 20th
century alone.
The smallpox vaccine was developed in 1796, but it was not widely available until the 20th
century. The first successful smallpox eradication program was launched in 1958 by the
World Health Organization (WHO).
The WHO smallpox eradication program was a global effort that involved over 100
countries. The program used a combination of vaccination, surveillance, and isolation to
eliminate smallpox from the world.
The last naturally occurring case of smallpox was in 1977. The WHO declared smallpox
eradicated in 1980.
These statistics show that epidemiology played a key role in the eradication of smallpox.
By understanding how the disease spread and developing an effective vaccine,
epidemiologists were able to design and implement a successful eradication program. The
eradication of smallpox is a testament to the power of epidemiology and the importance of
global cooperation in public health.
Here are some other specific statistics that support the role of epidemiology in the
eradication of smallpox:
In 1967, there were over 10 million cases of smallpox reported worldwide. By 1977, the
number of cases had been reduced to 2,000.
The last naturally occurring case of smallpox was in Somalia in 1977.
The WHO declared smallpox eradicated in 1980.
Editor's Notes
Epidemiology: A Brief History of Development
Epidemiology is the study of the frequency, distribution, and risk factors for diseases in populations. It has been a developing science since ancient times, when people began to observe that some diseases were more common in certain places than others.
One of the earliest epidemiologists was the Greek physician Hippocrates (460-370 BC). Hippocrates described many infectious diseases and proposed some preventive measures, such as personal hygiene and social distancing
.
In the 16th century, the Italian physician Girolamo Fracastoro (1483-1553) developed the concept of contagion, proposing that infectious diseases are spread by small, invisible particles that pass from an infected person to a healthy person.
In the 18th century, the English physician John Snow (1813-1858) conducted the first modern epidemiological study. Snow tracked the outbreak of a cholera epidemic in London and found that the source of the epidemic was contaminated drinking water. This study led to the implementation of public sanitation in London, which resulted in a significant decrease in cholera cases.
In the 19th century, epidemiology saw a major development, with the discovery of many infectious disease agents, such as bacteria and viruses. This led to the development of vaccines and drugs for infectious diseases, which contributed significantly to improved public health
.
In the 20th century, epidemiology continued to develop, with the development of new methods for studying diseases, such as biostatistics and data analysis. This contributed to the development of new methods for preventing diseases, such as vaccination programs and disease surveillance.
Today, epidemiology is a fundamental science in public health. Epidemiologists use their knowledge of epidemiology to study and prevent diseases in populations.
Some of the most notable recent developments in epidemiology include:
Development of new methods for diagnosing diseases, such as DNA testing.
Use of modern technology in disease surveillance, such as data analysis and geographic information systems.
Participation in efforts to respond to public health emergencies, such as outbreaks of infectious diseases and epidemics.
Overall, epidemiology is a vital science in public health, and it has played a key role in improving human health around the world