Pleural effusion is an abnormal collection of fluid in the pleural space between the lungs and chest wall. It can be classified as either exudative or transudative based on the mechanism and fluid type. Exudative effusions are caused by inflammation from conditions like infection, cancer, or trauma. Transudative effusions occur in non-inflammatory conditions like heart failure or liver disease. Symptoms include shortness of breath, chest pain, and cough. Diagnosis involves physical exam, chest x-ray, and fluid analysis via thoracentesis. Treatment focuses on resolving the underlying cause through medications, chest tube drainage, or surgery.