Transcription in eucriotes,_procariotes_and_rna_processing 2

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Transcription in eucriotes,_procariotes_and_rna_processing 2

  1. 1. TRANSCRIPTION IN EUCRIOTES, PROCARIOTES AND RNA PROCESSING Michelle Silvera Valera ID. 000172227 Third Semester Medicine- UPB
  2. 2. FOLDING
  3. 3. FOLDING
  4. 4. INTRODUCTION
  5. 5. INTRODUCTION <ul><li> Transcription </li></ul><ul><li>DNA single chain </li></ul><ul><li>RNA polymerases </li></ul><ul><li>+ promoter + other Maturing RNA </li></ul><ul><li>RNA </li></ul><ul><li>Introns exons </li></ul><ul><li>splicing </li></ul>
  6. 6. Age-Related Macular Degeneration: Key Mechanism in Geographic Atrophy Identified, Two Possible Therapies  ScienceDaily (Feb. 7, 2011)
  7. 7. Age-Related Macular Degeneration: Key Mechanism in Geographic Atrophy Identified, Two Possible Therapies   <ul><li>Alu RNA accumulates </li></ul><ul><li> in retina </li></ul><ul><li>It causes macular </li></ul><ul><li> degenaration </li></ul><ul><li>and death of retina </li></ul><ul><li>cells </li></ul>http://www.sciencedaily.com/releases/2011/02/110206132904.htm
  8. 8. Age-Related Macular Degeneration: Key Mechanism in Geographic Atrophy Identified, Two Possible Therapies <ul><li> Accumulation </li></ul><ul><li>due to </li></ul><ul><li> decreased levels of </li></ul><ul><li>“ dicer” enzyme </li></ul><ul><li> which </li></ul><ul><li>Degradates Alu RNA </li></ul>
  9. 9. Age-Related Macular Degeneration: Key Mechanism in Geographic Atrophy Identified, Two Possible Therapies <ul><li>Two Possible Solutions were proposed </li></ul><ul><li>Increase “dicer” Block Alu RNA </li></ul><ul><li>enzyme </li></ul>
  10. 10. Age-Related Macular Degeneration: Key Mechanism in Geographic Atrophy Identified, Two Possible Therapies <ul><li>STUDENT OBSERVATION </li></ul><ul><li>  </li></ul><ul><li>I think that this discovery has not only a relevant implication in the physiopatology of the Geographic Atrophy, it is also important to develop a treatment to heel the condition and even more, to prevent it. This will give a hope to those patients with the illness or to those who are prone to it. </li></ul><ul><li>Moreover, this news shows us that is important to investigate about the RNA processing and how can it be related to pathologies. </li></ul><ul><li>  </li></ul>
  11. 11. Advance Could Speed Use of Genetic Material RNA in Nanotechnology ScienceDaily (Jan. 19, 2011)
  12. 12. Advance Could Speed Use of Genetic Material RNA in Nanotechnology <ul><li>A change in the sugar ring </li></ul><ul><li>of the RNA, averts the effect </li></ul><ul><li>of the enzyme RNAse in this </li></ul><ul><li>molecule, making the RNA </li></ul><ul><li>more stable </li></ul>Enzyme RNAse
  13. 13. Advance Could Speed Use of Genetic Material RNA in Nanotechnology <ul><li>The RNA stability was proved </li></ul><ul><li>introducing a nanomotor of </li></ul><ul><li>bacteriophague phi29 in a </li></ul><ul><li>bacteria </li></ul><ul><li>The nanomotor, based on </li></ul><ul><li>modified RNA didn´t got </li></ul><ul><li>degraded even in the </li></ul><ul><li>presence of RNAse </li></ul>
  14. 14. Advance Could Speed Use of Genetic Material RNA in Nanotechnology <ul><li> </li></ul><ul><li>This modified RNA is useful in </li></ul><ul><li>nanotechnology because it is </li></ul><ul><li>not easily degraded and it </li></ul><ul><li>can adopt a 3D structure. </li></ul><ul><li>This discovery can be useful </li></ul><ul><li>in the development of </li></ul><ul><li>treatments for cancer </li></ul>
  15. 15. Advance Could Speed Use of Genetic Material RNA in Nanotechnology <ul><li>STUDENT OBSERVATION </li></ul><ul><li>I think that it is amazing that just change in a molecule ( RNA ) can adapt it to be part of a nanostructure, and I think it is even more amazing that the modified RNA through this nanotechnology can be useful in sick people, like in cancer patients. </li></ul><ul><li>  I also think that this nanotechnology allows the development of a new less invasive therapies due to its small size. </li></ul><ul><li>  </li></ul>
  16. 16. MEDICAL UTILITY
  17. 17. MEDICAL UTILITY <ul><li>Age-Related Macular Degeneration: Key Mechanism in Geographic Atrophy Identified, Two Possible Therapies   </li></ul><ul><li>Patients who suffer from Geographic Atrophy can have a hope due to the therapies that can be developed based on this scientific advance. </li></ul>
  18. 18. MEDICAL UTILITY <ul><li>Advance Could Speed Use of Genetic Material RNA in Nanotechnology </li></ul><ul><li>With this nanotechnolgy,based on RNA, therapies for cancer can be developed. </li></ul>
  19. 19. MEDICAL UTILITY <ul><li>Both discoveries can be used in the development of a mechanism in which illnesses can be prevented, for example the Geographic Atrophy, Cancer or another. </li></ul><ul><li>That prevention will allow a better perspective to those patients prone to suffer that illnesses. </li></ul>
  20. 20. BIBLIOGRAPHY <ul><li>MARTINEZ SANCHEZ Lina Maria. Libro de Clase Biología Molecular.6 ed.Editorial Universidad Pontificia Bolivariana.2011, pág 85, 95. </li></ul><ul><li>University of Kentucky. &quot;Age-related macular degeneration: Key mechanism in geographic atrophy identified, two possible therapies.&quot; ScienceDaily 7 February 2011. 25 February 2011 <http://www.sciencedaily.com­ /releases/2011/02/110206132904.htm>. </li></ul><ul><li>University of Cincinnati Academic Health Center. &quot;Advance could speed use of genetic material RNA in nanotechnology.&quot; ScienceDaily 19 January 2011. 25 February 2011 <http://www.sciencedaily.com­ /releases/2011/01/110119125312.htm>. </li></ul>
  21. 21. THANKS !!!

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