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PCOS Dr. Mridula A Benjamin Dept of Obs and Gyn RIPAS Hospital, Brunei
Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object]
ASRM/ ESHRE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ultrasound    ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
Gross appearance of ovaries ,[object Object],[object Object],[object Object]
 
 
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Metabolic syndrome 3 of the following 1. Waist circumference >88cm 2. Triglycerides >150 mg/dl 3. HDL <50 mg/dl 4. Blood pressure > 130/85 5. Fasting Blood glucose 110-126  &/or 2-h glucose 140-199 mg/dl
Prevalence ,[object Object],[object Object],[object Object]
Pathogenesis (etiology?) ,[object Object],[object Object],[object Object],[object Object]
Cholesterol Pregnenolone Progesterone 17 OH-Pregnenolone 17 OH-Progesterone DHEA Androstenandion 17-20 Lyase 17  hydroxylase Theca cell Estrone estradiol Granulosa cell FSH LH OVARIAN STEROIDOGENESIS T
Obesity Insulin Free testosterone SHBG IGF-1 5-alfa reductase activity is stimulated IGF*** insulin like growth factor
Obesity and insulin resistance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Wt. increase Insulin receptor  disorder Insulin increase Free estradiol increase High LH Low FSH Free testosterone increase Androstenandione  increase SHBG decrease atresia Theca (IGF-I) Endometrial  cancer Testosterone increase Estrone increase hirsutism IGFBP-I  **** decrease IGFBP*** insulin like growth factor binding protein
Presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Laboratory studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Long term risks in PCOS ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Long term consequences
Management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Contd ,[object Object],[object Object],[object Object],[object Object]
STEPWISE APPROACH FOR OVULATION INDUCTION IN PCOS  (ACOG,2002 ) 1.   Weight loss: If BMI >30 K/m 2 2. Clomiphene citrate  3. CC + corticosteroids if DHES > 2ug/ml 4. CC + Metformin 5. Low dose FSH injection 6. Low dose FSH injection + Metformin 7. Ovarian drilling  8. IVF
 
Mx of Hirsutism ,[object Object],[object Object],[object Object],[object Object],[object Object]
Reproductive Endocrinologist ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Guidelines (RCOG, May 2003) ,[object Object],[object Object],[object Object],[object Object]
Guidelines (RCOG, May 2003) ,[object Object],[object Object]
Guidelines (RCOG, May 2003) ,[object Object],[object Object],[object Object]
Guidelines (RCOG, May 2003) ,[object Object]
Thank you

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Polikistik Over Sendromu - PCOS - www.jinekolojivegebelik.com

  • 1. PCOS Dr. Mridula A Benjamin Dept of Obs and Gyn RIPAS Hospital, Brunei
  • 2.
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  • 15. Metabolic syndrome 3 of the following 1. Waist circumference >88cm 2. Triglycerides >150 mg/dl 3. HDL <50 mg/dl 4. Blood pressure > 130/85 5. Fasting Blood glucose 110-126 &/or 2-h glucose 140-199 mg/dl
  • 16.
  • 17.
  • 18. Cholesterol Pregnenolone Progesterone 17 OH-Pregnenolone 17 OH-Progesterone DHEA Androstenandion 17-20 Lyase 17 hydroxylase Theca cell Estrone estradiol Granulosa cell FSH LH OVARIAN STEROIDOGENESIS T
  • 19. Obesity Insulin Free testosterone SHBG IGF-1 5-alfa reductase activity is stimulated IGF*** insulin like growth factor
  • 20.
  • 21. Wt. increase Insulin receptor disorder Insulin increase Free estradiol increase High LH Low FSH Free testosterone increase Androstenandione increase SHBG decrease atresia Theca (IGF-I) Endometrial cancer Testosterone increase Estrone increase hirsutism IGFBP-I **** decrease IGFBP*** insulin like growth factor binding protein
  • 22.
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  • 27.
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  • 29. STEPWISE APPROACH FOR OVULATION INDUCTION IN PCOS (ACOG,2002 ) 1. Weight loss: If BMI >30 K/m 2 2. Clomiphene citrate 3. CC + corticosteroids if DHES > 2ug/ml 4. CC + Metformin 5. Low dose FSH injection 6. Low dose FSH injection + Metformin 7. Ovarian drilling 8. IVF
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