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ISF College Of Pharmacy
Ghal Kalan GT Road, Moga-142001, Punjab, INDIA
( An Autonomous College U/s UGC Act 1956 )
ALCOHOLIC LIVER DISEASE
Rajendra Kumar
Roll No.- 1813772
Class- PHARM D 2nd yr
Dept. Of Pharmacy Practice
ISF COLLEGE OF PHARMACY
1
Demographics
Ø Name : XYZ
Ø Date of admission : 11/10/2019
Ø Date of discharge : 16/10/2019
Ø Department : Gastroenterology ( GW 02)
Ø Sex : Male
Ø Age : 55 yrs
Weight : 85 kg
2
1. SUBJECTIVE EVIDENCES
ØChief complaints on admission
• Patient have complaints of yellowish discolaration of skin, swelling in both lower
leg.
• c/o hard stool and fatigue
• c/o abdominal distention
ØPast medical history : k/c/o Depression, Asthma
Ø Social History : Smoker ( 1-3 cigarette per day ) since 12 years
Alcoholic since 8 years ( 40 ml - 50 ml )
3
2.OBJECTIVE EVIDENCES
Ø Systemic Examination
Ø CNS : Conscious and oriented
Ø Per Abdomen : Distended
Ø Vital Signs
Ø BP : 130/80mmhg
Ø PR : 80 bpm
4
Ø LABORATORY DATA
INVESTIGATION TEST VALUE NORMAL VALUE
Hb 10.2 13-18 g/dl
TLC 9700 4000-10000 cells/cu.mm
ESR 18 0-20 mm/hr
Direct bilirubin 4.2 0-0.2 mg/dl
Indirect bilirubin 4 0.3-1.0 mg/dl
SGOT 126 Upto 35 IU/L
SGPT 72 Upto 45 IU/L
PT 27 11-15.8 sec
5
Ø Radiographic Data
Ø USG abdomen : Fatty liver with nodules surface of liver
6
3. ASSESSMENT
Subjective Evidences
• Yellow discoloration of skin
• Swelling in both lower leg
• Constipation and Abdominal distention
• Fatigue
• Alcoholic since 8 years
• Smoker since 12 years
Objective Evidence
• Hb↓
• Direct Bilirubin and Indirect bilirubin Serum↑
• SGOT, SGPT↑
• USG Abdomen : Fatty liver
7
Based on subjective evidence & objective evidence patient is diagnosed to have
ALCOHOLIC LIVER DISEASE
4. PLANNING
l To reduce liver injury due to excessive alcohol use
l To prevent progression of Disease
l To reduce symptom
l To prevent complication
l To reduce need of hospitalisation
8
DRUG TREATMENT CHART
BRAND NAME GENERIC NAME DOSE ROUTE FREQUENCY
Inj. THIAMINE HCL Thiamine HCL (vit B1) 100mg IV OD
Inj. HEPA MERZ L-Ornithine, L-Aspartate 5mg IV BD
Inj. VIT. K Vitamin K 10mg IV BD
Tab. FLOWPENT Pentoxiphylline 400mg ORAL TDS
Tab. RIXMIN Rifaximine 400mg ORAL BD
Tab. LASIX Furosemide 40mg ORAL BD
Syp. DUPHALAC Lactulose 20ml ORAL TDS
9
PROGRSS CHART
DAY 1 Patient admitted with complaints of yellowish discolouration of skin, swe
lling in both lower leg, abdominal distention etc. and was diagnosed with
ALCOHOLIC LIVER DISEASE
DAY 2 NO fresh complaints seen
BP : 120/80mmHg
Pulse rate :89 bpm
DAY 3 Patient improved symptomatically
Requested for Discharge
BP :120/80 mmHg
PR : 88 bpm
10
Goal achieved
Ø Reduce liver injury due to excessive alcohol use
reduced
Ø Disease progession prevented
Ø Signs and symptoms improved
Ø Patient quality of life improved
11
12

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Clinical case study of Alcoholic Liver Disease by Rajendra Keshkar

  • 1. ISF College Of Pharmacy Ghal Kalan GT Road, Moga-142001, Punjab, INDIA ( An Autonomous College U/s UGC Act 1956 ) ALCOHOLIC LIVER DISEASE Rajendra Kumar Roll No.- 1813772 Class- PHARM D 2nd yr Dept. Of Pharmacy Practice ISF COLLEGE OF PHARMACY 1
  • 2. Demographics Ø Name : XYZ Ø Date of admission : 11/10/2019 Ø Date of discharge : 16/10/2019 Ø Department : Gastroenterology ( GW 02) Ø Sex : Male Ø Age : 55 yrs Weight : 85 kg 2
  • 3. 1. SUBJECTIVE EVIDENCES ØChief complaints on admission • Patient have complaints of yellowish discolaration of skin, swelling in both lower leg. • c/o hard stool and fatigue • c/o abdominal distention ØPast medical history : k/c/o Depression, Asthma Ø Social History : Smoker ( 1-3 cigarette per day ) since 12 years Alcoholic since 8 years ( 40 ml - 50 ml ) 3
  • 4. 2.OBJECTIVE EVIDENCES Ø Systemic Examination Ø CNS : Conscious and oriented Ø Per Abdomen : Distended Ø Vital Signs Ø BP : 130/80mmhg Ø PR : 80 bpm 4
  • 5. Ø LABORATORY DATA INVESTIGATION TEST VALUE NORMAL VALUE Hb 10.2 13-18 g/dl TLC 9700 4000-10000 cells/cu.mm ESR 18 0-20 mm/hr Direct bilirubin 4.2 0-0.2 mg/dl Indirect bilirubin 4 0.3-1.0 mg/dl SGOT 126 Upto 35 IU/L SGPT 72 Upto 45 IU/L PT 27 11-15.8 sec 5
  • 6. Ø Radiographic Data Ø USG abdomen : Fatty liver with nodules surface of liver 6
  • 7. 3. ASSESSMENT Subjective Evidences • Yellow discoloration of skin • Swelling in both lower leg • Constipation and Abdominal distention • Fatigue • Alcoholic since 8 years • Smoker since 12 years Objective Evidence • Hb↓ • Direct Bilirubin and Indirect bilirubin Serum↑ • SGOT, SGPT↑ • USG Abdomen : Fatty liver 7 Based on subjective evidence & objective evidence patient is diagnosed to have ALCOHOLIC LIVER DISEASE
  • 8. 4. PLANNING l To reduce liver injury due to excessive alcohol use l To prevent progression of Disease l To reduce symptom l To prevent complication l To reduce need of hospitalisation 8
  • 9. DRUG TREATMENT CHART BRAND NAME GENERIC NAME DOSE ROUTE FREQUENCY Inj. THIAMINE HCL Thiamine HCL (vit B1) 100mg IV OD Inj. HEPA MERZ L-Ornithine, L-Aspartate 5mg IV BD Inj. VIT. K Vitamin K 10mg IV BD Tab. FLOWPENT Pentoxiphylline 400mg ORAL TDS Tab. RIXMIN Rifaximine 400mg ORAL BD Tab. LASIX Furosemide 40mg ORAL BD Syp. DUPHALAC Lactulose 20ml ORAL TDS 9
  • 10. PROGRSS CHART DAY 1 Patient admitted with complaints of yellowish discolouration of skin, swe lling in both lower leg, abdominal distention etc. and was diagnosed with ALCOHOLIC LIVER DISEASE DAY 2 NO fresh complaints seen BP : 120/80mmHg Pulse rate :89 bpm DAY 3 Patient improved symptomatically Requested for Discharge BP :120/80 mmHg PR : 88 bpm 10
  • 11. Goal achieved Ø Reduce liver injury due to excessive alcohol use reduced Ø Disease progession prevented Ø Signs and symptoms improved Ø Patient quality of life improved 11
  • 12. 12