This document discusses the challenges of transforming traditional healthcare systems to become more efficient, patient-centered, and results-oriented. It notes that aging populations and increasing chronic diseases are driving up healthcare costs. The major hindrances to achieving more preventative and predictive medicine are a lack of integration between departments, huge fragmentation among providers, and issues with sharing electronic health records. Future healthcare will see smaller hospitals focused on intensive care and day services, with more chronic disease management in the community by multidisciplinary teams. Performance challenges include developing a truly patient-centered approach, accountability, and using data and payments systems to incentivize better health outcomes.