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Dr Fathi 3/12/21
Describe the mechanism of
control of body pH by the renal
system
5 marks
Introduction
•Renal play important role and neutralize more acid
than both respiratory and chemical buffers
•It maintain the normal acid base balance by
reabsorption of HCO3- and excretion of H+
HCO3 reabsorption
•At the proximal collecting tubule
•Filtered HCO3- combined with
filtered H (by carbonic anhydrase)
to produce H20 and CO2 (lipid
soluble)
•In the PCT renal cell, it recombine
again to form HCO3- which
reabsorb through basolateral
membrane by Na+ HCO3- co
transport
H+ excretion
•At the late distal tubule and
collecting duct
•CO2 and H2O combined to form
carbonic acid which dissociated
to H+, HCO3-
•H+ will be excreted to lumen,
HCO3- will be absorbed
•
In high acidity condition
•Kidneys will conserve HCO3- : reabsorb all filtered
HCO3-
•Kidney will increase secretion of H+ and simultaneously
generate new HCO3-
•In alkaline condition, reverse of above will occur

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pg cme renal pH.pdf

  • 1. Dr Fathi 3/12/21 Describe the mechanism of control of body pH by the renal system 5 marks
  • 2. Introduction •Renal play important role and neutralize more acid than both respiratory and chemical buffers •It maintain the normal acid base balance by reabsorption of HCO3- and excretion of H+
  • 3. HCO3 reabsorption •At the proximal collecting tubule •Filtered HCO3- combined with filtered H (by carbonic anhydrase) to produce H20 and CO2 (lipid soluble) •In the PCT renal cell, it recombine again to form HCO3- which reabsorb through basolateral membrane by Na+ HCO3- co transport
  • 4. H+ excretion •At the late distal tubule and collecting duct •CO2 and H2O combined to form carbonic acid which dissociated to H+, HCO3- •H+ will be excreted to lumen, HCO3- will be absorbed •
  • 5. In high acidity condition •Kidneys will conserve HCO3- : reabsorb all filtered HCO3- •Kidney will increase secretion of H+ and simultaneously generate new HCO3- •In alkaline condition, reverse of above will occur