The document discusses how multipotent stem cells found in adults can differentiate into various cell types and have potential applications in organ replacements and tissue engineering. It describes how nanofibrous scaffolds that mimic the extracellular matrix can be used as platforms to support stem cell growth and differentiation for therapeutic tissue regeneration. The conclusion suggests that integrating nanotechnologies with stem cell research holds promise for advancing stem cell-based medical therapies.

1. khushifairy

2. Conclusion

4. Dima Sheyn
Gadi Pelled
Dan Gazit
Hebrew University
of Jerusalem

6. Presence of
Multipotent stem Open up new
cells in adults Therapeutic
Opportunities
play a vital role in Organ replacements and
Tissue-engineering approaches

7. MSCs give rise to a variety of cell
types
Bone Fat
cells cells
Connective
Cartilage
tissue cells
cells
(in tendons)

9. Provides
the Stromal
Support System for
hematopoietic stem
cells in the Bone
marrow

11. It is possible that cells that play a part
in the connective tissue differentiation
may be good candidates to serve as a
platform for
Therapeutic Tissue
Regeneration

12. Transplanted
Host’s MSCs (a engineered
paracrine effect) MSCs (an
autocrine effect)

13. Gazit laboratory (cont’d)

14. Gazit laboratory (cont’d)
Adhesion
Engineered Contribute not
MSCs only to the
Integration
Efficiency of
Localization Bone
properties
Formation but
also to its
Host’s Native
Migration Structure
MSCs
properties

16. Nanotechnologies (cont’d)

22. Nanofibrous Scaffolds (cont’d)

23. Nanofibrous Scaffolds (cont’d)

25. Phase Electro
Drawing separation spinning
Template Self-
synthesis assembly
have been used to prepare polymer Nanofibers
in recent years.

26. ECM is the main component of all types of
connective tissues (bone, cartilage, tendon and
blood vessels)
So, most Nanoscaffolds and related stem-
cell applications will be associated with
the engineering of connective tissues.

27. As Stem cells are able to proliferate and
differentiate into required tissue, but they
need a 3-dimensional structure for their
growth and support.
So, the Nanofibrous scaffolds are
combined with stem cells in tissue
engineering.

29. ECM Composition (cont’d)

31. Ranging
Composed of a from 500
copolymer to 800 nm
PLGA fibers in
(poly lactic-co- diameter
glycolic acid)
Their morphological characteristics were
similar to those of the ECM in natural
tissue.

37. Nerve Stem cells (cont’d)

38. Conclusion

39. Conclusion
Nanotechnologies are beginning to be implemented as
analytical and production tools in stem cell–based
therapeutic approaches.
Only a few tools available in the field of nanoscience have
been made available to advance the use of stem cells in
medicine

40. L'avenir
The gap between scientists
traditionally involved in
nanoscience and scientists
dealing with biotechnology will
be bridged during the coming
years, leading to an increased
use of nanotools in biomedicine.

41. The future looks bright…
We envision the application of nanotechnology in studies of:

42. Totally radical future
No doubt, this will drive stem-cell therapy closer to
clinical application in human beings.