Palmitoylethanolamide supplement – How does Palmitoylethanolamide (PEA) work for the pain?

Xuchang shangke Chemical Co., Ltd
Phcoker www.phcoker.com
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1
Palmitoylethanolamide supplement - How does PEA
work for the pain?
Reproduce from:
https://www.phcoker.com/palmitoylethanolamide-pea/
Palmitoylethanolamide supplement - How does PEA work for the pain?.............................................1
Palmitoylethanolamide (PEA) overview.................................................................................................2
What is Palmitoylethanolamide (PEA)?................................................................................................. 3
Palmitoylethanolamide benefits - What is Palmitoylethanolamide used for?......................................4
i. Supports brain health....................................................................................................... 5
ii. Relieve from multiple pain and Inflammation.................................................................5
iii. Helps reduce the symptoms of depression.................................................................... 6
iv. It relieves the common cold........................................................................................... 7
v. Lowers the symptoms of insular (multiple) sclerosis...................................................... 8
vi. Palmitoylethanolamide improves metabolism...............................................................8
vii. Palmitoylethanolamide can lower your appetite.......................................................... 9
viii. Palmitoylethanolamide anti-inflammatory effects during exercise.............................9
Who should take a supplement of Palmitoylethanolamide (PEA)?.....................................................10
What is PEA derived from?......................................................................................................... 10
Does PEA get you high?.............................................................................................................. 11
Is PEA supplement safe?.............................................................................................................12
What are the side effects of PEA?.....................................................................................12
Is Palmitoylethanolamide safe in pregnancy?...................................................................13
Palmitoylethanolamide half life - How long does it take for pea to work?................................13
How does PEA work for pain?..............................................................................................................13
What is PEA for pain relief?........................................................................................................ 14
Is Pea an anti inflammatory?.............................................................................................14
Is pea good for arthritis?................................................................................................... 15
What are the best painkillers for nerve pain?............................................................................ 15
How can I treat nerve pain at home?................................................................................15
Is Palmitoylethanolamide a cannabinoid?...........................................................................................16
Is Pea an endocannabinoid?....................................................................................................... 18
Palmitoylethanolamide (PEA) and Anandamide.........................................................................18
Palmitoylethanolamide VS Phenylethylamine............................................................................19
How do I take Palmitoylethanolamide (PEA) supplement?.................................................................19
Where to buy Palmitoylethanolamide (PEA) powder?...............................................................20

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Palmitoylethanolamide (PEA) overview
There is a reported that Food and Drug Administration approved to submit an
application for a clinical trial to treat COVID-19 by using a synthetic drug that mimics
the action of a molecule found in marijuana.
The synthetic drug, called ultramicronized palmitoylethanolamide (micro PEA), is
believed to act as an anti-inflammatory. Palmitoylethanolamide(PEA) is a “a naturally
occurring fatty acid” similar to an endocannabinoid, one of a suite of molecules found
in cannabis in that targets CB2 receptors. CB2 receptors are thought to modulate
both inflammation and pain throughout the human body.
Since [micro PEA] has been used in Europe for 20 years, some Italian health-care
providers were advocating the use of micro PEA to treat COVID-19 patients and they
were discovering some success.
Severe COVID-19 is characterized by an over-exuberant inflammatory response that
may lead to a cytokine storm. “micro PEA is not a virus killer, but they believe it can
mitigate that immune response, which can be fatal.

3
What is Palmitoylethanolamide (PEA)?
Palmitoylethanolamide (PEA) is a lipid that occurs naturally in our body in the
category of fatty acid amide. It is hence an endogenous lipid. PEA is also naturally
produced in plants and animals.
Palmitoylethanolamide (PEA) can be found in food such as milk, soy beans, garden
peas, soy lecithin, meat, eggs and peanuts.
Nobel Prize winner Levi-Montalcini identified Palmitoylethanolamide (PEA) as a
naturally occurring molecule, describing its value in treating chronic infections and
pains. Following her discovery, hundreds of scientific studies have been carried out to
show that it is very effective and safe to use. Palmitoylethanolamide (PEA) is
described in scientific writings as a natural painkiller.

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Palmitoylethanolamide benefits - What is
Palmitoylethanolamide used for?
Palmitoylethanolamide (PEA) is a fatty acid amide and is synthesized and acts inside
our body for regulation of various functions. It is an endogenous fatty acid amide,
belonging to the class of nuclear factor agonists. Palmitoylethanolamide (PEA) has
actually been actually widely discovered in a lots of inflammatory animal models,
along with in several medical tests.
It is a natural painkiller and can be used for chronic pain and inflammation. It also
exerts some other beneficial effect like neuropathic ache, fibromyalgia, several

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sclerosis, repetitive strain injury, infections of the respiratory tract, and many other
disorders.
Some of the reported palmitoylethanolamide benefits include;
i. Supports brain health
Palmitoylethanolamide benefits in enhancing brain health are associated with its
ability to fight neural inflammation and also promotion of neural cells survive. This is
noted more with people suffering from neurodegenerative disorders and stroke.
For instance, in a study of 250 people suffering from stroke, palmitoylethanolamide
supplement administered along with luteolin was found to enhance recovery. PEA
was found to enhance memory, the general brain health as well as day to day
functioning. These effects of palmitoylethanolamide powder were noticed 30 days
after supplementation and increased over one more month.
ii. Relieve from multiple pain and Inflammation
Scientists provide considerable evidences of palmitoylethanolamide pain relieving
properties. As a matter of fact, palmitoylethanolamide offers pain relief to diverse
types of pain and inflammation. Some studies that demonstrates

6
palmitoylethanolamide pain relief properties are;
In a study involving animals, palmitoylethanolamide supplement along with quercetin
was found to offer relief from joint pain as well as improve the joint functioning and
protection of cartilage from damage.
Some preliminary studies show that PEA can help reduce nerve pains in diabetic
patients (diabetic neuropathy).
In another study with 12 people, a palmitoylethanolamide dosage of 300 and 1,200
mg/day given for about 3 to 8 weeks was found to lower the intensity of chronic and
neuropathic pain.
A study of 80 patients suffering from Fibromyalgia syndrome found out that PEA in
addition to other medicines for the disorder potentially lower the pain.
Further, several other studies show the palmitoylethanolamide pain relief potential
including relieve from pelvic pain, sciatic pain, back pain, cancer pain among others.
iii. Helps reduce the symptoms of depression
PEA indirectly influences the receptors responsible for mood. Some studies

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demonstrate palmitoylethanolamide anxiety relief as a key role in fighting depression.
In a study of 58 patients with depression, palmitoylethanolamide supplement at 1200
mg/day along with antidepressant medication (citalopram) administered for 6 weeks
was found to significantly improve the mood and the general depression symptoms.
iv. It relieves the common cold
Palmitoylethanolamide benefits in combating the common cold lies in its ability to
destroy the virus responsible for the common cold (influenza virus). Surprisingly, the
common cold occurs widely and affects almost everybody especially people with
comprised immunity.
A study with 900 young soldiers demonstrated that a palmitoylethanolamide dosage
of 1200 mg per day reduced the time taken by the participant to heal from the cold
and also the symptoms such as headaches, fever and sore throat.

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v. Lowers the symptoms of insular (multiple) sclerosis
With the proven palmitoylethanolamide anti-inflammatory properties, PEA is
undoubtedly suitable for treating multiple sclerosis.
In a study of 29 patients suffering from advanced multiple sclerosis, PEA added to the
standard dose of interferon IFN-β1a was found to lower the pain as well as enhanced
the patients’ quality of life.
vi. Palmitoylethanolamide improves metabolism
Palmitoylethanolamide (PEA) is able to bind to PPAR- α, a receptor responsible for

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metabolism, appetite, weight loss and fats burning. When the PPAR- α receptor is
triggered you experience high energy levels which helps the body burn more fats in
exercises hence you lose weight.
vii. Palmitoylethanolamide can lower your appetite
Palmitoylethanolamide weight loss potential is demonstrated in its ability to influence
your appetite. Similar to enhancing the metabolism, when the PPAR- α receptor is
activated it leads to a feeling of fullness while eating thus helps you control the
amount of calories consumed.
Further, PEA is considered a fatty acid ethanolamides that plays a key role in feeding
behavior. In a study of overiectomized rats with high weight gain, PEA supplement at
30 mg/kg body weight for 5 weeks was found to significantly lower their food intake,
fat mass and consequently the body weight.
viii. Palmitoylethanolamide anti-inflammatory effects during exercise
One may experience pain and inflammation during and after workouts due to
excessive weight. Well, PEA supplement could help prevent this by stimulating
anti-inflammatory activity of the PPAR- α receptor. Palmitoylethanolamide can also
inhibit the release of inflammatory enzymes in the by the human adipose tissues.

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Who should take a supplement of
Palmitoylethanolamide (PEA)?
Palmitoylethanolamide (PEA) supplement is fit for all suffering from adverse pain or
inflammation and also anyone interested in weight loss whether on medication or not.
PEA has been seen to enhance the efficacy of other drugs. It is an option for those
who do not find relief in using the prescribed pain killers.
Palmitoylethanolamide anxiety relief is an excellent attribute anyone at risk of
depression or suffering from depression should take PEA for.
Furthermore, one would reap more of the PEA from supplements since
manufacturers seek formulations that increases palmitoylethanolamide bioavailability
in your body.
What is PEA derived from?
PEA is naturally produced in our bodies and also by animals and plants. However, for
people with chronic pain or inflammation, PEA occurs in insufficient amount hence

11
the need for PEA supplements.
Palmitoylethanolamide can be derived from food sources rich in proteins such as milk,
meat, soy beans, soy lecithin, peanuts and garden peas among others. However, the
PEA obtained from food sources is in small amounts. This makes
palmitoylethanolamide bulk production necessary to meet this dietary needs.
Does PEA get you high?
Phenethylamine and Palmitoylethanolamide both can call PEA, but they totally
different products.
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and
trace amine, which acts as a central nervous system stimulant in humans.
Phenethylamine stimulates the body to make certain chemicals that play a role in
depression and other psychiatric conditions.
Taken in doses of 500mg-1.5g per dosage, every few hours, PEA provides the user a
feeling of euphoria, energy, stimulation, and overall well being.
However, please kindly note that Phenethylamine (PEA) is not Palmitoylethanolamide
(PEA). Phenethylamine supplements have not been approved by the FDA for medical
use. Palmitoylethanolamide (PEA) is a natural substance produced by the body; it is

12
very effective and safe to use as a supplement for pain and inflammation.
Is PEA supplement safe?
Palmitoylethanolamide (PEA) is a natural substance produced by the body; it is very
effective and safe to use as a supplement for pain and inflammation. No adverse
palmitoylethanolamide side effects have been reported as well as no adverse
interactions with other drugs.
What are the side effects of PEA?
There are no serious side effects or drug-drug interactions have been reported so far.
Palmitoylethanolamide can be taken together with any other substance. It enhances
the pain-relieving effect of classic analgesics and anti-inflammatories.

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Is Palmitoylethanolamide safe in pregnancy?
Not to be used by pregnant women.
Palmitoylethanolamide may help nutritionally address inflammation and chronic pain.
It should only be taken under medical supervision.
Palmitoylethanolamide half life - How long does it take for pea to work?
Palmitoylethanolamide (PEA) can be taken together with other pain medication or
alone, as advised by your health care professional, to support pain relief.
Effectiveness for pain relief is 8 hr
Results variable; results within 48 hr in some people, but use for 8 weeks for
maximum results, can be used long term for chronic neurological pain.
How does PEA work for pain?
Research has shown that PEA possesses anti-inflammatory and anti-nociceptive
properties and taking it regularly may boost your body's natural response to pain by
dampening the response of the nervous system cells which cause pain.
Palmitoylethanolamide also works indirectly to induce the activities of some
receptors such as the cannabinoid receptors. PEA indirectly stimulates the

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cannabinoid receptors(CB1 and CB2) by acting as enzyme (FAAH -fatty acid amide
hydrolase) involved in the breakdown of the cannabinoid anandamide. This help in
raising the levels of anandamide in our bodies, which is responsible for relaxation and
combating pain.
What is PEA for pain relief?
Palmitoylethanolamide (PEA) is a natural substance produced by the body; it is an
endogenous fatty acid amide, belonging to the class of nuclear factor agonists, and
can be used as a supplement for pain and inflammation treatment . PEA is a natural,
protective, fatty molecule produced in our body, helping support the myelin nerve
sheaths for good nerve function.
PEA is a fatty acid that is involved in various cellular functions in inflammation and
chronic pain, and has been shown to have neuroprotective, anti-inflammatory,
anti-nociceptive (anti-pain) and anti-convulsant properties. It also reduces
gastrointestinal motility and cancer cell proliferation, as well as protecting the
vascular endothelium in the ischemic heart. Often in people with chronic disorders,
the body does not produce enough PEA, thus by taking PEA to supplement the body’s
shortage is may be beneficial in helping to treat these conditions.
Is Pea an anti inflammatory?

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Palmitoylethanolamide (PEA) is an interesting anti-inflammatory therapeutic
substance and might also hold great promise for the treatment of a number of
(auto)immune disorders, including inflammatory bowel disease and inflammatory
diseases of the CNS.
Is pea good for arthritis?
Palmitoylethanolamide (PEA) offers benefit for arthritis both in regards to reducing
the development and maintenance of chronic pain but also to help limit the progress
of joint destruction associated with arthritis.
What are the best painkillers for nerve pain?
PEA (palmitoylethanolamide) has been around since the 1970’s but is gaining a
reputation as a new agent in treating inflammation and pain. No drug interactions or
serious side effect have been identified.
PEA has demonstrated effectiveness for chronic pain of multiple types associated
with many painful conditions, especially with neuropathic (nerve) pain, inflammatory
pain and visceral pain such as endometriosis and interstitial cystitis.
How can I treat nerve pain at home?
PEA is a fatty molecule that helps support the myelin nerve sheaths for good nerve

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function.
Deficiency of vitamins from the B group can not only cause nerve pain, but also
increases it.
Additional unpleasant symptoms could also occur, such as a wobbly gait, tingling and
stinging of the hands and feet, a feeling as if one is walking on barbed wire or cotton
wool or even numbness of the
hands and feet.
Too little vitamin B1 leads to disturbance in the functioning of the nerves and
consequently to neuropathy and nerve pain. When adding vitamin B1, the pain
decreases and the nerve function improves. Vitamin B1 can be taken together with
PEA, this provides optimal support to the functioning of the nerves, prevents nerve
pain or worsening pains. Recent studies have shown that many people with chronic
pain, elderly people and diabetics have an inadequate amount of these vitamins in
their blood. This is one of the reasons that these people cannot be treated only with
painkillers; they need
more than that. PEA plus B vitamins supports the nervous and immune systems in
cases of nerve pain.
Is Palmitoylethanolamide a cannabinoid?
CBD (Cannabidiol) is a compounds extracted from hemp and marijuana. While the

17
body produces cannabinoids naturally, CBD has been supplemented to meet the
need.
Cannabinoids are the biological active chemicals produced in the body that are
responsible for memory, pain, appetite, and movement. Scientists speculate that
cannabinoids may be beneficial in reducing inflammation and anxiety, destroying
cancer cells, offering relaxation in muscles and also enhances appetite.
PEA is a fatty acid amide also produced in the body and can be referred to as a
cannabimimetic. This means it mimics the works of CBD in your body.
Both CBD and PEA acts indirectly by inhibiting the fatty acid amide hydrolase (FAAH),
which usually breakdown anandamide and weakens it. This results to high levels of
anandamide. Anandamide plays a major role in the mood and also motivation. The
increased levels of anandamide positively influence the endocannabinoid system.
PEA has gained popularity and competes with CBD. PEA is considered a safe
alternative to CBD due to the legal issues facing it and also the fact that most people
cannot tolerate the high levels of ‘stone’ that comes with the CBD.
Further, PEA is much cheaper than CBD. However, PEA can be used in addition to CBD
to achieve synergetic effects.

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Is Pea an endocannabinoid?
NO, Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with
analgesic and anti-inflammatory properties. PEA supports the ECS via modulating
endocannabinoid signaling and indirectly activating cannabinoid receptors.
The endocannabinoid system (ECS) is an important biological system that regulates
and balances a wide range of physiological functions in the body. Research on the ECS
has led to the identification of not only endocannabinoids such as anandamide (AEA)
and 2-arachidonoylglycerol (2-AG), but also endocannabinoid-like lipid mediators
such as palmitoylethanolamide (PEA). These endocannabinoid-like compounds often
share the same metabolic pathways of endocannabinoids but lack binding affinity for
the classical cannabinoid receptor type 1 and type 2 (CB1 and CB2).
Palmitoylethanolamide (PEA) and Anandamide
Palmitoylethanolamide and anandamide are closely related since they are both
endogenous fatty acid amide produced in the body.
PEA and anandamide are said to have synergistic effects in treatment of pain and also
enhance the pain killers used.
They are also broken down by the fatty acid hydrolase enzyme in the body, hence the

19
effects achieve when used together is more than when used on standalone
supplement.
Palmitoylethanolamide VS Phenylethylamine
Phenethylamine a chemical substance that is naturally produced by the body. It is
widely used for enhancing athletic performance and also can help relieve depression,
aid in weight loss and enhance mood.
Palmitoylethanolamide on the other hand is a fatty acid amide that is largely known
for pain and inflammation relief.
These two compounds are not related. The only thing that connects them is that they
are both abbreviated as PEA.
How do I take Palmitoylethanolamide (PEA)
supplement?
While we emphasized the palmitoylethanolamide anti-inflammatory benefit among
other benefits, it is worth bringing to your attention some more facts about PEA. PEA
occurs in large particles and is insoluble in water, this makes palmitoylethanolamide

20
bioavailability and absorption limited.
The good news, however, is that manufacturers target formulations that enhance
palmitoylethanolamide bioavailability for maximum utilization in your body. For these,
PEA powder are available in normal powder form and micromized powder form.
Where to buy Palmitoylethanolamide (PEA) powder?
We’re in an interesting era where online stores have become a one stop shop for
everything including palmitoylethanolamide bulk supplies. If you consider taking
PEA, research widely for legit palmitoylethanolamide bulk supplement manufacturers.
Most users of palmitoylethanolamide buy it from online stores and should consider
their reviews for the best PEA powder in the market.
Abbreviations
AEA: Anandamide
CB1:Cannabinoid type I receptor
CB2:Cannabinoid type II receptor
CENTRAL:Cochrane Central Register of Controlled Trials
FAAH:Fatty-acid amide hydrolase

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NAAA:N-acylethanolamine hydrolyzing acid amidase
NAE:N-acylethanolamines
PEA:Palmitoylethanolamid
PPARα:Peroxisome proliferator-activated receptor alpha
PRISMA-P:Preferred Reporting Items for Systematic Reviews and Meta-Analysis
Protocols
VAS Pain:Visual Analog Scale for Pain
ECS:endocannabinoid system
Reference:
[1] Artukoglu BB, Beyer C, Zuloff-Shani A, et al. Efficacy of palmitoylethanolamide for
pain: a meta-analysis. Pain Physician 2017;20(5):353-362.
[2] Schifilliti C, Cucinotta L, Fedele V, et al. Micronized palmitoylethanolamide reduces
the symptoms of neuropathic pain in diabetic patients. Pain Res Treat
2014;2014:849623.
[3] Keppel Hasselink JM, Hekker TA. Therapeutic utility of palmitoylethanolamide in
the treatment of neuropathic pain associated with various pathological conditions: a

22
case series. J Pain Res 2012;5:437-442.
[4] Keppel Hasselink JM, Kopsky DJ. The role of palmitoylethanolamide, an autacoid,
in the symptomatic treatment of muscle cramps: three case reports and review of
literature. J Clin Case Rep 2016;6(3).
[6] Costa B, Colombo A, Bettoni I, Bresciani E, Torsello A, Comelli F. The endogenous
ligand palmitoylethanolamide relieves neuropathic pain via mast cell and microglia
modulation. 21st Annual Symposium Of The International Cannabinoid Research
Society. St. Charles, Il. Usa: Pheasant Run; 2011.

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Palmitoylethanolamide supplement – How does Palmitoylethanolamide (PEA) work for the pain?