Mesopotamia, located in modern-day Iraq, Kuwait, Turkey, and Syria, is recognized as one of the earliest centers of human civilization, benefiting from its fertile location between the Tigris and Euphrates rivers. Important innovations such as cuneiform writing, agriculture, and urbanization emerged from the region, particularly during the Sumerian period, which saw the rise of city-states like Uruk. The history of Mesopotamia is characterized by changing ruling powers over millennia, contributing significantly to the development of human society.