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Prevention of
colorectal cancer
Jan Stanislav Dorosz M1770
Classification
Prevention can be classified into 3 main groups:
1. Primary (those preventive measures that prevent the onset of illness or injury before the disease
process begins)
- Healthy diet
- Avoidance of tobacco/alcohol
- Supplementation
1. Secondary (those preventive measures that lead to early diagnosis and prompt treatment of a
disease)
- Regular check-ups
- Screening/Imagining
- Not disregarding signs and symptoms
1. Tertiary (those preventive measures are aimed at rehabilitation following significant illness)
Diet
High intake of red and processed
meat, highly refined grains and
starches, sugars increases the risk
of colorectal cancer.
Dietary prevention
➔ Replacing highly processed and refined foods as primary source of protein
- Poultry
- Fish
- Plant resources
➔ Unsaturated fats as primary source of fats
➔ Unrefined grains and legumes/fruits as primary source of carbohydrates
➔ High fiber diet
Others
➔ Avoid smoking as it’s harmful in mutiple patterns
➔ Avoid heavy alcohol usage
➔ Maintain healthy weight
➔ Maintain physical activity
➔ Supplementation:
- Vitamins
- Calcium
- Magnessium
Supplementation:
- Aspirin
- NSAIDs
- Post-menopausal drugs
Proposed mechanisms
There are 3 main groups of proposed mechanisms:
1. Inflammation-related mechanism
2. Insulin-related mechanism
3. Folate/alcohol related mechanism
Notes
When meat undergoes prolonged frying, grilling, or broiling at high temperatures,
mutagenic heterocyclic amines are formed from creatinine, and these interact with amino
acids
As much as Calcium/Dietary products decrease risk of developing colorectal cancer its also
believed that it increases risk of developing other cancers like prostate cancer therefore
there are no specific recommendations regarding those substances.
Same with hormonal drugs in menopause in women that increase risk of heart diseases,
blood clots and cancers of breast or lungs.
References
1. Centers for Disease Control and Prevention, 09.12.2020,
<https://www.cdc.gov/cancer/colorectal/basic_info/prevention.htm>
2. American Cancer Society, 09.12.2020, <https://www.cancer.org/cancer/colon-
rectal-cancer/causes-risks-prevention/prevention.html>
3. National Institutes of Health, 09.12.2020,
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947820/>
Thank you for
your attention

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Prevention of Colorectal Cancer.pptx

  • 1. Prevention of colorectal cancer Jan Stanislav Dorosz M1770
  • 2. Classification Prevention can be classified into 3 main groups: 1. Primary (those preventive measures that prevent the onset of illness or injury before the disease process begins) - Healthy diet - Avoidance of tobacco/alcohol - Supplementation 1. Secondary (those preventive measures that lead to early diagnosis and prompt treatment of a disease) - Regular check-ups - Screening/Imagining - Not disregarding signs and symptoms 1. Tertiary (those preventive measures are aimed at rehabilitation following significant illness)
  • 3. Diet High intake of red and processed meat, highly refined grains and starches, sugars increases the risk of colorectal cancer.
  • 4. Dietary prevention ➔ Replacing highly processed and refined foods as primary source of protein - Poultry - Fish - Plant resources ➔ Unsaturated fats as primary source of fats ➔ Unrefined grains and legumes/fruits as primary source of carbohydrates ➔ High fiber diet
  • 5. Others ➔ Avoid smoking as it’s harmful in mutiple patterns ➔ Avoid heavy alcohol usage ➔ Maintain healthy weight ➔ Maintain physical activity ➔ Supplementation: - Vitamins - Calcium - Magnessium Supplementation: - Aspirin - NSAIDs - Post-menopausal drugs
  • 6. Proposed mechanisms There are 3 main groups of proposed mechanisms: 1. Inflammation-related mechanism 2. Insulin-related mechanism 3. Folate/alcohol related mechanism
  • 7.
  • 8.
  • 9. Notes When meat undergoes prolonged frying, grilling, or broiling at high temperatures, mutagenic heterocyclic amines are formed from creatinine, and these interact with amino acids As much as Calcium/Dietary products decrease risk of developing colorectal cancer its also believed that it increases risk of developing other cancers like prostate cancer therefore there are no specific recommendations regarding those substances. Same with hormonal drugs in menopause in women that increase risk of heart diseases, blood clots and cancers of breast or lungs.
  • 10. References 1. Centers for Disease Control and Prevention, 09.12.2020, <https://www.cdc.gov/cancer/colorectal/basic_info/prevention.htm> 2. American Cancer Society, 09.12.2020, <https://www.cancer.org/cancer/colon- rectal-cancer/causes-risks-prevention/prevention.html> 3. National Institutes of Health, 09.12.2020, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947820/>
  • 11. Thank you for your attention