This journals about the laparoscopy in paediatric surgery- Dr. Prakash Agarwal has sharing the experience in SRMC. He explanied paddiatric surgery and its diagnosis and procedure for analysis of children who underwent laparoscopy surgery.
Current status of minimal access surgery in childrenApollo Hospitals
Minimal Access Surgery (MAS) in children though late to start compared to adult MAS has
Received 1 October 2013 now reached widespread application. Currently most of the surgeries are being carried out
Accepted 13 November 2013 by -scopy surgeries, viz: laparoscopy, thoracoscopy, neuroendoscopy, etc. Newer advances
Available online 15 December 2013 continue to be incorporated into pediatric surgery and include Robotic and Single Incision
Laparoscopic surgeries. This article reviews the various applications and present status of
Keywords:
MAS in children.
Laparoscopic appendicectomy has several advantages over the traditional open approach. Special indication is in cases of undiagnosed right iliac fossa pain, in the female patient and the obese. Laparoscopic approach should be adopted as the standard approach over open for appendicectomy.
The introduction of canaloplasty into the glaucoma surgical armamentarium was motivated by the desire of clinicians to enhance the quality of patients’ glaucoma care. Patients’ long-term adherence to topical glaucoma medical therapy is well known to be relatively poor. Laser therapy offers a safe alternative to medical therapy but often still requires the addition of topical medication. Traditionally, glaucoma filtration surgery has been reserved for more advanced, uncontrolled glaucoma for obvious reasons. Despite its definite role in glaucoma care, patients undergoing standard trabeculectomy are at significant risk for the development of postoperative infection, cataract, hypotony, bleb dysesthesia, astigmatism, and decreased visual acuity. These potential complications have driven surgeons to pursue surgical alternatives. Canaloplasty is a well-established procedure that has, for the past 3 years, demonstrated impressive efficacy and safety in peer-reviewed prospective studies. Despite growing evidence of its value and increasing performance of the procedure by ophthalmologists all over the world, misconceptions regarding its long-term efficacy as well as challenges in its adoption, surgical
technique, and patient selection persist. Several experienced and leading surgeons share their experiences and pearls for optimizing success with canaloplasty.
— Steven D. Vold, MD
Anyone Can Intubate, or Not: Teaching airway skills the antifragile waySMACC Conference
Becoming competent in airway management requires good decision making and and technical skills. Ultimately what matters is how your clinical performance impacts patient outcomes. For this we need to have a clear understanding of what defines success ensuring that its more than just 'getting the tube'. Come to this talk and you'll experience a Canadian take on Guinness, adventure sports, flying a plane and how other factors including failure influence airway management outcomes.
Current status of minimal access surgery in childrenApollo Hospitals
Minimal Access Surgery (MAS) in children though late to start compared to adult MAS has
Received 1 October 2013 now reached widespread application. Currently most of the surgeries are being carried out
Accepted 13 November 2013 by -scopy surgeries, viz: laparoscopy, thoracoscopy, neuroendoscopy, etc. Newer advances
Available online 15 December 2013 continue to be incorporated into pediatric surgery and include Robotic and Single Incision
Laparoscopic surgeries. This article reviews the various applications and present status of
Keywords:
MAS in children.
Laparoscopic appendicectomy has several advantages over the traditional open approach. Special indication is in cases of undiagnosed right iliac fossa pain, in the female patient and the obese. Laparoscopic approach should be adopted as the standard approach over open for appendicectomy.
The introduction of canaloplasty into the glaucoma surgical armamentarium was motivated by the desire of clinicians to enhance the quality of patients’ glaucoma care. Patients’ long-term adherence to topical glaucoma medical therapy is well known to be relatively poor. Laser therapy offers a safe alternative to medical therapy but often still requires the addition of topical medication. Traditionally, glaucoma filtration surgery has been reserved for more advanced, uncontrolled glaucoma for obvious reasons. Despite its definite role in glaucoma care, patients undergoing standard trabeculectomy are at significant risk for the development of postoperative infection, cataract, hypotony, bleb dysesthesia, astigmatism, and decreased visual acuity. These potential complications have driven surgeons to pursue surgical alternatives. Canaloplasty is a well-established procedure that has, for the past 3 years, demonstrated impressive efficacy and safety in peer-reviewed prospective studies. Despite growing evidence of its value and increasing performance of the procedure by ophthalmologists all over the world, misconceptions regarding its long-term efficacy as well as challenges in its adoption, surgical
technique, and patient selection persist. Several experienced and leading surgeons share their experiences and pearls for optimizing success with canaloplasty.
— Steven D. Vold, MD
Anyone Can Intubate, or Not: Teaching airway skills the antifragile waySMACC Conference
Becoming competent in airway management requires good decision making and and technical skills. Ultimately what matters is how your clinical performance impacts patient outcomes. For this we need to have a clear understanding of what defines success ensuring that its more than just 'getting the tube'. Come to this talk and you'll experience a Canadian take on Guinness, adventure sports, flying a plane and how other factors including failure influence airway management outcomes.
Indian Dental Academy: will be one of the most relevant and exciting training
center with best faculty and flexible training programs for dental
professionals who wish to advance in their dental practice,Offers certified
courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry,
Prosthetic Dentistry, Periodontics and General Dentistry.
The Cosmetic Outcome Of External Dacryocystorhinostomy Scar And Factors Affec...Dr. Jagannath Boramani
Presented by- Dr. Saurabh Dhewale, Co-authors- Dr. Ajit Khune, Dr. Dhiraj Balwir ( Disclosure: Author has no financial interest ) Dr. Vasantrao Pawar Medical College, Nashik.
Now available a new issue !!
Hysteroscopy and cystic adenomyosis, interview with Prof. Osama Shawki, Tamoxifen and hysteroscopy, Postmenstrual vaginal bleeding, endoscopycongress, new devices, and much more
Clinical value of the laparoscopic transabdominal preperitoneal techniqueMohamedTag14
Current guidelines recommend that surgical treatment of recurrent inguinal hernia should avoid the anatomical difficulties caused by the primary surgery, and that the recurrence repair should be done via a different surgical approach to that used during the primary repair.
GEM Hospital Institute of Gastroenterology & Laparoscopy
Temple of LAPAROSCOPY
2017 CALENDAR
Prof. C. Palanivelu
It gives me immense pleasure to introduce 2017 to you with an
immense academic material. GEM has always been the forerunner in laparoscopic training and we are privileged to have trained who are now some of the best, not just in India but outside too.
Laparoscopy is now more standardised and accepted, but at the same time is becoming more challenging too. The days are gone where surgeons used to experiment and learn themselves.
Hence we have evolved with a ALL NEW FORMAT for laparoscopic training, especially giving more HANDS ON EXPERIENCE so that one could get back with more confidence.
All kinds of courses starting from basic laparoscopy to more specialised courses have been designed by the respective departments at GEM. Unlike conferences and training
programs of the past, here the operating room will be where most of your training is bound to happen.
In these training courses you would have opportunity to experience live Laparoscopic surgeries in 4k & 3D
No matter whether you are a General Surgeon or a Specialist Surgical Gastroenterologist or a Surgical Oncologist, laparoscopy is today an integral part of General & GI Surgery.
Go ahead !
www.gemhospital.co.in | info@geminstitute.in
When widespread use of laparoscopy and thoracoscopy in adult patients occurred in the first part of the 1990s, it did not transfer into widespread application in the pediatric population for a number of reasons.
Indian Dental Academy: will be one of the most relevant and exciting training
center with best faculty and flexible training programs for dental
professionals who wish to advance in their dental practice,Offers certified
courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry,
Prosthetic Dentistry, Periodontics and General Dentistry.
The Cosmetic Outcome Of External Dacryocystorhinostomy Scar And Factors Affec...Dr. Jagannath Boramani
Presented by- Dr. Saurabh Dhewale, Co-authors- Dr. Ajit Khune, Dr. Dhiraj Balwir ( Disclosure: Author has no financial interest ) Dr. Vasantrao Pawar Medical College, Nashik.
Now available a new issue !!
Hysteroscopy and cystic adenomyosis, interview with Prof. Osama Shawki, Tamoxifen and hysteroscopy, Postmenstrual vaginal bleeding, endoscopycongress, new devices, and much more
Clinical value of the laparoscopic transabdominal preperitoneal techniqueMohamedTag14
Current guidelines recommend that surgical treatment of recurrent inguinal hernia should avoid the anatomical difficulties caused by the primary surgery, and that the recurrence repair should be done via a different surgical approach to that used during the primary repair.
GEM Hospital Institute of Gastroenterology & Laparoscopy
Temple of LAPAROSCOPY
2017 CALENDAR
Prof. C. Palanivelu
It gives me immense pleasure to introduce 2017 to you with an
immense academic material. GEM has always been the forerunner in laparoscopic training and we are privileged to have trained who are now some of the best, not just in India but outside too.
Laparoscopy is now more standardised and accepted, but at the same time is becoming more challenging too. The days are gone where surgeons used to experiment and learn themselves.
Hence we have evolved with a ALL NEW FORMAT for laparoscopic training, especially giving more HANDS ON EXPERIENCE so that one could get back with more confidence.
All kinds of courses starting from basic laparoscopy to more specialised courses have been designed by the respective departments at GEM. Unlike conferences and training
programs of the past, here the operating room will be where most of your training is bound to happen.
In these training courses you would have opportunity to experience live Laparoscopic surgeries in 4k & 3D
No matter whether you are a General Surgeon or a Specialist Surgical Gastroenterologist or a Surgical Oncologist, laparoscopy is today an integral part of General & GI Surgery.
Go ahead !
www.gemhospital.co.in | info@geminstitute.in
When widespread use of laparoscopy and thoracoscopy in adult patients occurred in the first part of the 1990s, it did not transfer into widespread application in the pediatric population for a number of reasons.
Today, Laparoscopy is an alternative technique for carrying out many operations that have traditionally required an open approach. The benefits of minimal access surgery have been well recorded, including lower post-operative morbidity, shorter duration of hospital stay and a shorter return to work.
Laparoscopic assisted appendicectomy vs laparoscopic appendicectomy-a compara...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Laparoscopic colon resections are being performed with increasing frequency all over the world. However, the use of minimal access surgery in colorectal surgery has lagged behind its application in other surgical fields.
The Role of laparoscopy in the era of ARTDrRokeyaBegum
The advancement of new perspectives in assisted reproductive technology (ART) through the use of modern infertility evaluation technique Stillclinician needs to reassess how infertility should be best treated.
Recently the focus of treatment for infertility has shifted from systematic correction of each identified factor.
Current affairs for UPSC IAS are updated on a daily basis, watch the latest current affairs update on IAS Parliament the best website for your competitive exams. Shankar IAS Academy, South India best IAS academy for UPSC coaching.
The Hindu 17-Jul, 2019 -Prelims, Mains, Q &A ,Analysied by Shankar IAS Academygselva739
Shankar IAS Academy and IAS Parliament analysing the current affairs prelims, mains, with sample question and answer. This articles was published by THE Hindu news paper on 17th Jul, 2019
The Hindu- Civilpedia Articles Analysied by Shankar IAS Academygselva739
Shankar IAS Academy and IAS Parliament analysing the civilpedia articles with sample question and answer. This articles was published by THE Hindu news paper on 15th Jul, 2019
Improve Your Business Payments and Automated Business Testinggselva739
How you can improve your payments business or improve your testing capabilities with automated end-to-end testing before they become business problems with Renovite
2014 January KSN - Matrix Metals Casting Companygselva739
This slides about KSN and matrix metals casting company,
KSN distinguished himself in his long tenure with India Cements, founded by his father, and conceived and guided Chemplast, the flagship of what is now The Sanmar Group.
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2009 july matrix metal casting company - The Changing role of the entrepreneurgselva739
N Sankar’s lecture on entrepreneurship at the Madras Management Association elaborated the changing role of the Indian entrepreneur, cascading down from the early days to present times. Classifying an entrepreneur’s role into four stages - Identification, Organisation, Management and Sustenance of the Enterprise, the lecture caricatured the evolution of entrepreneurship with particular reference to South India.
Matrix Metal casting company - Sanmar Groupgselva739
The Sanmar Foundries’ Unit 2 large flaskless moulding line was commissioned on 26 June 2008 at Viralimalai near Trichy. The sand foundry facilities will now have a capacity of 30,000 tonnes
per annum of steel castings.
Matrix Metals is a leading global supplier of finished steel cast components for the oil/gas, construction and mining, transportation and military sectors.
Mba hospital and health system managment forms & prospectus.SRMC.edugselva739
This 2-year programme in Hospital and Health Systems Management (HHSM), approved by the AICTE, New Delhi, is aimed at producing professional managers skilled in the management of specialized areas in medium to large hospitals, provided by Sri Ramachandra University.
Paramedical health sciences degree programs forms & prospectus 2019, SRMCgselva739
Pharmacy graduates are required to learn and acquire adequate knowledge, necessary skills to practice the profession of pharmacy including thorough and exhaustive knowledge of Pharmacology and therapeutics including mode of action, drug interactions and patient counselling and professional information exchange with physicians and other paramedical personnel. This course is provided by Sri Ramachandra University.
Sri Ramachandra Medical College fee structure and course detailsgselva739
Sri Ramachandra Medical College & Research Institute, ranked among the top health sciences universities in India, had its origin as Sri Ramachandra Medical College and Research Institute which was established by Sri Ramachandra Educational and Health Trust in the year 1985 as a private not-for-profit self-financing institution and dedicated to serve the society as a centre of excellence with emphasis on medical education, research and health care.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. Original Article
LAPAROSCOPY IN PAEDIATRIC SURGERY – OUR EXPERIENCE
AT SRMCPrakash Agarwal*, R.K. Bagdi, S. Balagopal, R. Madhu, P.
Balamourougane
ABSTRACT related complications. Duration of hospital stay was reduced
compared to open appendicectomies due to less post
operative pain and early recovery.
a) Aim of the study: To review the current status
of laparoscopic surgery at Sri Ramachandra Medical
College Hospital (SRMCH), a paediatric tertiary care
centre in Chennai. We highlight our experience in
terms of feasibility, safety cost effectiveness and effect
on standard practices.
d) Discussion: Laparoscopic appendicectomy is still
the most common emergency operation performed
laparoscopically. Diagnostic laparoscopy was the second
largest group in our series. Initial results at our institution
are very encouraging and comparable to international
literature meta-analysis. We feel laparoscopic procedures
are safe for a wide range of indications in children. In
our child health care centre they account for all appendicectomies,
diagnostic laparoscopies, female herniotomies and few advanced procedure.
Although laparoscopic procedures have gained an integral place in
paediatric surgery and
are relatively safe, advanced laparoscopic procedures
should be developed, practiced and evaluated in
dedicated surgical units to ensure a broad base of
experience on which to base future decisions and
guidelines.
b) Methodology: It is a retrospective case series study.
All patients who were admitted to Paediatric Surgery at
SRMCH and underwent laparoscopic surgery were included
in the study group. We reviewed the literature in comparison
to our results.
c) Results: 25 cases were operated in a span of 9 months,
majority of the cases were appendicectomies followed by
diagnostic laparoscopy. We had only one case converted to
open.
The mean operating time was 65 minutes, median post
operative stay of 2.3 days for lap appendicectomies and
there were no intra operative or post operative procedure
Key words : Laparascopy, appendicitis, child
INTRODUCTION advances in miniaturised instrumentation, laparoscopy’s
place in the modern paediatric surgical armamentariumhas
finally become accepted.
One of the significant changes in medical practice that
has evolved gradually during the last three decades is the
reduction of the traumatic insult inevitable and incidental
to surgical interventions.
In the USA, it is estimated that 82% of paediatric
surgeons perform laparoscopic surgery.8
Thequestion is no
longer whether laparoscopic surgery should be done in
children, but what conditions should be treated
laparoscopically.
Laparoscopic surgery in children is not new. Paediatric
surgeons were among the pioneers of laparoscopic surgery
in the early1970s,1
but the vast potential of this “minimally
invasive”approach to treat children with surgical conditions
has only recentlybegun to be realised. For over three
decades,
paediatric laparoscopywas restricted mainly to diagnostic
use. In the early 1990s, an explosive expansion of
laparoscopic surgery occurred in adults as a result of the
success of laparoscopic cholecystectomy (1)
.
HOW IS LAPAROSCOPIC SURGERY DIFFERENT IN
CHILDREN?
It is important to recognize that in infants and small
children, the surface area for access is small, the abdominal
wall is thin and compliant, the liver margin is below the
rib cage, the bladder is largely an intra-abdominal structure,
the viscera is close to the anterior abdominal wall and the
abdominal cavity is small. In small infants, 400ml CO2
may be required to establish, a pneumoperitoneum. The
so-called obliterated structures, umbilical vein and arteries,
and urachus remain relatively large and partially patent in
infants.
Nevertheless, interest in laparoscopic surgery in children
remained confined to a few enthusiasts initially,2-4
while
the rest of the paediatricsurgical community adopted a
“wait
and see” attitude. More recentlyhowever, with increasing
experience in paediatric laparoscopic procedures,5-7
and
These anatomical characteristics make access and
manipulation in the younger age group a more demanding
and difficult task when compared to grown up children or
adults. On the other hand, young children have well-
defined anatomical landmarks due to lack of excess fat,
making recognition and dissection of structures a relatively
easy task.
CORRESPONDING
ADDRESS
*Dr. PRAKASH AGARWAL
Asst. Professor,
Dept. of Paediatric Surgery
SRMC & RI (DU)
Porur, Chennai-600116.
email: agarwal_prakash@hotmail.com
ꢀSri Ramachandra Hospital is one of the private best multispecialty hospital in Chennai, India
2. Original Article
OUR EXPERIENCE AT
SRMC:
in the placement of 3 ports for most of the laparoscopic
surgeries in compliance with the ergonomics of laparoscopic
surgery. Appendicectomy being the commonly performed
procedure in our department (73%), we have standardized
the procedure and follow the same principle in all cases.
Keeping in pace with demand for Paediatric
laparoscopy we started laparoscopic surgery in our
department in 2005. With the available infrastructure, we
made a modest start and within a span of 9 months had
26 cases of laparoscopy done in paediatric age group
(Table-1). Our youngest child was 8 months old and
oldest child was 18 years old. The cases ranged
commonly
from appendicectomies (73%) to diagnostic laparoscopy
(19%), intrabdominal lymph node biopsies, ovarian cyst
removal etc.
We use 3 ports inserted at the infraumbilical,
suprapubic and left iliac fossa. After skeletonising the
appendix, we pass 2 endoloops for ligating the appendix at
the base and do an appendicectomy in between the 2
endoloops. The appendix is usually removed by the
infraumbilical port. The wound at the umbilicus is closed
in layers and the rest of the wound are closed only at the
skin level. Of all the cases we had to convert to open
laparotomy in one case where the appendix had necrosed
and the patient had fecal peritonitis as a result of sloughing
of the appendix in entirety.
We usually prefer the open Hasson’s technique of first
umbilical port insertion in children as it is done under vision
and considered safe in children.
We tend to follow the principle of “triangularisation”
Table 1. shows an analysis health care of the children who underwent laparoscopic surgery for various reasons - at SRMC hosp
from 2005 till date.
TABLE -1. (n=26)
ANALYSIS OF CHILDREN WHO UNDERWENT LAPAROSCOPIC
SURGERY
Sl.No Name Age Sex Diagnosis Procedure
1. M
RR
K
12
14
7
F
F
AC APPENDICITIS LAP APPENDIX
2. AC APPENDICITIS LAP APPENDIX
3. M
F
MESENTERIC LYMPHADENOPATHY
AC APPENDICITIS
LAP LYMPH NODE BIOPSY
LAP APPENDIX4. SS
SS
G
B
15
10
14
1
5. F AC APPENDICITIS LAP APPENDIX
6. M
M
F
AC APPENDICITIS LAP APPENDIX
7. LEFT NON PALPABLE TESTIS
PERFORATED APPENDIX
PERFORATED APPENDIX
AC APPENDICITIS
DIAG LAP WITH LEFT ORCHIDECTOMY
LAP CONVERTED TO OPEN
LAP APPENDIX
8. S 13
89. D
RN
JE
M
M
M
F
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21
22
23
24
25
26
10
8
LAP APPENDIX
REC. APPENDICITIS LAP APPENDIX
S 8 REC APPENDICITIS LAP APPENDIX
P 16
15
F AC APPENDICITIS LAP APPENDIX
SF
T
F LEFT OVARIAN TUMOR LEFT OVARIECTOMY
DIAG LAP – OPEN CHOLECYSTECTOMY
LAP APPENDIX
8 MTHS M SUB HEPATIC CYST- CYSTIC DUCT PERF.
G
M
SS
LA
L
12
3
M
F
ACUTE APPENDICITIS
B/L INGUINAL HERNIA
ACUTE APPENDICITIS
ACUTE APPENDICITIS
TB ABDOMEN
B/L LAP HERNIOTOMY
LAP APPENDIX15
18
16
1 ½
9
F
F LAP APPENDIX
F DIAGNOSTIC WITH BIOPSY
DIAGNOSTIC LAP
LAP APPENDIX
KV
A
M
M
F
HIRSCHSPRUNG’S DISEASE
ACUTE APPENDICITIS
ACUTE APPENDICITS
ACUTE APPENDICITIS
ACUTE APPENDICITIS
ACUTE APPENDICITIS
E 9 LAP APPENDIX
DP
AK
N
10
12
16
F LAP APPENDIX
F LAP APPENDIX
F LAP APPENDIX
Sri Ramachandra Journal of Medicine Vol. 1 Issue 1 September 2006 Nꢀꢀ25
3. Original Article
One of our patient who had fecal peritonitis and had to be
converted to open appendicectomies had wound infection
and fecal fistula. She had her total appendix sloughed out
and stump blow out at the cecum. No other patient had
wound infection. All the patients recovered early, had less
post-operative pain and returned to school early compared
to open appendicectomy group.
post operative period, but also may become chronic.
Hypertrophic scars also may become a source of annoyance
causing pain, parasthesia and itching. Hypothermia and
desiccation of tissues are other adverse effects more
prominently noticed in open surgery.
Creation of pneumoperitoneum and extremes of patient
position, pose challenges to paediatric anesthesiologists in
laparoscopy. An ideal insufflating gas should have minimum
physiologic effect, should be absorbed minimally, excretion
should be rapid, should have high blood solubility and should
be non-combustible. Rarely, complications arise from CO2
insufflation for pneumoperitoneum during laparoscopy.
These include gas embolism, cardiovascularcompromise,
hypercapnia. The risks are minimised by the use of low
While the costs of performing laparoscopic surgery per
se was found to be higher compared to open surgery
however, all the parents expressed satisfaction post
operatively.
pressure CO insufflation in children. Intrabdominal pressure2
(IAP) up to 12 mm Hg has minimal effects on cardiac output
but IAP levels > 15 mm Hg are not well tolerated. Elevated
IAP shifts the diaphragm upwards and reduces its excursions.
Slight increases inend tidal CO and peak airway pressures2
might be detectable intraoperatively. This can usually be
compensated for by slight hyperventilation.9
Laparoscopy in children have been shown to have
distinct advantage over the traditional open methods in
causing less post-operative pain and wound complications,
faster recovery as well as shorter hospital stay. This
decrease
in morbidity could be attributed to smaller access wound,
hence less fascia, muscles, nerves being transected and
reduced water and heat loss10-11
Fig. 1 : Photograph showing
Laparosocpic
appendicectomy in progress
In our study group though the cost of laparoscopic
surgery is marginally higher than open surgery, but taking
all the factors (e.g.: reduced analgesia requirement, less
hospital stay, early return to school) into consideration, the
cost may be same compared to open surgery.
Operating time was more than open surgeries.
Comparatively we feel operating time may be reduced in
cases of retrocecal or complicated appendicitis. Finding
and
dealing with a buried or retrocecal appendix will be less
time consuming and less traumatic laparoscopically than
by open method. We feel laparoscopy is a very important
tool when the diagnosis is not certain.In a Meta analysis report by Aziz O et al 12
, they
compared studies published between 1992 and 2004 of
laparoscopy versus open appendicectomy in children. 23
studies including 6477 children (43% laparoscopic and 57%
open were included. They report suggests that laparoscopic
appendicectomy in children is associated with less wound
infection than open appendicectomy (1.5% Vs.
5%)Operative time was not significantly longer in the
laparoscopic group, and post-operative stay was significantly
shorter. This study results are comparable to ours.
Fig. 2 : Photograph showing
Laparoscopic ovariectomy in
progress
DISCUSSION:
The traditional Hippocratic ethos provides the
background of the idea that the less invasive the procedure,
the better. In conditions in which the body wall itself is not
affected, it is a pity that the body wall must be opened in a
classic open surgery. Body wall related complications do
occur, for example infection dehiscence and incisional
hernia. Even in the absence of body wall complications,
opening of the body wall results in morbidity. The larger
the wound, the more fascia, muscles and nerves are
transected and more morbidity can be expected. Pain related
to access trauma may not only be limited to the immediate
Incidence of postoperative adhesions is also reduced13
.
Due to magnification and good illumination, endoscopic
surgery gives a much better view of the operative field than
open surgery. This is particularly true in the pelvis and
cardiac
end of the oesophagus.
ꢀSri Ramachandra Master Health Checkup | Best Cardiac Hospital for Open heart Surgery
4. Original Article
Paediatric laparoscopy is here to stay. It has already
invaded the surgical domain. Therefore it would be prudent
for all of us not to be endoresistant. “Key hole surgery
revolution’’ has begun. Laparoscopic cholecystectomy and,
to an extent lap appendicectomy have become patient
demand operations and surgeons would lose patients if
they
cannot deliver the ‘keyhole’ approach.
4. Najmaldin A. Minimal access surgery in paediatrics.
Arch Dis Child 1995, 72:107-09
5. Lobe T. Laparoscopic surgery in children. Curr Probl
Surg 1998, 35:862-48.
6. Rothenberg SS, Chang JHT, Bealer JF. Experience
with minimally invasive surgery in infants. Am J Surg 1998,
176:654-58
LONG TERM
OBJECTIVES:
7. Chung DH and Georgeson KE. Fundoplication and
gastrostomy. Semin Pediatr Surg 1998, 7:213-191. Recognize the common pediatric conditions that may
be treated with minimally invasive surgery 8. Firilas AM, Jackson RJ, Smith SD. Minimally invasive
surgery: the pediatric surgery experience. J Am Coll Surg
1998, 186:542-44
2. Prospective randomizedclinical trials of laparoscopic
surgery in infants with miniaturized instruments.
9. Tobias JD. Anesthetic considerations for laparoscopy
in children. Semin Laparosc Surg 1998, 5:60-66ACKNOWLEDGEMENT
S:We wish to acknowledge with thanks the help and
support offered by the management in setting up
Paediatric
Minimally invasive services in the department of Paediatric
Surgery. We also wish to thank the department of
Anesthesiology for their help and preparedness to
anaesthetize all our patients who underwent laparoscopy.
10. Bessell JR, Karatassas A, Patterson JR et al.
Hypothermia induced by laparoscopic insufflation.
A randomized study in pig model. Surg. Endosc. 1995,
9:791-96.
11. Mansvelt B, Arnould P, Bertrand C et al. Utilization
of gas heater humidifier in the course of colioscopies.
Acta Chir. Belg. 1995, 95:100-02.REFERENCE
S: 12. Aziz O, Athanasiou T, Tekkis PP et al. Laparoscopic
versus open appendectomy in children: a meta-analysis.
Ann Surg. 2006, 243:17-27.
1. Gans SL and Berci G. Advances in endoscopy of
infants and children. J Pediatr Surg 1971, 6:199-33
2. Sackier JM. Laparoscopy in pediatric surgery. J
Pediatr Surg 1991, 26:1145-47 13. Jorgenson JO, Lalak NJ, Hunt DR. Is laparoscopy
associated with lower rate of pot-operative adhesions
than laparotomy? A comparative analysis in the rabbit.
Aust. NZ. J. Surg. 1995, 65:342-44.
3. Miller SS. Laparoscopic operations in paediatric
surgery. Br J Surg 1992, 79:986-87
Sri Ramachandra Journal of Medicine Vol. 1 Issue 1 September 2006 Nꢀꢀ27