Osteomyelitis is an infection and inflammation of bone that can be caused by bacteria or mycobacteria. The most common treatments are surgery to remove infected or dead bone portions followed by antibiotics administered either intravenously in the hospital or orally at home. For chronic osteomyelitis, treatment often requires a combination of long-term antibiotics and additional surgeries such as removing infected tissue or bone, draining pus, or amputating the affected limb if the infection has spread. Hyperbaric oxygen therapy may help some acute or chronic cases that do not respond to usual treatments by delivering high oxygen levels to promote healing, but more evidence is still needed on its effectiveness.