This document discusses how Cochrane reviews are used by Kaiser Permanente Southern California (KPSC) in developing clinical practice guidelines, conducting medical technology assessments, and supporting evidence-based implementation efforts. It provides examples of how Cochrane reviews have influenced guidelines on chronic obstructive pulmonary disease and breast cancer screening. Cochrane reviews are also frequently referenced in KPSC's medical technology assessments and evaluations of implementation strategies for chronic condition education. Overall, Cochrane is considered a primary source of systematic reviews that impact care delivery within the large health system.
This document summarizes a kick-off meeting for the SAFTINet project. The meeting welcomed collaborators and outlined goals of establishing a distributed research network to conduct comparative effectiveness research using electronic health data from multiple healthcare organizations. The agenda included introductions of participating organizations, presentations on comparative effectiveness research and the technical capabilities needed, and discussions around engaging partners and getting started with the work.
A clinical guide provides definitions for different stages of standing and walking ability after spinal cord injury. Stage 1 includes no walking capacity, with 1A having no lower extremity movement, 1B having voluntary but non-functional movement, and 1C having voluntary functional movement. Stage 2 involves therapeutic walking capacity indoors with maximal or moderate physical assistance. Standardized outcome measures are recommended to assess patients at each stage and track their progress.
The document discusses challenges in evaluating the effectiveness of diagnostic tests and linking test results to patient outcomes. It notes that tests provide information to guide therapeutic decisions, so test effects are realized in the context of available therapies. Randomized trials of tests alone are difficult to design, but trials can compare strategies incorporating tests. Observational studies using large databases can also assess tests, but have limitations like lacking test findings and clinical context. The National Oncology PET Registry prospectively collected real-world data on how PET impacts management plans and found changes in 36.5% of cases. However, it did not evaluate if changes improved outcomes. Combining registries with claims data can provide more longitudinal information but also has weaknesses. Evaluating newer diagnostics
The document is a presentation from Quest Diagnostics given at the UBS 2007 Global Life Sciences Conference. It summarizes that Quest Diagnostics is a leader in diagnostic testing and information technology solutions, touching over 150 million patient lives in 2006. It provides an overview of the company's network, services, growth opportunities around cancer diagnostics, personalized medicine, and near-patient testing, and approach to driving profitable growth.
A Presentation that promotes Evidence-Based Psychiatry and informed clinical decision making in the daily practice of Psychiatry. Prepared by Dr Yasser Amer and Dr Maged Elesely
The Adapted ADAPTE approach to CPG adaptation proposed by the Alexandria Center for Evidence-Based Clinical Practice Guidelines, Alexandria University, Egypt.
An oral presentation conducted by Prof. Tarek Omar during the national initiative of the Pediatrics Department, Armed Forces College of Medicine, themed; 'Towards National Guidelines' that was launched in 2018 and started by Pediatrics CPGs
This document provides an overview and agenda for an informational webinar on the NYS Health Innovation Challenge. The webinar will feature representatives from the NYS Department of Health and Health 2.0 who will describe the challenge, available data assets including SPARCS, QARR and cardiac reporting system data, and details about the challenge such as evaluation criteria and timeline. The challenge aims to create technology-driven solutions that enable various groups to explore quality, charges and costs data for medical procedures in NYS hospitals in order to increase usage of open health data, reduce healthcare costs, and empower consumers.
Part 1. An overview on implementation of CPGs
Part 2. CPGs & HTAs
Presented during the 2nd Regional Workshop for CPG Adaptation, Tunis, Tunisia May 24-26 2016
A collaborative between INA Sante, WHO-EMRO, KSU
This document summarizes a kick-off meeting for the SAFTINet project. The meeting welcomed collaborators and outlined goals of establishing a distributed research network to conduct comparative effectiveness research using electronic health data from multiple healthcare organizations. The agenda included introductions of participating organizations, presentations on comparative effectiveness research and the technical capabilities needed, and discussions around engaging partners and getting started with the work.
A clinical guide provides definitions for different stages of standing and walking ability after spinal cord injury. Stage 1 includes no walking capacity, with 1A having no lower extremity movement, 1B having voluntary but non-functional movement, and 1C having voluntary functional movement. Stage 2 involves therapeutic walking capacity indoors with maximal or moderate physical assistance. Standardized outcome measures are recommended to assess patients at each stage and track their progress.
The document discusses challenges in evaluating the effectiveness of diagnostic tests and linking test results to patient outcomes. It notes that tests provide information to guide therapeutic decisions, so test effects are realized in the context of available therapies. Randomized trials of tests alone are difficult to design, but trials can compare strategies incorporating tests. Observational studies using large databases can also assess tests, but have limitations like lacking test findings and clinical context. The National Oncology PET Registry prospectively collected real-world data on how PET impacts management plans and found changes in 36.5% of cases. However, it did not evaluate if changes improved outcomes. Combining registries with claims data can provide more longitudinal information but also has weaknesses. Evaluating newer diagnostics
The document is a presentation from Quest Diagnostics given at the UBS 2007 Global Life Sciences Conference. It summarizes that Quest Diagnostics is a leader in diagnostic testing and information technology solutions, touching over 150 million patient lives in 2006. It provides an overview of the company's network, services, growth opportunities around cancer diagnostics, personalized medicine, and near-patient testing, and approach to driving profitable growth.
A Presentation that promotes Evidence-Based Psychiatry and informed clinical decision making in the daily practice of Psychiatry. Prepared by Dr Yasser Amer and Dr Maged Elesely
The Adapted ADAPTE approach to CPG adaptation proposed by the Alexandria Center for Evidence-Based Clinical Practice Guidelines, Alexandria University, Egypt.
An oral presentation conducted by Prof. Tarek Omar during the national initiative of the Pediatrics Department, Armed Forces College of Medicine, themed; 'Towards National Guidelines' that was launched in 2018 and started by Pediatrics CPGs
This document provides an overview and agenda for an informational webinar on the NYS Health Innovation Challenge. The webinar will feature representatives from the NYS Department of Health and Health 2.0 who will describe the challenge, available data assets including SPARCS, QARR and cardiac reporting system data, and details about the challenge such as evaluation criteria and timeline. The challenge aims to create technology-driven solutions that enable various groups to explore quality, charges and costs data for medical procedures in NYS hospitals in order to increase usage of open health data, reduce healthcare costs, and empower consumers.
Part 1. An overview on implementation of CPGs
Part 2. CPGs & HTAs
Presented during the 2nd Regional Workshop for CPG Adaptation, Tunis, Tunisia May 24-26 2016
A collaborative between INA Sante, WHO-EMRO, KSU
PCMH: Part 4 – Learn How to Start or Improve Your Quality Improvement ProgramJulie Champagne
We wrap up our PCMH series with a deep dive into Standard 5-Care Coordination and Care Transitions and Standard 6- Performance Measurement and Quality Improvement. How are you handling referrals and transitions of care today? Do you need to make changes to optimize the process? We’ll review care coordination elements and factors as well as the performance improvement standards, elements, and associated factors in this webinar to complete your practice’s PCMH transformation!
IMS Health Clinical Trial Optimization SolutionsQuintilesIMS
IMS Health's Linda T. Drumright, general manager, Clinical Trial Optimization Solutions presents at the 3rd Annual Patient Recruitment & Retention Summit 2014 - San Francisco, CA
Practice guidelines-for-obstetric-anesthesiakiennguyen255
These guidelines update the 2006 American Society of Anesthesiologists guidelines on obstetric anesthesia. They were developed through a literature review and surveys of experts and anesthesiologists. The guidelines focus on anesthesia management during labor, delivery, and immediate postpartum care. They do not address all aspects of obstetric anesthesia or patients with medical complications. The guidelines are intended to improve quality of care, safety, and patient satisfaction for obstetric patients receiving anesthesia.
1) The document discusses guidelines adaptation versus de novo development, outlining the differences in processes and methodologies between the two approaches.
2) It provides an overview of the ADAPTE framework, a systematic approach to adapting existing high-quality clinical practice guidelines to different contexts and organizations. The ADAPTE framework consists of 3 phases and 9 modules over 23 steps.
3) Adaptation offers an alternative to de novo guideline development when high quality guidelines already exist, in order to customize them efficiently for local use while reducing duplication of efforts.
This clinical audit tool provides standards and guidance for auditing the use of ultrasound to determine viable intrauterine pregnancy in cases of ectopic pregnancy and miscarriage. The tool includes clinical audit standards, a data collection form, and an action plan template. It accompanies NICE clinical guideline 154 on the diagnosis and management of ectopic pregnancy and miscarriage. The audit is intended to help services improve their practice in line with recommendations in the guideline.
Predictive analytics for personalized healthcareJohn Cai
This document discusses how predictive analytics can help enable personalized health care through three main points:
1) Integrating diverse data sources like genomics, healthcare records, and insurance claims can provide insights for personalized care, drug development, and comparative effectiveness research.
2) Predictive models built using data from clinical trials can identify subgroups of patients most likely to respond or not respond to treatments early in the treatment course, improving outcomes.
3) Personalized comparative effectiveness research aims to determine which treatments work best for which patient subgroups and disease stages by integrating real-world data and predictive analytics into drug development and clinical decision-making.
1. This clinical practice guideline provides evidence-based recommendations for the early management of head injury in adults.
2. It covers pre-hospital care, emergency department management, investigations, medications, and considerations for special patient populations.
3. The guideline is intended to guide healthcare professionals, including doctors, pharmacists, and allied health professionals, involved in primary and secondary care of adult patients presenting with head injury.
This document describes the implementation and results of establishing an independent breast care clinic directed by an advanced practice clinician (APC) at a university hospital. The goals were to decrease wait times for appointments, improve financial viability, and increase patient, APC, and physician satisfaction. After applying "lean" principles to redesign clinic workflows, the APC began independently evaluating and treating patients under physician supervision. Results showed trends of decreased median wait times for new appointments, increased monthly charges billed by the APC from $388 to $30,800, and high patient satisfaction scores for both the APC and surgeon of over 95%. The study demonstrated how utilizing an APC can help meet goals of improved access, value, and satisfaction
A personalized training workshop for the PRM Department Staff at KSUMC at large. The specific target audience is the CPG working groups and new committee members.
An introduction on Evidence-Based Clinical Practice Guidelines in Health Care Organizations
Brief on Alexandria Center for EBCPGs in Alexandria University Hospitals, Egypt
By Dr. Yasser Sami Abdel Dayem Amer, MBBCh, MS 2013
Special Thanks to
Prof Dr Mahmoud Elzalabany
Prof Dr Tarek Omar
Prof Dr Nabil Dowidar
Prof Dr Afaf Gaber
How Researchers Can Get Science Done Faster Using an R&D Services MarketplaceSC CTSI at USC and CHLA
Date: Feb 6, 2019
Topic: How Researchers Can Get Science Done Faster Using an R&D Services Marketplace
Speaker: Dr. Zev Wisotsky is a Senior Scientist and R&D Specialist at Science Exchange, where he assists researchers in connecting with the right R&D providers for their experiments and alerts his clients to newly available technologies. Dr. Wisotsky earned his PhD in neuroscience investigating taste detection using fruit fly and mosquito models at UC Riverside. He then completed postdoctoral research at Stanford studying the role of brain regions involved in fear memory and addiction through optogenetic silencing of different brain circuits.
Overview: Science Exchange is an open marketplace for scientific research that breaks down barriers to collaboration and innovation. The platform makes it easy for researchers to access more than 6,000 services from a network of over 2,500 qualified research providers. In this webinar, you will learn how researchers can use Science Exchange to access new technologies, get competitive quotes for specific projects, and order from any service provider under a single, pre-established contract. The presentation will also include examples of successful projects and collaborations, initiated on the Science Exchange platform, that have accelerated breakthrough
Patient Blood Management: Impact of Quality Data on Patient OutcomesViewics
Patient blood management (PBM) has been proven to improve patient outcomes and save hospitals millions of dollars. Ensuring the quality of your data is central to decision making and critical to having a strong PBM program.
Would you like to learn how your organization can improve patient outcomes by implementing a PBM program based on accurate data?
If so, view this presentation by blood management expert Lance Trewhella. Lance presents how to develop a successful, evidence-based, multidisciplinary PBM program aimed at optimizing the care of patients who might need transfusion.
You’ll learn:
• Current recommendations for blood transfusion utilization
• The impact of quality data on PBM programs
• Best data practices in PBM
EVIDENCE-BASED CPGs FOR HEMATOLOGY - ONCOLOGY UNIT, KING SAUD UNIVERSITY HOPSITALS
Saudi Arabia, Riyadh
King Saud University Hospitals
CPGs Committee
Quality Management Dept
CPGs Program
By YASSER SAMI AMER
Lynne E. Becker is seeking a senior level position in corporate project research. She has over 10 years of experience managing multi-site clinical research projects, including experience in protocol development, site selection and training, patient recruitment and retention, and ensuring regulatory compliance. She is skilled in data analysis, database management, and using technology like telemedicine to efficiently achieve project goals. Her background includes managing both domestic and international clinical trials with budgets in the millions of dollars.
Big Data Analytics for Treatment Pathways John CaiJohn Cai
This document discusses using real-world big data analytics to understand treatment pathways. It begins by explaining the need for real-world evidence from real-world data to assess effectiveness and outcomes beyond randomized clinical trials. It then describes the volume, variety, and velocity characteristics of real-world big data from sources like claims, EMRs, surveys, and devices. Technical challenges of reconstructing complex patient journeys are discussed. Hadoop and MapReduce are presented as a potential solution by breaking the work into mappers that extract patient data and reducers that organize it into timelines. Examples are given of how this could enable cost, pathway, and outcomes analyses to better inform decision making.
Using alternative scholarly metrics to showcase the impact of your research: ...SC CTSI at USC and CHLA
Date: Feb 7, 2018
Speaker: Caroline Muglia, Co-Associate Dean for Collections and Technical Services; and Head, Resource Sharing and Collection Assessment, USC Libraries
Overview: Scholarship is increasingly being created, disseminated, and measured on digital and social platforms. If Twitter exchanges, Facebook “saves,” and YouTube hits are the new metrics for tracking scholarship, how are we measuring societal and educational impact and outreach? How can researchers display their research impact using social media on promotion and tenure dossiers? This webinar will discuss altmetrics, alternative scholarly metrics that measure the impact and use of scholarship. We will focus on PlumX, the tool used at USC, which combines traditional and new metrics to paint a comprehensive portrait of your scholarly output and its reach in various communities and with different stakeholders.
Organisational development within the Cochrane Collaboration: Establishing a ...Cochrane.Collaboration
The document discusses two organizational changes made within the Cochrane Collaboration: [1] establishing a Board of Co-ordinating Editors and [2] establishing the position of Editor-in-Chief. These changes were made to improve governance, accountability, and responsiveness in order to meet future challenges. Next steps include Board meetings to focus inward on skills and outward on governance, and selecting an Editor-in-Chief.
General Rules on Frequency Wobbles and Feathering Spooky2 Rife
The document discusses rules for frequency wobbles and feathering when using a Spooky2 device. For non-living things like metals and toxins, the harmonic wobble setting should be set to None, as non-living things cannot mutate. For living things that naturally belong in the body like organs, the setting should also be None to provide precise frequencies. However, for living things that do not belong in the body, like bacteria or viruses, the wobble setting should be other than None to account for their ability to mutate over time. The document also discusses wobbling individual frequencies versus all frequencies in a sequence and recommends a feathering of +-0.02% for remote use.
PCMH: Part 4 – Learn How to Start or Improve Your Quality Improvement ProgramJulie Champagne
We wrap up our PCMH series with a deep dive into Standard 5-Care Coordination and Care Transitions and Standard 6- Performance Measurement and Quality Improvement. How are you handling referrals and transitions of care today? Do you need to make changes to optimize the process? We’ll review care coordination elements and factors as well as the performance improvement standards, elements, and associated factors in this webinar to complete your practice’s PCMH transformation!
IMS Health Clinical Trial Optimization SolutionsQuintilesIMS
IMS Health's Linda T. Drumright, general manager, Clinical Trial Optimization Solutions presents at the 3rd Annual Patient Recruitment & Retention Summit 2014 - San Francisco, CA
Practice guidelines-for-obstetric-anesthesiakiennguyen255
These guidelines update the 2006 American Society of Anesthesiologists guidelines on obstetric anesthesia. They were developed through a literature review and surveys of experts and anesthesiologists. The guidelines focus on anesthesia management during labor, delivery, and immediate postpartum care. They do not address all aspects of obstetric anesthesia or patients with medical complications. The guidelines are intended to improve quality of care, safety, and patient satisfaction for obstetric patients receiving anesthesia.
1) The document discusses guidelines adaptation versus de novo development, outlining the differences in processes and methodologies between the two approaches.
2) It provides an overview of the ADAPTE framework, a systematic approach to adapting existing high-quality clinical practice guidelines to different contexts and organizations. The ADAPTE framework consists of 3 phases and 9 modules over 23 steps.
3) Adaptation offers an alternative to de novo guideline development when high quality guidelines already exist, in order to customize them efficiently for local use while reducing duplication of efforts.
This clinical audit tool provides standards and guidance for auditing the use of ultrasound to determine viable intrauterine pregnancy in cases of ectopic pregnancy and miscarriage. The tool includes clinical audit standards, a data collection form, and an action plan template. It accompanies NICE clinical guideline 154 on the diagnosis and management of ectopic pregnancy and miscarriage. The audit is intended to help services improve their practice in line with recommendations in the guideline.
Predictive analytics for personalized healthcareJohn Cai
This document discusses how predictive analytics can help enable personalized health care through three main points:
1) Integrating diverse data sources like genomics, healthcare records, and insurance claims can provide insights for personalized care, drug development, and comparative effectiveness research.
2) Predictive models built using data from clinical trials can identify subgroups of patients most likely to respond or not respond to treatments early in the treatment course, improving outcomes.
3) Personalized comparative effectiveness research aims to determine which treatments work best for which patient subgroups and disease stages by integrating real-world data and predictive analytics into drug development and clinical decision-making.
1. This clinical practice guideline provides evidence-based recommendations for the early management of head injury in adults.
2. It covers pre-hospital care, emergency department management, investigations, medications, and considerations for special patient populations.
3. The guideline is intended to guide healthcare professionals, including doctors, pharmacists, and allied health professionals, involved in primary and secondary care of adult patients presenting with head injury.
This document describes the implementation and results of establishing an independent breast care clinic directed by an advanced practice clinician (APC) at a university hospital. The goals were to decrease wait times for appointments, improve financial viability, and increase patient, APC, and physician satisfaction. After applying "lean" principles to redesign clinic workflows, the APC began independently evaluating and treating patients under physician supervision. Results showed trends of decreased median wait times for new appointments, increased monthly charges billed by the APC from $388 to $30,800, and high patient satisfaction scores for both the APC and surgeon of over 95%. The study demonstrated how utilizing an APC can help meet goals of improved access, value, and satisfaction
A personalized training workshop for the PRM Department Staff at KSUMC at large. The specific target audience is the CPG working groups and new committee members.
An introduction on Evidence-Based Clinical Practice Guidelines in Health Care Organizations
Brief on Alexandria Center for EBCPGs in Alexandria University Hospitals, Egypt
By Dr. Yasser Sami Abdel Dayem Amer, MBBCh, MS 2013
Special Thanks to
Prof Dr Mahmoud Elzalabany
Prof Dr Tarek Omar
Prof Dr Nabil Dowidar
Prof Dr Afaf Gaber
How Researchers Can Get Science Done Faster Using an R&D Services MarketplaceSC CTSI at USC and CHLA
Date: Feb 6, 2019
Topic: How Researchers Can Get Science Done Faster Using an R&D Services Marketplace
Speaker: Dr. Zev Wisotsky is a Senior Scientist and R&D Specialist at Science Exchange, where he assists researchers in connecting with the right R&D providers for their experiments and alerts his clients to newly available technologies. Dr. Wisotsky earned his PhD in neuroscience investigating taste detection using fruit fly and mosquito models at UC Riverside. He then completed postdoctoral research at Stanford studying the role of brain regions involved in fear memory and addiction through optogenetic silencing of different brain circuits.
Overview: Science Exchange is an open marketplace for scientific research that breaks down barriers to collaboration and innovation. The platform makes it easy for researchers to access more than 6,000 services from a network of over 2,500 qualified research providers. In this webinar, you will learn how researchers can use Science Exchange to access new technologies, get competitive quotes for specific projects, and order from any service provider under a single, pre-established contract. The presentation will also include examples of successful projects and collaborations, initiated on the Science Exchange platform, that have accelerated breakthrough
Patient Blood Management: Impact of Quality Data on Patient OutcomesViewics
Patient blood management (PBM) has been proven to improve patient outcomes and save hospitals millions of dollars. Ensuring the quality of your data is central to decision making and critical to having a strong PBM program.
Would you like to learn how your organization can improve patient outcomes by implementing a PBM program based on accurate data?
If so, view this presentation by blood management expert Lance Trewhella. Lance presents how to develop a successful, evidence-based, multidisciplinary PBM program aimed at optimizing the care of patients who might need transfusion.
You’ll learn:
• Current recommendations for blood transfusion utilization
• The impact of quality data on PBM programs
• Best data practices in PBM
EVIDENCE-BASED CPGs FOR HEMATOLOGY - ONCOLOGY UNIT, KING SAUD UNIVERSITY HOPSITALS
Saudi Arabia, Riyadh
King Saud University Hospitals
CPGs Committee
Quality Management Dept
CPGs Program
By YASSER SAMI AMER
Lynne E. Becker is seeking a senior level position in corporate project research. She has over 10 years of experience managing multi-site clinical research projects, including experience in protocol development, site selection and training, patient recruitment and retention, and ensuring regulatory compliance. She is skilled in data analysis, database management, and using technology like telemedicine to efficiently achieve project goals. Her background includes managing both domestic and international clinical trials with budgets in the millions of dollars.
Big Data Analytics for Treatment Pathways John CaiJohn Cai
This document discusses using real-world big data analytics to understand treatment pathways. It begins by explaining the need for real-world evidence from real-world data to assess effectiveness and outcomes beyond randomized clinical trials. It then describes the volume, variety, and velocity characteristics of real-world big data from sources like claims, EMRs, surveys, and devices. Technical challenges of reconstructing complex patient journeys are discussed. Hadoop and MapReduce are presented as a potential solution by breaking the work into mappers that extract patient data and reducers that organize it into timelines. Examples are given of how this could enable cost, pathway, and outcomes analyses to better inform decision making.
Using alternative scholarly metrics to showcase the impact of your research: ...SC CTSI at USC and CHLA
Date: Feb 7, 2018
Speaker: Caroline Muglia, Co-Associate Dean for Collections and Technical Services; and Head, Resource Sharing and Collection Assessment, USC Libraries
Overview: Scholarship is increasingly being created, disseminated, and measured on digital and social platforms. If Twitter exchanges, Facebook “saves,” and YouTube hits are the new metrics for tracking scholarship, how are we measuring societal and educational impact and outreach? How can researchers display their research impact using social media on promotion and tenure dossiers? This webinar will discuss altmetrics, alternative scholarly metrics that measure the impact and use of scholarship. We will focus on PlumX, the tool used at USC, which combines traditional and new metrics to paint a comprehensive portrait of your scholarly output and its reach in various communities and with different stakeholders.
Organisational development within the Cochrane Collaboration: Establishing a ...Cochrane.Collaboration
The document discusses two organizational changes made within the Cochrane Collaboration: [1] establishing a Board of Co-ordinating Editors and [2] establishing the position of Editor-in-Chief. These changes were made to improve governance, accountability, and responsiveness in order to meet future challenges. Next steps include Board meetings to focus inward on skills and outward on governance, and selecting an Editor-in-Chief.
General Rules on Frequency Wobbles and Feathering Spooky2 Rife
The document discusses rules for frequency wobbles and feathering when using a Spooky2 device. For non-living things like metals and toxins, the harmonic wobble setting should be set to None, as non-living things cannot mutate. For living things that naturally belong in the body like organs, the setting should also be None to provide precise frequencies. However, for living things that do not belong in the body, like bacteria or viruses, the wobble setting should be other than None to account for their ability to mutate over time. The document also discusses wobbling individual frequencies versus all frequencies in a sequence and recommends a feathering of +-0.02% for remote use.
Katherine Haxton presented a method for identifying and addressing student misconceptions in chemistry. She administered diagnostic concept tests to identify common misunderstandings among students. For example, many students did not consider water to be a chemical or thought that natural substances are inherently safer than synthetic ones. Haxton analyzed test responses to determine the level of student confidence and knowledge in order to identify questions where prior knowledge affected performance. The process of developing and refining concept tests can help instructors target the specific misconceptions hindering student learning.
This book is the first in a series published by Wiley entitled Technologies for the Pharmaceutical Industry. The series aims to bring opinion leaders together to address important topics for the industry, from technologies implemented to current challenges. It will describe how key technologies are likely to impact discovery and development. The book is split into five parts covering introduction to toxicology methods, computational methods, applying computers to toxicity assessment for pharmaceuticals and the environment, and new technologies, future perspectives and regulatory needs. Sean Ekins is the editor and his research focuses on computational and in vitro drug discovery approaches.
Gateways can connect legacy devices to the internet by translating between the device's protocols and IoT protocols. A gateway identifies the connected device and receives its datapoint definitions from the cloud. A semantic data model maps different devices' raw datapoints to standardized values to simplify access by applications.
This document discusses finding and screening clinical practice guidelines for adaptation. It outlines three filters for selecting guidelines: 1) assessing health questions and scope, 2) applying inclusion/exclusion criteria, and 3) using the AGREE II instrument. It identifies sources for finding guidelines, such as specialty societies, government agencies, and databases. Selection criteria are presented to narrow the list of guidelines, focusing on those published in the last five years, in English or French, and developed based on evidence rather than consensus. The document aims to reduce a large number of retrieved guidelines by screening their methodology of development.
The document discusses using a Rife machine frequency audio treatment for diabetes. It provides Rife machine frequency protocols for treating type 1 and type 2 diabetes, as well as general detoxification. The document claims many people have reported success using Rife machine frequency audio treatments for diabetes and directs the reader to an official website and support forums for more information on treatments and success stories.
The document provides tips for improving personal and work efficiency. Some key points include prioritizing tasks and getting difficult ones out of the way first, limiting distractions from instant messaging, getting a grip on email by checking and responding every two hours, breaking projects into smaller activities with mini deadlines, extensively researching before executing projects, assessing results, and continuously working to improve weaknesses and stay up-to-date in one's field.
1) The document presents a strategy for Lancome's luxury beauty segment based on research including an online survey, industry consultations, and store observations.
2) It provides a brief history of Lancome from its founding in 1935 to present partnerships and leadership.
3) The current organizational structure is outlined with divisions for research, operations, marketing, human resources, and regional management.
4) A literature review covers SWOT analysis and models like BCG matrix and Porter's five forces that were applied to evaluate Lancome's position.
5) Analysis of strengths, weaknesses, opportunities and threats leads to recommendations to match strengths to opportunities and address weaknesses through investment and pricing strategies.
Using the PEMF Coil with Spooky Central and Spooky2-XM GeneratorSpooky2 Rife
The PEMF coil can be used with both the Spooky Central generator and the Spooky2-XM generator, but there are differences. With Spooky Central, the PEMF coil helps induce electroporation at a fixed frequency and plasma is the most powerful feature. When used with Spooky2-XM, the power is reduced but the coil can be used for entrainment which requires variable frequencies. Contact information is provided for the official support and purchasing websites as well as customer service emails.
Five Ways to Use Social Media to Raise Awareness for Your Paper or ResearchSean Ekins
Presentation given at the AAPS 2016 conference in Denver. Some of the slides are from AAPS, Some from Kudos and some from Figshare. One slide is from Tony Williams. All slides used with permission.
Young's is relaunching its tomato ketchup in Pakistan. Previously, Young's ketchup failed due to a lack of variety and promotion. To succeed this time, Young's proposes introducing new flavors like chili garlic and chili ginger ketchup. It will target middle to upper income households and restaurants. Young's total marketing budget is Rs. 78 million, with 30% for promotion, 60% for production, and 10% for distribution. The promotional strategy includes TV, print, and radio ads, as well as sampling, demonstrations, and retailer incentives. The goal is to position Young's ketchup as a tastier option at a moderate price point.
Robert Parson has over 15 years of experience in leadership roles in the healthcare industry. He has a proven track record of guiding medical products from concept to commercialization and ensuring quality and regulatory compliance. Parson has expertise in areas such as strategic planning, regulatory affairs, clinical research, and pharmacoeconomics. He holds advanced degrees from the University of California San Diego, Rochester Institute of Technology, and Purdue University.
Evidence-based medicine has evolved from focusing primarily on randomized controlled trials to incorporating a broader range of evidence, including observational studies and evidence generated from practice settings. It aims to integrate the highest quality external evidence with internal organizational data and stakeholder perspectives to improve health outcomes.
This document discusses accountable care and evidence-based decision making in health care. It provides background on rising health care costs in the US and efforts to promote comparative effectiveness research (CER) and patient-centered outcomes research (PCOR) to address this. It describes the 2009 $1.1 billion ARRA investment in CER and subsequent funding opportunities for PCOR through the Patient-Centered Outcomes Research Trust Fund and the Patient-Centered Outcomes Research Institute (PCORI). The document also discusses challenges of using CER/PCOR findings and the need to incorporate clinical decision-maker perspectives. It analyzes how different payment models like fee-for-service, pay-for-quality programs, episode-based
This document discusses integrated care in Redbridge and the development of "polysystems" to improve care coordination and outcomes. It notes that Redbridge has many primary care providers, acute trusts, community providers and voluntary organizations. It proposes establishing several "polysystems", centered around GP practices, to function as local care delivery networks. These polysystems will promote population health, maximize independence for those with long-term needs, and improve acute care. They will be accountable for quality, access and costs and incentivized through aligned data and governance structures integrating primary, community and social care.
A surgical council was formed with members from different hospitals within a health system to establish a single standard of surgical care across all hospitals. The council used the ACS NSQIP program to measure surgical outcomes and identify areas for improvement. Initial efforts focused on educating surgeons and staff about NSQIP reporting. Process improvement projects addressed local needs identified in the NSQIP data. Collaboration with other departments led to standardization of resources to improve quality and reduce costs. As a result, problem areas were addressed, practices and equipment were standardized, and an electronic health record was implemented across the system. The matured surgical council continues working on a larger scale to share initiatives and lessons learned to achieve best practices system-wide.
An overview of the oncology clinical trials network (CTNeT) which is being implemented throughout Texas.
The non-profit network is a first of its kind and combines the innovative science of Texas cancer centers with the expertise and resources of both academic and community oncologists throughout the state.
To learn more, visit www.ctnet.org
MOC is a lifelong learning process designed to document that physician specialists, certified by one of the 24 Member Boards of the American Board of Medical Specialties, maintain the necessary competencies to provide quality patient care.
The document summarizes presentations from a health IT seminar in North Carolina. It discusses the NC strategy for health IT which aims to improve healthcare quality and outcomes through better use of technology. It also discusses using telehealth for rehabilitation and the CCNC informatics center which uses data to help manage patient populations. Finally, it discusses NCB Prepared which focuses on using analytics for early detection of biological hazards. Key themes included using data and technology to improve patient care, population health, and public health surveillance.
Jay Moskowitz - Good Health Made PossibleEngenuitySC
Health Sciences South Carolina (HSSC) aims to improve the health of all South Carolinians through collaborative health sciences research, developing innovative health IT infrastructure, and catalyzing economic growth in the state. HSSC works with multiple research centers and hospitals to gather clinical data, identify best practices, and conduct research that benefits patients and leads to new treatments and economic opportunities. The organization strives to foster multidisciplinary research, implement new technologies like electronic health records, and translate scientific discoveries into improved health outcomes and jobs for South Carolinians.
The document provides an overview of the University of California Health's data analytics platform which combines healthcare data from the six University of California medical centers. It includes details on the health data warehouse such as the total number of patients, types of data collected, and tools used. The platform aims to enable researchers across UC to conduct studies using the large collection of standardized clinical data.
This document describes the Pediatrix Clinical DataWarehouse and its role in quality improvement initiatives for neonatal medicine. The Clinical DataWarehouse contains clinical data on over 700,000 patients and is one of the largest databases for neonatal outcomes. Data from electronic medical records is extracted and analyzed to identify areas for improvement. Quality improvement projects are developed and tracked using the QualitySteps system. Analyzing outcomes data allows Pediatrix to benchmark performance and drive continuous quality improvement that improves patient care.
NTTAP Webinar Series - April 13, 2023: Quality Improvement Strategies in a Te...CHC Connecticut
Join us for a webinar on quality improvement in team-based care!
Building a quality improvement (QI) infrastructure within team-based care is an organizational strategy that will establish a culture of continuous improvement across departments and improve quality in all domains of performance.
Participants will learn about:
• QI infrastructure
• Facilitating QI committees
• Coach training within health centers
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Perspectives on Cochrane Reviews from a User in the U.S.
1. Perspectives on Cochrane
Reviews from a User in the U.S.
16th Cochrane Colloquium
Freiburg, Germany
October 5, 2008
Marguerite Koster, MA, MFT
Practice Leader
Technology Assessment and Guidelines Unit
Kaiser Permanente Southern California
2. Presentation Overview
About Kaiser Permanente (KP)
About KP Southern California (KPSC)
Functions of the KPSC Technology Assessment &
Guidelines Unit
How Cochrane Reviews are used in the TAG Unit
Examples of how Cochrane reviews have influenced
health care decision making
Input from Kaiser Permanente users of Cochrane
reviews
Potential collaborative activities
2
3. About Kaiser Permanente
A Prepaid Integrated Health Care Delivery System
Social Mission
Quality Driven Permanente
Medical
Shared
Group
Accountability for
Program Success
Integration along
Multiple Dimensions
Prevention & Health
Kaiser
Maintenance Focus Permanente
Kaiser Kaiser
Foundation Foundation
Hospitals Health Plan
3
4. About Kaiser Permanente
Description: Nation’s largest nonprofit
WA
health plan (founded 1945)
OR
Integrated health care
NCal delivery system
CO OH MD
SCal VA DC
GA People: 8.7 million members
14,000+ physicians
HI 40,000+ nurses
159,000+ employees
Facilities: 8 regions in 9 states and D.C.
32 hospitals and med centers
421 medical offices
Revenue: $37.8 billion annually
Based on year-end 2007 statistics
4
5. KP Southern California
Description: One of KP’s largest regions
WA
People: 3.3 million members
• from 140 countries
OR • 90 different languages spoken
6,000 physicians
NCal 13,000 nurses
CO OH MD 55,000 employees
SCal VA DC
GA
HI Facilities: 12 hospitals and med centers
130 medical offices
Revenue: $9 billion annually
Doctor Office Visits: 17.5 million annually
Prescriptions Filled: 24 million annually
Based on year-end 2007 statistics 5
6. KPSC Technology Assessment
& Guidelines Unit - Functions
Clinical Practice Develop evidence-based guidelines (n=30) to
support important KPSC clinical goals
Guidelines Provide evidence support for KP National
guidelines program
Produce evidence-based technology
Medical Technology assessments (e.g., evaluate devices, equipment,
Assessment medical and surgical procedures)
Staff a Medical Technology Inquiry Service
(respond to 500-600 physician inquiries per year)
Provide evidence support for KP National
technology assessment program
Evidence-Based Produce evidence reviews on the effectiveness of
implementation strategies for clinical
Implementation interventions
Produce evidence synopses to support clinical
content development for electronic health system
(“KP HealthConnect”)
6
7. KPSC Technology Assessment &
Guidelines Unit (cont.)
Functions have been performed within KPSC since the early
1990s
Unit includes 10 research analysts with backgrounds in
epidemiology, statistics and research methods
With support from senior leadership, a strong evidence-based
culture has developed among clinicians and administrators
Knowledge products generally well-received due to
involvement of key clinician leaders in all phases:
• topic selection
• evidence review/synthesis
• content development for knowledge products
• implementation and knowledge exchange activities
7
8. KPSC Evidence-Based Knowledge
Products
KPSC evidence reviews also support:
KP National Guideline Clinical
Medical
Technology
Development Program Guidelines
Assessment
KP Interregional New
Technology Committee
Clinical content development KPSC Knowledge
for KP’s electronic health Products
information system (EHS)
Evidence-Based Electronic
Implementation Health System
Reviews Evidence
Synopses
8
9. How Do We Use Cochrane Reviews?
Define clinical question of interest
Patient, Intervention, Comparison, Outcome (PICO)
Conduct evidence search
(PubMed, Cochrane, Clinical Evidence, etc.)
Is there an existing
rigorous, high-
quality systematic
NO review? YES
Conduct Update existing
systematic systematic
review review
Cochrane considered a primary “trusted source” of systematic reviews
9
10. How Do We Use Cochrane Reviews?
Cochrane reviews
can be accessed
by all physicians
and employees
through Kaiser
Permanente’s
online Clinical
Library
10
11. How Do We Use Cochrane Reviews?
KPSC analytical staff reviews abstract, background and objectives
sections of Cochrane review for applicability to the clinical question
of interest (does it meet “PICO” elements?)
If applicable, then search dates are reviewed and a new search is
conducted to update the Cochrane review
Results of the Cochrane review are summarized in evidence
documents using the following elements:
• Search methods for identification of studies and general methods of the
review
• Description of the methodological quality of the studies
• High-level overview of the results
• Evidence tables are developed combining the section on
“Characteristics of included studies” with quantitative data from the
“Results” section and the forest plots
11
12. How Do We Use Cochrane Reviews?
Examples of the ways in which Cochrane
Collaboration systematic reviews impact
care in a large health maintenance
organization
12
13. Example: Clinical Practice Guidelines
Cochrane reviews have
been used to develop and/
or update many of the
guidelines developed by
Kaiser Permanente in
Southern California, as
well as the entire KP
program (8 regions).
13
14. Clinical Practice Guidelines (cont.)
Topic: Chronic Obstructive Pulmonary Disease (COPD)
Clinical questions formulated for the following:
• Smoking cessation
• Influenza vaccination
• Pharmacologic management of stable COPD (beta-agonists,
anticholinergics, inhaled/oral corticosteroids, theophylline, mucolytics)
• Nonpharmacologic management of stable COPD (pulmonary
rehabilitation, self-management education, supplemental oxygen, nutritional
supplementation)
• Pharmacologic management of COPD exacerbations (antibiotics, oral
corticosteroids, anticholinergics)
• Nonpharmacologic management of COPD exacerbations (noninvasive
positive pressure ventilation)
• Screening for depression
14
15. Clinical Practice Guidelines (cont.)
Cochrane Reviews Used in Development of COPD Guideline (n=16):
Appleton S, Poole P, Smith B, Veale A, Lasserson TJ, Chan MM, Cates CJ. Long-acting beta2-agonists for poorly reversible chronic
obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2006, Issue 3.
Barr RG, Rowe BH, Camargo Jr CA. Methylxanthines for exacerbations of chronic obstructive pulmonary disease. Cochrane Database of
Systematic Reviews. 2003, Issue 2.
Bradley JM, O’Neill B. Short-term ambulatory oxygen for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews.
2005, Issue 4.
Cranston JM, Crockett AJ, Moss JR, Alpers JH. Domiciliary oxygen for chronic obstructive pulmonary disease. Cochrane Database of
Systematic Reviews. 2005, Issue 4.
Effing TW, Monninkhof EM, van der Valk PDLPM, Zielhuis GA, van Herwaarden CLA, Partridge MR, Walters EH, van der Palen J. Self-
management education for patients with chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2007, Issue 4.
Lacasse Y, Goldstein R, Lasserson TJ, Martin S. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database of
Systematic Reviews. 2006, Issue 4.
McCrory DC, Brown CD. Anticholinergic bronchodilators versus beta2-sympathomimetic agents for acute exacerbations of chronic obstructive
pulmonary disease. Cochrane Database of Systematic Reviews. 2003, Issue 1.
Nannini L, Cates CJ, Lasserson TJ, Poole P. Combined corticosteroid and long-acting beta-agonist in one inhaler versus inhaled steroids for
chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews. 2007, Issue 4.
Nannini L, Cates CJ, Lasserson TJ, Poole P. Combined corticosteroid and long-acting beta-agonist in one inhaler versus placebo for chronic
obstructive pulmonary disease. Cochrane Database of Systematic Reviews. 2007, Issue 4.
Nannini L, Cates CJ, Lasserson TJ, Poole P. Combined corticosteroid and long-acting beta-agonist in one inhaler versus long-acting beta-
agonists for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews. 2007, Issue 4.
Poole PJ, Chacko E, Wood-Baker RWB, Cates CJ. Influenza vaccine for patients with chronic obstructive pulmonary disease. Cochrane
Database of Systematic Reviews 2006, Issue 1.
Ram FSF, Picot J, Lightowler J, Wedzicha JA. Non-invasive positive pressure ventilation for treatment of respiratory failure due to
exacerbations of chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews. 2004, Issue 3.
Ram FSF, Rodriguez-Roisin R, Granados-Navarrete A, et al. Antibiotics for exacerbations of chronic obstructive pulmonary disease.
Cochrane Database of Systematic Reviews. 2006, Issue 2.
Walters JAE, Walters EH, Wood-Baker R. Oral corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database of
Systematic Reviews. 2005, Issue 3.
Wood-Baker RR, Gibson PG, Hannay M, Walters EH, Walters JAE. Systemic corticosteroids for acute exacerbations of chronic obstructive
pulmonary disease. Cochrane Database of Systematic Reviews 2005, Issue 1.
Yang IA, Fong KM, Sim EHA, Black PN, Lasserson TJ. Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Cochrane
Database of Systematic Reviews 2007, Issue 2.
15
16. Clinical Practice Guidelines (cont.)
Topic: Breast Cancer Screening
Cochrane Reviews Used in Evidence Assessment:
Gøtzsche PC, Nielsen M. Screening for breast cancer with mammography.
Cochrane Database of Systematic Reviews 2006, Issue 4.
Kösters JP, Gøtzsche PC. Regular self-examination or clinical examination for
early detection of breast cancer. Cochrane Database of Systematic Reviews 2003,
Issue 2, updated October 2007.
KPSC Leads Nation in Breast Cancer Screening
2008 Quality Compass® report from the National
Committee on Quality Assurance (NCQA)
of all reporting U.S. health plans, Kaiser Permanente
Southern California had the highest breast cancer screening
rate
more than 87 out of 100 KP patients, ages 52 to 69, received
their recommended mammograms
U.S. national average is slightly more than 72 out of 100
16
17. Example: Medical Technology
Assessment
Cochrane reviews are
frequently used in the
assessments for KP
Southern California’s
•Medical Technology
Assessment Team
•Medical Technology Inquiry
Service (500-600 inquiries
per year)
Technology assessments
produced by Southern
California are often used
to support evaluation of
technologies for the KP
Interregional New
Technology Committee.
17
18. Medical Technology Assessment
(cont.)
Topic: Lumbar Fusion vs. Nonsurgical Management for the
Treatment of Chronic Low Back Pain
Examples of Cochrane Reviews Used in Technology Assessment (n=6):
Gibson JNA, Waddell G. Surgery for degenerative lumbar spondylosis. Cochrane Database of
Systematic Reviews 2005, Issue 4.
Guzmán J, Esmail R, Karjalainen K, Malmivaara A, Irvin E, Bombardier C. Multidisciplinary
bio-psycho-social rehabilitation for chronic low-back pain. Cochrane Database of Systematic
Reviews 2006, Issue 2.
Hayden JA, van Tulder MW, Malmivaara A, Koes BW. Exercise therapy for treatment of non-
specific low back pain. Cochrane Database of Systematic Reviews 2005, Issue 3.
Heymans MW, van Tulder MW, Esmail R, Bombardier C, Koes BW. Back schools for non-
specific low-back pain. Cochrane Database of Systematic Reviews 2004, Issue 4.
Ostelo RWJG, van Tulder MW, Vlaeyen JWS, Linton SJ, Morley SJ, Assendelft WJJ.
Behavioural treatment for chronic low-back pain. Cochrane Database of Systematic Reviews
2005, Issue 1.
Schonstein E, Kenny DT, Keating J, Koes BW. Work conditioning, work hardening and
functional restoration for workers with back and neck pain. Cochrane Database of Systematic
Reviews 2003, Issue 3.
18
19. Example: Evidence-Based
Implementation
Cochrane reviews are also
used in assessments of the
evidence to support Kaiser
Permanente Southern
California’s implementation
efforts.
The EPOC group’s
methodology resources have
been especially useful in the
development of the evidence-
based implementation function
in Southern California.
19
20. Evidence-Based Implementation
Support (cont.)
Topic: Online vs. In-Person Education for Adults With Chronic
Conditions
Examples of Cochrane Reviews Used in EBI Assessment (n=6):
Deakin T, McShane CE, Cade JE, Williams RDRR. Group based training for self-
management strategies in people with type 2 diabetes mellitus. Cochrane Database of
Systematic Reviews 2005, Issue 2.
Fahey T, Schroeder K, Ebrahim S. Interventions used to improve control of blood pressure in
patients with hypertension. Cochrane Database of Systematic Reviews 2006, Issue 4.
Gibson PG, Powell H, Coughlan J, Wilson AJ, Hensley MJ, Abramson M, Bauman A,
Walters EH. Limited (information only) patient education programs for adults with asthma.
Cochrane Database of Systematic Reviews 2002, Issue 1
Haby MM, Waters E, Robertson CF, Gibson PG, Ducharme FM. Interventions for educating
children who have attended the emergency room for asthma. Cochrane Database of
Systematic Reviews 2001, Issue 1.
Rueda S, Park-Wyllie LY, Bayoumi AM, Tynan AM, Antoniou TA, Rourke SB, Glazier RH.
Patient support and education for promoting adherence to highly active antiretroviral therapy for
HIV/AIDS. Cochrane Database of Systematic Reviews 2006, Issue 3.
Wolf FM, Guevara JP, Grum CM, Clark NM, Cates CJ. Educational interventions for asthma
in children. Cochrane Database of Systematic Reviews 2002, Issue 4.
20
21. Example: Electronic Health Information
System Support
In the past several years,
KP has implemented an
extensive electronic health
system – KP
HealthConnect™
Offers opportunity to
integrate evidence and
influence clinician decision
making at the point of care
Cochrane reviews are
frequently used in
evidence synopses
produced to support the
integration of evidence-
based clinical content into
the KP Southern California
system
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22. Electronic Health Information System
Support (cont.)
Examples of Cochrane Reviews Used in Evidence Synopses:
Treatment of Acute Gout
• Schlesinger N, Schumacher R, Catton M, Maxwell L. Colchicine for acute gout. Cochrane Database of
Systematic Reviews 2006, Issue 4.
• Janssens HJEM, Lucassen PLBJ, Van de Laar FA, Janssen M, Van de Lisdonk EH. Systemic corticosteroids
for acute gout. Cochrane Database of Systematic Reviews 2008, Issue 2.
Epogen for Patients with Chronic Anemia
• Bohlius J, Wilson J, Seidenfeld J, Piper M, Schwarzer G, Sandercock J, Trelle S, Weingart O, Bayliss S,
Brunskill S, Djulbegovic B, Benett CL, Langensiepen S, Hyde C, Engert A. Erythropoietin or Darbepoetin for
patients with cancer. Cochrane Database of Systematic Reviews 2006, Issue 3.
Oral vs. Topical Treatments for Fungal Nail Infections
• Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane
Database of Systematic Reviews 2007, Issue 3.
Negative Pressure Therapy for Chronic Wounds
• Ubbink DT, Westerbos SJ, Evans D, Land L, Vermeulen H. Topical negative pressure for treating chronic
wounds. Cochrane Database of Systematic Reviews 2008, Issue 3.
Naltrexone for Opiate Withdrawal Under Heavy Sedation
• Gowing L, Ali R, White JM. Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal.
Cochrane Database of Systematic Reviews 2006, Issue 2.
Pelvic Floor Exercises for Urinary Urgency/Frequency
• Hay-Smith EJC, Dumoulin C. Pelvic floor muscle training versus no treatment, or inactive control treatments, for
urinary incontinence in women. Cochrane Database of Systematic Reviews 2006, Issue 1.
22
23. Input on Cochrane Reviews from Kaiser
Permanente Users
Solid, rigorous methodology – impressive
Explicit and transparent in reporting of studies/results
• Criteria for selecting studies, search methods and description, data
collection and analysis, assessment of biases, consistency of authors'
conclusions with evidence
Well-organized and comprehensive review format
• Background, objectives, methods, study characteristics, results,
discussion, conclusions, figures/tables, excluded studies
• Sections on characteristics of studies, methodological quality and
forest plots for multiple outcomes especially useful
Plain language summary helpful to clinicians – allows for
quick summary of evidence in patient discussions
PDF format for reviews very useful
23
24. Input From Kaiser Permanente Users –
“Wish List” for Cochrane Reviews
Provide evidence tables that incorporate study characteristics and
quantitative results
List key study information in table format with columns across the top; difficult to
compare across studies in current format
Update reviews more frequently
Dates are sometimes confusing (issue date vs. original online publication
date vs. last update)
Provide updates on protocols and/or remove old protocols
Consider enhancements to current searching capabilities
use Google or other search engine; search by hierarchical topics (i.e., Urology ->
prostate cancer); capture acronyms in searches
Formalize evidence-grading system
this may already be occurring with incorporation of SoF tables and GRADE system
Provide more information on condition, alternative treatments/standard of
care used as comparators, and technology/procedure under investigation
Provide more detail on selection of meta-analysis method (i.e., fixed- or
random-effects models), why it is appropriate to combine the studies, and
include heterogeneity scores
24
25. Potential Collaborative Activities
Greater coordination in selection of review topics with groups of
users in the U.S. (e.g., established interorganizational guideline and
technology assessment groups)
When KP updates a Cochrane assessment, send list of new studies
to review authors
Work toward acceptance of a uniform evidence grading system
across organizations (Cochrane, organizations developing
guidelines/technology assessments)
Collaborate on methodology training activities for review authors
and developers of evidence-based guidelines/tech assessments
25
26. Special thanks to Cochrane authors, reviewers
and review groups for a job well done!
26