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1. EVOLUTION OF THEORIESEVOLUTION OF THEORIES
DIFFERENCES BETWEENDIFFERENCES BETWEEN
GROWTH SITES AND GROWTHGROWTH SITES AND GROWTH
CENTRESCENTRES
SUTURAL DOMINANCESUTURAL DOMINANCE
THEORYTHEORY
CARTILAGENOUS THEORYCARTILAGENOUS THEORY
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3. Craniofacial biology as “NormalCraniofacial biology as “Normal
Science”Science”
David S. CarlsonDavid S. Carlson
Craniofacial biologyCraniofacial biology
Normal scienceNormal science
ParadigmParadigm
Scientific RevolutionScientific Revolution
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4. CRANIOFACIAL BIOLOGYCRANIOFACIAL BIOLOGY
Study of growth, function and adaptation of theStudy of growth, function and adaptation of the
craniofacial skeleton and related structures.craniofacial skeleton and related structures.
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5. ACCORDING TO KUHNACCORDING TO KUHN
Normal scienceNormal science
Research firmly based upon one or more pastResearch firmly based upon one or more past
scientific achievements that some particularscientific achievements that some particular
scientific community acknowledges as supplyingscientific community acknowledges as supplying
the foundation for its further practice.the foundation for its further practice.
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6. PARADIGM
Paradigm provides a coherent conceptualParadigm provides a coherent conceptual
scheme to organize observations and ideas,scheme to organize observations and ideas,
determining which are relevant, whichdetermining which are relevant, which
problems are legitimate and indicating howproblems are legitimate and indicating how
these problems may be solved.these problems may be solved.
A single paradigm may be the basis for manyA single paradigm may be the basis for many
theories and certainly for numeroustheories and certainly for numerous
hypothesis, even if they are in conflict withhypothesis, even if they are in conflict with
each other.each other.
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9. EVOLUTION OF PARADIGMS
Normal science-Scientific revolution-Normal scienceNormal science-Scientific revolution-Normal science
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10. 1920-19401920-1940
Early research -study of structure of theEarly research -study of structure of the
craniofacial skeletoncraniofacial skeleton
No consideration to the functionNo consideration to the function
This was done byThis was done by
--Anthropologic craniometryAnthropologic craniometry
--Racial analysisRacial analysis
--Comparative anatomyComparative anatomy
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11. Two periods by MossTwo periods by Moss
- Pre radiologic - craniometry- Pre radiologic - craniometry
-Radiologic-Radiologic
Dominant paradigm was –Dominant paradigm was –GENOMICGENOMIC
PARADIGMPARADIGM
Focus-----dentoalveolar changes------not onFocus-----dentoalveolar changes------not on
skeletal modificationskeletal modification
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12. 1940-19601940-1960
Period of increased animal researchPeriod of increased animal research
-Radio opaque implants-Radio opaque implants
-Vital dyes-Vital dyes
-Autoradiography-Autoradiography
Mid 1950’ also called –Mid 1950’ also called – PRE REVOLUTIONARY PERIODPRE REVOLUTIONARY PERIOD
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13. KUHN SAYSKUHN SAYS
-Pre revolutionary periods are characterised by-Pre revolutionary periods are characterised by
growing disenchantment with the currentgrowing disenchantment with the current
paradigm, which leads to the development of aparadigm, which leads to the development of a
new paradigm.new paradigm.
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14. MOSSMOSS
-Did experiments on sutures and concluded-Did experiments on sutures and concluded
that sutures are site of active but compensatorythat sutures are site of active but compensatory
growthgrowth
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15. Moss- “Classic Triad”
Sutures are primary growth sites
Growth of the cranial vault occurs only by
periosteal deposition and endosteal resorption.
All cephalic cartilages are primary
growth centers under direct genetic
control
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16. By end of 1950s there were mutuallyBy end of 1950s there were mutually
acceptable approaches within genomicacceptable approaches within genomic
paradigmparadigm
--Comprehensive approachComprehensive approach
--Structurofunctional approachStructurofunctional approach
Sutures - adaptive phenomenaSutures - adaptive phenomena
Function as affecting growth gainedFunction as affecting growth gained
momentummomentum
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18. 1960-19801960-1980
Saw the coming of a new paradigm-Saw the coming of a new paradigm-
FUNCTIONAL PARADIGMFUNCTIONAL PARADIGM
Moss gave theMoss gave the functional matrix hypothesisfunctional matrix hypothesis
Genetic influence not deniedGenetic influence not denied
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21. CONCLUSIONCONCLUSION
Genetic paradigmGenetic paradigm cannot be rejectedcannot be rejected as suchas such
Both genetic and functional paradigmBoth genetic and functional paradigm have to coexisthave to coexist
and be applicable for the benefit of the patient.and be applicable for the benefit of the patient.
Functional matrix hypothesis isFunctional matrix hypothesis is not synonymousnot synonymous withwith
functional paradigm. It is an extreme but legitimate wayfunctional paradigm. It is an extreme but legitimate way
of expressing the functional paradigm.of expressing the functional paradigm.
Experimental design andExperimental design and results are influencedresults are influenced by theby the
paradigm maintained by the investigator.paradigm maintained by the investigator.
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