Presentation12
•Download as PPT, PDF•
0 likes•34 views
The document discusses cancer cell immortality and apoptosis. It states that cancer cells cannot govern themselves and have derived problems. Macrophages pour nitric oxide, cytokines, growth factors, and prostaglandins onto cancer cells via mutated receptors and aberrant signaling pathways. These signals continuously direct cancer cells to proliferate. However, normal DNA wants to undergo apoptosis due to mutations but lacks sufficient energy. Both cancer cells and normal DNA have opposing actions but share the same problem of inadequate energy. The document likens foreign and normal DNA within cancer cells to having separate identities or personalities.
Report
Share
Report
Share
Recommended
Efruzhu cancer 12
The document discusses a theory of cancer carcinogenesis. It states that cancer cells cannot govern themselves and have derived problems. Macrophages pour nitric oxide, cytokines, growth factors, and prostaglandins onto cancer cells via mutated receptors and aberrant signaling pathways. These signals continuously direct proliferative and additional low level energy from outside sources. However, normal DNA sequences want to undergo apoptosis due to mutations, but there is not enough energy for this. Both proliferative and apoptotic actions have opposing dual roles and share the problem of inadequate energy. Foreign and normal DNA act like two separate republics with separate characteristics at the same basic level.
Plegable biomol
Researchers discovered a protein involved in cancer metastasis that also inhibits two proteins linked to neurodegenerative diseases. They also identified a non-coding RNA called INXS that modulates a gene important for apoptosis. In mouse studies, tumors treated with INXS decreased in size compared to controls. Both studies could help develop future cancer treatments by inhibiting metastasis genes or activating apoptosis through increasing INXS expression.
2014 BDSRA Palmer CLN 5 and CLN 6
The Batten Animal Research Network (BARN) is an international collaboration between research groups studying animal models of Batten disease. The groups share resources like cell cultures and animal models, exchange students, visit each other, and plan research together. BARN has developed measures of disease progression in sheep models to test potential drug and gene therapies. Recent work includes developing neuronal cultures from sheep models to study early disease stages, identifying mutations that cause two forms of CLN6 disease and CLN5 disease, and analyzing the neuroinflammatory response over time. Gene therapy trials using AAV vectors are underway in CLN5 and CLN6 sheep models.
Monogenic Diseases
The document discusses two studies, one on cracking the genetic code of Huntington's disease which found that modifying protein structures could help reduce disease symptoms, and another finding that adding fat-soluble vitamins to antibiotics may help combat antibiotic resistance in cystic fibrosis patients by allowing the antibiotics to attack bacteria more effectively. A student comments that these strategies could provide alternatives to changing antibiotics and help develop treatments before severe symptoms appear.
FOLDING (Central dogma of genetics)
Eukaryotic cells have their genetic material in the nucleus, in the other side, prokaryotes have it dispersed in the cytoplasm.
From this DNA will be synthesized RNA, which will act as an intermediary, carrying genetic information from the nucleus to the ribosomes located in the cytoplasm to carry out protein synthesis.
genetic code consists of 64 triplets (codons) of nucleotides, each codon encodes for one of the 20 amino-acids used in the synthesis of proteins.
The study of the genetic code, allow s us identify mutations in specific genes, to detect diseases or predispositions to some pathologies such as those proposed by the articles, and with tan information, implement a PREVENTIVE MEDICINE.
Knowing the sequence of genes that cause certain genetic diseases, is essential for GENE THERAPY branch. In brief it consist in introduce a correct copy of the defective gene that was visualized into the cells, by some vectors, previously studied.
With the knowledge of genetic information, can be provided counseling before and after pregnancy to future parents (Give information about the diseases to which it is susceptible and existing treatments), having always instilled an ethical principle: THE HUMAN LIFE RESPECT.
Promote investigation in medicine basic areas, such as cell biology, molecular biology, biochemistry and pharmacology, with the aim of implement humanity solutions .
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both studies provide insights with potential medical applications like gene therapy for Down syndrome.
Seminario biologia molecular. MicroRNA 197-3p y daño endotelial en la enferme...
Seminario biologia molecular. MicroRNA 197-3p y daño endotelial en la enferme...VALEVEROVILLADAORTIZ
En esta exposición se hace referencia a un artículo en el que se estudió la relación entre el MicroRNA 197-3p y el daño en células endoteliales de arteria coronaria en niños con enfermedad de Kawasaki. Recommended
Efruzhu cancer 12
The document discusses a theory of cancer carcinogenesis. It states that cancer cells cannot govern themselves and have derived problems. Macrophages pour nitric oxide, cytokines, growth factors, and prostaglandins onto cancer cells via mutated receptors and aberrant signaling pathways. These signals continuously direct proliferative and additional low level energy from outside sources. However, normal DNA sequences want to undergo apoptosis due to mutations, but there is not enough energy for this. Both proliferative and apoptotic actions have opposing dual roles and share the problem of inadequate energy. Foreign and normal DNA act like two separate republics with separate characteristics at the same basic level.
Plegable biomol
Researchers discovered a protein involved in cancer metastasis that also inhibits two proteins linked to neurodegenerative diseases. They also identified a non-coding RNA called INXS that modulates a gene important for apoptosis. In mouse studies, tumors treated with INXS decreased in size compared to controls. Both studies could help develop future cancer treatments by inhibiting metastasis genes or activating apoptosis through increasing INXS expression.
2014 BDSRA Palmer CLN 5 and CLN 6
The Batten Animal Research Network (BARN) is an international collaboration between research groups studying animal models of Batten disease. The groups share resources like cell cultures and animal models, exchange students, visit each other, and plan research together. BARN has developed measures of disease progression in sheep models to test potential drug and gene therapies. Recent work includes developing neuronal cultures from sheep models to study early disease stages, identifying mutations that cause two forms of CLN6 disease and CLN5 disease, and analyzing the neuroinflammatory response over time. Gene therapy trials using AAV vectors are underway in CLN5 and CLN6 sheep models.
Monogenic Diseases
The document discusses two studies, one on cracking the genetic code of Huntington's disease which found that modifying protein structures could help reduce disease symptoms, and another finding that adding fat-soluble vitamins to antibiotics may help combat antibiotic resistance in cystic fibrosis patients by allowing the antibiotics to attack bacteria more effectively. A student comments that these strategies could provide alternatives to changing antibiotics and help develop treatments before severe symptoms appear.
FOLDING (Central dogma of genetics)
Eukaryotic cells have their genetic material in the nucleus, in the other side, prokaryotes have it dispersed in the cytoplasm.
From this DNA will be synthesized RNA, which will act as an intermediary, carrying genetic information from the nucleus to the ribosomes located in the cytoplasm to carry out protein synthesis.
genetic code consists of 64 triplets (codons) of nucleotides, each codon encodes for one of the 20 amino-acids used in the synthesis of proteins.
The study of the genetic code, allow s us identify mutations in specific genes, to detect diseases or predispositions to some pathologies such as those proposed by the articles, and with tan information, implement a PREVENTIVE MEDICINE.
Knowing the sequence of genes that cause certain genetic diseases, is essential for GENE THERAPY branch. In brief it consist in introduce a correct copy of the defective gene that was visualized into the cells, by some vectors, previously studied.
With the knowledge of genetic information, can be provided counseling before and after pregnancy to future parents (Give information about the diseases to which it is susceptible and existing treatments), having always instilled an ethical principle: THE HUMAN LIFE RESPECT.
Promote investigation in medicine basic areas, such as cell biology, molecular biology, biochemistry and pharmacology, with the aim of implement humanity solutions .
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both studies provide insights with potential medical applications like gene therapy for Down syndrome.
Seminario biologia molecular. MicroRNA 197-3p y daño endotelial en la enferme...
Seminario biologia molecular. MicroRNA 197-3p y daño endotelial en la enferme...VALEVEROVILLADAORTIZ
En esta exposición se hace referencia a un artículo en el que se estudió la relación entre el MicroRNA 197-3p y el daño en células endoteliales de arteria coronaria en niños con enfermedad de Kawasaki. Monogenic disorders
This document discusses several studies on monogenic disorders and their potential medical applications. It first introduces monogenic disorders as involving mutations in a single gene, which can be inherited or spontaneous. Two studies are then summarized: one finding that brain stimulation may help restore breathing capacity in Duchenne muscular dystrophy patients by activating the diaphragm muscle, and another observing changes in mucus protein structure in cystic fibrosis patients that could provide insight into treatment. The document concludes that these studies bring researchers closer to potential treatments for currently incurable genetic diseases and improve patients' quality of life.
mRNA in Cardiology
1. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression on a post-translational level and play important roles in homeostasis and disease.
2. miRNAs can regulate the expression of over 100 mRNAs each and there are over 2,600 miRNAs identified so far that are involved in processes like brain development, immune response, and apoptosis.
3. Dysregulation of specific miRNAs is associated with various cardiovascular diseases and miRNAs show potential as biomarkers for conditions like coronary heart disease and heart failure.
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
The BATCure Consortium will investigate Batten disease through 8 experimental work packages and 3 supporting work packages. The experimental work will focus on developing new models and tools, identifying therapeutic pathways and targets, natural disease history, identifying compound and gene therapy leads, and delivering new treatments to mice. The consortium involves 10 research groups, 3 companies, and 1 patient organization working to advance understanding of Batten disease and develop effective treatments.
Novel Compound to Halt Virus replication Identified AND Spasticity Gene Findi...
Novel Compound to Halt Virus replication Identified AND Spasticity Gene Findi...Nora Piedad Velasquez
1) A team of scientists identified a novel compound that inhibits viruses from replicating, which could lead to new drugs to block poxviruses like monkeypox.
2) Mutations in the reticulon 2 gene were found to cause a form of hereditary spastic paraplegia by disrupting endoplasmic reticulum shaping and causing axon degeneration.
3) Identifying the specific location of genetic mutations, such as deletions in chromosomes, allows for a better understanding of disease incidence and development, aiding in potential prevention and treatment.Jmp gene therapy_intro
Genetic disorders can be caused by abnormalities in chromosomes or single genes. Chromosomal disorders occur when there are errors in chromosome number or structure during meiosis, leading to conditions like Down syndrome. Single gene disorders are caused by mutations in genes, and result in diseases like cystic fibrosis, sickle cell anemia, and Huntington's disease. Gene therapy aims to treat genetic disorders by inserting a normal gene into cells to replace the mutated version, using viral vectors to deliver the healthy gene. While some successes have been seen, challenges remain in developing safe and effective vector delivery systems.
Newer definition and theory of cancer-
This document discusses a new definition and theory of cancer proposed by Dr. RK Dhaugoda called the stem cell-microRNA Theory of Cancer. The key points of the theory are:
1) It proposes that cancer stem cells arise from normal stem cells due to decreased production of mature microRNAs in the stem cells caused by persistent exposure to cellular stress factors or decreased anti-stress factors.
2) This leads to deregulation of stem cell physiology including abnormal gene expression and uncontrolled growth, resulting in the transformation of normal stem cells into cancer stem cells.
3) The theory applies the concept of "opposites within opposites" from dialectics to describe the relationship between normal and cancer stem cells
Diagnosis Of Genetic Disorders & Infectious Diseases
This document provides an overview of genetic disorders and infectious diseases. It discusses several types of genetic disorders including autosomal dominant disorders like Huntington's disease, autosomal recessive disorders like Niemann-Pick disease, X-linked dominant disorders like Incontinentia pigmenti, X-linked recessive disorders like color blindness, and Y-linkage disorders like male infertility. For infectious diseases, it describes miliary tuberculosis caused by Mycobacterium tuberculosis and feline leukemia virus (FeLV) in cats. Diagnosis of these conditions involves tests such as genetic testing, imaging, semen analysis, and blood tests to detect viral proteins for conditions like FeLV. Treatment depends on the specific condition but may include medications, gene
2013 ANCL Mole
This document summarizes research from the MRC Laboratory for Molecular Cell Biology on adult Batten disease. The laboratory aims to identify the genetic causes of adult onset neuronal ceroid lipofuscinosis (NCL) by collecting cases, analyzing for mild mutations in known NCL genes, and using new sequencing technologies to identify novel genes. They have identified mutations in several known childhood NCL genes that can cause adult onset disease. By collaborating with other labs and using their diagnostic approach, they have also identified some new NCL genes underlying adult variants. Identifying the causal genes is the first step towards developing targeted therapies for these currently untreatable genetic diseases.
Stem cells & Neurodegenerative diseases And Some clinical CNS
Stem cells & Neurodegenerative diseases And Some clinical CNSAll India Institute of Medical Sciences, Bhopal
This document discusses several neurodegenerative diseases including Parkinson's disease, ALS, and poliomyelitis. For Parkinson's, stem cell therapies show promise by producing dopamine neurons. For ALS, mesenchymal stem cells and neural progenitor cells have been shown to protect motor neurons and promote recovery in rodent models. Clinical trials are underway injecting neural progenitor cells into the spinal cords of ALS patients. Poliomyelitis destroys motor neurons and can cause paralysis, though vaccines have nearly eradicated it. The document also briefly discusses post-polio syndrome and tabes dorsalis.GENE THERAPY
INTRODUCTION OF GENE THERAPY, HISTORY OF GENE THERAPY, Process of gene therapy, Methods of gene therapy, Ex vivo gene therapy , In Vivo Gene Therapy , Uses of gene therapy, Target sites for Gene Therapy , Vectors for gene therapy , Viral Vectors, Non Viral Vectors,
1 medical genetics
This document provides an overview of medical genetics and heredity. It discusses key topics such as gene expression, alleles, Mendel's laws of inheritance, and different types of genetic disorders. The main points are:
1) Medical genetics applies genetics to medical practice, dealing with the diagnosis and treatment of diseases with a genetic basis.
2) Genetics explores heredity and variation in living organisms. Key early figures included Mendel who discovered the laws of inheritance, and Watson and Crick who discovered the structure of DNA.
3) There are different types of genetic disorders including single-gene, polygenic, chromosomal, and mitochondrial disorders. Common diseases like cancer and birth defects can also have genetic
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
May is National Cancer Research Month. In recognition, here's a glimpse of key achievements in cancer research over the last 12 months (May 2010 - May 2011) at Cold Spring Harbor Laboratory, which has been an NCI-designated Cancer Center since 1987.
Lrrk2 nww-wood
This document discusses various topics related to LRRK2 gene mutations and Parkinson's disease (PD), including:
1. It outlines several proven pathogenic mutations in the LRRK2 gene associated with PD cases, including Gly2019Ser which accounts for 1.6% of sporadic and 29% of familial PD cases in Ashkenazi Jewish populations.
2. It summarizes a meta-analysis of Caucasian genome-wide association studies that identified several gene loci associated with increased risk of PD, including MAPT, SNCA, HLA-DR, and LRRK2.
3. It notes that the LRRK2 gene shows alternative splicing and higher expression in the occipital cortex
terapi gen kelainan genetik genetic disorders treatment
This document discusses various therapies for genetic disorders, including preventive methods, metabolic manipulation, gene product replacement, cell or organ transplantation, and somatic gene therapy. It provides details on preventive therapy through prenatal diagnosis and screening. Metabolic therapies include dietary restriction or supplementation, chelation, and metabolic inhibitors. Gene product replacement involves administering hormones, proteins, or enzymes. Somatic gene therapy introduces recombinant genes into somatic cells to treat genetic diseases. The document outlines the process of gene therapy and some challenges, such as immune responses, safety issues, and difficulties with multigenic disorders.
EACR Travel Grant Page
Dino Masic traveled to Cincinnati Children's Hospital from March to September 2014 to collaborate on developing a disease model for IGH-CEBPD B-cell precursor acute lymphoblastic leukemia. The project aims to recreate the genetic insults that initiate leukemia by transducing cord blood with a retroviral vector containing the IGH-CEBPD fusion partner. This mimics the patient phenotype and may help answer questions about cell lineage commitment. While there, Masic learned new techniques for developing disease models, including transducing cord blood and engrafting cells in animals. He is now integrating these techniques into his research group in Newcastle to further investigate the developmental mechanisms behind this leukemia subtype.
2012 ANCL Smith, Dahl, Damiano. Bahlo &Berkovic
Adult Batten disease (also known as adult onset neuronal ceroid lipofuscinosis or ANCL) is a group of rare genetic diseases characterized by seizures, poor balance, intellectual decline, and sometimes blindness in late teens to sixties. Diagnosis was previously difficult but recent research has identified mutations in four genes - CLN6, DNAJC5, GRN, and "Gene B" - that cause different forms of ANCL. Identifying the genetic basis allows diagnosis via blood DNA testing instead of brain biopsy and provides information for patients and families. While progress has been made, more research is still needed to understand the functions of the mutated genes and develop future therapies.
Neuroblastoma research paper(2015)
in this research paper ,researchers found a new therapeutic drug that is SULFASALAZINE for the treatment of neuroblastoma that has a action on SEPIATERIN REDUCTASE
severe combined immunodeficiency
Severe combined immunodeficiency (SCID) is a genetic disorder characterized by the absence of functional T lymphocytes and B lymphocytes, resulting in impaired adaptive immune system. There are several known types of SCID caused by mutations in different genes. The most common treatment is bone marrow transplantation, with success seen in transplants done in early infancy. Gene therapy is also being explored as a potential treatment through inserting missing genes into hematopoietic stem cells, though past trials increased leukemia risk and more research is still needed.
La vaqueria tole3
El documento habla sobre la vaquería y el trabajo de llano en Colombia. Describe las labores tradicionales de la ganadería como marcar, vacunar y ordeñar el ganado. También explica que los cantos de trabajo del llano son una expresión cultural de más de 200 años asociada a estas actividades ganaderas. Finalmente, resalta el papel central del hombre llanero en el trabajo diario con el ganado desde muy temprano en la mañana.
PERÚ - USIL - Networking y Marca personal 25.10.16
La Unión Europea ha acordado un paquete de sanciones contra Rusia por su invasión de Ucrania. Las sanciones incluyen restricciones a las transacciones con bancos rusos clave y la prohibición de la venta de aviones y equipos a Rusia. Los líderes de la UE esperan que las sanciones aumenten la presión económica sobre Rusia y la disuadan de continuar su agresión contra Ucrania.
Certificados de profesionalidad, un reto para el sector (Sergio Oliva)
El documento habla sobre la historia de la formación profesional en España desde la década de 1950 hasta la actualidad. Detalla diferentes leyes y acuerdos clave que han moldeado el sistema de formación profesional a lo largo de los años, incluyendo la creación de escuelas de formación, leyes educativas, y acuerdos entre el gobierno, sindicatos y empresas para promover la formación continua de trabajadores.
El valor de la Formación de Oferta (Claudia Paz SEPE)
Ponencia: El valor de la Formación de Oferta.
Dª. Claudia Paz, Coordinadora del Área de Seguimiento del Servicio Estatal Público de Empleo.
More Related Content
What's hot
Monogenic disorders
This document discusses several studies on monogenic disorders and their potential medical applications. It first introduces monogenic disorders as involving mutations in a single gene, which can be inherited or spontaneous. Two studies are then summarized: one finding that brain stimulation may help restore breathing capacity in Duchenne muscular dystrophy patients by activating the diaphragm muscle, and another observing changes in mucus protein structure in cystic fibrosis patients that could provide insight into treatment. The document concludes that these studies bring researchers closer to potential treatments for currently incurable genetic diseases and improve patients' quality of life.
mRNA in Cardiology
1. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression on a post-translational level and play important roles in homeostasis and disease.
2. miRNAs can regulate the expression of over 100 mRNAs each and there are over 2,600 miRNAs identified so far that are involved in processes like brain development, immune response, and apoptosis.
3. Dysregulation of specific miRNAs is associated with various cardiovascular diseases and miRNAs show potential as biomarkers for conditions like coronary heart disease and heart failure.
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
The BATCure Consortium will investigate Batten disease through 8 experimental work packages and 3 supporting work packages. The experimental work will focus on developing new models and tools, identifying therapeutic pathways and targets, natural disease history, identifying compound and gene therapy leads, and delivering new treatments to mice. The consortium involves 10 research groups, 3 companies, and 1 patient organization working to advance understanding of Batten disease and develop effective treatments.
Novel Compound to Halt Virus replication Identified AND Spasticity Gene Findi...
Novel Compound to Halt Virus replication Identified AND Spasticity Gene Findi...Nora Piedad Velasquez
1) A team of scientists identified a novel compound that inhibits viruses from replicating, which could lead to new drugs to block poxviruses like monkeypox.
2) Mutations in the reticulon 2 gene were found to cause a form of hereditary spastic paraplegia by disrupting endoplasmic reticulum shaping and causing axon degeneration.
3) Identifying the specific location of genetic mutations, such as deletions in chromosomes, allows for a better understanding of disease incidence and development, aiding in potential prevention and treatment.Jmp gene therapy_intro
Genetic disorders can be caused by abnormalities in chromosomes or single genes. Chromosomal disorders occur when there are errors in chromosome number or structure during meiosis, leading to conditions like Down syndrome. Single gene disorders are caused by mutations in genes, and result in diseases like cystic fibrosis, sickle cell anemia, and Huntington's disease. Gene therapy aims to treat genetic disorders by inserting a normal gene into cells to replace the mutated version, using viral vectors to deliver the healthy gene. While some successes have been seen, challenges remain in developing safe and effective vector delivery systems.
Newer definition and theory of cancer-
This document discusses a new definition and theory of cancer proposed by Dr. RK Dhaugoda called the stem cell-microRNA Theory of Cancer. The key points of the theory are:
1) It proposes that cancer stem cells arise from normal stem cells due to decreased production of mature microRNAs in the stem cells caused by persistent exposure to cellular stress factors or decreased anti-stress factors.
2) This leads to deregulation of stem cell physiology including abnormal gene expression and uncontrolled growth, resulting in the transformation of normal stem cells into cancer stem cells.
3) The theory applies the concept of "opposites within opposites" from dialectics to describe the relationship between normal and cancer stem cells
Diagnosis Of Genetic Disorders & Infectious Diseases
This document provides an overview of genetic disorders and infectious diseases. It discusses several types of genetic disorders including autosomal dominant disorders like Huntington's disease, autosomal recessive disorders like Niemann-Pick disease, X-linked dominant disorders like Incontinentia pigmenti, X-linked recessive disorders like color blindness, and Y-linkage disorders like male infertility. For infectious diseases, it describes miliary tuberculosis caused by Mycobacterium tuberculosis and feline leukemia virus (FeLV) in cats. Diagnosis of these conditions involves tests such as genetic testing, imaging, semen analysis, and blood tests to detect viral proteins for conditions like FeLV. Treatment depends on the specific condition but may include medications, gene
2013 ANCL Mole
This document summarizes research from the MRC Laboratory for Molecular Cell Biology on adult Batten disease. The laboratory aims to identify the genetic causes of adult onset neuronal ceroid lipofuscinosis (NCL) by collecting cases, analyzing for mild mutations in known NCL genes, and using new sequencing technologies to identify novel genes. They have identified mutations in several known childhood NCL genes that can cause adult onset disease. By collaborating with other labs and using their diagnostic approach, they have also identified some new NCL genes underlying adult variants. Identifying the causal genes is the first step towards developing targeted therapies for these currently untreatable genetic diseases.
Stem cells & Neurodegenerative diseases And Some clinical CNS
Stem cells & Neurodegenerative diseases And Some clinical CNSAll India Institute of Medical Sciences, Bhopal
This document discusses several neurodegenerative diseases including Parkinson's disease, ALS, and poliomyelitis. For Parkinson's, stem cell therapies show promise by producing dopamine neurons. For ALS, mesenchymal stem cells and neural progenitor cells have been shown to protect motor neurons and promote recovery in rodent models. Clinical trials are underway injecting neural progenitor cells into the spinal cords of ALS patients. Poliomyelitis destroys motor neurons and can cause paralysis, though vaccines have nearly eradicated it. The document also briefly discusses post-polio syndrome and tabes dorsalis.GENE THERAPY
INTRODUCTION OF GENE THERAPY, HISTORY OF GENE THERAPY, Process of gene therapy, Methods of gene therapy, Ex vivo gene therapy , In Vivo Gene Therapy , Uses of gene therapy, Target sites for Gene Therapy , Vectors for gene therapy , Viral Vectors, Non Viral Vectors,
1 medical genetics
This document provides an overview of medical genetics and heredity. It discusses key topics such as gene expression, alleles, Mendel's laws of inheritance, and different types of genetic disorders. The main points are:
1) Medical genetics applies genetics to medical practice, dealing with the diagnosis and treatment of diseases with a genetic basis.
2) Genetics explores heredity and variation in living organisms. Key early figures included Mendel who discovered the laws of inheritance, and Watson and Crick who discovered the structure of DNA.
3) There are different types of genetic disorders including single-gene, polygenic, chromosomal, and mitochondrial disorders. Common diseases like cancer and birth defects can also have genetic
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
May is National Cancer Research Month. In recognition, here's a glimpse of key achievements in cancer research over the last 12 months (May 2010 - May 2011) at Cold Spring Harbor Laboratory, which has been an NCI-designated Cancer Center since 1987.
Lrrk2 nww-wood
This document discusses various topics related to LRRK2 gene mutations and Parkinson's disease (PD), including:
1. It outlines several proven pathogenic mutations in the LRRK2 gene associated with PD cases, including Gly2019Ser which accounts for 1.6% of sporadic and 29% of familial PD cases in Ashkenazi Jewish populations.
2. It summarizes a meta-analysis of Caucasian genome-wide association studies that identified several gene loci associated with increased risk of PD, including MAPT, SNCA, HLA-DR, and LRRK2.
3. It notes that the LRRK2 gene shows alternative splicing and higher expression in the occipital cortex
terapi gen kelainan genetik genetic disorders treatment
This document discusses various therapies for genetic disorders, including preventive methods, metabolic manipulation, gene product replacement, cell or organ transplantation, and somatic gene therapy. It provides details on preventive therapy through prenatal diagnosis and screening. Metabolic therapies include dietary restriction or supplementation, chelation, and metabolic inhibitors. Gene product replacement involves administering hormones, proteins, or enzymes. Somatic gene therapy introduces recombinant genes into somatic cells to treat genetic diseases. The document outlines the process of gene therapy and some challenges, such as immune responses, safety issues, and difficulties with multigenic disorders.
EACR Travel Grant Page
Dino Masic traveled to Cincinnati Children's Hospital from March to September 2014 to collaborate on developing a disease model for IGH-CEBPD B-cell precursor acute lymphoblastic leukemia. The project aims to recreate the genetic insults that initiate leukemia by transducing cord blood with a retroviral vector containing the IGH-CEBPD fusion partner. This mimics the patient phenotype and may help answer questions about cell lineage commitment. While there, Masic learned new techniques for developing disease models, including transducing cord blood and engrafting cells in animals. He is now integrating these techniques into his research group in Newcastle to further investigate the developmental mechanisms behind this leukemia subtype.
2012 ANCL Smith, Dahl, Damiano. Bahlo &Berkovic
Adult Batten disease (also known as adult onset neuronal ceroid lipofuscinosis or ANCL) is a group of rare genetic diseases characterized by seizures, poor balance, intellectual decline, and sometimes blindness in late teens to sixties. Diagnosis was previously difficult but recent research has identified mutations in four genes - CLN6, DNAJC5, GRN, and "Gene B" - that cause different forms of ANCL. Identifying the genetic basis allows diagnosis via blood DNA testing instead of brain biopsy and provides information for patients and families. While progress has been made, more research is still needed to understand the functions of the mutated genes and develop future therapies.
Neuroblastoma research paper(2015)
in this research paper ,researchers found a new therapeutic drug that is SULFASALAZINE for the treatment of neuroblastoma that has a action on SEPIATERIN REDUCTASE
severe combined immunodeficiency
Severe combined immunodeficiency (SCID) is a genetic disorder characterized by the absence of functional T lymphocytes and B lymphocytes, resulting in impaired adaptive immune system. There are several known types of SCID caused by mutations in different genes. The most common treatment is bone marrow transplantation, with success seen in transplants done in early infancy. Gene therapy is also being explored as a potential treatment through inserting missing genes into hematopoietic stem cells, though past trials increased leukemia risk and more research is still needed.
What's hot (18)
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
Novel Compound to Halt Virus replication Identified AND Spasticity Gene Findi...
Novel Compound to Halt Virus replication Identified AND Spasticity Gene Findi...
Diagnosis Of Genetic Disorders & Infectious Diseases
Diagnosis Of Genetic Disorders & Infectious Diseases
Stem cells & Neurodegenerative diseases And Some clinical CNS
Stem cells & Neurodegenerative diseases And Some clinical CNS
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
terapi gen kelainan genetik genetic disorders treatment
terapi gen kelainan genetik genetic disorders treatment
Viewers also liked
La vaqueria tole3
El documento habla sobre la vaquería y el trabajo de llano en Colombia. Describe las labores tradicionales de la ganadería como marcar, vacunar y ordeñar el ganado. También explica que los cantos de trabajo del llano son una expresión cultural de más de 200 años asociada a estas actividades ganaderas. Finalmente, resalta el papel central del hombre llanero en el trabajo diario con el ganado desde muy temprano en la mañana.
PERÚ - USIL - Networking y Marca personal 25.10.16
La Unión Europea ha acordado un paquete de sanciones contra Rusia por su invasión de Ucrania. Las sanciones incluyen restricciones a las transacciones con bancos rusos clave y la prohibición de la venta de aviones y equipos a Rusia. Los líderes de la UE esperan que las sanciones aumenten la presión económica sobre Rusia y la disuadan de continuar su agresión contra Ucrania.
Certificados de profesionalidad, un reto para el sector (Sergio Oliva)
El documento habla sobre la historia de la formación profesional en España desde la década de 1950 hasta la actualidad. Detalla diferentes leyes y acuerdos clave que han moldeado el sistema de formación profesional a lo largo de los años, incluyendo la creación de escuelas de formación, leyes educativas, y acuerdos entre el gobierno, sindicatos y empresas para promover la formación continua de trabajadores.
El valor de la Formación de Oferta (Claudia Paz SEPE)
Ponencia: El valor de la Formación de Oferta.
Dª. Claudia Paz, Coordinadora del Área de Seguimiento del Servicio Estatal Público de Empleo.
Proyecto mac sexto año
Este documento presenta un proyecto educativo que tiene como objetivo conocer y comprender el conocimiento artístico a través de la apropiación de los lenguajes artísticos y el uso de recursos tecnológicos como las ceibalitas. El proyecto busca facilitar el uso de las ceibalitas y plataformas virtuales, así como contribuir al plan Ceibal. Se proponen actividades como el análisis de obras de arte, la representación artística usando software, y la pintura. El proyecto abarca disciplinas artísticas,
Egl m3 u4a2
El documento describe varios recursos web 2.0 que pueden ser útiles para la educación, incluyendo blogs para discutir temas con estudiantes, comunicación a través de aplicaciones móviles como WhatsApp, almacenamiento y presentaciones en plataformas como SlideShare y Dropbox, videos educativos en YouTube y redes sociales como Facebook, y herramientas en línea para crear gráficos y diagramas. El documento concluye que el uso de estas y otras herramientas tecnológicas puede ser de gran ayuda para la enseñanza.
Recursos didacticos
Este documento resume recursos educativos de la Web 2.0 como blogs, buscadores, comunicación, cursos en línea, gráficos y diagramas, microblogging, música y redes sociales. Describe brevemente cada recurso, sus aplicaciones didácticas y algunos sitios destacados.
2015 Rising Star JL
Jennifer Lish is a 35-year-old mother of two who lives in a small town outside of Chicago. She works as an administrative assistant at a local law firm to support her family. In her free time, Jennifer enjoys reading, gardening, and spending time with her children.
Jornal são dimas e adjacências
O documento resume as atividades do vereador Catanese no primeiro semestre de 2013, incluindo reuniões com empresas de telefonia para melhorar a cobertura, pedidos de melhorias de infraestrutura para bairros, e indicações para a prefeitura sobre serviços de manutenção.
FUTURO 2012 | PEDRO RIBEIRO | Lista A
Este documento contiene una lista de miembros y suplentes que apoyan la candidatura de Pedro Ribeiro a la presidencia del Partido Socialista de Cartaxo. La lista incluye 41 miembros y 41 suplentes con sus respectivos números de militante del partido.
Mentefacto
La información periodística debe ser veraz, segura, actualizada y verificable. Se comunica a través de varios medios como páginas web, radio, noticieros de televisión, videojuegos y obras de teatro o comedia.
MOÇÃO POLÍTICA | SÚMULA | PEDRO RIBEIRO
Este documento apresenta a moção política da candidatura de Pedro Ribeiro à presidência do Partido Socialista do Cartaxo. O documento descreve três eixos estratégicos para 2012-2014: 1) reforçar a militância e participação; 2) constituir equipas para vencer as eleições autárquicas de 2013; 3) desenvolver uma visão de futuro para o concelho do Cartaxo centrada na sustentabilidade, oportunidades e competitividade.
3 slides
This document discusses editing a visualization called "Customer Credit by Region" in the "Sales" dashboard. It provides instructions to change the chart type of an existing visualization to a "Dual Axis" chart. It also shows a pie chart displaying regional sales breakdowns with percentages for each region.
Historia oral - Dar voz a los sin voz
Trabajo de investigación de historia de 4º de la ESO.
Conversaciones con dos personas mayores de nacionalidades distintas, estudio comparativo de las sociedades polaca y española en la 2ª mitad del siglo XX.
2º premio concurso Eustory 2013.
Telmex
Telmex es una empresa mexicana de telecomunicaciones líder en servicios de telefonía, televisión e Internet en México y Latinoamérica. Ofrece una amplia gama de productos y servicios relacionados con las telecomunicaciones a través de una extensa red fija y móvil. Además de servicios comerciales, Telmex impulsa programas educativos gratuitos como Aldea Digital, Comunidad Digital del Conocimiento y TELMEX HUB para promover la inclusión digital en México.
Viewers also liked (20)
PERÚ - USIL - Networking y Marca personal 25.10.16
PERÚ - USIL - Networking y Marca personal 25.10.16
Certificados de profesionalidad, un reto para el sector (Sergio Oliva)
Certificados de profesionalidad, un reto para el sector (Sergio Oliva)
El valor de la Formación de Oferta (Claudia Paz SEPE)
El valor de la Formación de Oferta (Claudia Paz SEPE)
Similar to Presentation12
Efruzhu cancer laws com. 25.2.
This document discusses the "Inadequate Energy Cancer (Carcinogenesis) Theory". It proposes that cancer may be triggered by mutations, but the main driver is inadequate or inefficient energy production within the cell. A variety of internal and external factors can disrupt energy production, especially oxidative processes, leading to inhibited or low-level energy generation over time. This stimulates an immune response and stresses the cell to find ways to survive, which can later lead to malignancy depending on the energy balance and accumulation of further mutations over time. Cancer cells mainly rely on anaerobic glycolysis for energy due to repression of normal aerobic pathways.
Efruzhu cancer 13.
The document discusses the role of cytokines, growth factors, and nitric oxide in cancer cell proliferation and differentiation. It states that high amounts of these substances cause cancer cells to constantly proliferate in an immature, cloned state as they are stimulated to divide. This creates metabolic stress for the cancer cells as they do not have enough time, energy, or biosynthesis capabilities to properly store lipids, nitrogen, and proteins. The low or normal amounts of these substances, on the other hand, have a differentiative effect and allow normal functions to occur step-by-step in a repairable manner.
S8 presentation8
This document outlines the Efruzhu Cancer Theory which proposes two pathways to carcinogenesis. The first involves cancer stem cells that fail to fully mature due to chronic inflammation, inadequate energy or mutations. The second involves the dedifferentiation of mature cells back to an immature state due to immune cells, allowing cancer cells to renew and continue living. Carcinogenesis can thus occur through either the persistence of immature cancer stem cells or the dematuration of mature cells.
Presentation8
This document outlines the Efruzhu Cancer Theory which proposes that carcinogenesis can occur through two opposing dynamics. The first is through cancer stem cells that fail to fully mature due to chronic inflammation, inadequate energy or mutations. The second is through dedifferentiation of mature cells back to an immature state due to immune cells, allowing cancer cells to renew and continue living. Carcinogenesis results from a balance between the primordial and mature forms of cells being disrupted.
Efruzhu cancer 24.
The document discusses the lifestyle of cancer cells, describing it as complicated and stressful. Cancer cells experience metabolic stress, have hypermethylated DNA that should not be transcribed, and have impaired energy production and biosynthesis. They also display characteristics like immortality and continuous proliferation. The document suggests that cancer cell renewal is transformed from normal to neoplastic by chronic inflammation from immune cells like macrophages, representing a stress response and cultural adaptation.
Academia edu cancer short comments 2.
Efruz Asiloglu is an independent researcher whose primary research interest is molecular cancer biochemistry. Their profile page provides information on their publications, books, talks and teaching documents related to their "Efruzhu Cancer (Carcinogenesis) Theory". They have been actively posting status updates discussing various aspects of cancer cell metabolism, signaling pathways, DNA mutations and potential treatment approaches.
Efruzhu cancer 8.
This document discusses the Efruzhu Cancer (Carcinogenesis) Theory which proposes that cancer develops through two opposing dynamics. The first is through cancer stem cells that need maturation but interact with chronic inflammation or mutations and become neoplastic cancer cells. The second is through dedifferentiation of mature cells into immature cells by immune cells. This theory states that cancer cells renew themselves through cultural adaptation to continue living under suboptimal conditions in a microenvironment with oxidative stress and low energy production, relying on anaerobic glycolysis and producing excess lactic acid.
Presentation24
The document discusses the poor living conditions of cancer cells. It states that the life of a cancer cell is complex, with metabolic stress both inside and outside the cell. Cancer cells have abnormal DNA transcription and hypermethylated genes. Their energy production and biosynthesis abilities are impaired. They also have imbalanced ions and issues with nuclear and cytoplasmic membranes. Cancer cells live parasitically and are immortal and continuously proliferative, with multi-antigenic characteristics. All of these problems contribute to the complicated and problematic nature of cancer cell proliferation.
Efruzhu cancer 22.
This document discusses the role of cytokines and growth factors in cell proliferation and differentiation, and how their levels impact these processes. It explains that the T3 receptor is located in the nucleus and mitochondria, and that energy generation is important for proliferation and differentiation. The document suggests that cancer cells continuously take high levels of ligand signaling, favoring proliferation over differentiation, and that their energy generation and DNA sequences are disrupted, making differentiation impossible.
Efruzhu cancer laws com. 25.1.
This document presents the "Efruzher Cancer (Carcinogenesis) Theory". It proposes that for a normal cell to become cancerous, it requires more than just mutations - it needs energy inefficiency, chronic inflammation, or suppression of normal DNA. Cancer cells take on a group identity defined by many mutations, seeking to live irregularly and being transferred from outside influences like macrophages. The malignancy level depends on energy ratios - low energy means more mutations and malignancy, while high energy means fewer mutations and potential benign conditions. Cancer cells are seen as selfish, parasitic, irregular and immortal due to their transferred mutational group identity from outside influences.
Efruzhu cancer 11
The document discusses a theory about cancer (carcinogenesis) and benign versus malignant conditions. It states that the transformation from a normal cell to a neoplastic cell is determined by various factors that decide whether it will be malignant or benign. These factors influence the energy degree or level, with lower energy corresponding to increased malignancy and aggressiveness, and higher energy corresponding to decreased malignancy and a more benign condition. It suggests that partial transcription expression of the normal DNA sequence, at a certain energy level, allows for cellular metabolic actions to be regulated in homeostatic balance, but insufficient transcription expression at different energy levels prevents opening of histones and hypermethylation of CpG islands in promoter regions, leading to malignancy due to
S5 presentation5
Aberrant signaling pathways in cancer work through guanylate cyclase and guanosine monophosphate molecules, as well as continuous nitric oxide and cytokine-growth factor signaling from outside cells. Chronic inflammation from immune cells like macrophages and cytokines can cause cell proliferation and differentiation dependence on ligand amounts. High ligand amounts promote proliferation while low amounts enable differentiation. Normal signaling pathways use adenylate cyclase via cyclic adenosine monophosphate dependent on ATP. Phosphorylation is important as conformational changes activate molecules. In normal cells, DNA in promoter regions is hypermethylated and histones are not sufficiently modified, suppressing transcription and expression.
Presentation5
The document discusses aberrant and normal signaling pathways in relation to cancer development. Aberrant signaling pathways involve guanylate cyclase and guanosine monophosphate molecules, as well as continuous nitric oxide and cytokines from outside cells. Chronic inflammation from immune cells and cytokines can cause cell proliferation and differentiation dependence on ligand amounts. Normal signaling pathways use adenylate cyclase and cyclic adenosine monophosphate dependent on ATP. Phosphorylation is important for conformational changes that activate molecules. Normal DNA sequences have hypermethylated CpG islands in promoter areas and decreased histone modifications, which suppress transcription and expression.
Efruzhu cancer 5.
The document discusses aberrant and normal signaling pathways in relation to cancer development. Aberrant signaling pathways involve guanylate cyclase and guanosine monophosphate molecules, as well as continuous nitric oxide and cytokines from outside cells. Chronic inflammation from immune cells and cytokines can cause cell proliferation and differentiation dependence on ligand amounts. Normal signaling pathways use adenylate cyclase and cyclic adenosine monophosphate dependent on ATP. Phosphorylation is important for conformational changes that activate molecules. Normal DNA sequences have hypermethylated CpG islands in promoter areas and decreased histone modifications, which suppress transcription and expression.
Efruzhu cancer theory oppositions of cancer cell3
This document presents Efruz Asiloglu's theory of cancer carcinogenesis. It suggests that cancer starts with mutations in nuclear DNA and mitochondrial DNA that suppress apoptosis and promote anti-apoptotic activity. These mutations allow cancer cells to avoid identification and removal by macrophages through aberrant signaling pathways, enabling uncontrolled growth.
Presentation19
The document discusses a cancer cell theory where cancer cells are seen as behaving parasitically. It states that cancer cells have a dual identity and are constantly signaling from outside via mutated receptors and aberrant signaling pathways to stimulate proliferative behavior. This forces cancer cells to carry large amounts of raw materials for biosynthesis purposes, but they do not have enough energy. Ultimately, the document argues that cancer cells should not prefer a parasitic behavior.
S19 presentation19
Cancer cells behave like parasites by changing their identity and stealing nutrients from healthy cells. Cancer cells mutate and form a group identity that is constantly signaling from outside the cell via abnormal receptor pathways. This stimulates proliferation but the cancer cells cannot produce enough energy to sustain their fast growth. As a result, cancer cells must act parasitically by taking more materials than they can produce, losing the balance between biosynthesis and destruction.
Sunu 25.1.2
Cancer cells have a binary identity - one originating from outside immune cells like macrophages, making them non-self. Cancer cells have accumulated so many mutations that their group identity wants to live exceptionally and irregularly, transferred from outside. The main point is that cancer cells depend on inadequate energy, which increases mutations. Malignancy occurs with increasing mutations due to low energy. Benign conditions are possible with high energy and low mutations. Cancer cells are selfish, parasitic, irregular, immortal and immature due to their transferred mutated group identity from outside. Normal DNA sequences cannot be transcribed or expressed due to inadequate energy.
Sunu 25.1.2
Cancer cells have a binary identity - one originating from outside immune cells like macrophages, making them non-self. Cancer cell personalities become defined by many mutations that allow them to live exceptionally and irregularly. Malignancy occurs when energy levels are inadequate, increasing mutations, while benign conditions are possible when energy levels increase and mutations decrease. Cancer cells are selfish, parasitic, irregular, immortal, and immature due to their dependence on transferred group identities and mutations from outside influences, causing normal DNA sequences to not be transcribed or expressed due to inadequate energy levels.
S11 presentation11
This document discusses a cancer theory where the degree or level of energy in a cell determines whether a neoplastic transformation leads to a malignant or benign condition. A decreasing energy level causes increased malignancy and aggressiveness, while an increasing energy level decreases malignancy or leads to benign conditions. It suggests that partial transcription expression of a normal DNA sequence, at a level that provides nearly regulated cellular metabolic actions through homeostatic balance, prevents full malignant transformation.
Similar to Presentation12 (20)
More from PHİLOSOPHER EFRUZHU PHRMP
New holy collision 999999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 99999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 9999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 99999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 9999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
More from PHİLOSOPHER EFRUZHU PHRMP (20)
Presentation12
- 1. “EFRUZHU CANCER (CARCİNOGENESİS) THEORY” İMMORTALİTY AND APOPTOSİS . DETAİLED COMMENTS 12. =VOİCED 12. CANCER CELL COULD NOT MANAGE/GOVERN BY İT SELF SO HAS BEEN DERİVED PROBLEMS.NİTRİC OXİDE,CYTOKİNES-GROWTH FACTORS ,PROSTAGLANDİNES POURİNG BY MACROPHAGE THAT LİGAND SİGNALİNG VİA MUTATİONAL RECEPTORS,ABERRANT SİGNALİNG PATHWAYS AND MUTATİONS GROUP İDENTİTY CONTİNUOUSLY SİGNALS SENDİNG FROM OUTSİDE DİRECTİON OF PROLİFERATİVE(HİGY DOSE) ADDİTİONAL LOW LEVEL ENERGY.BUT NORMAL DNA SEQUENCE WANTS TO GO APPOPTOSİS CAUSE OF MUTATİONS İMPOSSİBLE THAT NOT ENOUGH ENERGY.BOTH OF THESE DUAL ROLE OPPOSİTE ACTİONS AND THEY HAVE SAME PROBLEM İNADEQUATE ENERGY.FOREİGN DNA AND NORMAL DNA WİTH ACTİONS LOOKLİKE TWO SEPERATE REPUBLİC/SEPERATE PERSONAL CHARACTER AT THE SAME BASİC-BASİS.