2. WHAT IS NEEDLE-FREE
INJECTION TECHNOLOGY
Brief Introduction :
oNeedle-free injection systems are novel ways to introduce various
medicines into patients without piercing the skin with a
conventional needle.
oNeedle-free injection techniques can be used to administer
vaccines and medications in the pork industry.
oThey are promoted as a possible option for patients with needle
phobia.
4. NANO PATCH
o This is the latest form of needle free drug delivery system where a patch
contains a medicament and is placed on the skin.
o Nano-patch has a specially designed surface having approximately 20,000
micro-projections per square centimeter. The size of the patch is about the
size of a stamp used in postal services.
o Micro-projections hold the drug in extreme minute volume. Due to the
presence of a high number of micro-projections a sufficient volume of drug
is delivered.
5. JET PRESSURE NEEDLE
FREE INJECTION
o Needle-free injectors use jet pressure to inject the drug rapidly into
the tissue at the correct depth.
o The jet is achieved by forcing the drug through a specially designed
nozzle, which is completed in only 300 milliseconds.
o There is no puncture when the Jet Pressured Needle free Injection is
used , due to the specially developed nozzle the drug penetrates
through a skin pore and is immediately dispersed into the epidermis,
thus enabling a faster transport to the body.
7. MECHANISM OF
OPERATION
o A force is generated by the Injector Body which contains a spring that
drives the drug through an orifice at a very high speed.
o To deliver the drug quickly into the system’s blood circulation an ultra-
fine stream of fluid penetrates the skin layer.
o The whole process of delivering the injection takes place in less than 1/3
of a second. It occurs in three stages -
1. Peak pressure phase - It is optimal pressure required for penetrating the skin
which lasts about less than 0.025 sec.
2. Dispersion phase - This phase lasts about 0.2 sec.
3. The drop-off phase - which lasts about less than 0.05 sec. ……(1/2)
8. MECHANISM OF
OPERATION
o The diagram above shows the mechanism of drug delivery of a Needle and
a Jet pressured Needle Free Injection. Diagram on the left shows the
needle based delivery where there is a distinct puncture of the skin surface
and the drug after delivery gets trapped for a while without being diffused
immediately.
o On the other hand, there is no puncture when the Jet Pressured Needle
free Injection is used , due to the specially developed nozzle the drug
penetrates through a skin pore and is immediately dispersed into the
epidermis, thus enabling a faster transport to the body. ……(2/2)
9. ADVANTAGES OF NEEDLE-
FREE INJECTION
TECHNOLOGY
o Painless Procedure.
o Relief to patients who have to be administered with Transdermal
Inoculation many times a day.
o Pandemic effective.
o Self administrable.
o Zero Contamination.
o Better drug diffusion.
o Zero disposal Hazard .
10. WHY THERE IS A NEED OF
NEEDLE-FREE
INJECTIONS
o Needle Phobia- 10-15% of the population has a fear of Needles, Which causes
avoidance of treatment which leads to serious issues.
o Bloodborne pathogens- Needlestick injury exposes healthcare workers to over
20 different bloodborne pathogens including
o Insulin- A survey in 2014 revealed that 422 millions (42.2 Crore) people had
Type II Diabetes. Such patients have to be administered with insulin at regular
intervals to keep a check on their blood sugar levels. Needle free Injection
Technology thus comes as a blessing to such people.
HIV, Hepatits B, Hepatitis C.
11. BRANDS IN THE
MARKET
oInjex30 (Mfd. By: Injex UK Ltd)
oPharmajet Tropis (Mfd. By: Pharmajet, Inc.)
oSDI Injector (Mfd. By: Glide Pharmaceutical Technology)
oBiojectorr 2000 (Mfd. By: iHealthNet LLC)
oVitajet 3 (Mfd. By: Medgadget, LLC)
oSeroJet (Mfd. By: Serojet Freight Private Limited)
oMedi-Jector VISION (Mfd. By: Antares Pharma, Inc.)
oIject (Mfd. By: Biojet, Inc.)
Special Mention:
RECOJET : Recojet is the Indias first needle-free insulin which comes with Antares
Pharma’s Medi-Jector and is distributed by Mumbai-based Shreya Life Sciences.
13. LIMITATIONS OF NEEDLE-
FREE INJECTION
TECHNOLOGY
o High pressure delivery of drugs by the Jet pressured needle free Injection can
damage fragile molecules beneath our skin surface, especially Monoclonal
antibodies.
o This can be resolved if a specialized device is employed to control the exact
pressure of drug delivery.
o Though this problem is faced only by patients who undergo multiple
inoculations within a short period of time thus is not of a major concern for the
generally ill patients or patients for vaccination.
14. CONCLUSION
o Needle free technology are capable of delivering a wide spectrum of
medicinal formulations into the body with the same bioequivalence as that
which could have been achieved by drug administration by a two-piece
syringe system, without inflating unnecessary pain to the patients.
o These devices are very easy to be used, don't require any expert
supervision or handling, easy to store, and dispose.
