This document summarizes four cases: 1. Capillary hemangioma, characterized by dilated vascular channels lined by endothelium containing red blood cells and separated by stroma. 2. Cavernous lymphgioma, characterized by dilated lymphatic channels lined by endothelium containing lymph and inflammatory cells and separated by stroma. 3. Hemangioendothelioma, characterized by nodules of epitheloid cells separated by stroma, containing intracytoplasmic vacuoles with red blood cells. 4. Kaposi Sarcoma, characterized by a dermal nodule of spindle cells forming slit-like vascular spaces containing erythrocytes.

1. Pathology practical 1
(Atherosclerosis)
By : Osama Al-Zahrani
@OSAMA_Z96

2. Capillary Hemangioma

3. Diagnosis :
(Capillary Hemangioma).
Comment :
- Multiple dilated vascular channels
(VCs) lined by attenuated
endothelium.
- The lumen contain blood elements
mainly RBCS.
- VCs are separated by intervening
stroma.
- Inflammatory cells are seen in
intervening stroma.Dilated VCs
Attenuated
endothelium
Intervening stroma
and inflammatory cells
RBCs

4. Cavernous lymphgioma

5. Diagnosis :
(Cavernous lymphgioma).
Comment :
- Multiple dilated lymphatic channels
(LCs) lined by attenuated endothelium.
- The lumen contain lymph and
inflammatory cells.
- LCs are separated by intervening
stroma
- Inflammatory cells are also seen in
intervening stroma.
Lymph
Inflammatory cells
Stroma
Lymphatic channel
Lymphatic channel

6. Hemangioendothelioma

7. Diagnosis :
(Hemangioendothelioma).
Comment :
- Nodules of epitheloid cells separated by
fibromyxoid stroma.
- Epithelioid cells are rounded with eosinophilic
cytoplasm, mild to moderately atypical nuclei with
prominent nucleoli and no /rare mitotic figures.
- Epithelioid and fibromyxoid tumor cells have
focal intracytoplasmic vacuoles containing red
blood cells embedded in fibromyxoid matrix
Nodule
Fibromyxoid matrix
Intracytoplasmic
vacuoles
Epitheloid cells

8. Kaposi Sarcoma

9. Diagnosis :
(Kaposi Sarcoma).
Comment :
- A cellular dermal nodule comprised of a spindle
cell proliferation forming slit-like vascular
spaces.
- Intra and extra cellular hyaline globules are
present, though to represent engulphed
erythrocytes.
- Erythrocytes (RBCs) are seen within the slit like
spaces and throughout the tumor.
Slit-like vascular spaces
Fascicles of spindle shaped cells