There is an interplay of physiological processes occurring during the second stage of labour. Second stage is said to have two phases, latent and active. It is during the latent phase that the presenting part passes through the fully dilated cervix to the birth canal.
Puerperium is the period following childbirth during which the body tissues, specially the pelvic organs revert back approximately to the pre-pregnant state both anatomically and physiologically. puerperium begins as soon as the placenta is expelled and lasts for approximately 6 weeks when the uterus becomes regressed almost to the non-pregnant size.
Puerperium is the period following childbirth during which the body tissues, specially the pelvic organs revert back approximately to the pre-pregnant state both anatomically and physiologically. puerperium begins as soon as the placenta is expelled and lasts for approximately 6 weeks when the uterus becomes regressed almost to the non-pregnant size.
The second stage of labor begins when the cervix is completely dilated (open), and ends with the birth of your baby. Contractions push the baby down the birth canal, and you may feel intense pressure, similar to an urge to have a bowel movement. Your health care provider may ask you to push with each contraction.
The second stage of labor begins when the cervix is completely dilated (open), and ends with the birth of your baby. Contractions push the baby down the birth canal, and you may feel intense pressure, similar to an urge to have a bowel movement. Your health care provider may ask you to push with each contraction.
The ability of the fetus to successfully negotiate the pelvis during labor involves changes in the position of its head during its passage in labor. The mechanisms of labor, also known as the cardinal movements, are described in relation to a vertex presentation, as is the case in 95% of all pregnancies.
Irritable bowel syndrome is a common condition affecting the digestive system.
Symptoms of irritable bowel syndrome include stomach cramps, bloating, diarrhoea and constipation. These may come and go over time.
Making changes to your diet and lifestyle, like avoiding things that trigger your symptoms, can help ease irritable bowel syndrome.
blockage or problem in the urinary tract can mean urine is unable to drain from the kidneys or is able to flow the wrong way up into the kidneys. This can lead to a build-up of urine in the kidneys, causing them to become stretched and swollen.
An injury higher on the spinal cord can cause paralysis in most of your body and affect all limbs (tetraplegia or quadriplegia). A lower injury to the spinal cord may cause paralysis affecting your legs and lower body (paraplegia)
Scoliosis is the abnormal twisting and curvature of the spine. It is usually first noticed by a change in appearance of the back. Typical signs include: a visibly curved spine. one shoulder being higher than the other.
Osteoarthritis (OA) is the most common form of arthritis. Some people call it degenerative joint disease or “wear and tear” arthritis. It occurs most frequently in the hands, hips, and knees.
With OA, the cartilage within a joint begins to break down and the underlying bone begins to change. These changes usually develop slowly and get worse over time. OA can cause pain, stiffness, and swelling. In some cases it also causes reduced function and disability; some people are no longer able to do daily tasks or work.
About 4 out of 5 cases of acute pancreatitis improve quickly and don't cause any serious further problems. However, 1 in 5 cases are severe and can result in life-threatening complications, such as multiple organ failure. In severe cases where complications develop, there's a high risk of the condition being fatal.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. second stage of labor
• It start from the full dilatation of the cervix and the ends with
expulsion of the fetus from the birth canal.
• It has got two phases:
a. Propulsive phases- starts from full dilatation up to the descent
of the presenting part to the pelvic floor.
b. Expulsive phase-is distinguished by maternal bearing down
efforts and ends with delivery of the baby.
3. • Its average duration is 2hours in primigravida and 30minutes in
multipara.
• This period is typically characterized by maternal restlessness,
discomfort, desire for pain relief, a feeling that the process is never
ending and demands to birth attendants to get the birth process over
as quickly as possible.
4. Principles of second stage of labor
To assist in the natural expulsion of the fetus slowly and steadily
To prevent perineal injuries.
5. Physiology of second stage of labor
• The physiological changes result from a continuation of the
same forces that have been at work during the first stage of
labor but activity is accelerated once the cervix has become
fully dilated.
UTERINE ACTION:
• contractions become stronger and longer but may be less
frequent, allowing both mother and fetus to rest in between
contractions.
6. • The membrane often rupture spontaneously towards the end of
the first stage during transition to the second stage.
• The consequent drainage of liquor allows the fetal head to be
directly applied to the cervix, this pressure aids distension.
• Fetal axis pressure increases flexion of the head, which results
in smaller presenting diameters, more rapid progress and less
trauma to both mother and fetus.
8. • The contractions become expulsion as the fetus descends
further into the vagina.
• Pressure from the presenting part stimulates nerve receptors in
the pelvic floor (ferguson reflex) and the women experiences
the urge to push.
• The reflex may initially be controlled to a limited extent but
becomes increasingly compulsive, overwhelming and
involuntary during each contraction.
9. • The mother then employs her secondary powers of expulsion
i.e. the abdominal muscles and diaphragm to push out the baby.
SOFT TISSUE DISPLACEMENT:
• The descending fetal head displaces the soft tissues of the
pelvis.
• Anteriorly, the bladder is pushed upwards into the abdominal
cavity where it is at less risk of injury during fetal descent.
• This results in the stretching and thinning of the urethra.
10. • Posteriorly, the rectum becomes flattened into the sacral curve
and the pressure of the advancing head expels any residual
faecal matter.
• The levatoani muscles dilate, thin out and are displaced laterally
and the perineal body is flattened, stretched and thinned.
• The fetal head becomes visible at the vulva, advancing with
each contraction and receding between contractions until
crowning takes place.
13. • The head is then born and the shoulders and body follow with the
contraction accompanied by a gush amniotic fluid and sometimes
blood.
• The second stage culminates in the birth of the baby.
14. Recognition of the commencement of the second
stage
This is not clinically apparent. Several of the signs are
presumptive and can only be confirmed by vaginal examination.
These include:
Expulsion uterine contractions: Although this is usually a sign
that the cervix is fully dilated, it is possible for the women to feel
the urge to push before full dilatation occurs e.g. when rectum is
full, etc..
15. Rupture of forewaters: This may occur at anytime during labor but
physiologically, it occurs at the end of 1st stage when cervix is fully
dilated and can no longer support the bag of waters.
Dilatation & gaping of the anus: As the fetal head descends and
touches the pelvic floor, there’s increased pressure especially on the
rectum. This results in dilation and gaping of the anus and may result in
discharge of faecal matter.
17. Appearance of the presenting part: Although this is usually definitive,
it is important to be aware that excessive moulding may result in the
formation of a large caput succedaneum, which can protrude through
the cervix prior to full dilatation. Similarly, a breech presentation may be
visible when the cervix is not fully dilated.
19. Show: this is the loss of bloodstained mucus which often
accompanies rapid dilatation towards the end of 1st stage of
labor. It must be distinguished from frank fresh blood loss
caused by partial separation of the placenta, or that caused by
ruptured vasa previa.
Congestion of the vulva: the pressure of the fetal head on the
vulva results in venous congestion, however, premature
pushing may also cause this.
21. COMFIRMATORY EVIDENCE
This is only done by vaginal examination which reveals no cervix and it
is done to:
Ensure the women is not pushing too early before the cervix is fully
dilated.
To provide a baseline for timing the length of 2nd stage of labor.
22. Principles of mechanism of labor
• Descent takes place throughout the labor.
• Whichever part leads and first meet the resistance of the
pelvic floor will rotate until it comes under the symphysis
pubis.
• Whatever emerges from the pelvis will pivot around the
pubic bone.
23. mechanism of labor
Definition:
The series of movement that occur on the head in the process of
adaptation, during its journey through the pelvis is called
mechanism of labor.
At the onset of labor, the most common presentation is the vertex
and most common position either left or right occipitoanterior;
therefore it is this mechanism which will be described.
24. • In this instance:
The lie is longitudinal.
The presentation is cephalic.
The position is right or left occipito-anterior
The attitude is one of good flexion
The denominator is the occiput
The presenting part is the posterior part of the anterior parietal
bone.
25. Main movement of fetus
• Engagement
• Descent
• Flexion
• Internal rotation
• Crowning
• Extension of the head
• Restitution
• External rotation
• Birth of the shoulder and trunk
26. Engagement
• When the bi-parietal diameter of the head passes the pelvic
inlet, the head is said to be engaged.
• In the most nulliparous pregnancies this occurs before the onset
of active labor because the firmer abdominal muscle directs the
presenting part into the pelvis.
• In multiparous pregnancies, in which the abdominal
musculature is more relaxed, the head often remains freely
movable above the pelvic brim until labor is established.
32. Descent
• Following engagement, descent of the head occurs. In fact
descent is a continuous process occurring throughout the labor
till the head is born.
• Descent of the fetal head into the pelvis often begins before the
onset of labor. For a primigravida women this usually occurs
during the later weeks of pregnancy.
• In multigravida women muscle tone is often more lax and
therefore descent of the fetal head and engagement of the fetal
may not occur until labor actually begins.
33. • Throughout the first stage of labor the contraction and retraction of the
uterine muscles allow less room in the uterus, exerting pressure on the
fetus to descend further.
34. Flexion
• As soon as head meets resistance from the cervix, pelvic wall or pelvic
floor during descent, full flexion is achieved.
• Flexion is essential for descent, since it reduces the shape and size of
the plane of the advancing diameter of the head.
35.
36. Internal rotation:
• The occiput rotates anteriorly and the fetal head assumes an oblique
orientation.
• It is a movement of great importance without which there will be
no further descent.
It is probably due to slope of pelvic floor, pelvic shape and
inequalities in flexibility
of component parts of the fetus. Torsion of the neck is an
inevitable phenomenon
during internal rotation of head. There is no movement of the
shoulders from the
oblique diameter as the neck sustains a torsion of only 1/8th of a
circle.
37. Crowning
• After internal rotation of the head, further descent occurs until the sub-
occiput lies underneath the pubic arch. At this stage, the maximum
diameter of the head (bi-parietal) stretches the vulval outlet without any
recession of the head even after the contraction is over called crowning
of the head.
38.
39. Extension of the head
Once crowning has occurred the fetal head can extend, pivoting on the
sub-occipital region around the pubic bone. This releases the sinciput,
face, and chin, which sweep the perineum, and then are born by a
movement of extension.
40.
41. Restitution
the twist in the neck of the fetus which resulted from internal rotation is
now corrected by a slight untwisting movement. The occiput moves 1/8 of
a circle towards the side from which it started.
42. External rotation
It is movement of rotation of the head visible externally due to internal
rotation of the shoulders. As the anterior shoulder rotates toward the
symphysis pubis from the oblique diameter, it carries the head in a
movement of external rotation through 1/8th of a circle in the same
direction as restitution.
43. Birth of shoulder and trunk
After the shoulders are positioned in anteroposterior diameter of the
outlet, further descent takes place until anterior shoulder escapes below
the symphysis pubis first, by a movement of lateral flexion of the spine,
the posterior shoulder sweeps over the perineum. Rest of the trunk is
then expelled out by lateral flexion.
44. Management of second stage of labor
The transition from the first stage to the second stage is
evidenced by the following features:
Increasing intensity of uterine contractions
Appearance of bearing down efforts.
Urge to defecate with descent of the presenting part.
Complete dilatation of the cervix as evidenced on vaginal
examination.
45. Aims of management of second stage of labor
• To deliver the baby safely in healthy condition.
• To prevent maternal injuries like perineal tear.
• To prevent infection during the conduct of delivery.
46. Constant monitoring of the mother and fetus
• Maternal pulse and BP are frequently recorded.’
• FHR are monitored every 5 minutes
• Vaginal examination is done to note the status of membrane, color of
the liquor and to detect cord accident following rupture of membranes if
any. Presentation, position and progressive descent of fetus are also
noted.
47. Position: The common preferred position is dorsal with
15degree lateral tilt. Patient may vary according to the patient’s
choice.
The accoucheur scrubs up and puts on sterile gown, mask
and gloves and stands on the right side of the table.
Toileting the external genitalia and inner side of the thighs is
done with cotton swabs soaked in savlon or Dettol solution. On
sterile sheet is placed beneath the buttocks of the patient and
one over the abdomen.
48. Essential aseptic procedure are remembered as 3 ‘C’:
Clean hands
Clean surface
Clean cutting and ligaturing of the cord.
49. Catheterization: catheterize the bladder if it full.
Examination of the patient: After the catheterization, the patient is
again examined per abdominally and vaginally.
50. CONFIRM ESSENTIAL SUPPLIERS ARE AT BEDSIDE
AND PREPARE FOR DELIVERY
For mother:
• Gloves
• Alcohol-based hand rub or soap and clean water.
• Oxytocin 10 units in syringe.
For baby:
• Clean towel.
• Tie or cord clamp.
• Sterile blade to cut cord.
• Suction device.
• Bag-and-mask.
51. The assistance required in spontaneous delivery is divided into three
phases:
DELIVERY OF HEAD:
The patient is encouraged for the bearing down efforts during uterine
contractions. This facilitates descent of the head.
When the scalp is visible for about 5cm in diameter, flexion of the head
is maintained during contractions.
52. This is achieve by pushing the occiput downwards and
backwards by using thumb and index fingers of the left hand
while pressing the perineum by the right palm with a sterile
vulval pad.
If the patient passes stool, it should be cleaned and the region
is washed with antiseptic lotion.
the process is repeated during subsequent contractions until
the sub-occiput is placed under the symphysis pubis. At this
stage, the maximum diameter of the head (biparietal diameter)
stretches the vulval outlet without any recession of the head
even after the contraction is over and it is called “crowning of
the head”.
53. When the perineum is fully stretched and threatens to tear specially
in primigravida, episiotomy is done at this stage after prior infiltration
with 10ml of 1% lignocaine. Bulging thinned perineum is better
criteria. Episiotomy is selectively and not as a routine.
The forehead, nose , mouth and the chin are born successively over
the stretched perineum by extension.
54. Care following delivery of the head
Immediately following delivery of the head, the mucus and
blood in the mouth and pharynx are to be wiped with sterile
gauze piece on a little finger. Alternatively, mechanical or
electrical sucker may be used. This simple procedure prevents
the serious consequences of mucus blocking the air passage
during vigorous inspiratory efforts.
The eyelids are then wiped with sterile dry cotton swabs using
one for each eye starting from the medial to the lateral canthus
to minimize contamination of the conjunctival sac.
55. The neck is then palpated to exclude the presence of any loop of cord
(if it found and if loose enough, it should be slipped over the head or
over the shoulders as the baby is being born. But it is sufficiently tight
enough, it is cut in between two pairs of Kocher’s forceps placed 1 inch
apart.
56. Prevention of perineal laceration
More attention should be paid not to the perineum but to the
controlled delivery of the head.
• Delivery by early extension is to avoided: flexion of the sub-
occiput comes under the symphysis pubis so that lesser sub-
occipitofrontal 10cm (4’’) diameter emerges out of the introitus.
• Spontaneous forcible delivery of the head is to be avoided by
assuring the patient not to bear down during contractions.
57. • To deliver the head in between contractions.
• To perform timely episiotomy (when indicated).
• To take care during delivery of the shoulders as the wider bisacromial
diameter (12cm) emerges out of the introitus.
58. DELIVERIES OF THE SHOULDERS
Wait for the uterine contractions to come and for the
movements of restitution and external rotation of the head to
occur. Following restitution and external rotation of the head,
the shoulders (bisacromial diameter) come in anteroposterior
diameter of the pelvis.
During next contraction, the anterior shoulder is born behind the
symphysis pubis. If there is delay, the head is grapsed by both
hands and is gently drawn posteriorly until the anterior shoulder
is released from under the pubis.
59. By drawing the head in upward direction, the posterior shoulder is
delivered out of the perineum.
Traction on the head should be gentle to avoid excessive stretching of
the neck causing injury to the brachial plexus, hematoma of the neck or
fracture of the clavicle.
60. DELIVERY OF THE TRUNK
After the delivery of the shoulders, the fore fingers of each hand are
inserted under the axillae and the trunk is delivered gently by lateral
flexion.
61. References
• https://www.slideshare.net/rabimohd07/the-second-stage-of-
labour
• Dc Dutta’s, 7th edition, Textbook of obstetrics, Jaypee brothers
medical publishers page no:123-126,135-137
• Arup Kumar Majhi, 2nd edition, Bedside clinics in obstetrics,
academic publishers. Page no: 377-380
• Myles, 5th edition, Textbooks of Midwives. Page no:515-516]
• Durga Subedi, Saraswoti Gautam, midwifery nursing part-II.
Page no: 69-71