Out-of-pocket (OOP) expenditure on health care has significant implications for poverty in many developing countries. The extent of direct payments for health services are producing severe consequences on both equity and efficiency, making health care services unaffordable for most people, and leading to underfunding of essential inputs. Even relatively modest out-of-pocket health expenditure frequently causes indebtedness and can lead to poverty. This study presents an outlook of the role of out-of-pocket payments for health services, formal and informal, in the Albania, Bangladesh, Eritrea, India and Nepal to generate and utilize evidences in broader understanding of patient payment policies. The main purpose of the study is to: (a) compare the health care systems of the countries based on patient payment policy perspectives (b) to analyze the differences and similarities that exist in regards to the role of out of pocket (formal & informal) in the countries. Based on reviewed literatures in five countries, the finding shows these all countries are low and upper middle income countries except Eritrea, which is a low income country. The health care systems vary from totally centralized (Albania, Eritrea, Bangladesh), Decentralized (India and Nepal). The coverage of Public Sector Social Health Insurance is non -existent in all the given countries except Albania and India. Regarding the private health insurance, the evidences show that there are limited private health insurance coverage in Nepal and Bangladesh and India; however no coverage in Eritrea, and around 53 % in Albania. In average, about 85 % of share of national health economy is contributed by out of pocket payment in each of these countries. In each of the countries, there is an exemption policy to alleviate the inaccessibility of groups in immediate needs of health care. The predominant effects of official fees are underutilization of health care especially among the vulnerable groups, poor quality of health to poor groups, inequity, over-prescription, increasing poverty, and creating fertile ground for informal payments and corruption.