Efruzhu cancer 12
•Download as DOCX, PDF•
0 likes•64 views
The document discusses a theory of cancer carcinogenesis. It states that cancer cells cannot govern themselves and have derived problems. Macrophages pour nitric oxide, cytokines, growth factors, and prostaglandins onto cancer cells via mutated receptors and aberrant signaling pathways. These signals continuously direct proliferative and additional low level energy from outside sources. However, normal DNA sequences want to undergo apoptosis due to mutations, but there is not enough energy for this. Both proliferative and apoptotic actions have opposing dual roles and share the problem of inadequate energy. Foreign and normal DNA act like two separate republics with separate characteristics at the same basic level.
Report
Share
Report
Share
Recommended
Presentation12
The document discusses cancer cell immortality and apoptosis. It states that cancer cells cannot govern themselves and have derived problems. Macrophages pour nitric oxide, cytokines, growth factors, and prostaglandins onto cancer cells via mutated receptors and aberrant signaling pathways. These signals continuously direct cancer cells to proliferate. However, normal DNA wants to undergo apoptosis due to mutations but lacks sufficient energy. Both cancer cells and normal DNA have opposing actions but share the same problem of inadequate energy. The document likens foreign and normal DNA within cancer cells to having separate identities or personalities.
Plegable biomol
Researchers discovered a protein involved in cancer metastasis that also inhibits two proteins linked to neurodegenerative diseases. They also identified a non-coding RNA called INXS that modulates a gene important for apoptosis. In mouse studies, tumors treated with INXS decreased in size compared to controls. Both studies could help develop future cancer treatments by inhibiting metastasis genes or activating apoptosis through increasing INXS expression.
Plegable pp1
Eukaryotic DNA is organized differently than prokaryotes, containing multiple chromosomes made of linear DNA molecules packaged around histone proteins to form chromatin. The cell cycle regulates cell division, ensuring daughter cells receive a full copy of the genome through DNA replication and cell growth or repair. Researchers found inhibiting signaling pathways in brain cancer cells stopped their reproduction and migration, making them more sensitive to chemotherapy. Studying chromatin remodeling genes in pancreatic cancer showed restoring expression of missing genes slowed cancer cell growth and induced senescence.
Plegable pp1
Eukaryotic DNA is organized differently than prokaryotic DNA, containing multiple chromosomes made of linear DNA molecules packaged around histone proteins to form chromatin. The cell cycle regulates cell division, ensuring daughter cells receive a complete copy of the genome through DNA replication and cell growth or repair. Researchers found inhibiting signaling pathways in brain cancer cells stopped their reproduction and migration, making them more sensitive to chemotherapy. Studying chromatin remodeling genes in pancreatic cancer showed restoring expression of missing genes slowed cancer cell growth and induced senescence.
REPARATION AND GENE EXPRESSION
The document discusses recent scientific findings related to DNA repair and gene expression regulation. It describes a study that linked epigenetic mechanisms controlling gene expression to bone and joint damage in ankylosing spondylitis. The study examined 75 patients over several years, finding that genes are not always expressed and require triggers to start expression processes. Maintaining high DNA methylation can also relate to non-expression of genes. Separately, it mentions the discovery of a "DNA ambulance" motor protein complex in yeast cells that repairs damaged DNA, though inaccurately and in a way that could lead to cancer. Researchers are working to better understand these DNA repair mechanisms and how genomic damage relates to disease progression and pathology.
Cancer cell i̇mmortal dynami̇cs photos 13.
Cancer cells are immortal due to continuously sending signals to a group of mutations that overexpress anti-apoptotic genes and proteins, preventing cell death. This signaling and mutations originally come from outside influences. The normal DNA side wants to die but lacks adequate energy for apoptosis to fully occur, so cancer cell dynamics are dominantly governed by accumulated mutations.
Presentación3
This document discusses the central dogma of genetics, how DNA is replicated and transcribed into RNA which is then translated into protein. It also discusses how mutations in genes can cause cancer and be inherited. Scientists found that inherited susceptibility to bowel cancer was common among patients with a family history of the disease. Retroviruses can incorporate their RNA genome into host cell DNA using reverse transcriptase. Endogenous retroviruses make up around 5% of human DNA and may play a role in brain cell development and function. Understanding genetic mutations could help develop new cancer therapies like gene editing. Retroviruses may also be used in the future for gene therapy and cancer prevention.
DNA Stretching Mystery and Chaperone Enzyme Provides new Target for Cancer T...
Scientists have uncovered new insights into how DNA can stretch without nicks or loose ends, as was previously believed. They found that intact DNA stretches at the same force as nicked DNA, indicating the stretching mechanism is the same. Separately, researchers discovered that a chaperone enzyme involved in DNA repair is regulated by another protein called Cdc7. Controlling this chaperone enzyme may provide a new target for cancer therapies since inaccurate DNA repair can lead to cancer.
Recommended
Presentation12
The document discusses cancer cell immortality and apoptosis. It states that cancer cells cannot govern themselves and have derived problems. Macrophages pour nitric oxide, cytokines, growth factors, and prostaglandins onto cancer cells via mutated receptors and aberrant signaling pathways. These signals continuously direct cancer cells to proliferate. However, normal DNA wants to undergo apoptosis due to mutations but lacks sufficient energy. Both cancer cells and normal DNA have opposing actions but share the same problem of inadequate energy. The document likens foreign and normal DNA within cancer cells to having separate identities or personalities.
Plegable biomol
Researchers discovered a protein involved in cancer metastasis that also inhibits two proteins linked to neurodegenerative diseases. They also identified a non-coding RNA called INXS that modulates a gene important for apoptosis. In mouse studies, tumors treated with INXS decreased in size compared to controls. Both studies could help develop future cancer treatments by inhibiting metastasis genes or activating apoptosis through increasing INXS expression.
Plegable pp1
Eukaryotic DNA is organized differently than prokaryotes, containing multiple chromosomes made of linear DNA molecules packaged around histone proteins to form chromatin. The cell cycle regulates cell division, ensuring daughter cells receive a full copy of the genome through DNA replication and cell growth or repair. Researchers found inhibiting signaling pathways in brain cancer cells stopped their reproduction and migration, making them more sensitive to chemotherapy. Studying chromatin remodeling genes in pancreatic cancer showed restoring expression of missing genes slowed cancer cell growth and induced senescence.
Plegable pp1
Eukaryotic DNA is organized differently than prokaryotic DNA, containing multiple chromosomes made of linear DNA molecules packaged around histone proteins to form chromatin. The cell cycle regulates cell division, ensuring daughter cells receive a complete copy of the genome through DNA replication and cell growth or repair. Researchers found inhibiting signaling pathways in brain cancer cells stopped their reproduction and migration, making them more sensitive to chemotherapy. Studying chromatin remodeling genes in pancreatic cancer showed restoring expression of missing genes slowed cancer cell growth and induced senescence.
REPARATION AND GENE EXPRESSION
The document discusses recent scientific findings related to DNA repair and gene expression regulation. It describes a study that linked epigenetic mechanisms controlling gene expression to bone and joint damage in ankylosing spondylitis. The study examined 75 patients over several years, finding that genes are not always expressed and require triggers to start expression processes. Maintaining high DNA methylation can also relate to non-expression of genes. Separately, it mentions the discovery of a "DNA ambulance" motor protein complex in yeast cells that repairs damaged DNA, though inaccurately and in a way that could lead to cancer. Researchers are working to better understand these DNA repair mechanisms and how genomic damage relates to disease progression and pathology.
Cancer cell i̇mmortal dynami̇cs photos 13.
Cancer cells are immortal due to continuously sending signals to a group of mutations that overexpress anti-apoptotic genes and proteins, preventing cell death. This signaling and mutations originally come from outside influences. The normal DNA side wants to die but lacks adequate energy for apoptosis to fully occur, so cancer cell dynamics are dominantly governed by accumulated mutations.
Presentación3
This document discusses the central dogma of genetics, how DNA is replicated and transcribed into RNA which is then translated into protein. It also discusses how mutations in genes can cause cancer and be inherited. Scientists found that inherited susceptibility to bowel cancer was common among patients with a family history of the disease. Retroviruses can incorporate their RNA genome into host cell DNA using reverse transcriptase. Endogenous retroviruses make up around 5% of human DNA and may play a role in brain cell development and function. Understanding genetic mutations could help develop new cancer therapies like gene editing. Retroviruses may also be used in the future for gene therapy and cancer prevention.
DNA Stretching Mystery and Chaperone Enzyme Provides new Target for Cancer T...
Scientists have uncovered new insights into how DNA can stretch without nicks or loose ends, as was previously believed. They found that intact DNA stretches at the same force as nicked DNA, indicating the stretching mechanism is the same. Separately, researchers discovered that a chaperone enzyme involved in DNA repair is regulated by another protein called Cdc7. Controlling this chaperone enzyme may provide a new target for cancer therapies since inaccurate DNA repair can lead to cancer.
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
May is National Cancer Research Month. In recognition, here's a glimpse of key achievements in cancer research over the last 12 months (May 2010 - May 2011) at Cold Spring Harbor Laboratory, which has been an NCI-designated Cancer Center since 1987.
Folding
The document discusses recent discoveries in DNA and stem cells that are enabling new cancer treatments. It describes how the protein MutL helps repair DNA errors, and how this relates to hereditary cancers. It also discusses how stem cell research is helping understand tumor risk from stem cell therapies by identifying pathways for stem cell self-propagation and differentiation. The discoveries provide opportunities to develop targeted cancer therapies and better understand genetic diseases and stem cell behavior.
Muting lives news
1. Researchers identified a mutant gene, STAG2, that is commonly mutated in cancers like glioblastoma, malignant melanoma, and Ewing's sarcoma. When mutated, this gene causes abnormal chromosome counts leading to cancer.
2. Scientists developed an inexpensive method called CISH to detect ALK gene rearrangements in lung cancer patients. CISH was found to be as effective as the standard FISH method.
3. Understanding the roles and effects of mutated genes is important for advancing cancer treatments and medical practice. Further research on gene mutations can help develop new targeted therapies.
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both studies provide insights with potential medical applications like gene therapy for Down syndrome.
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
EACR Travel Grant Page
Dino Masic traveled to Cincinnati Children's Hospital from March to September 2014 to collaborate on developing a disease model for IGH-CEBPD B-cell precursor acute lymphoblastic leukemia. The project aims to recreate the genetic insults that initiate leukemia by transducing cord blood with a retroviral vector containing the IGH-CEBPD fusion partner. This mimics the patient phenotype and may help answer questions about cell lineage commitment. While there, Masic learned new techniques for developing disease models, including transducing cord blood and engrafting cells in animals. He is now integrating these techniques into his research group in Newcastle to further investigate the developmental mechanisms behind this leukemia subtype.
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
The BATCure Consortium will investigate Batten disease through 8 experimental work packages and 3 supporting work packages. The experimental work will focus on developing new models and tools, identifying therapeutic pathways and targets, natural disease history, identifying compound and gene therapy leads, and delivering new treatments to mice. The consortium involves 10 research groups, 3 companies, and 1 patient organization working to advance understanding of Batten disease and develop effective treatments.
FOLDING (Central dogma of genetics)
Eukaryotic cells have their genetic material in the nucleus, in the other side, prokaryotes have it dispersed in the cytoplasm.
From this DNA will be synthesized RNA, which will act as an intermediary, carrying genetic information from the nucleus to the ribosomes located in the cytoplasm to carry out protein synthesis.
genetic code consists of 64 triplets (codons) of nucleotides, each codon encodes for one of the 20 amino-acids used in the synthesis of proteins.
The study of the genetic code, allow s us identify mutations in specific genes, to detect diseases or predispositions to some pathologies such as those proposed by the articles, and with tan information, implement a PREVENTIVE MEDICINE.
Knowing the sequence of genes that cause certain genetic diseases, is essential for GENE THERAPY branch. In brief it consist in introduce a correct copy of the defective gene that was visualized into the cells, by some vectors, previously studied.
With the knowledge of genetic information, can be provided counseling before and after pregnancy to future parents (Give information about the diseases to which it is susceptible and existing treatments), having always instilled an ethical principle: THE HUMAN LIFE RESPECT.
Promote investigation in medicine basic areas, such as cell biology, molecular biology, biochemistry and pharmacology, with the aim of implement humanity solutions .
Tumor stem cell reprogramming as a driver of cancer as
This document discusses the concept of tumor stem cell reprogramming as an alternative model for how oncogenes drive cancer development. It proposes that oncogenic lesions can reprogram stem/progenitor cells by imposing a new, pathological differentiation program, rather than acting homogeneously within cancer cell populations. Experimental evidence from models of chronic myeloid leukemia and multiple myeloma supports this hypothesis by demonstrating that cancer stem cells can arise through a reprogramming-like process, and that oncogenes may act as "passengers" in this reprogramming rather than being required long-term. This tumor stem cell reprogramming concept could change our understanding of cancer development and open new opportunities for therapeutic intervention.
16. identification and characterization of cancer stem cells in liver cancer ...
16. identification and characterization of cancer stem cells in liver cancer ...Dr. Wilfred Lin (Ph.D.)
This document summarizes research on cancer stem cells (CSCs) in hepatocellular carcinoma (HCC). It first provides background on HCC as the 5th most common cancer and 3rd leading cause of cancer death, with risk factors including HBV/HCV infection, aflatoxin B1, alcohol, and obesity. It then defines CSCs as cells within tumors that self-renew and cause heterogeneous lineages. Studies identified a CD133+ subpopulation in HCC with CSC properties like tumorigenicity, self-renewal, differentiation, and chemoresistance. Further research showed this CD133+ CSC population contributes to chemoresistance through specific pathways and can be better characterized by APlegable/BioMol
This presentation discusses methods used in molecular biology like pulsed-field gel electrophoresis (PFGE) and whole genome sequencing (WGS) to detect errors in DNA, and their applications in detecting Listeria monocytogenes bacteria. PFGE and WGS analysis of Listeria samples from infected individuals was able to link outbreaks to contaminated apple sources. WGS identified two strains present in both pregnant and non-pregnant infected groups. Maintaining good hygiene practices can help reduce incidence of diseases like Listeriosis.
July 2011 Scientific News
This document discusses three main topics:
1) Pericytes, not glial cells, are the primary cell type that forms scar tissue after spinal cord injuries. In the absence of pericytes, lesions do not scar over properly.
2) Increased rigidity of cancer cells activates proteins associated with cancer growth and metastasis. Applying mechanical forces to cells mimics this effect.
3) Discovering the role of pericytes and cell rigidity may help scientists develop new treatments for spinal cord injuries and cancer respectively.
DNA REPLICATION
The document summarizes two scientific articles from ScienceDaily about recent discoveries related to cell division and DNA replication that could provide new insights into cancer. The first article discusses a discovery of a protein complex called Ska that helps anchor DNA and distribute it correctly as cells divide. Understanding this complex could help develop new anti-cancer drugs. The second article describes an international study that improves ability to predict hereditary cancer risk by better classifying genetic variants associated with Lynch syndrome. This allows more accurate genetic counseling and preventive measures for at-risk families.
SOJ Genetic Science
SOJ Genetic Science (SOJGS) is an Open Access Publication which aims to reveal the intriguing secrets encoded in the genetic codons. SOGS is a Scientific Journal that has dedicated itself for promoting genetic research and facilitating the application of this research in the fight against diseases. The deadliest of diseases like cancer and HIV can also be effectively managed by controlling the genetic pathways for these diseases.
SOJGS encompasses genomic constitution, gene expression & regulation, heredity, genetic variation, gene mutations and genomic evolution etc. in all life forms (plants, animals and microcellular organisms). The scope of the journal covers cell reproduction, protein synthesis, metabolic molecular pathways, immune mechanisms, disease transmission and molecular origin of diseases.
Efruzhu cancer 13.
The document discusses the role of cytokines, growth factors, and nitric oxide in cancer cell proliferation and differentiation. It states that high amounts of these substances cause cancer cells to constantly proliferate in an immature, cloned state as they are stimulated to divide. This creates metabolic stress for the cancer cells as they do not have enough time, energy, or biosynthesis capabilities to properly store lipids, nitrogen, and proteins. The low or normal amounts of these substances, on the other hand, have a differentiative effect and allow normal functions to occur step-by-step in a repairable manner.
Neuroblastoma research paper(2015)
in this research paper ,researchers found a new therapeutic drug that is SULFASALAZINE for the treatment of neuroblastoma that has a action on SEPIATERIN REDUCTASE
Clinical features of retinoblastoma
This document discusses the clinical features of retinoblastoma. It begins by covering the epidemiology, including that it typically presents within the first 3 years of life and can occur in adults in rare cases. It then discusses family history patterns and consanguinity. Several atypical presentations are described from studies in India. Common clinical features include leukocoria, strabismus, poor vision, and proptosis. Differential diagnoses for leukocoria include conditions like toxocara endophthalmitis and Coats disease. Rare presentations in adults and older children are also reviewed.
Genetic screening
Genetic screening uses techniques like karyotyping, amniocentesis, and preimplantation genetic diagnosis to detect abnormalities or predict diseases. Karyotyping examines chromosomes for changes in number or structure. Amniocentesis analyzes amniotic fluid to detect fetal abnormalities, while chorionic villus sampling analyzes placental tissue. Preimplantation genetic diagnosis screens embryos before implantation. Genetic screening can prevent birth of babies with diseases but also raises issues like determining which genes to screen and the economic and social impact of results.
More Related Content
What's hot
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
May is National Cancer Research Month. In recognition, here's a glimpse of key achievements in cancer research over the last 12 months (May 2010 - May 2011) at Cold Spring Harbor Laboratory, which has been an NCI-designated Cancer Center since 1987.
Folding
The document discusses recent discoveries in DNA and stem cells that are enabling new cancer treatments. It describes how the protein MutL helps repair DNA errors, and how this relates to hereditary cancers. It also discusses how stem cell research is helping understand tumor risk from stem cell therapies by identifying pathways for stem cell self-propagation and differentiation. The discoveries provide opportunities to develop targeted cancer therapies and better understand genetic diseases and stem cell behavior.
Muting lives news
1. Researchers identified a mutant gene, STAG2, that is commonly mutated in cancers like glioblastoma, malignant melanoma, and Ewing's sarcoma. When mutated, this gene causes abnormal chromosome counts leading to cancer.
2. Scientists developed an inexpensive method called CISH to detect ALK gene rearrangements in lung cancer patients. CISH was found to be as effective as the standard FISH method.
3. Understanding the roles and effects of mutated genes is important for advancing cancer treatments and medical practice. Further research on gene mutations can help develop new targeted therapies.
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both studies provide insights with potential medical applications like gene therapy for Down syndrome.
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
EACR Travel Grant Page
Dino Masic traveled to Cincinnati Children's Hospital from March to September 2014 to collaborate on developing a disease model for IGH-CEBPD B-cell precursor acute lymphoblastic leukemia. The project aims to recreate the genetic insults that initiate leukemia by transducing cord blood with a retroviral vector containing the IGH-CEBPD fusion partner. This mimics the patient phenotype and may help answer questions about cell lineage commitment. While there, Masic learned new techniques for developing disease models, including transducing cord blood and engrafting cells in animals. He is now integrating these techniques into his research group in Newcastle to further investigate the developmental mechanisms behind this leukemia subtype.
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
The BATCure Consortium will investigate Batten disease through 8 experimental work packages and 3 supporting work packages. The experimental work will focus on developing new models and tools, identifying therapeutic pathways and targets, natural disease history, identifying compound and gene therapy leads, and delivering new treatments to mice. The consortium involves 10 research groups, 3 companies, and 1 patient organization working to advance understanding of Batten disease and develop effective treatments.
FOLDING (Central dogma of genetics)
Eukaryotic cells have their genetic material in the nucleus, in the other side, prokaryotes have it dispersed in the cytoplasm.
From this DNA will be synthesized RNA, which will act as an intermediary, carrying genetic information from the nucleus to the ribosomes located in the cytoplasm to carry out protein synthesis.
genetic code consists of 64 triplets (codons) of nucleotides, each codon encodes for one of the 20 amino-acids used in the synthesis of proteins.
The study of the genetic code, allow s us identify mutations in specific genes, to detect diseases or predispositions to some pathologies such as those proposed by the articles, and with tan information, implement a PREVENTIVE MEDICINE.
Knowing the sequence of genes that cause certain genetic diseases, is essential for GENE THERAPY branch. In brief it consist in introduce a correct copy of the defective gene that was visualized into the cells, by some vectors, previously studied.
With the knowledge of genetic information, can be provided counseling before and after pregnancy to future parents (Give information about the diseases to which it is susceptible and existing treatments), having always instilled an ethical principle: THE HUMAN LIFE RESPECT.
Promote investigation in medicine basic areas, such as cell biology, molecular biology, biochemistry and pharmacology, with the aim of implement humanity solutions .
Tumor stem cell reprogramming as a driver of cancer as
This document discusses the concept of tumor stem cell reprogramming as an alternative model for how oncogenes drive cancer development. It proposes that oncogenic lesions can reprogram stem/progenitor cells by imposing a new, pathological differentiation program, rather than acting homogeneously within cancer cell populations. Experimental evidence from models of chronic myeloid leukemia and multiple myeloma supports this hypothesis by demonstrating that cancer stem cells can arise through a reprogramming-like process, and that oncogenes may act as "passengers" in this reprogramming rather than being required long-term. This tumor stem cell reprogramming concept could change our understanding of cancer development and open new opportunities for therapeutic intervention.
16. identification and characterization of cancer stem cells in liver cancer ...
16. identification and characterization of cancer stem cells in liver cancer ...Dr. Wilfred Lin (Ph.D.)
This document summarizes research on cancer stem cells (CSCs) in hepatocellular carcinoma (HCC). It first provides background on HCC as the 5th most common cancer and 3rd leading cause of cancer death, with risk factors including HBV/HCV infection, aflatoxin B1, alcohol, and obesity. It then defines CSCs as cells within tumors that self-renew and cause heterogeneous lineages. Studies identified a CD133+ subpopulation in HCC with CSC properties like tumorigenicity, self-renewal, differentiation, and chemoresistance. Further research showed this CD133+ CSC population contributes to chemoresistance through specific pathways and can be better characterized by APlegable/BioMol
This presentation discusses methods used in molecular biology like pulsed-field gel electrophoresis (PFGE) and whole genome sequencing (WGS) to detect errors in DNA, and their applications in detecting Listeria monocytogenes bacteria. PFGE and WGS analysis of Listeria samples from infected individuals was able to link outbreaks to contaminated apple sources. WGS identified two strains present in both pregnant and non-pregnant infected groups. Maintaining good hygiene practices can help reduce incidence of diseases like Listeriosis.
July 2011 Scientific News
This document discusses three main topics:
1) Pericytes, not glial cells, are the primary cell type that forms scar tissue after spinal cord injuries. In the absence of pericytes, lesions do not scar over properly.
2) Increased rigidity of cancer cells activates proteins associated with cancer growth and metastasis. Applying mechanical forces to cells mimics this effect.
3) Discovering the role of pericytes and cell rigidity may help scientists develop new treatments for spinal cord injuries and cancer respectively.
DNA REPLICATION
The document summarizes two scientific articles from ScienceDaily about recent discoveries related to cell division and DNA replication that could provide new insights into cancer. The first article discusses a discovery of a protein complex called Ska that helps anchor DNA and distribute it correctly as cells divide. Understanding this complex could help develop new anti-cancer drugs. The second article describes an international study that improves ability to predict hereditary cancer risk by better classifying genetic variants associated with Lynch syndrome. This allows more accurate genetic counseling and preventive measures for at-risk families.
SOJ Genetic Science
SOJ Genetic Science (SOJGS) is an Open Access Publication which aims to reveal the intriguing secrets encoded in the genetic codons. SOGS is a Scientific Journal that has dedicated itself for promoting genetic research and facilitating the application of this research in the fight against diseases. The deadliest of diseases like cancer and HIV can also be effectively managed by controlling the genetic pathways for these diseases.
SOJGS encompasses genomic constitution, gene expression & regulation, heredity, genetic variation, gene mutations and genomic evolution etc. in all life forms (plants, animals and microcellular organisms). The scope of the journal covers cell reproduction, protein synthesis, metabolic molecular pathways, immune mechanisms, disease transmission and molecular origin of diseases.
Efruzhu cancer 13.
The document discusses the role of cytokines, growth factors, and nitric oxide in cancer cell proliferation and differentiation. It states that high amounts of these substances cause cancer cells to constantly proliferate in an immature, cloned state as they are stimulated to divide. This creates metabolic stress for the cancer cells as they do not have enough time, energy, or biosynthesis capabilities to properly store lipids, nitrogen, and proteins. The low or normal amounts of these substances, on the other hand, have a differentiative effect and allow normal functions to occur step-by-step in a repairable manner.
Neuroblastoma research paper(2015)
in this research paper ,researchers found a new therapeutic drug that is SULFASALAZINE for the treatment of neuroblastoma that has a action on SEPIATERIN REDUCTASE
Clinical features of retinoblastoma
This document discusses the clinical features of retinoblastoma. It begins by covering the epidemiology, including that it typically presents within the first 3 years of life and can occur in adults in rare cases. It then discusses family history patterns and consanguinity. Several atypical presentations are described from studies in India. Common clinical features include leukocoria, strabismus, poor vision, and proptosis. Differential diagnoses for leukocoria include conditions like toxocara endophthalmitis and Coats disease. Rare presentations in adults and older children are also reviewed.
Genetic screening
Genetic screening uses techniques like karyotyping, amniocentesis, and preimplantation genetic diagnosis to detect abnormalities or predict diseases. Karyotyping examines chromosomes for changes in number or structure. Amniocentesis analyzes amniotic fluid to detect fetal abnormalities, while chorionic villus sampling analyzes placental tissue. Preimplantation genetic diagnosis screens embryos before implantation. Genetic screening can prevent birth of babies with diseases but also raises issues like determining which genes to screen and the economic and social impact of results.
What's hot (18)
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
2016 BDSRA Mole CLN1, CLN2, CLN3, CLN5, CLN6, CLN7,
Tumor stem cell reprogramming as a driver of cancer as
Tumor stem cell reprogramming as a driver of cancer as
16. identification and characterization of cancer stem cells in liver cancer ...
16. identification and characterization of cancer stem cells in liver cancer ...
More from PHİLOSOPHER EFRUZHU PHRMP
New holy collision 999999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 99999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 9999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 999999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 99999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 9999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
New holy collision 999
1. APEX DEGREE MEDICAL PHILOSOPHER EFRUZHU1 PHRMP "HOLY COLLISION" THEORYEM NCY. TCY ®© INSTEAD OF BIG BANG THEORY
https://essafihucancertrea.wixsite.com/universalspaceallahu …
https://www.flickr.com/photos/efruzhucancerfinished/ …
THE BIG BANG THEORY AND THE EVOLUTIONARY THEORY THE END COMPLETELY FINISHED
More from PHİLOSOPHER EFRUZHU PHRMP (20)
Efruzhu cancer 12
- 1. “EFRUZHU CANCER (CARCİNOGENESİS) THEORY” İMMORTALİTY AND APOPTOSİS . DETAİLED COMMENTS 12. CANCER CELL COULD NOT MANAGE/GOVERN BY İT SELF SO HAS BEEN DERİVED PROBLEMS.NİTRİC OXİDE,CYTOKİNES-GROWTH FACTORS ,PROSTAGLANDİNES POURİNG BY MACROPHAGE THAT LİGAND SİGNALİNG VİA MUTATİONAL RECEPTORS,ABERRANT SİGNALİNG PATHWAYS AND MUTATİONS GROUP İDENTİTY CONTİNUOUSLY SİGNALS SENDİNG FROM OUTSİDE DİRECTİON OF PROLİFERATİVE(HİGY DOSE) ADDİTİONAL LOW LEVEL ENERGY.BUT NORMAL DNA SEQUENCE WANTS TO GO APPOPTOSİS CAUSE OF MUTATİONS İMPOSSİBLE THAT NOT ENOUGH ENERGY.BOTH OF THESE DUAL ROLE OPPOSİTE ACTİONS AND THEY HAVE SAME PROBLEM İNADEQUATE ENERGY.FOREİGN DNA AND NORMAL DNA WİTH ACTİONS LOOKLİKE TWO SEPERATE REPUBLİC/SEPERATE PERSONAL CHARACTER AT THE SAME BASİC-BASİS.