Machine learning with Python is a guide to applying machine learning using the Python programming language. It discusses why machine learning is important due to growing data and a shortage of data analysts. Machine learning has applications in astronomy, healthcare, automotive, finance, gaming, and agriculture. The guide also provides an overview of the data science process, which incorporates skills from computer science, statistics, and mathematics to extract knowledge from large datasets and apply insights to solve problems. It discusses the relationships between artificial intelligence, machine learning, deep learning, and data science. Finally, it outlines the steps to learn data science, including choosing a programming language, machine learning algorithms, IDEs, data visualization, and more.