Poster 27 biochimie
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1) The study measured levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients presenting with cardiogenic shock without acute coronary syndrome to determine if Lp-PLA2 levels could predict outcomes. 2) Lp-PLA2 levels were elevated in patients with cardiogenic shock compared to healthy controls and were higher in those with ischemic cardiomyopathy. 3) Higher Lp-PLA2 levels were associated with worse cardiac outcomes, with a cutoff of 254 μg/L predicting major cardiac events.
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Poster 27 biochimie
- 1. Lipoprotein-associated Phospholipase A2 Levels: Prognostic Value in Cardiogenic Shock M. Daubord 1 , J.C. Charniot 1,2 , R. Khani-Bittar 1,3 , J.P. Albertini 4 , P. Giral 3,5 , C. Cherfils 1 , C. Cosson 6,7 , E. Guillerm 1 , D. Bonnefont-Rousselot 1,7 1 Department of Metabolic Biochemistry, La Pitié-Salpêtrière Hospital (AP-HP), Paris, France 2 AP-HP, Avicenne Hospital, Department of cardiology, Université Paris 13, UFR SMBH Bobigny, France 3 UPMC University Paris 06 UMR S 939 F-75013 Paris France 4 AP-HP Biochemistry Laboratory, Avicenne Hospital (AP-HP), Université Paris 13, UFR SMBH Bobigny, France 5 AP-HP Unité de prévention cardiovasculaire, Service d’Endocrinologie-Métabolisme Pitié-Salpêtrière Hospital, Paris, France 6 AP-HP Biochemistry Laboratory, Bicêtre Hospital, Le Kremlin-Bicêtre, France 7 Département de Biologie Expérimentale, Métabolique et Clinique, EA 4466, Faculté de Pharmacie, Université Paris Descartes, France 2011 Biochimie Biochemistry Poster 27
- 7. Results (2) Poster 27 Serial Lp-PLA2 assays: t0: upon admission; t1: dobutamine withdrawal; t2: after 1 month. (*: p<0.03: comparison Lp-PLA2 levels between t0 and t1). Lp-PLA2 decreased significantly upon Dobutamine withdrawal in ICM group: 266.3 ± 74.1 vs 208.1 ± 63.4 (-19.6%) p<0.03