This study evaluated the use of hand-held echocardiography (HHE) as point-of-care ultrasound scanning (POCUS) to detect potential sources of embolism in 130 patients with non-lacunar ischemic stroke within 24 hours of onset. Main sources of embolism (MSEs) detected by HHE included embolic valvulopathies and severe ventricular dysfunction, and were confirmed in 19.23% of patients by comparison with transthoracic echocardiography (TTE). Large vessel occlusion and chronic heart failure independently predicted the detection of MSEs. HHE also identified an enlarged left atrium as an independent predictor of later detection of atrial fibrillation in patients
Cardiac imaging in prosthetic paravalvular leaksPaul Schoenhagen
Abstract: Prosthetic paravalvular leaks (PVL) is an uncommon but serious complication after surgical valve replacement. Although surgery has been the traditional treatment of choice in hemodynamically significant PVL, percutaneous transcatheter closure is emerging as a novel and less invasive option for patients with high operative risk. Cardiac imaging, especially two- and three-dimensional transoesophageal echocardiography, plays an essential role in the diagnosis, guidance of intervention and subsequently in the evaluation of the outcomes of the procedure. The aim of this manuscript is to review the role of cardiac imaging techniques in the interventional management of patients with symptomatic PVL.
Safety, risk of complications and the functional feasibility among different kinds of central venous access are still a matter of debate.Not many clinical trials have reported a comparison of complications and patency of CVCs versus Peripherally Inserted Catheters (PICC) as central venous access for indoor patients with advanced gastrointestinal disorder. The aim of the present study was to compare CVCs and PICCs regarding function, complications and convenience in a controlled clinical study on patients aimed for oncology surgery aimed for cure.
Distributions of patients were comparable. Malignant diagnoses were significantly higher among CVC-patients. CVCs and PICCs were used for treatment during equal number of days, without any signifi cant complication rates and with comparable number of days on antibiotics and other potent drugs. The overall cumulative hazard (risk) for treatment interruptions, due to either full-filled clinical indications or due to any complication among the subgroups of patients did not differ.Central Venous Catheter and Peripheral Inserted Central Venous Catheter, for central venous access, did not differ among consecutive unselected patients with serious gastro-intestinal disorders.
Cardiac imaging in prosthetic paravalvular leaksPaul Schoenhagen
Abstract: Prosthetic paravalvular leaks (PVL) is an uncommon but serious complication after surgical valve replacement. Although surgery has been the traditional treatment of choice in hemodynamically significant PVL, percutaneous transcatheter closure is emerging as a novel and less invasive option for patients with high operative risk. Cardiac imaging, especially two- and three-dimensional transoesophageal echocardiography, plays an essential role in the diagnosis, guidance of intervention and subsequently in the evaluation of the outcomes of the procedure. The aim of this manuscript is to review the role of cardiac imaging techniques in the interventional management of patients with symptomatic PVL.
Safety, risk of complications and the functional feasibility among different kinds of central venous access are still a matter of debate.Not many clinical trials have reported a comparison of complications and patency of CVCs versus Peripherally Inserted Catheters (PICC) as central venous access for indoor patients with advanced gastrointestinal disorder. The aim of the present study was to compare CVCs and PICCs regarding function, complications and convenience in a controlled clinical study on patients aimed for oncology surgery aimed for cure.
Distributions of patients were comparable. Malignant diagnoses were significantly higher among CVC-patients. CVCs and PICCs were used for treatment during equal number of days, without any signifi cant complication rates and with comparable number of days on antibiotics and other potent drugs. The overall cumulative hazard (risk) for treatment interruptions, due to either full-filled clinical indications or due to any complication among the subgroups of patients did not differ.Central Venous Catheter and Peripheral Inserted Central Venous Catheter, for central venous access, did not differ among consecutive unselected patients with serious gastro-intestinal disorders.
A Study on Awareness of Needle sticks injury in students undergoing paramedic...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Content server (10)A randomized, controlled, double-blind prospective trial w...Missing Man
A randomized, controlled, double-blind prospective trial
with a Lipido-Colloid Technology-Nano-OligoSaccharide
Factor wound dressing in the local management of
venous leg ulcers
XXVII Reunión anual de la sección de Hemodinámica y Cardiología Intervencionista
16 y 17 de junio de 2016 León
http://secardiologia.es/xxvii-reunion-anual-de-la-seccion-de-hemodinamica-y-cardiologia-intervencionista
Aportaciones del grupo CORPAL en intervencionismo coronario
Alfonso Medina Fernández-Aceytuno (Hosp. Univ. Doctor Negrín. Las Palmas de Gran Canaria)
Journal of Ophthalmology & Visual Sciences is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Ophthalmology & Visual Sciences.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Ophthalmology & Visual Sciences. Journal of Ophthalmology & Visual Sciences accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Ophthalmology & Visual Sciences.
Journal of Ophthalmology & Visual Sciences strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
To describe the frequency, type, and clinical course
of hearing loss in Wegener’s granulomatosis and assess hearing
loss as an indicator of disease activity.
Early Detection of Left Ventricular Dysfunction in Type II Diabetic Patients ...Premier Publishers
To assess Left ventricular (LV) systolic dysfunction using 2D speckle tracking echocardiography (STE) in asymptomatic type II Diabetic patients. We acquired three LV short-axis, and three LV apical views in 100 asymptomatic diabetic patients with normal LV ejection fraction (EF) and 25 age-matched healthy volunteers. We measured end-systolic longitudinal strain (LS), radial strain (RS), and circumferential strain (CS) in 18 LV segments. There were no significant differences in LVEF between two groups. Diabetic patients had more advanced diastolic dysfunction and increased LV mass compared with controlled group. Basal, middle, and apical LSs were significantly lower in diabetic patients compared with control subjects, with 43% (43/100) of the diabetic patients showing abnormal global LS values (cut-off value: 217.2 mean 2SD in control subjects Conclusion: Detecting subclinical LV systolic dysfunction by using 2D speckle tracking echocardiography (STE) might provide useful information of the risk stratification in an asymptomatic diabetic population.
A Study on Awareness of Needle sticks injury in students undergoing paramedic...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Content server (10)A randomized, controlled, double-blind prospective trial w...Missing Man
A randomized, controlled, double-blind prospective trial
with a Lipido-Colloid Technology-Nano-OligoSaccharide
Factor wound dressing in the local management of
venous leg ulcers
XXVII Reunión anual de la sección de Hemodinámica y Cardiología Intervencionista
16 y 17 de junio de 2016 León
http://secardiologia.es/xxvii-reunion-anual-de-la-seccion-de-hemodinamica-y-cardiologia-intervencionista
Aportaciones del grupo CORPAL en intervencionismo coronario
Alfonso Medina Fernández-Aceytuno (Hosp. Univ. Doctor Negrín. Las Palmas de Gran Canaria)
Journal of Ophthalmology & Visual Sciences is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Ophthalmology & Visual Sciences.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Ophthalmology & Visual Sciences. Journal of Ophthalmology & Visual Sciences accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Ophthalmology & Visual Sciences.
Journal of Ophthalmology & Visual Sciences strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
To describe the frequency, type, and clinical course
of hearing loss in Wegener’s granulomatosis and assess hearing
loss as an indicator of disease activity.
Early Detection of Left Ventricular Dysfunction in Type II Diabetic Patients ...Premier Publishers
To assess Left ventricular (LV) systolic dysfunction using 2D speckle tracking echocardiography (STE) in asymptomatic type II Diabetic patients. We acquired three LV short-axis, and three LV apical views in 100 asymptomatic diabetic patients with normal LV ejection fraction (EF) and 25 age-matched healthy volunteers. We measured end-systolic longitudinal strain (LS), radial strain (RS), and circumferential strain (CS) in 18 LV segments. There were no significant differences in LVEF between two groups. Diabetic patients had more advanced diastolic dysfunction and increased LV mass compared with controlled group. Basal, middle, and apical LSs were significantly lower in diabetic patients compared with control subjects, with 43% (43/100) of the diabetic patients showing abnormal global LS values (cut-off value: 217.2 mean 2SD in control subjects Conclusion: Detecting subclinical LV systolic dysfunction by using 2D speckle tracking echocardiography (STE) might provide useful information of the risk stratification in an asymptomatic diabetic population.
Predictors of Ischaemia and Outcomes in Egyptian Patients with Diabetes Mellitus Referred for Perfusion Imaging. Samir Rafla*, Ahmed Abdel-Aaty, Mohamed Ahmed Sadaka, Aly Ahmed Abo Elhoda and Ahmed Mohamed Shams
Correlation Between ECG Changes and 2D Speckle Tracking Echocardiography with...Premier Publishers
The clinical presentation of acute coronary syndrome is variable Patients with suspected NSTE-ACS are a heterogeneous group. Coronary occlusion may or may not be present. To correlate 2D speckle tracking echocardiography with coronary angiography results in non-ST segment elevation myocardial infarction patients and test its ability to predict culprit lesion. It is a prospective study where 100 patients with non-ST elevation myocardial infarction were enrolled in the study where regional wall motion score index was obtained by echocardiography then 2D speckle tracking echocardiography was done and territorial longitudinal strain for each vessel was obtained and finally coronary angiography was done. By using the bull’s eye view of the territorial LS values obtained from the 17 myocardial segments to predict the culprit artery for each patient the sensitivity for prediction of culprit LAD was 93.3 %, specificity was 92.7 %, For LCX; sensitivity was 82.7 %, specificity was 92.9 % and for RCA; sensitivity was 84 %, specificity was 93.3 %. Longitudinal strain imaging by 2D speckle-tracking might help in the work-up of non-ST elevation myocardial infarction patients. In addition, it may be helpful to localize coronary artery stenosis in a given perfusion territory.
Background: Myocarditis is a relatively common inflammatory disease that affects the myocardium. Infectious disease accounts for most of the cases either because of a direct viral infection or post-viral immune-mediated reaction. Cardiovascular magnetic resonance (CMR) has become an established non-invasive diagnosis tool for acute myocarditis. A recent large single centre study with patients with biopsy-proven viral myocarditis undergoing CMR scans found a high rate of mortality. The aim of this study was to assess the rate of clinical events in our population of patients with diagnosed myocarditis by CMR scan.
Methods: Patients who consulted to the emergency department with diagnosis of myocarditis by CMR were retrospectively included in the study from January 2008 to May 2012. A CMR protocol was used in all patients, and were followed up to assess the rate of the composite endpoint of all-cause death, congestive heart failure, sudden cardiac death, hospitalization for cardiac cause, recurrent myocarditis or need of radiofrequency ablation or implantable cardiac defibrillator (ICD). A descriptive statistical analysis was performed.
Results: Thirty-two patients with myocarditis were included in the study. The mean age was 42.6±21.2 years and 81.2% were male. In a mean follow up of 30.4±17.8 months, the rate of the composite endpoint of all-cause death, congestive heart failure, sudden cardiac death, hospitalization for cardiac cause, recurrent myocarditis or need of radiofrequency ablation or ICD was 15.6% (n=5). Two patients had heart failure (one of them underwent heart transplant), one patient needed ICD because of ventricular tachycardia and two other patients were re-hospitalized, for recurrent chest pain and for recurrent myocarditis respectively.
Conclusions: In our series of acute myocarditis diagnosed by CMR we found a low rate of cardiovascular events without mortality. These findings might oppose data from recently published myocarditis trials.
Assessment of Intermediate Coronary Artery Lesion with Fractional Flow Reserv...Premier Publishers
Fraction flow reserve (FFR) is considered the gold standard for assessing intermediate coronary lesions. Retrospective data analyses showed variable relationship between intravascular ultrasound (IVUS) parameters and FFR results. This study aimed to determine the optimal minimum lumen area (MLA) by IVUS that correlates with FFR and to assess the correlation between two modalities in assessing intermediate coronary lesions. Methods: Fifty eight intermediate coronary lesions mainly located in proximal and mid segments of large main coronary vessels with RVD (3-4mm) were analyzed using both IVUS and FFR to assess the significance of coronary stenting and to determine the optimal IVUS-MLA that correlates with FFR value < 0.8. Results: IVUS-MLA ranged from 2.5 to 4.2 mm2 had a highly significant positive correlation with FFR value < 0.8 (p < 0.0001). Using the ROC curve analysis, IVUS-MLA < 3.9 mm2 (84.2% sensitivity, 80% specificity, area under curve (AUC) = 0.68) was the best threshold value for identifying FFR <0.8>< 0.8 in coronary vessels with RVD (3-4mm). Different MLA cutoffs should be used for different vessel diameters.
Role of Left Ventricular Mass Index Versus Left Ventricular Relative Wall Thi...Premier Publishers
In non-cardioembolic stroke patients, the cardiac manifestations of elevated blood pressure are of particular interest. The value of LV geometry in the prediction of cardiovascular risk is controversial. Many reports detected that left ventricular hypertrophy is independently associated with risk of ischemic stroke. The primary objective of this study was to identify the frequency of different patterns of altered left ventricular geometry in patients with non cardioembolic stroke, and to assess whether a significant number of patients will miss the diagnosis of LV remodeling if the left ventricular relative wall thickness(RWT) is not evaluated or reported. 100 patients were referred within 48 hours after an acute non cardioembolic ischemic stroke for a transthoracic echocardiogram. The echocardiographic findings were analyzed. Mean age was 61.86 ± 12.59 years, 45 % men. Concentric remodeling carried the highest frequency (43%), followed by normal pattern (27%), concentric hypertrophy (22%), and eccentric hypertrophy (8%). The frequency of abnormal left ventricular RWT (61.4%) was significantly higher than that of abnormal LVMI.
Introduction: There is growing evidence that Obstructive Sleep Apnea (OSA) is a risk factor for Pulmonary Embolism (PE). This
association represents a major public health burden.Aims and Objectives: To investigate Computed Tomography Obstruction Index (CTOI) and the Right Ventricular (RV) to Left Ventricular (LV) diameter ratio with OSA severity. Materials and Methods: 46 Patients with (PE) were evaluated for OSA. Pulmonary Artery Obstruction Index (PAOI) and RV/ LV diameter ratio was measured by pulmonary angiography. Pulmonary Embolism Severity Index (PESI) was determined. Epworth Sleepiness Scale (ESS) and Polysomnography (PSG) was performed for all patients. Based on the PAOI, patients divided into (< 15%, 15-50%, > 50%).
The Association of Left Atrial Enlargement in Different Subtypes of Ischemic ...pateldrona
LAE related rhythm disturbance that characterize atrial fibrillation is also associated with other atrial derangement such as endothelial dysfunction and impaired myocyte function
The Association of Left Atrial Enlargement in Different Subtypes of Ischemic ...AnonIshanvi
LAE related rhythm disturbance that characterize atrial fibrillation is also associated with other atrial derangement such as endothelial dysfunction and impaired myocyte function. The role of LAE in acute cerebral infarction patient is not sufficiently described in literature.
The Association of Left Atrial Enlargement in Different Subtypes of Ischemic ...komalicarol
LAE related rhythm disturbance that characterize atrial fibrillation is
also associated with other atrial derangement such as endothelial dysfunction and impaired myocyte
function. The role of LAE in acute cerebral infarction patient is not sufficiently described in literature.
Hence of this study was undertaken to look for the frequency of left atrial enlargement in acute stroke
subtypes.
Coronary angioplasty has revolutionized the management of coronary artery disease. It has not ceased to develop to become the reference method of myocardial revascularization. The aim of our study is to evaluate the ultrasound parameters of left ventricular function after coronary angioplasty. This is a prospective analytical study including patients with stable coronary artery disease with a known coronary artery anatomy programmed for coronary angioplasty. Transthoracic echocardiography was performed four hours before and seven days after myocardial revascularization.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Stroke Unit or Emergency Department at our center from
January 2016 to January 2018. All patients were evalu-
ated within the first 24 h from stroke onset. We excluded
patients with a poor echocardiographic window, clinical
instability or any condition that did not allow HHE
examination. We collected demographic data, vascular
risk factors, stroke severity and cerebral infarct charac-
teristics.
Certified neurologists graded stroke severity
according to the National Institutes of Health Stroke
Scale (NIHSS). Strokes scored 8 points were classi-
fied as moderate, and those scored 9 points as
severe (Muchada et al. 2014). Reperfusion treatment
(intravenous fibrinolysis) and/ or endovascular treat-
ment were decided based on consensus guidelines for
the treatment of acute stroke (Powers et al. 2018).
HHE is TTE performed by a trained neurologist
as a focused echo on stroke sources according to
POCUS recommendations adapted to the acute phase
of the stroke to avoid treatment delay. Therefore,
HHE studies were performed in the Emergency
Department, Stroke Unit, computed tomography (CT)
suite or angiography suite after acute neuroimaging
or stroke reperfusion therapy was concluded (Ribo
et al. 2017). In the acute phase, all patients with
non-lacunar stroke underwent CT scan to rule out
intracranial hemorrhage. Extracranial and intracranial
circulation was assessed by CT angiography or arteri-
ography to detect branch or mainstem occlusion of
intracranial arteries probably of embolic origin and
known as large vessel occlusion (LVO) (Leslie-
Mazwi et al. 2018). Patients were classified as hav-
ing cardioembolic (CE) strokes or large arterial ath-
erosclerosis (LAA) strokes if significant symptomatic
(50%) stenosis or occlusion, presumably caused by
atherosclerosis or stroke of undetermined etiology
based on the Trial of Org 10172 in Acute Stroke
Treatment (TOAST) classification of stroke (Adams
et al. 1993) was detected. Strokes of undetermined
etiology were cases without known CE cause of
stroke or LAA by diagnostic workup. We evaluated
predictors of MSE and AF detection with HHE in
patients with undetermined etiology. Patients in
whom MSEs were not detected were monitored with
a cardiac telemetry monitoring device to detect hid-
den, undiagnosed AF (Fig. 1).
Study design
The study was approved by the Committee of
Ethics in Medical Research of the Hospital Project
Research Area General (PR (AG) 146/2016) and carried
out in line with the second Declaration of Helsinki. Writ-
ten informed consent was obtained from all participants
or their relatives.
Echocardiographic protocol
The HHE protocol was carried out using an ultra-
portable device (Vscan, GE Healthcare, Chicago, IL,
USA) that acquires 2-D echo miniaturized images (size:
135 £ 73 £ 28 mm, weight: 390 g); it is a battery-oper-
ated (total scan time of 1 h) device with a broadband
width (1.7À3.8 MHz) phased array probe (120 £ 33 £
26 mm). This system can store digital still frames or
image loops, uses a color-coded overlay for real-time
blood flow imaging and allows distance measurements
using integrated electronic calipers, but has neither spec-
tral nor tissue Doppler capability. We examined all four
transthoracic windows after regular echocardiography
examination routine. Each HHE study was conducted by
the same stroke neurologist, who had been trained for 1
y in focused echocardiography and had performed more
than 350 echocardiographic studies under the appropri-
ate supervision of an expert echocardiographer in a high-
volume laboratory (Popescu et al. 2009). This physician
was blind to patient medical records. HHE was used to
assess cardiac structure and function as follows. To eval-
uate cardiac function, first we performed a qualitative
assessment of left ventricular (LV) systolic function in
the apical four-and two-chamber views (Cardim et al.
2019)), based on visual estimation of LV ejection frac-
tion (LVEF). Second, we classified LVEF into the fol-
lowing categories: normal (LVEF 50%), moderately
reduced (LVEF 30%À50%) and severely reduced
(LVEF 30%) (akinesia) (Amiel et al. 2012).
Similarly, valvular heart evaluation focuses on
valve morphology (including rheumatic disease). Mitral
stenosis was suspected on the basis of color aliasing in
combination with the reduction in mobility of the mitral
valve. Presence of turbulent flow was assessed qualita-
tively on a 2-D basis and on color Doppler images; quan-
titative assessment of valvular heart disease is
impossible because of the absence of spectral Doppler
(Cardim et al. 2019). Left atrial (LA) diameter was
obtained in the parasternal long-axis view, and LA area,
in the four-chamber apical window on echocardio-
graphic consensus (Lang et al. 2015).
All patients underwent TTE examination within the
first 72 h of stroke as standard-of-care protocol in our
center. We compared HHE with TTE (gold standard
test) to evaluate the ability to detect MSEs, which were
defined as embolic valvulopathies (EVs) and severe ven-
tricular dysfunction (SVD). In detail, EVs included
masses suggestive of endocarditis or fibroelastoma,
mitral or aortic mechanical prosthesis and rheumatic
mitral valve stenosis. SVD was defined as ventricular
akinesia or global hypokinesia with severely depressed
LVEF and intracardiac masses or floating thrombi. We
considered transient embolic sources (as mobile throm-
bus, takotsubo disease, or cardiomyopathies that
ARTICLE IN PRESS
2 Ultrasound in Medicine Biology Volume 00, Number 00, 2020
3. disappeared or improved after days in control TTE)
(Bersano et al. 2014). Emergent transesophageal echo-
cardiography (TEE) was ordered only for cases with
valvular prostheses or with suspected endocarditis
(Habib et al. 2010; Sala-Padro et al. 2017). In addition,
ambulatory TEE was performed in those suspected of
Fig. 1. Flowchart of the study. The study included eligible patients with non-lacunar symptoms and brain computed
tomography imaging that excluded brain hemorrhage or tumor. On the basis of medical records and acute neuroimaging,
patients were classified as known source of stroke, such as cardioembolic (CE) strokes in patients with known atrial fibrilla-
tion (AF) or prosthetic valves, and large arterial atherosclerosis (LAA) strokes. Strokes of unknown etiology with good con-
cordance between hand-held echocardiography (HHE) and transthoracic echocardiography (TTE) studies were divided into
patients with large vessel occlusion (LVO) and patients without LVO. There were two main groups of interest: strokes
related to diagnosis of main sources of embolism (MSEs), and strokes in patients with no MSEs in HHE studies. Patients
without MSEs were considered to have strokes of undetermined source and were classified as an enlarged left atrium (LA)
if the LA area was 20 cm2
on HHE studies and as AF until 1 y of follow-up was recorded in each group.
ARTICLE IN PRESS
Hand-held echocardiography as POCUS in acute ischemic stroke J. JUEGA et al. 3
4. having complex aortic atheromatosis or on detection of
patent foramen ovale.
Atrial fibrillation detection
Atrial fibrillation was defined as irregularly irregu-
lar RÀR intervals without P-wave signal. Heart rhythm
analyses were carried out with electrocardiograms, in-
hospital cardiac telemetry monitoring with automatic
software and medical record review up to 1 y from hos-
pital discharge. We evaluated LA diameter and LA area
measured by HHE as surrogates of AF detection until 1
y of follow-up in patients with sinus rhythm and undeter-
mined stroke (Table 1).
Diagnostic yield
Diagnostic yield was defined as the ability of HHE
to detect at least one MSE confirmed by TTE. We
described the main differences between patients with
and without MSE detection according to demographic
characteristics, previous diseases and stroke characteris-
tics (Table 2). The correlation with the final detection of
AF was measured by risk of AF detection in patients
with enlarged LA area measured by HHE. The aim was
to detect unknown CE sources of stroke: MSE diagnosis
or AF detection according to HHE predictors.
Data analysis
We employed the SPSS 17 statistical package to
analyze the data. The results of HHE studies were coded
in dichotomous variables according to the presence or
absence of the event, and the comparison was made by
x2
or Fisher’s exact test when required. A p value
0.05 was considered to indicate statistical significance.
To test the validity of HHE, we calculated its sensitivity,
specificity, positive predictive value (PPV) and negative
predictive value (NPV). In addition, the k concordance
coefficient was calculated. Multivariate logistic regres-
sion analysis including significant variables in univariate
analysis was employed to predict MSE and AF detection.
The predictive accuracy of HHE covariates related to AF
detection was evaluated using receiver operating charac-
teristic (ROC) curve analysis.
RESULTS
Of 155 eligible patients, we included 130 patients
with HHE and TTE evaluation. Those patients who did
not have a good thoracic window, were lost to follow-up
and did not have an ischemic stroke were excluded.
Fifty-seven percent of HHE examinations were per-
formed within the first 6 h from stroke onset (75/130).
The average duration of the HHE examination was
9.2 min (standard deviation 5.3). Twenty-four patients
were classified as having stroke secondary to a known
cause (LAA or CE strokes) based on medical records
and acute neuroimaging, whereas 106 patients were clas-
sified as having a stroke of unknown etiology (Fig. 1).
According to the validation of HHE, 98.46% of
patients (128/130) were properly diagnosed by HHE,
and 1.54% (2/130) were misdiagnosed: 1 patient with
papillary fibroelastoma and one false diagnosis of SVD
in a patient with mild dysfunction according to TTE.
The percentage of MSE detection was 19.23% (25/130).
With respect to MSE type, 7 patients had EV, 17 patients
had SVD and 1 patient had both EV and SVD, which
were analyzed separately. TEE was superior for
Table 1. Baseline characteristics of strokes with no MSE on hand-held echocardiography and diagnosis of AF on follow-up (N =
130)*
No MSEy
(n = 87) AF (n = 18) No AF (n = 69) p Value
Age, y [IQR] 76 [63À82] 79 [77À83] 72 [60À80] 0.007
Sex (female) 52.9% (46)y
44.4% (8) 55.1% (38) 0.421
Hypertension 75% (63) 83.3% (15) 72.7 (48) 0.357
Diabetes mellitus 22.4% (19) 16.7% (3) 23.9% (16) 0.514
Dyslipidemia 54.1% (46) 66.7% (12) 50.7% (34) 0.229
Former or past smoker 25.9% (22) 16.7% (3) 28.4% (19) 0.315
Coronary artery disease 12.6% (11) 5.6% (1) 14.5% (10) 0.310
Chronic heart failure 7.1% (6) 3% (17.6) 4.5% (3) 0.060
Previous stroke 18.8% (16) 4.7% (4) 14.1% (12) 0.678
Basal NIHSS, median [IQR] 7.0 [3.7À14.0] 11.0 [7.0À17.5] 6 [2.5À11.0] 0.016
Mild strokes 56.3% (49) 44.4% ( 8) 59.4% (41) 0.254
Moderate to severe stroke 43.7% (38) 55.6% (10) 40.6% (28) 0.254
Large vessel occlusion 48.3% (42) 83.3% (15) 39.1% (27) 0.001
Intravenous alteplase 43.7% (38) 61.1% (11) 39.1% (27) 0.094
Endovascular treatment 33.3% (29) 50% (9) 29% (20) 0.092
Left atrial diameter, cm [IQR] 4.0 [3.7À4.6] 4.5 [4.0À4.9] 4.0 [3.6À4.5] 0.043
Left atrial area, cm2
[IQR] 20.0 [15.6À23.0] 22.3 [20.2À26.2] 18.6 [15.0À23.0] 0.001
AF = atrial fibrillation; IQR = interquartile range; MSE = main source of embolism; NIHSS = National Institutes of Health Stroke Scale/Score
(moderate to severe stroke, NIHSS 8).
ARTICLE IN PRESS
4 Ultrasound in Medicine Biology Volume 00, Number 00, 2020
5. diagnosis of non-obstructive thrombosis in patients
known to have a prosthetic valve.
Sensitivity analysis and validation are outlined in
Table 3. The overall agreement between HHE and TTE
was 0.95, and with respect to each MSE type, 0.93 for
SVD and 0.92 for EV. Among the cases SVD, 22.2% (4/
18) had transient embolic sources. Figure 2 illustrates a
left ventricle thrombus and a right atrial thrombus.
Table 2 summarizes the baseline characteristics of
104 patients with unknown stroke etiology. MSEs were
detected in 16% (17/104); in all cases anticoagulation
was started as secondary prevention treatment. Anticoa-
gulation was initiated within the first 48 h of stroke onset
in 41% of cases (7/17). We did not observe intracranial
bleeding or any other related problems. Coronary artery
disease (35.3% vs. 12.6%, p = 0.021) and chronic heart
failure (52.9% vs. 6.8%, p 0.001) were more prevalent
in patients diagnosed with MSEs. According to stroke
characteristics, LVO was more commonly observed in
patients with MSEs (82.4% vs. 48% p = 0.010). Also,
patients in whom MSEs were detected more frequently
underwent intravenous fibrinolysis (76.5% vs. 43.7%,
p = 0. 01). Multivariate analysis indicated that LVO
(odds ratio [OR]: 4.24, 95% confidence interval [CI]:
1.01À17.85) and previous chronic heart failure (OR:
13.25, 95% CI: 3.54À49.50) were independent predic-
tors of MSEs.
Of 87 patients with undetermined stroke and no
MSE detection, we observed that the global rate of AF
detection was 20% (18/87) (Table 1). These patients
were older, 79 y versus 72 y (p = 0.003), and had more
severe strokes according to NIHSS score (11 points vs. 6
points, p = 0.016). Also, LVO (83.3% vs. 39.1%, p =
0.001) was more prevalent. Regarding HHE characteris-
tics, LA diameter and LA area were greater in patients in
whom AF was detected (4.5 cm vs. 4 cm, p = 0.043, and
22.3 cm2
vs. 18.6 cm2
, p = 0.001, respectively). The area
under the ROC curve was 0.74 (95% CI: 0.64À0.85) for
LA area to detect AF, and the best cutoff point to detect
AF was LA area 20 cm2
, yielding a sensitivity of
83.3% and a specificity of 62.7%. Almost half of the
cases of undetermined strokes without MSE detection
(40/87) were patients with an LA area 20 cm2
by
HHE. AF was detected in 37.5% of these patients
(15/40) with enlarged LA area, as illustrated in
Figure 1. Multivariate logistic regression analysis
indicated that LVO (OR: 6.54, 95% CI: 1.62À26.27)
and LA area 20 cm2
(OR: 7.01, 95% CI:
Table 2. Baseline characteristics of unknown stroke etiology
All (n = 104) MSE (n = 17) No MSE (n = 87) p Value
Age, median [IQR] 74 [61À81] 67 [55À78] 76 [63À82] 0.123
Sex (female) 50% (52) 35.3% (6) 52.9% (46) 0.185
Hypertension 71.15% (74) 64. 7% (11) 72. 4% (63) 0.382
Diabetes mellitus 24.0% (25) 35. 3% (6) 21.83% (19) 0.257
Dyslipidemia 50% (52) 35.3% (6) 52.8% (46) 0.156
Former or past smoker 28.8%(30) 47% (8) 25.2% (22) 0.080
Coronary artery disease 16.3% (17) 35.3% (6) 12.6% (11) 0.021
Chronic heart failure 14.4% (15) 52.9% ( 9) 6.8% ( 6) 0.001
Previous stroke 17. 3% (18 ) 11.8% (2) 18.3% (16) 0.486
NIHSS, median [IQR] 8 (3.0À14.0) 9 (6.0À15.5) 7 (3.0À14.0) 0.309
Mild strokes 52.9% (55) 35.3% (6) 56.3% (49) 0.112
Moderate to severe stroke 47.1% (49) 64.7% (11) 43.7% ( 38) 0.112
Large vessel occlusion 53.8% (56) 82.4% (14) 48.3% (42) 0.010
Intravenous alteplase 49% (51) 76.5% (13) 43.7% (38) 0.013
Endovascular treatment 34.6% (36) 41.2% (7) 33.3% (29) 0.534
AF = atrial fibrillation; IQR = interquartile range; MSE = main sources of embolism; NIHSS = National Institutes of Health Stroke Scale/Score
(moderate to severe stroke, NIHSS 8).
*Results are expressed as the percentage (number) of cases unless otherwise indicated.
y
“No MSE” describes patients with strokes of undetermined etiology without diagnosis of main sources of embolism with point-of-care ultrasound.
Table 3. Agreement and accuracy of acute HHE and conventional transthoracic echocardiography (N = 130)
N (%) k Sensitivity Specificity PPV NPV
MSEs 25 (19.23) 0.95 (0.88À1.0) 96.00 (77.68À99.79) 99.05 (94.04À99.95) 96.00 (77.68%À99.79) 99.05 (94.04À99.95)
SVD 18y
(13.85) 0.93 (0.84À1) 94.44 (70.62À99.71) 99.11 (94.40À99.95) 94.44 (70.62À99.71) 99.11 (94.40À99.95)
EV 8y
(6.15) 0.92 (0.79À1) 87.50 (47.35À99.68) 100 (97.02À100) 100 (59.04À100) 99.19 (95.55À99.98)
EV = embolic valvulopathy; HHE = hand-held echocardiography; MSE = main sources of embolism; NPV = negative predictive value; PPV = pos-
itive predictive value; SVD = severe ventricular dysfunction; k = kappa concordance coefficient
*Results are expressed as the percentage (number) of cases.
y One patient had SVD and EV simultaneously.
ARTICLE IN PRESS
Hand-held echocardiography as POCUS in acute ischemic stroke J. JUEGA et al. 5
6. 1.75À28.09) were both independently associated with
detection of AF.
DISCUSSION
We evaluated HHE in the detection of sources of
embolism in the acute phase of stroke as early as possi-
ble. Previous work revealed that POCUS is feasible,
enabling reliable quantification of cardiac parameters in
stroke patients (Kraft et al. 2017); however, our study is
the first experiment designed for POCUS in the acute
phase of stroke. The implementation of ultraportable
devices allows the performance of studies not only at the
bedside of the patient, but also in the CT or angiography
suite. Images and loops of video can be stored for cardi-
ology to review. Also, stored data can be exported for
offline expert interpretation (Singh et al. 2013).
Our protocol was designed to prioritize emergent
stroke reperfusion treatment. Therefore, POCUS may
help to detect SVD or EV once acute reperfusion treat-
ment is performed. Because ’’time is brain,’’ POCUS
has been scheduled after reperfusion treatment. The
advantage of such early screening is the possibility of
detecting an embolic source that may not be diagnosed
later. Some researchers have stated that the rate of
thrombus detected by TTE in patients with ischemic
stroke is low (Abreu et al. 2005). We assume that an
intracardiac thrombus may disappear and not be detected
in the post-acute phase. The validation study revealed
that HHE is reliable in detecting MSEs when compared
with TTE. The number of misdiagnoses was pretty low.
Our protocol was not designed to study complex aortic
atheromatosis or patent foramen ovale, which may
require TEE beyond the acute phase of the stroke.
Fig. 2. Thrombi in cardiac chambers diagnosed by point-of-care ultrasound scanning. (a, c) Left ventricle thrombus
(white arrow) in parasternal short-axis view (a) and apical four-chamber view (b). (c, d) Right atrial thrombus (white
arrow) in apical four-chamber view (c) and subcostal view (d)
ARTICLE IN PRESS
6 Ultrasound in Medicine Biology Volume 00, Number 00, 2020
7. In our protocol, we focused HHE on finding MSEs
to anticipate the detection of potential causes of stroke
that deserve anticoagulation for secondary prevention. In
our study, the MSE diagnostic yield was considerable, as
we detected MSEs in nearly 1 in 5 patients evaluated.
Regarding patients with undetermined stroke, 16% (17/
104) were new MSE diagnoses. We found that LVO and
chronic heart disease were independent predictors of MSE
detection; therefore, HHE should be prioritized in patients
with LVO and chronic heart disease based on our data.
The main cover cause is AF in patients with unde-
termined stroke, which means AF screening should be
performed in all patients with cryptogenic stroke. Some
authors suggest new diagnostic methods to improve the
diagnostic yield in the shortest time after stroke (Sposato
et al. 2015). Latest stroke guidelines recommend 30-d
rhythm monitoring without delay if no other apparent
cause has been detected (Kernan et al. 2014). HHE may
help to select patients to start earlier inpatient cardiac
monitoring and to prolong the monitoring with devices
such as external or implantable recorders once conven-
tional AF screening (electrocardiogram, cardiac teleme-
try) has been performed.
Our hypothesis is that MSEs and hidden undiagnosed
AF in patients with enlarged left atria were linked to LVO
because large thrombi could be formed inside cardiac
chambers. On the basis of our treatment protocol there
was a therapeutic impact after HHE in 30.76% (32/104) of
patients. MSEs were detected in 17 cases and 15 patients
with an LA area 20 cm2
were diagnosed with AF.
Our treatment protocol calls for anticoagulation
starting in the first 48 h after stroke. This was the case in
almost half of the patients with MSEs. Our study was
not designed to evaluate this treatment. Randomly allo-
cated, controlled trials to assess the optimal time to initi-
ate anticoagulation after acute stroke are underway
(Smythe et al., 2020).
Limitations
The study has certain limitations. The considerable
prevalence of MSEs could be justified by the characteris-
tics of the study population. The high prevalence of
severe strokes evaluated may have influenced the high
positive and negative predictive values. On the other
hand, the study was carried out with patients in the
supine position to avoid treatment delay, which may
have influenced the quality of the registry and increased
the percentage of patients with a poor thoracic window.
Still, less than 10% of patients (14/156) were excluded
only because of a poor thoracic window. This work
should be used only as primary experience in MSE
detection with HHE in the acute phase of stroke, and its
results should be confirmed by other studies before mak-
ing further recommendations.
CONCLUSIONS
Patients with LVO and chronic heart disease may
benefit from HHE as part of point-of-care ultrasound in
the acute phase of ischemic stroke. The left atrial area
measured was an independent predictor of AF in strokes
of undetermined etiology.
Acknowledgments—This work was supported by the Research Fund of
the Spanish Society of Neurology (SEN) through the Spanish Society
of Neurosonology (SONES).
Conflict of interest disclosure—The authors declare no competing
interests.
REFERENCES
Abreu TT, Mateus S, Correia J. Therapy implications of transthoracic
echocardiography in acute ischemic stroke patients. Stroke
2005;36:1565–1566.
Adams HP, Jr, Bendixen BH, Kappelle, Biller J, Love BB, Gordon DL,
Marsh EE. Classification of subtype of acute ischemic stroke: Defi-
nitions for use in a multicenter clinical trial. TOAST. Trial of Org
10172 in Acute Stroke Treatment. Stroke 1993;24:35–41.
Amiel JB, Gru¨mann A, Lheritier G, Clavel M, Fran¸cois B, Pichon N,
Dugard A, Marin B, Vignon P. Assessment of left ventricular ejec-
tion fraction using an ultrasonic stethoscope in critically ill patients.
Crit Care 2012;16:R29.
Arboix A, Alio J. Acute cardioembolic cerebral infarction: answers to
clinical questions. Curr Cardiol Rev 2012;8:54–67.
Bersano A, Melchiorre P, Moschwitis G, Tavarini F, Cereda C, Micieli
G, Parati E, Bassetti C. Tako-tsubo syndrome as a consequence and
cause of stroke. Funct Neurol 2014;29:135–137.
Cardim N, Dalen H, Voigt JU, Ionescu A, Price S, Neskovic AN,
Edvardsen T, Galderisi M, Sicari R, Donal E, Stefanidis A, Del-
gado V, Zamorano J, Popescu BA. The use of handheld ultrasound
devices: a position statement of the European Association of Car-
diovascular Imaging (2018 update). Eur Heart J Cardiovasc Imag-
ing 2019;20:245–252.
Evangelista A, Galuppo V, Mendez J, Evangelista L, Arpal L, Rubio C,
Vergara M, Liceran M, Lopez F, Sales C, Miralles V, Galinsoga A,
Perez J, Arteaga M, Salvador B, Lopez C, Garcıa-Dorado D. Hand-
held cardiac ultrasound screening performed by family doctors
with remote expert support interpretation. Heart 2016;102:376–
382.
Ferreira JP, Girerd N, Gregson J, Latar I, Sharma A, Pfeffer MA,
McMurray JJV, Abdul-Rahim AH, Pitt B, Dickstein K, Rossignol
P, Zannad F. Stroke risk in patients with reduced ejection fraction
after myocardial infarction without atrial fibrillation. J Am Coll
Cardiol 2018;71:727–735.
Habib G, Badano L, Tribouilloy C, Vilacosta I, Zamorano JL, Galderisi
M, Voigt JU, Sicari R, Cosyns B, Fox K, Aakhus S. Recommenda-
tions for the practice of echocardiography in infective endocarditis.
Eur J Echocardiogr 2010;11:202–219.
Jordan K, Yaghi S, Poppas A, Chang AD, MacGrory B, Cutting S, Bur-
ton T, Jayaraman M, Tsivgoulis G, Sabeh MK, Merkler AE, Kamel
H, Elkind MSV, Furie K, Song C. Left atrial volume index is asso-
ciated with cardioembolic stroke and atrial fibrillation detection
after embolic stroke of undetermined source. Stroke
2019;50:1997–2001.
Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI,
Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston
SC, Kasner SE, Kittner SJ, Mitchel PH, Rich MW, Richardson D,
Schwamm LH, Wilson JA. American Heart Association Stroke
Council, Council on Cardiovascular and Stroke Nursing Council
on Clinical Cardiology, and Council on Peripheral Vascular Dis-
ease. Guidelines for the prevention of stroke in patients with stroke
and transient ischemic attack: A guideline for healthcare professio-
nals from the American Heart Association/American Stroke Asso-
ciation. Stroke 2014;45:2160–2236.
ARTICLE IN PRESS
Hand-held echocardiography as POCUS in acute ischemic stroke J. JUEGA et al. 7
8. Kraft P, Fleischer A, Wiedmann S, Ru¨cker V, Mackenrodt D, Morbach
C, Malzahn U, Kleinschnitz C, St€ork S, Heuschmann PU. Feasibil-
ity and diagnostic accuracy of point-of-care handheld echocardiog-
raphy in acute ischemic stroke patients—A pilot study. BMC
Neurol 2017;17:159.
Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L,
Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancel-
lotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer
KT, Tsang W, Voigt JU. Recommendations for cardiac chamber
quantification by echocardiography in adults: an update from the
American Society of Echocardiography and the European Associa-
tion of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging
2015;16:233–270.
Leslie-Mazwi T, Chandra RV, Baxter BW, Arthur AS, Hussain MS,
Singh IP, Frei DF, Klucznik RP, Albuquerque FC, Hirsch JA.
ELVO: an operational definition. J Neurointerv Surg 2018;10:507–
509.
Muchada M, Rubiera M, Rodriguez-Luna D, Pagola J, Flores A, Kallas
J, Sanjuan, Meler P, Alvarez-Sabin J, Ribo M, Molina CA, et al.
Baseline National Institutes of Health stroke scale-adjusted time
window for intravenous tissue-type plasminogen activator in acute
ischemic stroke. Stroke 2014;45:1059–1063.
Pagola J, Gonzalez-Alujas T, Muchada M, Teixido G, Flores A, De
Blauwe S, Sero L, Luna DR, Rubiera M, Ribo M, Boned S,
Alvarez-Sabin J, Evangelista A, Molina CA. Stroke Echoscan pro-
tocol: A fast and accurate pathway to diagnose embolic strokes. J
Neuroimaging 2015;25:365.
Pagola J, Juega J, Francisco-Pascual J, Moya A, Sanchis M, Busta-
mante A, Penalba A, Usero M, Cortijo E, Arenillas JF, Calleja AI,
Sandin-Fuentes M, Rubio J, Mancha F, Escudero-Martinez I,
Moniche F, de Torres R, Perez-Sanchez S, Gonzalez-Matos CE,
Vega A, Pedrote AA, Arana-Rueda E, Montaner J, Molina CA.
Yield of atrial fibrillation detection with textile wearable holter
from the acute phase of stroke: Pilot study of Crypto-AF registry.
Int J Cardiol 2017;251:45–50.
Pepi M, Evangelista A, Nihoyannopoulos P, Flachskampf FA, Athanas-
sopoulos G, Colonna P, Habib G, Ringelstein EB, Sicari R, Zamor-
ano JL, Sitges M, Caso P. Recommendations for echocardiography
use in the diagnosis and management of cardiac sources of embo-
lism: European Association of Echocardiography (EAE) (a regis-
tered branch of the ESC). Eur J Echocardiogr 2010;11:461–476.
Perez de Isla L, Dıaz Sanchez S, Pagola J, Garcıa de Casasola Sanchez
G, Lopez Fernandez T, Sanchez Barrancos IM, Martınez-Sanchez
P, Zapatero Gaviria A, Anguita M, Ruiz Serrano AL, Torres Macho
J. Consensus Document of the SEMI, semFYC, SEN, and SEC on
Focused Cardiac Ultrasound in Spain. Rev Esp Cardiol (Engl Ed)
2018;71:935–940.
Popescu BA, Andrade MJ, Badano LP, Fox KF, Flachskampf FA, Lan-
cellotti P, Varga A, Sicari R, Evangelista A, Nihoyannopoulos P,
Zamorano JL, European Association of Echocardiography, Deru-
meaux G, Kasprzak JD, Roelandt JR. European Association of
Echocardiography recommendations for training, competence, and
quality improvement in echocardiography. Eur J Echocardiogr
2009;10:893–905.
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis
NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B,
Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA,
Sheth KN, Southerland AM, Summers DV, Tirschwell DL. 2018
guidelines for the early management of patients with acute ische-
mic stroke: A guideline for healthcare professionals from the
American Heart Association/American Stroke Association. Stroke
2018;49:e46–e110.
Ribo M, Boned S, Rubiera M, Tomasello A, Coscojuela P, Hernandez
D, Pagola J, Juega J, Rodriguez N, Muchada M, Rodriguez-Luna
D, Molina CA. Direct transfer to angiosuite to reduce door-to-punc-
ture time in thrombectomy for acute stroke. J Neurointerv Surg
2017;10:221–224.
Sala-Padro J, Pagola J, Gonzalez-Alujas MT, Sero L, Juega J, Rodri-
guez-Villatoro N, Boned S, Rodriguez-Luna D, Muchada M, Fer-
nandez-Galera R, Rubiera M, Ribo M, Evangelista A, Molina C.
Prosthetic valve thrombosis in the acute phase of the stroke: Rele-
vance of detection and follow-up. J Stroke Cerebrovasc Dis
2017;26:1110–1113.
Saric M, Armour AC, Arnaout MS, Chaudhry FA, Grimm RA, Kron-
zon I, Landeck BF, Maganti K, Michelena HI, Tolstrup K. Guide-
lines for the use of echocardiography in the evaluation of a cardiac
source of embolism. J Am Soc Echocardiogr 2016;29:1–42.
Singh S, Bansal M, Maheshwari P, Adams D, Sengupta SP, Price R,
Dantin L, Smith M, Kasliwal RR, Pellikka PA, Thomas JD, Narula
J, Sengupta PP, ASE-REWARD Study Investigators. American
Society of Echocardiography: Remote echocardiography with web-
based assessments for referrals at a distance (ASE-REWARD)
Study. J Am Soc Echocardiogr 2013;26:221–233.
Smythe MA, Parker D, Garwood CL, Cuker A, Messe SR. Timing
of initiation of oral anticoagulation after acute ischemic stroke
in patients with atrial fibrillation. Pharmacotherapy 2020;40:
55–71.
Sposato LA, Cipriano LE, Saposnik G, Ruız Vargas E, Riccio PM,
Hachinski V. Diagnosis of atrial fibrillation after stroke and tran-
sient ischaemic attack: A systematic review and meta-analysis.
Lancet Neurol 2015;14:377–387.
Yang H, Nassif M, Khairy P, de Groot JR, Roos YBWEM, de Winter
RJ, Mulder BJM, Bouma BJ. Cardiac diagnostic work-up of ischae-
mic stroke. Eur Heart J 2018;39:1851–1860.
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