SENERGY was founded in 2014 with the goal of providing a complete solution for Internet of Things technology. We offer a variety of different IoT technologies, such as energy management, data management and more. Our mission is to help our clients save money and increase efficiency by utilizing our cutting-edge IoT solutions.
Green buildings : Challange in Operation and MaintenanceTejwant Navalkar
The paper looks at the existing maintenance practices with some telling pictures and goes on to suggest changes in the approach to maintenance in line with the Green Building requirements.
A brief insight of what goes to make a building green is given to put the challenges in Operation and Maintenance in proper perspective.
Green buildings : Challange in Operation and MaintenanceTejwant Navalkar
The paper looks at the existing maintenance practices with some telling pictures and goes on to suggest changes in the approach to maintenance in line with the Green Building requirements.
A brief insight of what goes to make a building green is given to put the challenges in Operation and Maintenance in proper perspective.
Power System Operation and Control- Module 1Ansho Anto
1.Power Scenario in Indian Grid
2.Growth of Electricity Consumption
3.NLDC & RLDC
4.Speed Governor
5.Regulation of two generators in parallel
6.Load forecasting and its classification
7.Unit commitment and its constraints
8.Load Scheduling/Load dispatching
The Secret to Controlling Excessive Energy Consumption & CostAffinity Energy
Complex utility rate structures like peak demand rates, low power factor penalties, and time-of-use charges plague industrial owners and operators. Extremely volatile energy usage suggests the management of high energy costs is a necessary evil.
Unfortunately, few systems are in place to monitor and control energy usage, which leads to company-wide inefficiency and spikes in operational costs. By examining a manufacturing case study, discover how a modified control sequence allowed operators to initiate automated energy conservation modes to manage consumption and eliminate excessive spikes during peak demand.
Learn to implement conservation control strategies through an industrial power management system, identify power quality inefficiencies that lead to additional manufacturing costs, and optimize facility operation by adjusting equipment set points, processes, and production schedules in relation to utility tariffs.
Power System Operation and Control- Module 1Ansho Anto
1.Power Scenario in Indian Grid
2.Growth of Electricity Consumption
3.NLDC & RLDC
4.Speed Governor
5.Regulation of two generators in parallel
6.Load forecasting and its classification
7.Unit commitment and its constraints
8.Load Scheduling/Load dispatching
The Secret to Controlling Excessive Energy Consumption & CostAffinity Energy
Complex utility rate structures like peak demand rates, low power factor penalties, and time-of-use charges plague industrial owners and operators. Extremely volatile energy usage suggests the management of high energy costs is a necessary evil.
Unfortunately, few systems are in place to monitor and control energy usage, which leads to company-wide inefficiency and spikes in operational costs. By examining a manufacturing case study, discover how a modified control sequence allowed operators to initiate automated energy conservation modes to manage consumption and eliminate excessive spikes during peak demand.
Learn to implement conservation control strategies through an industrial power management system, identify power quality inefficiencies that lead to additional manufacturing costs, and optimize facility operation by adjusting equipment set points, processes, and production schedules in relation to utility tariffs.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
In silico drugs analogue design: novobiocin analogues.pptx
Oxygen Solution for Hospitals
1. SEnergy Application for Process Monitoring - Case Study for Monitoring & Controlling the Process of
Oxygen Generation executed thru SEnergy
Location - A Multispeciality Hospital in India
Situation Task
Result Action
• Cost of energy spent for per unit measure of oxygen generated was
unknown
• Steep increase in overall energy usage
• Unable to quantity the Oxygen Generator’s energy consumption
• Root cause of supply disturbance unidentified
• Consumption of Oxygen unknown
• Oxygen pressure and its leakages remain as blind spots
• Cost of Oxygen Generated has been quantified
• Customer able to manage the power demand vs load properly
• Timely cutoff of the equipment eliminating the energy
wastage due to continuous run
• Ensured efficient operation of oxygen generator, by eliminating
wastage of oxygen generated
• Identified and corrected load imbalances and blind spots
• Curbed Unnecessary Usage
• Overall Target bill reduced by 30%
• Obviated need for frequent and expensive energy audits
• Measure various electrical parameters of the equipment
• Identify distribution imbalances, Consumption and
leakages
• Measure & alert users about threshold breaches in real
time
• Improve maintainability
• Get into the process and identify blind spots
• Monitor and Control quantity and pressure of the oxygen
supplied
• Mandate to Reduce Energy Consumption
• Supplied and Installed
▪Smart Oxygen Flow meter and networked with SEnergy Cloud
▪Smart Multi function electrical meters on feeding DB of the oxygen
generator and networked with SEnergy Cloud
• Analyzed Consumption, usage and wastage pattern and Provided
periodical visual analytics and reports
• Quantified Peak and Off-Peak consumption
• Provided real time alerts of energy and power quality metrics
• Isolated and alerted on abnormalities
• Suggestions Made to enhance the performance and efficiency
• Arrest the leakage in the delivery pipelines and valves
• Redesign / retune the generator such that equipment cuts off,
o there is no consumption
o desired quantity of oxygen at required pressure is stored in
the tank