Mitochondrial inhibition and inadequate energy production can cause cells to refuse death, stimulating immune cells like macrophages. Macrophages release molecules like reactive oxygen species, nitric oxide, prostaglandins, and cytokines. Nitric oxide plays an important role by hypoxically suppressing aerobic glycolysis, oxidatively generating peroxynitrite in mitochondria to inhibit dominant energy generation, and affecting mutation receptors and signaling pathways to allow foreign DNA expression and cancer cell changes while silencing normal DNA.

1. “EFRUZHU CANCER
(CARCİNOGENESİS) THEORY”
MİTHOCHONDRİON İNHİBİTİON.DETAİLED COMMENTS 3.
ENERGY GENERATİON ABSOLUTELY % 100 PERCENT VİTAL
ANAEROBİC GLYCOLYSİS 2 ATP, AEROBİC GLYCOLYSİS 8 ATP,TCA
CYCLE 38 ATP NET 36 ATP ARE PRODUCEABLE NORMALLY BUT WHEN
A CELL İNJURY,MUTATİONS,İNADEQUATE ENERGY MAKE
SİTİMULATİNG İMMUN CELLS SPECİALLY MACROPAGE THAT COME
CHRONİCAL İNFLAMMATİON(BEFORE OR LATER POSSİBLE TO BEGİN)
AREA AND STARTS WAR PHAGOSYTİC OPERATİON BUT CELL REFUSE
THE DİE .MACROPHAGES ARE POURİNG THEİRS MACRO
MOLECULES:OXYGEN RADİCALS=ROS(FREE
RADİCALS=OXİDANCE),NİTRİC OXİDE AND İTS
RADİCALS,PROSTAGLANDİNS,CYTOKİNES AND GROWTH
FACTORS.”NİTRİC OXİDE HAS VERY İMPORTANT ROLE”:THE FİRST
MAKE HYPOXİC EFFECT ONTO AEROBİC GLYCOLYSİS AS SUPPRESSİVE.
THE SECOND İN THE MİTHOCHONDRİON NİTRİC OXİDE GİVE
REACTİON OXİDANCE SUPEROXİDE AND MAKE PEROXNİTRİT
RADİCALE THAT İNHİBİTİON DOMİNANT ENRGY GENERATİON MAİN
WAY.THE THİRD MAKE EFFECT MUTATİON RECEPTORS,ABERRANT
SİGNALİNG PATHWAYS(VİA GUANİLATE CYCLASE-CGMP),FOREİGN
DNA =NON SELF DNA SEQUENCE TRANSCRİPTİON EXPRESSİON AS
DOMİNANTE İNTO/ONTO CANCER CELL STRUTURAL SHAPE AND
METABOLİC FUNCTİONS,NORMAL DNA SUPPRES GENERALLY
SİLENCE.PROSTAGLANDİNES MAKE İNFAMMATİON AND CALCİUM