1. The document discusses necessary institutional and organizational changes to implement ICT in chronic disease management from the perspective of Tuscany Region in Italy. 2. It outlines where Tuscany currently stands in terms of health performance and rates of chronic disease. New needs are emerging for patients, healthcare workers, and institutions. 3. Functional changes already made include agreements with general practitioners and specialists and establishing 100 Functional Territorial Aggregations across the region. Structural changes proposed include increasing primary healthcare centers to one per municipality. 4. An ICT-based disease registry and telemedicine network connecting all healthcare facilities and providers is presented as a holistic model to help manage chronic diseases in an integrated manner across the region